Periactin (cyproheptadine hydrochloride) Appetite Stimulant profile

akn · May 31, 2014

periactin Description:
Cyproheptadine hydrochloride is a first-generation
prescription histamine and serotonin antagonist. This drug is
most often given in the U.S. for the treatment of allergyrelated
symptoms, including hay fever, runny nose, irritated
eyes, hives, and swelling. It is also FDA approved for the
treatment of anaphylactic reactions caused by allergens, often
as an adjunct to injectable epinephrine (adrenalin). The
serotonin inhibiting effect of this drug also gives it a unique
ability to increase appetite. This has led to a considerable
amount of off-label use as a weight-gain medication,
particularly with patients who are suffering from a lean
tissue wasting associated with AIDS infection, cancer, or
other debilitating diseases. Cyproheptadine hydrochloride is
also used on occasion as an adjunct to growth hormone
therapy in children, to foster greater nutrient uptake and
increases in linear growth beyond what is normally achieved
with rHGH alone.667 Bodybuilders and athletes use the drug
on occasion to help increase caloric intake, usually during
periods of bulking training where increased mass is desired,
and often used in conjunction with anabolic/androgenic
steroids.
Although this is a controversial use of the drug, references to
the appetite stimulating properties of cyproheptadine
hydrochloride are abundant in the medical literature. One of
the more detailed papers compares the appetite increasing
effects of cyproheptadine hydrochloride to megestrol
acetate668 in a group of 14 men with weight loss associated
with HIV infection. The other agent, megestrol, is a progestin
that was approved by the FDA in 1993 for the treatment of
anorexia, cachexia, or weight loss in patients with AIDS. In
this investigation, cyproheptadine hydrochloride was shown
to have a similar level of benefit to FDA approved agent
megestrol, with patients consuming about 500 extra calories
per day, and gaining a moderate amount of weight with either
medications. While the benefits were similar, the side effects
were not. The investigators reported that more than 50% of
the patients taking megestrol suffered impotence during the
investigation, while the cyproheptadine hydrochloride group
had no such side effects. Cyproheptadine hydrochloride may
offer an effective alternative to megestrol therapy for many
patients, especially those prone to negative side effects
associated with this type of hormone manipulation.
History:
Cyproheptadine hydrochloride is an early anti-histamine
drug, and has been sold as a prescription medication in most
developed nations for decades. It was introduced to the U.S.
in 1961 under the Periactin® brand name by Merck & Co.
This brand of cyproheptadine hydrochloride was sold for
many years in the U.S, but was voluntarily discontinued by
Merck in 2003 (in both the U.S. and Canada). While Merck
& Co. has withdrawn Periactin from a number of other
nations (likely due to low financial interest), the brand is still
sold in more than one dozen countries including Australia,
Austria, Belgium, Ireland, Italy, Netherlands, New Zealand,
South Africa, Spain, Sweden, Thailand, and the United
Kingdom. It is also sold under dozens of other brand names
around the world, in both single- and multi-ingredient
preparations. A number of generic products are still sold in
both the U.S. and Canada as well. Subsequent to studies
questioning the long-term weight gaining value of
cyproheptadine hydrochloride therapy, in 1994 the World
Health Organization warned against using the drug for this
purpose.669 Regardless of this report, many still support the
value of cyproheptadine hydrochloride as a short-term
appetite stimulant.
How Supplied:
Cyproheptadine hydrochloride is most commonly supplied in
tablets of 4 mg.
Structural Characteristics:
Cyproheptadine hydrochloride is antihistaminic and
antiserotonergic agent with the chemical designation 4- ( 5H
- dibenzo [a,d] cyclohepten - 5 - ylidene) - 1 -
methylpiperidine hydrochloride sesquihydrate.
Side Effects:
As a first-generation anti-histamine, cyproheptadine
hydrochloride may be prone to producing a number of side
effects in its users. The most common of which is sedation or
the classic “anti-histamine lethargy”, which is common to
these types of drugs. For some users, the tiredness that
cyproheptadine hydrochloride will produce will outweigh
any potential as a weightgaining/performance-enhancing
agent. For most, this side effect of cyproheptadine
hydrochloride is not very noticeable, and perhaps a nuisance
(not strong enough to an ingredient. necessitate
discontinuation) at best. Other less common side effects of
concern include, but are not limited to, dizziness, disturbed
coordination, muscular weakness, nausea, vomiting,
diarrhea, constipation, dryness of the mouth, difficulty
urinating, vertigo, blurred vision, tightness of the chest,
wheezing, stuffed nose, sweating, early period, headaches,
and faintness. Any strong incidence of unwelcome side
effects would immediately warrant discontinuing the drug, or
even seeking immediate medical attention if severe.
Administration:
The dosage required for medical purposes may vary
depending on the individual and their particular needs. The
established therapeutic range for cyproheptadine
hydrochloride is 4 mg to 20 mg per day, with most adults
requiring 12 mg to 16 mg daily. The total daily dosage is
usually divided into three separate applications. When used
(off-label) as an appetite stimulant, a dosage of 4mg is
commonly taken 2-3 times per day (8-12 mg).Above this
level, side effects may become more noticeable (most
notably sleepiness), often interfering with the benefit of the
drug. This may be used during a steroid cycle focused on
bulking, with the intake of cyproheptadine hydrochloride
usually lasting no more than 4-8 weeks. For those who
tolerate this anti-histamine’s side effects (mainly tiredness),
cyproheptadine hydrochloride is often reported to offer
significant value as an appetite stimulant during weight
gaining cycles. This is especially so in individuals that have
trouble eating enough food to meet the high calorie/protein
requirements for optimal muscle growth.
Availability:
Cyproheptadine hydrochloride is produced in a wide number
of countries. Although it is not commonly traded on the black
market, high supply and the relatively benign nature of this
drug (loose controls) make it easily diverted for sale when
needed. Given its low demand, counterfeiting of
cyproheptadine hydrochloride preparations is not common.
It is interesting to also note that the Dominican steroid
product, Anabolex, actually includes 1.5 mg of
cyproheptadine hydrochloride in each 3 mg
methandrostenolone tablet, which was added by its
developers to facilitate increased caloric intake and weight
gain during anabolic therapy. The 2:1 ratio provided is
optimal for a daily dose of 24 mg Dianabol (a very common
amount), as it would provide 12 mg of cyproheptadine
hydrochloride (the maximum common daily dose). This is the
only common anabolic steroid product that includes
cyproheptadine hydrochloride as an ingredient

By William Llewellyn

[h=2]Periacten Peractin Perictin Perciatin[/h]

DEMIGOD · Jun 1, 2014

I work with hospice, I see this prescribed every day.

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Presser · Mar 10, 2018

Not familiar with it personally but since it’s being searched for daily so much I figured I’d bump this article up for anyone here interested in reading up on its effects , uses, dosages and duration

Presser · Jun 29, 2018

Eating stimulants, you dont see that everyday.

drtbear1967 · Jun 29, 2018

This is used a lot with the elderly that do not eat enough.

Periactin (cyproheptadine hydrochloride) Appetite Stimulant profile

akn

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DEMIGOD

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Presser

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Presser

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drtbear1967

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