Results 1 to 14 of 14

Thread: GHRP-2 vs GHRP-6 vs Ipamorelin...Which to use and Why

  1. #1
    Registered Member mike ross's Avatar
    Join Date
    Jan 2011
    Location
    PA and FL
    Posts
    852
    Credits
    0
    Thanks (Given)
    0
    Thanks (Received)
    0
    Likes (Given)
    16
    Likes (Received)
    37
    Dislikes (Given)
    0
    Dislikes (Received)
    0
    Rep Power
    1093081

    Default GHRP-2 vs GHRP-6 vs Ipamorelin...Which to use and Why



    IGF-1 Sale!
    GHRP-2

    Growth-Hormone-Releasing-Peptide-Two (GHRP-2) is a synthetic ghrelin analogue. It causes the release of endogenous (internal) Growth Hormone (GH) from somatotropes in the anterior pituitary gland. It works synergistically with GHRHs and lacks the lipogenic properties (fat creation/storage) of ghrelin. GHRP-2 excites the hypothalamus and causes a high release of GH which tapers back to baseline by the third hour post admin. This pulse closely represents that of the natural pulse of the human body giving it an advantage over synthetic GH use.


    Benefits and Potential of GHRP-2


    Similar to Ipamorelin, GHRP-2 has great benefit and potential in athletes and wellness. GHRP-2 has been studied and shown to be effective in treating age-related GH decline when used in combination with a GHRH such as CJC-1295. GHRP-2 when use with an equal dose of a GHRH creates a 3-hour pulse of GH that is double the amplitude of 8IU of synthetic GH. This makes it a more effective, healthier substitute to synthetic Growth Hormone with the added safety and lower cost benefits.




    GHRP-6


    Growth-Hormone-Releasing-Peptide-6 (GHRP-6) is a Growth Hormone (GH) secretagogue and ghrelin mimetic.


    The peptide GHRP-6 works similarly to GHRP-2 and Ipamorelin, however it induces hunger consistently in mammals. It also does have some lipogenic properties that are dependent on the status on insulin and glucose. GHRP-6 may cause weight and adipose tissue gain if insulin is present. So don't eat for 30 mins post injection, nothing, nada. You'll be starving but dont eat.


    Benefits and Potential of GHRP-6


    Again, similar to GHRP-2 and Ipamorelin, GHRP-6 has many benefits and uses. Due to the increased GH release, the following benefits may be observed:


    Increased Energy
    Improved Sleep
    Increased Lean Body Mass
    Decreased Body Fat
    Increased Collagen Production
    Increased Healing Capability



    Ipamorelin


    Ipamorelin or NNC 26-0161, a polypeptide hormone, is a growth hormone secretagogue and ghrelin mimetic and analog developed by Novo Nordisk[3]. Ipamorelin belongs to the most recent generation of GHRPs from the mid 1990s and causes significant release of growth hormone by itself, due both to its suppression of somatostatin (an antagonist to GHRH) and stimulation of release of GH from the anterior pituitary, similar to GHRP-2 and GHRP-6 which are compounds from the same class (growth hormone releasing peptides).[1] The cells that produce and release GH are known as somatotropes.[2] Like GHRP-2, ipamorelin does not have ghrelin’s lipogenic properties. Like GHRP-2 and unlike GHRP-6 ipamorelin never induces hunger in mammals. Ipamorelin acts synergistically when applied during a native GHRH (growth-hormone releasing hormone) pulse or when coadministered with GHRH or a GHRH analog such as Sermorelin or GRF 1-29 (growth releasing factor, aminos 1-29).[1] The synergy comes both due to the suppression of somatostatin and the fact that ipamorelin increases GH release per-somatotrope, while GHRH increases the number of somatotropes releasing GH.[1,2] There is also a secondary effect of neuronal excitation in the hypothalamus caused by ipamorelin, which lasts for approximately 3 hours after application, similar to GHRP-2 and GHRP-6.


    Ipamorelin has a unique property among the GHRP class of peptides. That property is known as selectiveness. Whereas GHRP-6 and GHRP-2 cause a release and increase in cortisol and prolactin levels, ipamorelin only selectively releases GH at any dose. Further, a mega-dose of ipamorelin results in a concomitant mega-release of GH (up to the entire amount present in the pituitary), whereas GHRP-2 and GHRP-6 have limits of approximately 1mcg/kg in humans for their maximal GH release.[4,5]



    Now comes some scientific study info. If you cant follow it, just as i'll translate it for you...



