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Thread: IGF-1 Lr3 Reconstituted with Benzyl Alcohol, Acetic Acid, Cycle, Dosage How it works

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    MuscleChemistry Guru gandhisays's Avatar
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    Default IGF-1 Lr3 Reconstituted with Benzyl Alcohol, Acetic Acid, Cycle, Dosage How it works



    IGF-1 Lr3 Reconstituted with Benzyl Alcohol, Acetic Acid, Cycle, Dosage How it works
    IGF-1 and IGF-1 Lr3
    When HGH makes it pass through the liver, a release of IGF-1 is a result. IGF-1 appears to be the key player in muscle growth. It stimulates both the differentiation and proliferation of myoblast. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. While HGH will cause an increase in your IGF-1 level over the course of a few months, HGH has a cumulative effect, so the addition of IGF-1 will greatly speed up the time to results.

    There are two types of IGF-1 that will typically be used by bodybuilders. One is bio-identical HuIGF-1, a 70 amino acid string. The other is Long R3 IGF-1, which is an 83 amino acid analog of human IGF-I comprising the complete human IGF-I sequence with the substitution of an Arg for the Glu at position 3 (hence R3), and a 13 amino acid extension peptide at the N-terminus (hence the long). Which of these you use depends on your goal.

    HuIGF-1 is very short lived in the body (half life of probably around 10 minutes). This type of IGF-1 is very useful if you are seeking local site growth. Since it is so short lived, little of the IGF-1 makes it to other tissues and IGF-1 receptors in the body. The way to inject this is immediately post work out into the muscle that you wish to have local site growth. Use a U100 insulin syringe, and inject 80mcg's bilaterally into the desired muscle immediately post workout. For this type of IGF-1, I would use it workout days only or if desired you could inject on non-workout days first thing in the morning into a muscle group worked the previous day.

    For Long R3 IGF-1, it isn't as critical that you inject into a local site as long R3 has a active window of many hours, and is designed specifically to resist being bound. Since it is common to reconstitute this type of IGF-1 with Benzyl Alcohol, Acetic Acid, or Hydrochloric Acid I would still recommend that you inject intra-muscular. It can and probably will leave a nice red irritated spot if you inject Sub-C. I still inject into a muscle just worked to take advantage of increased IGF-1 receptors, but because of the long activity window of this type of IGF-1 any muscle will work well and give you good results,. I would suggest that you inject between 40-80mcg's per day everyday immediately post workout on workout days, and first thing in the morning on non-workout days.

    Use a U-100 insulin syringe with 1/2" needle to inject IGF-1 intramuscular (bilaterally for HuIGF-1, bilaterally optional for Long R3)

    - - - Updated - - -

    Insulin
    Working out causes us to end up in a catabolic state. It is important to back in a positive nitrogen balance as soon as possible. When not using insulin, we drink some dextrose with our protein to cause an insulin spike immediately post workout to help shuttle the protein and sugars to the muscles.

    Insulin is very good at shuttling nutrients to the muscles, and works in a very complimentary manner with GH in the types of things that they shuttle. Also, HGH can cause an amount of insulin resistance, so adding some insulin to your cycle will offset any potential resistance that might occur during your HGH cycle.

    For the purposes that we are using insulin, a dosage of 4-10IU's is adequate and should be used immediately post workout. I personally prefer using Humalog intramuscular as it will cause a rapid spike and clear out of your system quickly. You can use it sub-q or use Humulin-R instead, but each of these will result in a longer active window, thus a longer time to avoid eating any fats and watching your carb intake. Any fats or over abundance of carbs will end up being stored as fat during insulin's active window. The approximate windows are:
    Humalog
    Intramuscular---- 2-3 hours
    subcutaneous --- 3-4 hours
    Humulin R
    Intramuscular ---- 3-4 hours
    subcutaneous --- 4-5 hours

    Use a U-100 insulin syringe with 1/2" needle to inject IM immediately post workout. Alternatively, you can inject Sub-C if desired or if you wish a longer active window for some reason. Begin with a dose of 2IU's or so, and increase the dose each workout day until you reach your 8IU's.

