Crystals in my liquid orals (help)

[lee_marvin]

I just made a batch of liquid femara. I bought a gram, and dumped it into an empty rubbing alcohol bottle, and filled it with Bacardi 151 (yum). Now there is still white powder (crystals) in the bottom. I have never really made liquid stuff before, and I m wondering if I should have dissolved the fem in BA or BB first. What can I do to prevent this? I used 1 gram of fem, and 250 mls of 151 (for a 4mg/ml product). Where did I go wrong?

 

[Bignick]

try heating it up, maybe in the microwave for second or even on the stove......it should take the crystals out.

 

[brew]

Bro you didn't do anything wrong, you just went a little high in the mg/ml department. If you want it cyrstal clear then dilute it down to where its 2-2.5 mg/ml. I have used jsut about every carrier I know of and fem is a bitch to get much higher than 2.5. 4 would have worked with PG but not 151. Nick is right, a little LOW heat will help speed it up, Iwouldn't advise the microwave though.

 

[Presser]

fem is one of the easiest of all anti-es to dissolve isnt it? i do beleiev so ( i'll answer my own question thank you,lol) Now tamox is a bitch,, and dont use pg that shit is worse then grain alcohol,lol

all in all its just a matter of adding some solvent and heating a bit as "punky Brew-ster" here said

 

[brew]

press its 'easy' because most of use make it in the 1-2.5 range. for that everclear works like a champ, Also take into consideration that 151 isn't quite the solvent that everclear is, its close but alittle lighter on the alcohol percentage. Even your better solvents like PG and such won't hold much above that. I got some 5mg/ml in Peg300 now and it won't all go into solution, its more of a suspension.

 

[lee_marvin]

So what would you reccomend over 151? I can't get everclear. Should I use PEG? I microwaved my femara for 30 seconds. It is now crystal free, but I'm thinking I might've nuked it.
Thoughts?

 

[Bignick]

microwave has never steered me wrong.....one time i did forget to take the damn lid off of the dropper.....kaboom! Yeah that was a retarded move i know

 

[brew]

yeah that happened to me once, and the other time it was running over the top. Neither was a bright move on my part but you live and you learn, lol.

 

[lee_marvin]

Cool. Thanks guys. I'm looking to make a bunch of liquid oral stuff now. How much do I need to shake my stuff for accurate dosing (in 151)?

 

[brew]

just give it a good shake untill all the powder is suspeneded. This will get you close, but I wouldn't call it accurate. For that I would bring up the volume with alcohol until I was at the 2 or 2.5 mg mark, it should be 100% dissolved at the point.

 

[lee_marvin]

Also, I don't understand why it would be so difficult to dissolve one drug at 2.5 mg/ml, and easy for another at 50mg. Just because femara works at 2.5mg a day, should really have nothing to do with its suspension in alcohol. I don't understand...

 

[brew]

Also, I don't understand why it would be so difficult to dissolve one drug at 2.5 mg/ml, and easy for another at 50mg. Just because femara works at 2.5mg a day, should really have nothing to do with its suspension in alcohol. I don't understand...

well bud, wihtout getting to technical into this, each hormone will have a different solubility in each solvent. Chemical structure, bonding affinity, etc... will play a role to determine the highest concertation at which a true solution can be held. I did a quick search this morning and couldn't find the exact solubilities in the solvents I wanted, but this should give you and idea of what I mean. Lets compare fem and a-dex, here is a little cut and paste

Letrozole

Chemical Name: 4,4’ -(1H-1,2,4-Triazol-1-ylmethylene)dibenzonitrile
Empirical Formula: C17H11N5
Molecular Weight: 285.31 amu
Melting Range: 184-185 °C
Therapeutic Category: Anti-cancer
Solubility: Freely soluble in chloroform, slightly soluble in methanol, practically insoluble in water.

Now to A-dex
Its molecular formula is C17H19N5 Anastrozole is an off-white powder with a molecular weight of 293.4. Anastrozole has moderate aqueous solubility (0.5 mg/mL at 25°C); solubility is independent of pH in the physiological range. Anastrozole is freely soluble in methanol, acetone, ethanol, and tetrahydrofuran, and very soluble in acetonitrile

Just look at each compounds solubility in methanol. Dex is freely soluble and fem partialy. Same with water. It goes back to the bonding affinity and stucture of the compounds. I'm not as educated in chem as I would like to be, but if I remember right I would attribute this to femara's doublebonded carbon atoms. As you can see form the formula fem has 8 less hydrogen
atoms, indicating 4 double bonds more than dex. These double bonds are harder to break and thus would limit its solublity. Hope this example helps

 

[lee_marvin]

Where did you find that info? Do you have info like that for all drugs? Wow. Is that from the Merck index?

 

[BiggerStronger]

You can get some info on different pharmaceuticals from rxlist.com