    Raun et al demonstrated the selectiveness of ipamorelin for GH release only in a study:
    The development and pharmacology of a new potent growth hormone (GH) secretagogue, ipamorelin, is described. Ipamorelin is a pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2), which displays high GH releasing potency and efficacy in vitro and in vivo. As an outcome of a major chemistry programme, ipamorelin was identified within a series of compounds lacking the central dipeptide Ala-Trp of growth hormone-releasing peptide (GHRP)-1. In vitro, ipamorelin released GH from primary rat pituitary cells with a potency and efficacy similar to GHRP-6 (ECs) = 1.3+/-0.4nmol/l and Emax = 85+/-5% vs 2.2+/-0.3nmol/l and 100%). A pharmacological profiling using GHRP and growth hormone-releasing hormone (GHRH) antagonists clearly demonstrated that ipamorelin, like GHRP-6, stimulates GH release via a GHRP-like receptor. In pentobarbital anaesthetised rats, ipamorelin released GH with a potency and efficacy comparable to GHRP-6 (ED50 = 80+/-42nmol/kg and Emax = 1545+/-250ng GH/ml vs 115+/-36nmol/kg and 1167+/-120ng GH/ml). In conscious swine, ipamorelin released GH with an ED50 = 2.3+/-0.03 nmol/kg and an Emax = 65+/-0.2 ng GH/ml plasma. Again, this was very similar to GHRP-6 (ED50 = 3.9+/-1.4 nmol/kg and Emax = 74+/-7ng GH/ml plasma). GHRP-2 displayed higher potency but lower efficacy (ED50 = 0.6 nmol/kg and Emax = 56+/-6 ng GH/ml plasma). The specificity for GH release was studied in swine. None of the GH secretagogues tested affected FSH, LH, PRL or TSH plasma levels. Administration of both GHRP-6 and GHRP-2 resulted in increased plasma levels of ACTH and cortisol. Very surprisingly, ipamorelin did not release ACTH or cortisol in levels significantly different from those observed following GHRH stimulation. This lack of effect on ACTH and cortisol plasma levels was evident even at doses more than 200-fold higher than the ED50 for GH release. In conclusion, ipamorelin is the first GHRP-receptor agonist with a selectivity for GH release similar to that displayed by GHRH. The specificity of ipamorelin makes this compound a very interesting candidate for future clinical development.[3]



    Cititations:
    [1] Bowers CY, Momany F, Reynolds GA. In vitro and in vivo activity of a small synthetic peptide with potent GH releasing activity. 64th Annual Meeting of the Endocrine Society, San Francisco, 1982, p. 205.
    [2]Bowers CY, Momany F, Reynolds GA, Sartor O. Multiple receptors mediate GH release. 7th International Congress of Endocrinology, Quebec, Canada, 1984, p. 464.
    [3] Raun K, Hansen BS, Johansen NL, Thøgersen H, Madsen K, Ankersen M, Andersen PH. Ipamorelin, the first selective growth hormone secretagogue. Eur J Endocrinol. 1998 Nov;139(5):552-61.
    [4] Brosnan-Cook, M. et al. (1998) Iontophoretic delivery of ipamorelin, a growth hormone secretagogue. Proceedings of 80th Annual Meeting Endocrine Society, New Orleans, USA. Abstract Pp1-186.
    [5] Jogarao V S Gobburu; Henrik Agerso; William J Jusko . Pharmacokinetic-Pharmacodynamic Modeling of Ipamorelin, a Growth Hormone Releasing Peptide in Human Volunteers. Lars Ynddal Pharmaceutical Research: Sep 1999; 16, 9; ProQuest Nursing & Allied Health Source p. 1412.


    I've included my citations from the articles i've studied. Ive read hundreds of articles on the peptides but this is just what ive used for the Ipam stuff


    See why i always suggest Ipam to everyone, yet no one wants to try it. The GH benefits with it are tremendous.
    Likes Jewelz, eswol liked this post
     


    For the highest quality proteins and supplements visit Rxwhey.com and support your board sponsors

    Like us on Facebook to receive exclusive deals, tips, and other fitness related news

  2. #2
    Registered Member mike ross's Avatar
    Join Date
    Jan 2011
    Location
    PA and FL
    Posts
    852
    Credits
    0
    Thanks (Given)
    0
    Thanks (Received)
    0
    Likes (Given)
    16
    Likes (Received)
    37
    Dislikes (Given)
    0
    Dislikes (Received)
    0
    Rep Power
    1093081

