PDA

View Full Version : Clen and Adrenal/Cortisol response



DecaDent*
06-11-2002, 11:25 AM
This study,altough done on rats,demonstrated increased cortisol levels and enlargement of the adrenal glands after 45d of Clen. If the same holds for gymrats,this effect would be counterproductive to adding muscle mass. Comments ??



The effect of clenbuterol on adrenal function in rats.
.
The aim of this study was to evaluate whether the administration of clenbuterol causes stressful effects in rats, as reflected by the adrenal function. Anabolic doses of clenbuterol (1 mg kg-1, 99% purity) were administered orally by stomach tube daily for 45 d to female Long . Hormonal levels of cortisol and corticosterone, and histopathological analysis, were used as indicators of the adrenal function. Increased corticosterone and cortisol secretion was found in the treated group (p < 0.001), both in adrenal homogenates and peripheral blood samples, compared with control animals. Higher relative adrenal gland weight (adrenal gland-to-body weight ratio) was also found in the treated group (p < 0.01). The major histopathological finding was the presence of hyperplasia in the adrenocortical cells.
It was concluded that the administration of an anabolic dose of clenbuterol causes a hyperstimulation of adrenal gland secretion that could adversely affect animal welfare.

Analyst 1998 Dec;123(12):2521-4 (ISSN: 0003-2654)
Illera JC; Silvan G; Blass A; Martinez MM; Illera M
Departamento de Fisiologia Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, Spain

mr456
06-11-2002, 11:32 AM
Deca...maybe they should give those rats a little "V" to keep the cortisol levels down....lol.
I have been doing some heavy duty reseach on cortico-steroids and AAS and how they interact within the body when administered at the same time. Haven't found any REAL concrete proof that they affect one another but I have found some correlation in there competition for certain receptors.......456

DecaDent*
06-11-2002, 11:48 AM
Blood hormones as markers of training stress and overtraining.
.
. Endogenous hormones are essential for physiological reactions and adaptations during physical work and influence the recovery phase after exercise by modulating anabolic and catabolic processes. Testosterone and cortisol are playing a significant role in metabolism of protein as well as carbohydrate metabolism. Both are competitive agonists at the receptor level of muscular cells. The testosterone/cortisol ratio is used as an indication of the anabolic/catabolic balance. This ratio decreases in relation to the intensity and duration of physical exercise, as well as during periods of intense training or repetitive competition, and can be reversed by regenerative measures. Correlations have been noted with the training-induced changes of strength. However, it seems more likely that the testosterone/cortisol ratio indicates the actual physiological strain in training, rather than overtraining syndrome. The sympatho-adrenergic system might be involved in the pathogenesis of overtraining. Overtraining appears as a disturbed autonomic regulation, which in its parasympathicotonic form shows a diminished maximal secretion of catecholamines, combined with an impaired full mobilisation of anaerobic lactic reserves. This is supposed to lead to decreased maximal blood lactate levels and maximal performance. Free plasma adrenaline (epinephrine) and noradrenaline (norepinephrine) may provide additional information for the monitoring of endurance training. While prolonged aerobic exercise conducted at intensities below the individual anaerobic threshold lead to a moderate rise of sympathetic activity, workloads exceeding this threshold are characterised by a disproportionate increase in the levels of catecholamines. In addition, psychological stress during competitive events is characterised by a higher catecholamines to lactate ratio in comparison with training exercise sessions. Thus, the frequency of training sessions with higher anaerobic lactic demands or of competition, should be carefully limited in order to prevent overtraining syndrome. In the state of overtraining syndrome and overreaching, respectively, an intraindividually decreased maximum rise of pituitary hormones (corticotrophin, growth hormone), cortisol and insulin has been found after a standardised exhaustive exercise test performed with an intensity of 10% above the individual anaerobic threshold
Sports Med 1995 Oct;20(4):251-76 (ISSN: 0112-1642)
Urhausen A; Gabriel H; Kindermann W
Institute of Sports and Preventive Medicine, University of Saarland, Saarbrucken, Germany

mr456
06-11-2002, 07:07 PM
Good read bro. The way i am reading it...it sounds like I can actually control my anabolic/catabolic balance within my own body by using cortico's and AAS? I am still a bit confused. If they are both agonsists for the muscle cell receptor then isn't one being eihter wasted or just not being used? And which one gets there 1st....the AAS because its intramuscular or the cortico's because they are oral?? Right now I am still on 30mg Prednisone a day..some Imuran(lovely stuff)..Prilosec...and Carafate.
I am all jacked up..just on the wrong shit....oh yeah and for those of you who like "V" don't take 2 after you just popped 2 Darvocet's:D mighty long night/day of sleep i had..lol.

DecaDent*
06-11-2002, 07:37 PM
Hope this helps explain it......

. If they are both agonsists for the muscle cell receptor then isn't one being eihter wasted or just not being used?

Think of it more in terms of ratio and proportion,in otherwords there is always a balence and a competition for these receptors and the more molecules you have on your side the greater the number of receptors you will occupy. It becomes much more complicated than that due to binding affinity(ability to hook up with a receptor) and half-life of the steroid-receptor complex which also is multivariate.



And which one gets there 1st....the AAS because its intramuscular or the cortico's because they are oral??

Route of administration isn't important at all,it's the concentration that is achieved in the serum that matters.


.
I am all jacked up..just on the wrong shit....oh yeah and for those of you who like "V" don't take 2 after you just popped 2 Darvocet's:D mighty long night/day of sleep i had..lol.

I'm usually not one for mellow sleepy buzzes either...tranquility is not always my idea of a good time :cool:

mr456
06-11-2002, 10:40 PM
When I was in the hospital they were giving my cortico steroids (salumyrate) or something like that..through my 1 of 4 (lol) IV's. When I came off the IV and switched to oral Prednisone I had a very bad reaction and had to start taking 2 Darvocets every 4 hrs to combat the pain. It was not muscular pain but as if every joint/ligament in my upper body was ruined..it even hurt to swallow. My doc explained it and said it was normal because the IV drugs work so much quicker. I think I should go to school to be an Internal Medicine doc or something...lol.
Anywho....I think I am just gonna stay natural until I get 100% for now. And Deca thanks again for your input bro. I looked at a lot of those sites you gave me but really couldn't find jack shit...lol:confused: