drtbear1967

Musclechemistry Board Certified Member
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Ran across an interesting study last night while researching creatine. The study showed that guanidinoacetic acid elevated plasma creatine levels higher than creatine itself. It was a very small study, where subjects took either 3.4g or creatine mono(CM) or 3g of guanidinoacetic acid(GA) daily for 4 weeks. Researchers found that subjects in the GA group had creatine levels 3.3X higher than the CM group. Before you go out and buy GA, researchers also saw a sharp rise in homocysteine levels. Elevated levels of homocysteine has been linked to being a risk factor in several diseases, including thrombosis, cardiovascular disease and renal dysfunction. Once again, CM seems to be the best, tried and true version of a creatine supplement.
 
After trying a lot of products over the years, I keep going back to creatine monohydrate.
 
Question: How many of you use creatine while ON? I've used both on and off and found zero difference. Now when I'm off creatine does make an impact.
 
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