    Default Chart Ive made as a cheat sheet for my clients

    Comparison Chart for GHRP’s




    Name
    Work with GHRH
    Better than Synthetic GH
    Stimulates Hunger
    Stimulate Possible Fat Storage
    Raise ACTH, Cortisol, Prolactin Levels


    GHRP- 2


    Yes


    Yes


    No


    No


    Yes












    GHRP-6
    Yes
    Yes
    Yes
    Yes
    Yes












    Ipamorelin
    Yes
    Yes
    No
    No
    No
















    All GHRP’s Have the Following Benefits:



    • Increased energy
    • Improved sleep and mood
    • Increased lean muscle mass
    • Decreased body fat
    • Increased healing ability
    • Increased collagen production
    • No marked effect on FSH, LH, or TSH plasma levels



    * For best results use with GHRH’s such as CJC-1295
    Likes BEASTZ6 liked this post
     


    For the highest quality proteins and supplements visit Rxwhey.com and support your board sponsors

    Like us on Facebook to receive exclusive deals, tips, and other fitness related news

  3. #3
    MuscleChemistry member nuknuk's Avatar
    Join Date
    May 2008
    Age
    34
    Posts
    6,298
    Credits
    313
    Thanks (Given)
    0
    Thanks (Received)
    0
    Likes (Given)
    158
    Likes (Received)
    308
    Dislikes (Given)
    0
    Dislikes (Received)
    0
    Rep Power
    158490191

    Default

    love this post!!!
    Sponsored by ---

  4. #4
    Musclechemistry Site Representative Buffalo's Avatar
    Join Date
    Mar 2012
    Age
    34
    Posts
    4,095
    Credits
    8,595
    Thanks (Given)
    46
    Thanks (Received)
    35
    Likes (Given)
    817
    Likes (Received)
    833
    Dislikes (Given)
    0
    Dislikes (Received)
    0
    Rep Power
    51148591

    Default

    Printed it out. This one is great!!!

  5. #5
    Musclechemistry Site Representative Buffalo's Avatar
    Join Date
    Mar 2012
    Age
    34
    Posts
    4,095
    Credits
    8,595
    Thanks (Given)
    46
    Thanks (Received)
    35
    Likes (Given)
    817
    Likes (Received)
    833
    Dislikes (Given)
    0
    Dislikes (Received)
    0
    Rep Power
    51148591

    Default

    Is the rise in prolactin and cortisol in the GHRP's dose related or cycle length related?

    What would you recommend for a IPAM cycle?

    This is good stuff. I can't afford GH but I'm excited to see the benefits of running IPAM.

  6. #6
    MuscleChemistry Registered Member The Dude's Avatar
    Join Date
    Aug 2009
    Posts
    7,237
    Credits
    4,487
    Thanks (Given)
    0
    Thanks (Received)
    21
    Likes (Given)
    671
    Likes (Received)
    1043
    Dislikes (Given)
    0
    Dislikes (Received)
    0
    Rep Power
    51550844

    Default

    I just alternate them. I like GHRP 2 the best. For some reason I see and feel the most benefit from it with CJC. IPAM made me a little tighter and GHRP 6 made me a little softer... probably from pigging out more
    The Dude Abides

  7. #7
    Registered Member mike ross's Avatar
    Join Date
    Jan 2011
    Location
    PA and FL
    Posts
    852
    Credits
    0
    Thanks (Given)
    0
    Thanks (Received)
    0
    Likes (Given)
    16
    Likes (Received)
    37
    Dislikes (Given)
    0
    Dislikes (Received)
    0
    Rep Power
    1093081

    Default

    Quote Originally Posted by Buffalo View Post
    Is the rise in prolactin and cortisol in the GHRP's dose related or cycle length related?

    What would you recommend for a IPAM cycle?

    This is good stuff. I can't afford GH but I'm excited to see the benefits of running IPAM.
    both...after 90 days the body has it figured out so you just come off for a brief period, then hop right back on.

    For the IPAM cycle, use cjc with it and the dose is the same as the ghrp 2 or 6 for the most part. start at 250mcg and go up from there


    For the highest quality proteins and supplements visit Rxwhey.com and support your board sponsors

    Like us on Facebook to receive exclusive deals, tips, and other fitness related news

  8. #8
    MuscleChemistry Registered Member The Dude's Avatar
    Join Date
    Aug 2009
    Posts
    7,237
    Credits
    4,487
    Thanks (Given)
    0
    Thanks (Received)
    21
    Likes (Given)
    671
    Likes (Received)
    1043
    Dislikes (Given)
    0
    Dislikes (Received)
    0
    Rep Power
    51550844

    Default

    Quote Originally Posted by mike ross View Post
    both...after 90 days the body has it figured out so you just come off for a brief period, then hop right back on.

