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View Full Version : Protien Synthisis (AAS) vs. Ibuprofen



buffgrandpa
06-19-2002, 09:49 AM
Just curious to what the vets think on this subject since I doubt that there are any published studies. I've read a lot of articles lately that report that taking Ibuprofen or Tylenol to relieve pain will actually reduce your protien synthisis by as much as 70%. Ouch.. My question is, are the reductions this severe when on AAS or to they tend to counteract the effects of these pain killers?

DecaDent*
06-19-2002, 10:17 AM
.Effect of ibuprofen and acetaminophen on postexercise muscle protein synthesis.

We examined the effect of two commonly consumed over-the-counter analgesics, ibuprofen and acetaminophen, on muscle protein synthesis and soreness after high-intensity eccentric resistance exercise. Twenty-four males (25 +/- 3 yr, 180 +/- 6 cm, 81 +/- 6 kg, and 17 +/- 8% body fat) were assigned to one of three groups that received either the maximal over-the-counter dose of ibuprofen (IBU; 1,200 mg/day), acetaminophen (ACET; 4,000 mg/day), or a placebo (PLA) after 10-14 sets of 10 eccentric repetitions at 120% of concentric one-repetition maximum with the knee extensors. Postexercise (24 h) skeletal muscle fractional synthesis rate (FSR) was increased 76 +/- 19% (P < 0.05) in PLA (0.058 +/- 0.012%/h) and was unchanged (P > 0.05) in IBU (35 +/- 21%; 0.021 +/- 0.014%/h) and ACET (22 +/- 23%; 0.010 +/- 0.019%/h). Neither drug had any influence on whole body protein breakdown, as measured by rate of phenylalanine appearance, on serum creatine kinase, or on rating of perceived muscle soreness compared with PLA. These results suggest that over-the-counter doses of both ibuprofen and acetaminophen suppress the protein synthesis response in skeletal muscle after eccentric resistance exercise. Thus these two analgesics may work through a common mechanism to influence protein metabolism in skeletal muscle

Am J Physiol Endocrinol Metab 2002 Mar;282(3):E551-6 (ISSN: 0193-1849)

Trappe TA; White F; Lambert CP; Cesar D; Hellerstein M; Evans WJ
Donald W. Reynolds Center on Aging, Department of Geriatrics, University of Arkansas for Medical Sciences, and the Central Arkansas Veterans HealthCare System, Little Rock, Arkansas 72205, USA. trappetodda@uams.edu.

BStrongBwell*
06-19-2002, 03:40 PM
Those are some pretty high doses they used. I wonder what the results would have been if they just 500mg, which is typical for both of those pain relievers. In addition, using AAS may negate those results as protein synthesis is enhanced. In any case, I won't be taking either before I workout again though...just in case.

buffgrandpa
06-19-2002, 04:13 PM
That's pertty consistant with the articles that I read. ( I think the most recent was in the latest or last months issue of Muscle and Fitness or Muscular Developement magazines). That'w why I was wondering about the increased anabolic responce of AAS users, if the effect was just as dramatic or maybe even more so. I guess Bstrong said it best, just to be safe, don't use them unless you absolutely have too..