lee_marvin said:
Also, I don't understand why it would be so difficult to dissolve one drug at 2.5 mg/ml, and easy for another at 50mg. Just because femara works at 2.5mg a day, should really have nothing to do with its suspension in alcohol. I don't understand...
well bud, wihtout getting to technical into this, each hormone will have a different solubility in each solvent. Chemical structure, bonding affinity, etc... will play a role to determine the highest concertation at which a true solution can be held. I did a quick search this morning and couldn't find the exact solubilities in the solvents I wanted, but this should give you and idea of what I mean. Lets compare fem and a-dex, here is a little cut and paste
Letrozole
Chemical Name: 4,4’ -(1H-1,2,4-Triazol-1-ylmethylene)dibenzonitrile
Empirical Formula: C17H11N5
Molecular Weight: 285.31 amu
Melting Range: 184-185 °C
Therapeutic Category: Anti-cancer
Solubility: Freely soluble in chloroform, slightly soluble in methanol, practically insoluble in water.
Now to A-dex
Its molecular formula is C17H19N5 Anastrozole is an off-white powder with a molecular weight of 293.4. Anastrozole has moderate aqueous solubility (0.5 mg/mL at 25°C); solubility is independent of pH in the physiological range. Anastrozole is freely soluble in methanol, acetone, ethanol, and tetrahydrofuran, and very soluble in acetonitrile
Just look at each compounds solubility in methanol. Dex is freely soluble and fem partialy. Same with water. It goes back to the bonding affinity and stucture of the compounds. I'm not as educated in chem as I would like to be, but if I remember right I would attribute this to femara's doublebonded carbon atoms. As you can see form the formula fem has 8 less hydrogen
atoms, indicating 4 double bonds more than dex. These double bonds are harder to break and thus would limit its solublity. Hope this example helps