Does Nolvadex reduce free cortisol??

I have been doing dome research and I can't find any info on this topic. I am trying to find out whether or not Nolv reduces the level of cortisol in the body. ........456


BTW...wouldn't having a very low level of  cortisol in your system make you suceptable to stomach viruses...etc? After all cortisol is our internal immune system. I understand it is catabolic but never the less we still need some in our system right?
  I have been having some problems that weren't present last cycle..and I think its from the Nolv. I take 20mg ED..but I also have Chrohns disease....which is kept in check with cortisol medications. This could possible the beginning of the end of my AAS career...I'll find out more soon..hopefully.



<!--EDIT|mr456|May 13 2002,5:03-->

I will give ya a BUMP cause I would like to know as well. 456, let us know what u find out about your Chrohns. Hope it doesn't keep ya from continuing to use.

Hopefully I can still continue to use but they will have to be very low doseages to keep me from having to use an anti-estrogen. I ahve been working so hard at keeping my cortisol levels down to slim and none to keep my gains that i forgot about my Chrohns...and now it is kickin my ass. Sick as fuck...I got some prednisone but am going to take every other route beforw I take that nasty shit

mr456,I've never seen a study showing Nolva reducing cortisol. There is some cortisol receptor binding with AAS that can be either competativly antagonistic(get's in the way of cortisol and blocks the receptor) or agonistic(binds to the receptor and turns it on like cortisol,usually only partially) For example,winnie will compete and block....thus the reputation for joint pain; whereas deca will bind and partially turn on the receptor...and thus the rep for lubeing you up. All will have enough cross reactivity to lessen the effects of exogenous cortisone(like prednisone tabs),so that you will not get as much anti-inflammatory effect from your pred. tabs if you are on an AAS due to the receptor competition.
Two stratigies to consider....if you have frequent flares stick to short half life AAS cycles so that you can stop your program and start pred. if the chron's flares. If your disese is more "quiet" go with agonistic AAS like Durabolin,Deca that give a mild cortisol-like effect. I'll see if I can find any more studies and pass them your way bro.

Deca...I have just been on 50 mg of prop EOD starting last week. I just stopped the shots yesterday. I am going to end my extended cycle RIGHT NOW. i am gonna go ahead and run my clomid starting tommorw and I already took 5mg of Prednisone today..there goes all my fukin gains!! damn! <!--emo&/?--><img src="http://musclechemistry.mantisforums.com/iB_html/non-cgi/emoticons/sneaky2.gif" border="0" valign="absmiddle" alt='/?'><!--endemo-->
   My cycle last year of Durabolin/Prop for 8 weeks I had no problems. This cycle was Tren/T-3/ prop at higher doses. Plus I had to start the Nolv early in my cycle and have been taking it 20 mg ED since then. Any more info you could come up with would be great. I am hoping that if I stop all my AAS usage temporarily and take small doses of Prednisone that I can turn catabolic quickly..which as sad as it sounds..is  exactly what i need.....thanks again.....456
 
Don't wish this disease on your worst fuckin enemy....last week I was all jacked up feeling good...today I am doing what i can to get thru the day of work..and I am on midnights...lovely.
     :angry:

Ok I am gonna take 10mg Prednisone a day and go ahead and continue my Prop 50mg EOD...to get thru the catabolic part of the Prednisone. I am going to gain a little fat but I am sure I can make this work..wish me luck!!
 BTW Deca....can you point me in the direction where you get some of your info...I would be interested in reading some on my own...thanks again.........456

mr456 PM'd you bro.

mr456, I've always use cytadren at 250mg ED to reduce cortisol level. Give that a try.

An article on the effects of deca on cortisol......

.Neurosci Lett 2000 Apr 28;284(3):190-4    (ISSN: 0304-3940)
Schlussman SD; Zhou Y; Johansson P; Kiuru A; Ho A; Nyberg F; Kreek MJ
The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY, USA. [email protected].
There is increasing abuse of androgenic anabolic steroids (AAS) by non-athletes. AAS abuse has been associated with psychiatric symptoms such as mania, major depression and aggression and the development of dependence. Little is known about the effects of AAS on hypothalamic-pituitary-adrenal axis function or corticotropin releasing factor, which may be involved in mediating some of the psychiatric symptoms associated with AAS abuse. Male Sprague-Dawley rats received one daily intra-muscular injection of the AAS nandrolone decanoate (ND, 15 mg/kg) or vehicle for 3 days. Animals were sacrificed either 1 h or 24 h after the last injection, brain regions dissected and trunk blood collected. Corticotropin releasing factor (CRF), CRF receptor1 (CRF-R1) and proopiomelanocortin (POMC) mRNAs were measured with solution hybridization/RNase protection. Circulating levels of corticosterone and adrenocorticotropin hormone (ACTH) were determined using radioimmunoassays. One hour following the last injection, ND significantly increased circulating levels of both corticosterone and ACTH levels. In the amygdala, CRF mRNA levels were unchanged 1 h after the last injection of ND but were significantly reduced at 24 h. The same was found for hypothalamic POMC. No significant AAS effects were observed on: hypothalamic CRF mRNA; POMC mRNA in the amygdala or CRF R1 mRNA in the anterior pituitary.

great question and better answer!

and where the hell is decadent been, i seen him logged in this past year actualy