    For the IPAM cycle, use cjc with it and the dose is the same as the ghrp 2 or 6 for the most part. start at 250mcg and go up from there
    What do you think about that boom dosing protocol? I haven't tried it, but alot of Internet bodybuilders swear by it. I'm curious if it has any merit in real life
    The Dude Abides

  9. #9
    Registered Member mike ross's Avatar
    Join Date
    Jan 2011
    Location
    PA and FL
    Posts
    852
    Credits
    0
    Thanks (Given)
    0
    Thanks (Received)
    0
    Likes (Given)
    16
    Likes (Received)
    37
    Dislikes (Given)
    0
    Dislikes (Received)
    0
    Rep Power
    1093081

    Default

    Quote Originally Posted by The Dude View Post
    What do you think about that boom dosing protocol? I haven't tried it, but alot of Internet bodybuilders swear by it. I'm curious if it has any merit in real life
    i cant buy into the boom method on anything. I remember palumbo and other bodybuilders claiming that gh blast cycles were best. They were using 80ius every 2wks or something ridiculous, yes it was at least 80, then come to find out there was no real merit in that. If it works for you, im all for it. i do better with moderate doses and longer use. You would literally have to test it out and see what sides popped up etc.
    Last edited by mike ross; 08-29-2012 at 09:16 PM.


    For the highest quality proteins and supplements visit Rxwhey.com and support your board sponsors

    Like us on Facebook to receive exclusive deals, tips, and other fitness related news

  10. #10
    MuscleChemistry Registered Member Chris250's Avatar
    Join Date
    Dec 2003
    Posts
    6,923
    Credits
    0
    Thanks (Given)
    0
    Thanks (Received)
    1
    Likes (Given)
    1
    Likes (Received)
    69
    Dislikes (Given)
    0
    Dislikes (Received)
    0
    Rep Power
    8194

    Default

    ghrp 2 and cjc1295 is a killer combo...crazy ass fullness

  11. #11
    MuscleChemistry Newbie
    Join Date
    May 2014
    Posts
    17
    Credits
    151
    Thanks (Given)
    0
    Thanks (Received)
    0
    Likes (Given)
    1
    Likes (Received)
    9
    Dislikes (Given)
    0
    Dislikes (Received)
    0
    Rep Power
    0

    Default

    Awesome post

  12. #12
    MuscleChemistry Newbie
    Join Date
    Jan 2014
    Posts
    66
    Credits
    425
    Thanks (Given)
    1
    Thanks (Received)
    4
    Likes (Given)
    3
    Likes (Received)
    19
    Dislikes (Given)
    0
    Dislikes (Received)
    0
    Rep Power
    98

    Default

    GHRP-2 100mcg and mod 1-29 100mcg makes me hungry. Not like 6 but I deft have to use ipam if I don't want to eat. Took me a long time to figure it out cause everyone says "GHRP 2 doesn't induce hunger" well that's just not true for me.

  13. #13
    MuscleChemistry Newbie JuicedVenom's Avatar
    Join Date
    Feb 2014
    Location
    Here
    Posts
    23
    Credits
    184
    Thanks (Given)
    0
    Thanks (Received)
    2
    Likes (Given)
    1
    Likes (Received)
    9
    Dislikes (Given)
    0
    Dislikes (Received)
    0
    Rep Power
    0

    Default

    AWSOME POST. I'm loving these peps.

  14. #14
    MuscleChemistry Guru BEASTZ6's Avatar
    Join Date
    Jan 2009
    Posts
    789
    Credits
    2,455
    Thanks (Given)
    2
    Thanks (Received)
    7
    Likes (Given)
    277
    Likes (Received)
    192
    Dislikes (Given)
    0
    Dislikes (Received)
    0
    Rep Power
    850

    Default



    In order of strength for GHRP's:
    Hexalarin
    GRHP-2
    GHRP-6
    Ipam.

    Check out Mike Arnolds discussion of running GHRP and GHRH combos here: Traditional Growth Hormone and the Rise of GH Peptides ? Part 3

    Its a great read.

Bookmarks

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •