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View Full Version : HCG and your bodies "natural" Deca



DecaDent*
06-04-2002, 10:04 AM
Some interesting points from an article I ran across,I've included the abstract in case anyone else wanted to read it.

My take on this: your body does make it's own Nandrolone(Deca). This "natural" property may account for the relatively low incidence of sides with Deca. Administration of HCG increased natural deca levels by 250%,but HCG also increased estrogen levels by an even larger percentage(260%). That accounts for HCG's reputaion for gyno when used post cycle.This appears to be aromatase dependant,another good reason to use the arimidex at the same time as HCG. After HCG administration,estrogen peaks at day 1,but Test didn't peak until 3 days after HCG. I'm not sure if you need to dose HCG ED,maybe every 3rd day would do it. Any comments,please add 'em.

J Clin Endocrinol Metab 2001 Jan;86(1):146-50 (ISSN: 0021-972X)
Reznik Y; Dehennin L; Coffin C; Mahoudeau J; Leymarie P
Service d'Endocrinologie, Laboratoire de Biochimie B, Centre Hospitalier Universitaire Cote de Nacre 14033 Caen, France.
19-Nortestosterone (nandrolone) is an anabolic steroid compound widely used as a doping agent by athletes. The analysis of its urinary metabolites, 19-norandrosterone (NA) and 19-noretiocholanolone (NE) glucuronides, allows the detection of surreptitious administration of nandrolone in sport. A threshold concentration at 2 microgram/L urinary nandrolone metabolites is advocated by the International Olympic Committee for the detection of doping, but some controversy concerning the validity of this threshold arose from the demonstration of endogenous production of nandrolone in mammals, including humans. The regulation of human nandrolone production and its contribution in vivo to the process of aromatization remain unknown. In the present study 10 healthy men were successively submitted to insulinic stress and gonadal stimulation by hCG administration. Urinary NA and NE concentrations were quantified by gas chromatography-mass spectrometry. NA was detected in basal urine samples from all subjects, with a mean urinary excretion rate (UER) of 3.17 +/- 0.35 ng/h, whereas NE was detected in 4 of 10 (UER range, 0.8-4.7 ng/h). Insulinic hypoglycemia did not significantly modify mean NA UER despite random intraindividual variations between timed urine collections. After hCG administration, NA UER increased by 250% (P < 0.01) and estradiol (E(2)) UER by 260% (P < 0.001). The maximum NA concentration obtained after stimulation was 0.43 microgram/L. NA UER, plasma E(2), and E(2)/T ratio peaked on day 1 after hCG administration, whereas plasma T peaked later on day 3. NA UER correlated with plasma E(2) (r = 0.61; P < 0.001) and E(2)/T (r = 0.51; P < 0.001), but not with plasma T. In conclusion, insulinic stress did not significantly alter nandrolone metabolism, whereas the effect of hCG was a stimulation of NA excretion in all subjects, which constitutes strong support for the endogenous origin of low basal NA excretion. The comparative kinetics of NA UER, plasma E(2), and E(2)/T ratio suggest a contribution of the aromatase process to nandrolone biosynthesis in man.

Gear101*
06-07-2002, 06:26 PM
good thread..