drtbear1967
Musclechemistry Board Certified Member
theguerillachemist
Palmitoylethanolamide (PEA) is your body's natural anti-inflammatory molecule that is endogenously produced during periods of inflammation. It was first discovered in the 1930s and was isolated from egg yolk, and since then has had over 500 published studies on it. PEA works by reducing the activation and mitigation of mast cells. Mast cells are white blood cells that releases mediators that are pro-inflammatory such as histamines, inflammatory cytokines, prostaglandins, and reactive oxygen species(ROS).
In a meta analysis, PEA was shown to be more effective at reducing pain that 2 commonOTC anti-inflammatory drugs(NSAIDs). Some studies also suggest that it can bind to COX-2(same as ibuprofen) as well as your endocannibinoid receptors, which can help mediate pain and inflammation. Worth noting, to date PEA has no known drug interactions which implies it's very safe for anyone to supplement with. Doses vary but as little as 200mg a day has been shown to have an effect on inflammation.
Palmitoylethanolamide (PEA) is your body's natural anti-inflammatory molecule that is endogenously produced during periods of inflammation. It was first discovered in the 1930s and was isolated from egg yolk, and since then has had over 500 published studies on it. PEA works by reducing the activation and mitigation of mast cells. Mast cells are white blood cells that releases mediators that are pro-inflammatory such as histamines, inflammatory cytokines, prostaglandins, and reactive oxygen species(ROS).
In a meta analysis, PEA was shown to be more effective at reducing pain that 2 commonOTC anti-inflammatory drugs(NSAIDs). Some studies also suggest that it can bind to COX-2(same as ibuprofen) as well as your endocannibinoid receptors, which can help mediate pain and inflammation. Worth noting, to date PEA has no known drug interactions which implies it's very safe for anyone to supplement with. Doses vary but as little as 200mg a day has been shown to have an effect on inflammation.
