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login_name
04-09-2002, 04:27 PM
can someone tell me what this is? pro's con's shit like that too if you have any...thanks.

occam
04-09-2002, 04:53 PM
It was originally used in 1900 to ignite TNT. Chemically, DNP is structured as C6 H4 N2 05. For all the science buffs out there, it is a metabolic uncoupler of oxidative phosphorylation.

What actually happens occurs on a cellular level. Cells have "walls" around them called membranes. These maintain the integrity of the cell and make it a living organism. In the early days of chemical evolution, simpler forms formed that did not have integral membranes. They were like soap bubbles precariously floating around in the "chemical soup" of earth. It was a pre-life chemistry of cells, which were called myocells. Myocells made the basic attempts to defend their chemical integrity by taking on one or two of the 7 characteristics of life.

These continued to evolve and eventually higher-level myocells evolved with thicker and stronger membranes around them. These floated around within the soup, still not able to move by themselves and still unable to reproduce. Therefore, without those two critical criteria, the super myocells could not really be defined as life.

Chemicals came and chemicals went and through billions of reactions and transcriptions, basics helices started to emerge, as did chemicals that could replicate themselves (RNA). Once myocells held onto an RNA helix and were able to replicate itself, we were on the very cusp of life. It was one leap of chemistry as myocells impregnated one another. Boom! Life began. The by-product in the invading myocell was energy in the form of ATP; the host myocell could harness this energy for movement and replication. In return, it fed and protected the invaded myocell. We had the first living cell as we knew it.

Even today's muscle cells have a host cell, organelles called mitochondria. If you look at these little organelles, it is apparent that they have a completely different RNA structure for the host cells. They move around in the host cell and give off energy for the host cell to use in the form of ATP.
Within the surrounding double-layered membrane of the mitochondria are tiny folds called cristae and a highly concentrated mixture of enzymes and DNA. A series of chemical reactions, called the Krebs Cycle, occur within the mitochondria, which are responsible for the breakdown of food molecules to form CO2, H2O, and energy (ATP).

DNP is a metabolic poison that attacks the mitochondria. It pumps hydrogen ions in between the two outer membranes. Without getting too detailed in the chemistry, it effects the Krebs Cycle and makes the organelle produce heat instead of ATP. Once energy is converted, this preserves the laws of the conservation of energy. Now we see a marked increase in metabolic, rate, surface body temperature, and under the right conditions, fat loss.

50 percent rises in metabolic rate can be achieved, which results in fat losses in the order of 10 LB over an 8 day period.

Other considerations are that you get an immense craving for carbs, a "climb the walls" kind of craving. It is my suggestion that people take appetite suppressants with DNP, especially if you're using insulin at the same time.

The use of insulin, as proposed by the late and great Dan Duchaine, was due to the fact that DNP truncates the insulin molecule, which means that it is unlikely to send you hypo. Insulin also makes us big, but also makes us fat. DNP prevents the gain of fat from insulin.


Protect your head. It is the most important part of your body above your genitals. When you sleep at night, keep a fan on your head but keep the rest of your body covered. DNP does not significantly increase core body temperature, only surface body temperature. If it did, the former would be deadly.

The lethal dose for DNP is about 14mg per kg of bodyweight. The maximum safe dose is 5mg per kg of bodyweight.

Be careful of your source. I believe that DNP is a useful tool that has to be handled with extreme caution.





There are many articals of a similar nature, many with quite disparate conclusions, available if you will just search for them. I hope you do a hell of a lot of research on this before doing anything, that being said I'm getting ready for my third run.

stumpy
04-09-2002, 05:35 PM
I guess I can't add much to that.  

Any way, i will reenforce the importance of how cautious to be with DNP.  I've read that you can literally cook yourself from the inside out.