    If for some reason you wish to avoid insulin, I would still suggest that immediately post workout you spike you own endogenous insulin by drinking 80 grams of dextrose / 40 grams of whey isolate protein. While this certainly won't do the work of 8-10 IU's of Humalog, it will most certainly assist getting your muscle back in a nitrogen positive environment in a short amount of time.
    T3
    HGH can have a slight inhibitory effect on your thyroid. For most people this is minimal and does not require any additional thyroid be taken, but if you wish to augment protein synthesis as well as give yourself a slight boost in thyroid without shutting down your own production, you can add 12.5mcg of T3 daily to your HGH, IGF-1, Insulin cycle. This will aid both in bulking and cutting.

    If you add this, you should also consider taking some thyroid support supplements such as t-100x, bladderwrack, coleus forskolin. You should check and make sure your intake of trace minerals (selenium, zinc, copper) is sufficient to aid in the conversion of T4 to T3.

    If you are going to take more than 12.5 mcg of T3, you will need to cycle the dose both up and down to avoid a rebound effect when going off cycle, but for our use with an HGH cycle and use in assisting with protein synthesis, 12.5mcg will be sufficient. If you wish to use T3 in conjunction with the above for heavy cutting, begin with 12.5mcgs, ramp up to 100-150mcgs, then slowly back down tapering back to 12.5 mcgs for a time before discontinuing use. This will minimize the chance for rebound while your own thyroid gets back in gear.

    Well, I think that about covers it. add a cycle or two of your favorite testosterone and you have a great combination for bulking or cutting.
    By RED BARON
     

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    There is much confusion as to how stable Long R3IGF-1 is once reconstituted, however unlike wild-type IGF-1, Long R3IGF-1 should be stable for several months once reconstituted even at room temperature, but ideally kept at 4oC, if not -20oC (manufacturers of Long R3IGF-1 recommend reconstitution in 100mM acetic acid to 1mg/ml and stored at -20oC for up to 3 months). This stability is dependent upon correct reconstitution with 100mM acetic acid. The concentration of Long R3IGF-1 is usually at 1mg/ml, thus 0.04ml would be required for 40mcg (4IU on an insulin needle). I know people who have used IGF-1 after having kept it reconstituted in acetic acid in the freezer for 1 year and still got great results. If this is a concern though, one can purchase the lyophilised form of Long R3IGF-1, which can be stored at 2-8oC, and reconstitute themselves, however bear in mind this reconstitution must be done with a sterile solvent and using sterile techniques. Finding the actual studies for this has proven to be somewhat troublesome, as they don't exist publicly, but rather we have to rely on the information given by GroPep on their website. NB: GroPep are the company that produce LongR3 IGF-1, and also own the patent (see www.gropep.com.au for more information):


    How long is the stock solution stable for under these storage conditions?

    Liquid stability data shows that Long R3IGF-1 is stable for 3 years (-20C to 37C). Therefore, the stock solution should be stable at 4C for 3 years.


    Is Long R3IGF-1 stable?
    Re-test date for freeze-dried peptide is 3 years. Liquid formulation stability studies have recently been completed. It is stable for 3 years (-20C to +37C). We have data indicating stability in media at 4C for 1 year.

    Please note, that when GroPep state 'liquid stability' they are referring to LongR3 IGF-1 that has been reconstituted by their recommended techniques, i.e. 100mM acetic acid to a stock concentration of 1mg/ml. Some websites sell media grade Long R3 IGF-1 in both lyophilised and reconstituted form, with the latter being reconstituted according to GroPep's recommendations (100mM acetic acid). If you state in your order from some reputable companies that you would like some extra acetic acid, they usually include an extra 5ml or so for free, so you can dilute your solution further if desired.
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    I posted this before but couldn't find it through a search in this forum, so decided i would add it to this thread, as stated above a lot confusion, and a lot of peptide companies selling garbage coming out of china.

    So yeah the people who owned the patent on IGF-1 lr3 have listed this info long ago! We bought direct from Gropep for over a decade, until word got out and Gropep started to tighten up things and not just sell to anyone.

