Lutalyse® (diniprost tromethamine) non-steroidal anabolic agent profile and its use

akn · May 29, 2014

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Dinoprost tromethamine is a pharmaceutical form of the
natural prostaglandin PGF2alpha. Prostaglandins are a series
of natural oxygenated unsaturated cyclic fatty acids, which
have a variety of hormone-like actions in the body. Among
other things, PGF2alpha is involved in vasoconstriction,
increasing protein synthesis in skeletal muscle tissue, and
reducing adipose tissue mass. This hormone-like chemical
also stimulates smooth muscle contraction, and is involved in
pain, inflammation, fever, ovulation, gastric motility, and
fluid absorption in the gastrointestinal tract. In veterinary
medicine dinoprost tromethamine is most commonly used in
estrus synchronization/fertility timing, for treating chronic
endometriosis, and to induce abortion or labor. Dinoprost is
not widely used in human medicine, but is sometimes applied
to terminate pregnancy or induce labor.
Athletes and bodybuilders are attracted to dinoprost
tromethamine for its strong thermogenic and muscle-building
properties. The anabolic effect of this drug has been
substantiated by clinical studies, which have shown PGF2a
to be a strong stimulator of protein synthesis, and key to both
the immediate and long-term physiological adaptations to
resistance training.643 644 645 646 Reports from athletes who
have experimented with this agent generally support this
compound being an excellent promoter of localized muscle
growth, usually resulting in both increases in muscle size and
definition. Dinoprost is also reported to be a very fast acting
drug, with many claiming it has caused noticeable effect after
being injected in a particular muscle group for only a couple
of weeks. Clinical data also supports it being a substantially
potent fat-loss drug, with PGF2a shown in studies to inhibit
the stimulation of lipogenesis in fat cells.645 Again there is a
great deal of anecdotal support for this property of dinoprost
tromethamine among athletes and bodybuilders, with many
claiming they notice a slight temperature elevation and
marked fat loss during therapy.
History:
Dinoprost tromethamine was first introduced into clinical
medicine in the early 1970s. The first approved use of the
drug in human patients was to stimulate abortion during the
second trimester. It has since remained of use for this
purpose, but is most commonly associated these days with
veterinary medicine. Here, it is widely applied to help
farmers regulate the estrous cycle and fertility of various
livestock. Interest in dinoprost tromethamine as an
anabolic/thermogenic drug for athletes and bodybuilders did
not appear until the late 1990s. This likely occurred
subsequent to the release of numerous medical studies linking
PGF2alpha to muscle hypertrophy. Early theoretical concepts
stemming from this research evolved into modern application
protocols for the drug, which in spite of a high propensity to
generate side effects, have proven to be highly successful for
many athletes and bodybuilders.
Over the years dinoprost tromethamine has appeared as a
human medicine under a wide number of trade names,
including such popular drug products as Amoglandin
(Sweden), Prostin (Sweden), Prostin F2 alpha (U.S.,
Australia, Israel, Italy, New Zealand, South Africa, and the
United Kingdom), Minprostin F2a (Germany), Enzaprost
(Greece, Poland) and Prostarmon (Japan). Prostin F2 is no
longer sold in the U.S., however, and there is presently no
FDA approved replacement available for human use.
Veterinary versions are more widely available and tend to
provide significantly more active drug for less money than
their human counterpart medicines, and as a result have been
the products most commonly associated with the physique- or
performance-enhancing use of dinoprost tromethamine.
Popular veterinary brands have included Lutalyse
(Pharmacia Animal Health), Prostamate (Pfizer), Panacelan
(Daiichi Pharmaceutical Co.) and Dinolytic (Upjohn).
Several corporate mergers have taken place in this segment
of the market, and the (now larger) conglomerate Pharmacia
has emerged as the worldwide leader in dinoprost sales.
Lutalyse is consequently the most common form of dinoprost
tromethamine of use among the athletic/bodybuilding
community.
How Supplied:
Dinoprost tromethamine is most commonly supplied in a
multi-dose vial (5 mL-100 mL) in a dose of 5 mg per mL. It
is prepared in a sterile solution of water with benzyl alcohol
added as a preservative and sodium hydroxide and/or
hydrochloric acid to adjust pH.
Structural Characteristics:
Dinoprost tromethamine is the tromethamine salt of
prosta,5,13-dien-1-oic acid (PGF2alpha).
Side Effects:
Possible side effects or signs of dinoprost tromethamine
overexposure may include such respiratory effects as
bronchoconstriction, wheezing, coughing, lung irritation,
rapid breathing, and anaphylaxis. Asthmatic individuals may
be particularly susceptible to these effects. Dinoprost may
also cause gastrointestinal disturbances such as abdominal
cramping, diarrhea, vomiting and nausea. Other effects may
include increased pulse rate, elevated blood pressure, chills,
fever, and anorexia, and in women uterine contractions,
vaginal bleeding, and uterine or urinary infections. Pregnant
women should not take or handle dinoprost. Reports of side
effects among athletes using dinoprost for physique- or
performance-enhancing purposes are common, and often
extreme. This includes pronounced soreness at the site of
injection; often beginning with a dull burning almost
immediately after the shot is given. Chills and flu-like
feelings are also commonly reported during cycles, as are
bouts of shortness of breath. Injections are also commonly
followed by uncontrollable urges to urinate or defecate,
including strong spasmodic contractions of the muscles
involved in the control of these functions. Nausea and
vomiting have also been commonly reported. For many, the
cramping, diarrhea, pain, and general feelings of upset
stomach, malaise, and discomfort make dinoprost a drug they
experiment with only briefly. Others, however, continue on
with the drug, and often report that side effects become more
tolerable over time.
Administration:
As a human medication, dinoprost tromethamine is most
commonly given intra-amniotically at a dose of 40 mg for the
termination of pregnancy. It is also sometimes given orally to
pregnant women at a dose of 30-100 mg to induce labor,
although this tends to produce more side effects than other,
more recently adopted, medications. When used for
physique- or performance-enhancing purposes, dinoprost
tromethamine is generally given by intramuscular injection.
Most noted for its ability to generate localized growth,
common sites of injection include the shoulders, biceps,
triceps, calves, chest, back, and legs. The user will typically
inject in only one site per day at the start of therapy, but this
may be increased to 2 or more injections per day as they
become more accustomed to the drug and its side effects.
Therapy begins slowly, and is initiated with a low starting
dose of approximately .5 milligram per injection. If the first
injection were given without significant side effects, the next
injection would be increased to 1 milligram. This is slowly
increased by .5-1 mg per application until a peak dose is
reached. This might be a maximum of 5 mg per injection site.
Injection sites are also regularly rotated so that several days
separate administration in the same muscle group. Note that
for some, the pain after injection is so severe that training for
that specific muscle group must be delayed for at least a few
days. Individual sensitivity to the drug may, therefore,
require modifications of their injection and training schedule
to maximize results and comfort.
Availability:
Dinoprost tromethamine is available in the U.S. and many
other nations as a prescription drug product. It is also found
infrequently on the black market

By William Llewellyn

Presser · Mar 10, 2018

Idk man lol there’s a lot of other things I’d use for localized muscle growth before using this stuff.

Maybe its it’s just me but the whole TERMINATE PREGNANCY thing is a bit of a turn off lol

Lutalyse® (diniprost tromethamine) non-steroidal anabolic agent profile and its use

akn

Musclechemistry Member

Presser

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