BStrongBwell*
04-09-2002, 05:41 PM
I've seen quite a few posts on this board from guys who use and like it.  It is anti-catabolic and is very effective at converting stored fat to energy.  I'll BUMP ya to see if anyone with personal experience wants to add their .02.   I'd never use it, because I fucking sweat at 70degrees as it is.  I couldn't handle being that hot all the time in an office environment.  Then again, I don't do clen for that same reason.

ronin738
04-10-2002, 09:41 AM
What's up. Saw this thread today. I am currently on my fourth day of dnp cycle. Started at 200mgs twice a day at 10 am and 10pm but i felt fine with no sides, no nausea, no heat no nothing, did that for two days and then added a 200mg cap on crucial day three at 4 pm and here comes the heat and a light sweat. Workouts haven't suffered at all and no lethargy but feel like i'm starving all the time because of low carbs. Also from day one would wake up soaked in sweat. Today i amped up the dose to 800 mgs. Did one at 8 am, gonna do another at 1pm, another at 530pm and the last at 10pm before i go to bed. I do my workouts between 800 and 900pm. Today the carb cravings are a bitch. It's gonna be a hard one. Am making sure that i drink 2 gallons of water per day and supplementing with vitamin c and e.

BStrongBwell*
04-10-2002, 10:11 AM
ronin, nice first post bro.  Would you mind giving us periodic updates on your DNP experience?  I doubt I'll ever do it, but I know quite a few others here are considering it.

login_name
04-10-2002, 01:24 PM
thanks alot guys...very informative as usual!!!

sasha
04-10-2002, 02:04 PM
a little more info on DNP...


Ion channels are membrane proteins that control the flux of ions across an otherwise impermeable cell membrane. Potassium (K) channels were first decribed by Noma [1] in 1983, and later in 1991 the ATP-sensitive K channel (KATP) was described by the same researcher [2]. Potassium channels determine cell membrane potential.
KATP channels exist in most excitable cells. They are regulated by the intracellular level of ATP as well as by various nucleotide diphosphates, pH and lactate concentrations. The activity of KATP channels is inhibited by increasing the intracellular ATP concentration. Closure of these channels in response to glucose metabolism depolarises the cell, stimulating voltage-dependent electrical activity, and calcium ion (Ca) entry. In the pancreatic beta cells, an increase in blood sugar level leads to an elevated ATP/ADP ratio, which in turn inhibits KATP channels, so as to alter the membrane potential and cause insulin release. It is accompanied by increases in respiratory rate, pyridine and flavin nucleotide reduction state, and intracellular pH [3].
Thus, the KATP channel couples nutrient metabolism to the membrane potential.
o Increase in blood glucose -> increase in glucose metabolism -> increase in intracell ATP -> inhibition of KATP channel.
o Channel CLOSED: cell depolarized, Ca++ uptake, insulin exocytosis.
KATP channels play an important role in the control of vascular tone [4]. Polarization following potassium channel activation (opening) results in lessened calcium influx and smooth muscle relaxation.
o KATP channel BLOCKED -> vascular tone increases.
o KATP channel ACTIVATED -> vascular tone decreases.
Besides being regulated by intracellular signals, potassium channels may also be regulated by membrane potential. Thus, in excitable cells in the heart, muscle, and nervous system, voltage-gated potassium channels are activated during an action potential; the activities of these potassium channels determine to a large extent the shape of the action potential, hence the strength of the signaling.
o KATP BLOCKED -> more strength
o KATP ACTIVATED -> less strength
Drugs which block KATP channels: tolbutamide, glyburide, glibenclamide.
Drugs which activate KATP channels: Prostaglandin E2 and I2, adenosine,
lemakalim.
Drugs which activate K channels: pinacidil, cromakalim.
Mitochondria also contain a K+ channel that causes rapid K+ uptake when open [5].
DNP
===
What happens when someone takes the decoupler dinitrophenol (DNP)? Blood glucose will result in increased metabolism, but the level of ATP in the cell does not increase! In fact, it is depleted. So in this case, the KATP channel is not inhibited, and it stays open. Calcium is not taken into the cell, and insulin is not released. The person taking DNP has in effect given himself temporary diabetes.
Insulin is needed to facilitate the uptake of glucose into cardiac, skeletal, and adipose tissue, and to convert glucose to glycogen in the liver. It is anti-proteolytic and protects against the various ailments commonly seen in diabetics, such as vision problems and polyneuropathy. Not coincidentally, the same problems can result from ingesting DNP.
This is why, when one takes DNP, one also needs to take exogenous insulin.
Since the KATP channel remains open, vascular and muscular tone relax. Probably blood pressure will decrease. Strength will diminish.
It would seem that an antidote for DNP might be anything that causes the KATP channel to close, for example the drug glibenclamide.
References:
1. Noma A. 1983. Nature 305: 147.
2. Noma A, Takano M. 1991. The ATP-sensitive K+ channel. Jpn J Physiol 41(1):77-87.
3. Civelek VN, Deeney JT, et al. 1996. Temporal sequence of metabolic and ionic events in glucose-stimulated clonal pancreatic-cells. Biochem. J. 315: 1015-1019. Boston University Medical Center.
4. Nichols, C.G. and Lederer, W.J. 1991. ATP-sensitive potassium channels in the cardiovascular system. American Journal of Physiology 261:H1675-H1686.
5. Paucek, P, Mironova, G, et al. 1992 "Reconstitution and partial purification of the glibenclamide-sensitive, ATP-dependent K+ channel from rat liver and beef heart mitochondria," J. Biol. Chem. 267, 26062.
6. Nakamura S. 1989. Glucose reverses DNP induced changes in action potentials. Cardiovascular Res. 23(4):286-294.