    Anyhow, be careful out there buying your igf-1 lr3, loads of fake shit going around, but theres still some very reputable companies doing right by their customers!

    Guys who buy direct from Gropep or one of their subsidiaries/distributors if you will, buy 20mg and 50mg of lyophilized powder in one big vial, and they then add the aa solution, so if 50mg was purchased, then 50ml aa solution is added to the vial. Then they dose out 1mg/ml per vial at a time.

    The Bigger manufacturers of IGF-1 lr3 don't usually bother selling single 1mg lyophilized IGF-1 lr3.

    So i thought i would throw this info out there as its been a while since the old thread wight his info was bumped up, and a lot of OLD articles on IGF-1 lr3 are still being read and confusing guys!

    Thats about that lol
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    Bump for recent questions
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    MuscleChemistry Registered Member Powderguy's Avatar
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    Just Bumping this for others to read
     

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    Presser,

    New member here, long time lifter, and researcher. Looking to pick up some of MCs IGF-LR3, however after spending a few days trolling the forums I could not find anything that indicated whether or not it came reconstituted in AA?
     

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    bumping for people to read, yes igf-1 lr3 holds best with aa, and ba solution. Bact and sterile water starts degrading igf-1 lr3 very very fast! MC IGF-1 lr3 is 1mg/ml with aa solution!

    Old articles will state never buy prediluted igf-1 lr3, this means when in water, bact or sterile water. Acetic acid solution, ba, and glacial are the absolute best solutions to suspend igf-1 lr3 in and keep it viable from start to finish or store for months!

    This is how its been sold since we started selling it over 13 or 14 years ago!

    All Customer reviews you read in this forum and all other forums about our IGF-1 lr3 all have used the same exact igf-1 lr3 with aa solution!

    Thank you!

    P.S. we encourage customers to read this forum as much as possible and post questions if they dont understand something! we are quite simply #1 at what we do and happy to answer any and all questions!
    Last edited by Presser; 12-31-2015 at 04:06 PM.
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    Will i have to take Insulin with IGF-1 Lr3 or just IGF 1 Lr3 to get effects.
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    Quote Originally Posted by Daveo77 View Post
    Will i have to take Insulin with IGF-1 Lr3 or just IGF 1 Lr3 to get effects.
    No not all
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    Will i get good results with just IGF 1 Lr3 and no insulin?
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    Quote Originally Posted by Daveo77 View Post
    Will i get good results with just IGF 1 Lr3 and no insulin?
    Yes very good
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    Please help. If i use bac water to mix igf lr3 , how many mls per 1000 mcg vial. Thanks so much.
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    bact and sterile water will degrade your igf very fast. this is why acetic acid solution is used. you can only use the water when your going to use the contents up within a day or two, but 1mg(1,000mcg) of igf-1 lr3 you are not going to use up in a day or so .
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    In you order from MC is it already mixed with the acetic acid solution?
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    Quote Originally Posted by drtbear1967 View Post
    In you order from MC is it already mixed with the acetic acid solution?
    Yes sir.
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    If you take .20 per day how long would a bottle last?
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    Quote Originally Posted by drtbear1967 View Post
    If you take .20 per day how long would a bottle last?
    I think about a month and a half.
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    WHATS .20 ??
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    the 2 on a insulin needle correct?
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    20mcg a day should last 50 days.
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    Correct
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    Presser

    i got your igf-1 lr3. It's already mixed with the acid correct? I pinned each bicep with .20 and man my bicep felt like a HUGE pump. Normal? Didn't hurt just felt like I did Curls to failure
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    Quote Originally Posted by MNIRON View Post
    Presser

    i got your igf-1 lr3. It's already mixed with the acid correct? I pinned each bicep with .20 and man my bicep felt like a HUGE pump. Normal? Didn't hurt just felt like I did Curls to failure
    Huge pump means you have some potent igf right there brother! Very normal. Yes the igf is already reconstituted with aa.


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    Yep! That's the insulin-like effects that shuttle / force more nutrients than normal into your muscles , which is how and why we grow and reason behind added pumps
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