login_name
04-10-2002, 03:30 PM
i don't think im messing with this shit...ty

ronin738
04-11-2002, 12:15 PM
This stuff has been cake so far. The only irrating thing is the sweating and it's the worst at night for some reason. Even during my workouts i sweat less than i do at night. Other than that no sides. The heat is kinda pleasant. Gives me a slight energized feeling.

dog
04-14-2002, 12:05 AM
Hey Sasha would taking high doses of ala help with glucose transport while on dnp thanks. I can see why V.D.C. aways recomends you <!--emo&:p--><img src="http://musclechemistry.mantisforums.com/iB_html/non-cgi/emoticons/tounge.gif" border="0" valign="absmiddle" alt=':p'><!--endemo-->

thor
04-14-2002, 12:05 PM
I&#39;ve used it ones before, and started my sekond cycle today&#33;
I love it&#33;
Drink tons of water, take the propper supplements, and start with a low dose for 3days to see how u react to it.

jstrong20
04-14-2002, 04:09 PM
I&#39;ve used it once before and will use it again post cycle. &nbsp;Its good shit when and safe when used cautiously IMO.

ronin738
04-15-2002, 02:13 PM
On my finished dnp cycle i lost a total of 15lbs. This does not include any of the water that i am holding that i will lose over the next couple of days. I loved it. Went from a 34 inch waist to a 32-33. Had no serious problems on it. Just a lot of sweat. Especiallly at night. I sweated more at night than during any of my workouts. Workouts didn&#39;t suffer at all. Again went up to 800mgs per day. I was hungry all the time. Will use an appetite suppressant when i go back on next week.

Auriflex
04-15-2002, 02:27 PM
I think that it&#39;s important to note that most people won&#39;t start feeling the full side effects until about day 3-4.

I won&#39;t ever use that shit again.

asone
04-16-2002, 01:07 PM
DNP is great if used with respect. I did a 10-day cycle and lost 7lbs of fat. Drink at least 2 gallons of H2o a day. Yes it takes about 2-3 day before you feel it kick in. So, on the 2nd day don&#39;t up the amount. You want keep the fat intake low. One thing to remember, the more carbs you eat the more you &#39;ll sweat, the more you sweat the more fat you lose. Start with simple carbs like apples, oranges, and frozen grapes works wonders.Then move on to complex carbs. Make sure to take tons of anti-ox&#39;s.
ALA 1200mg/ed
Vitaminm C 2000mg/ed
Vitamin E 200iu&#39;s/ed
Beta Carotene 25,000iu&#39;s/ed
CoQ10 60mg/ed
Potassium 100mg-400mg/ed
Taurine 1g-4g/ed &nbsp;


asone.........

Auriflex
04-16-2002, 01:13 PM
Good advice Asone