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    Default Longer Telomeres with Higher Insuline-like growth factor-1 Levels IGF-1 Lr3 Longevity

    Fot those who arent sure what telomeres are, its highly recommended you research them. Then you'll better understand why IGF-1 lr3 is touted as the fountain of youth, and why so many claims have been made as to how well IGF-1 works in reversing the aging process. Yes Reversing, Not just slowing down the aging process, but literally reversing it.

    Pubmed on IGF-1 and Telomeres!

    Higher circulating levels of IGF-1 are associated with longer leukocyte telomere length in healthy subjects.




    Abstract


    Mutations that inhibit the insulin-like growth factor-1 (IGF-1) extend the lifespan of worms, flies and mice. However, it appears that relatively low circulating levels of IGF-1 in humans are associated with aging-related diseases and diminished longevity. As leukocyte telomere length (LTL) is ostensibly a biomarker of human aging, we examined the relationship between LTL and blood IGF-1 in a healthy cohort. Our sample comprised 476 healthy, unrelated Caucasians (208 men and 268 women), aged 16-104 years, living in the West Coast of Southern Italy. We measured LTL by Southern blots and IGF-1 by enzyme-linked immunoassay. Both IGF-1 and LTL diminished with age (IGF-1, r=-0.601, P<0.001; LTL, r=-0.706, P<0.001). Age-adjusted LTL was positively associated with IGF-1 level throughout the age range of the cohort (r=0.270, P<0.001). IGF-1 accounted for about 10% of the inter-individual variation in LTL over and above the effect of age. Our findings suggest that both circulating IGF-1 and LTL are indices of healthy aging in humans. Further research will be necessary to establish whether LTL will ultimately be used in clinical settings as an index of healthy aging.

    Last edited by Presser; 08-25-2016 at 12:15 PM.
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    Insulin-like growth factors and leukocyte telomere length: the cardiovascular health study.

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    Abstract

    The insulin-like growth factor (IGF) axis may affect immune cell replicative potential and telomere dynamics. Among 551 adults 65 years and older, leukocyte telomere length (LTL), insulin-like growth factor-1 (IGF-1), and insulin-like growth factor-binding proteins 1 and 3 (IGFBP-1, IGFBP-3) were measured. Multivariate linear regression was used to model the association of LTL with IGF-1 and IGFBPs, while controlling for confounding and increasing precision by adjusting for covariates. We observed a significant association between higher IGF-1 and longer LTL after adjustment for age, sex, race, smoking status, body mass index, hypertension, diabetes, and serum lipids. The results suggested an increase of .08 kb in LTL for each standard deviation increase of IGF-1 (p = .04). IGFBP-1 and IGFBP-3 were not significantly associated with LTL. High IGF-1 may be an independent predictor of longer LTL, consistent with prior evidence suggesting a role for IGF-1 in mechanisms relating to telomere maintenance.

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    Telomeres and endocrine dysfunction of the adrenal and GH/IGF-1 axes.

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    Abstract

    Telomeres, located at the end of linear chromosomes, are essential to maintain genomic stability. Telomere biology has recently emerged as an important player in the fields of ageing and disease. To maintain telomere length (TL) and reduce its degradation after mitosis, the telomerase enzyme complex is produced. Genetic, epigenetic, hormonal and environmental factors can regulate telomerase function. These include stress hormones such as cortisol and growth factors. The hypothalamic-pituitary-adrenal (HPA) axis has been evaluated in psychiatric diseases where hypercortisolism and oxidative stress are often present. Some researches have linked TL shortening to increases in stress-related cortisol, but others have not. The effects of cortisol on the telomere system are complex and may depend on the intensity and duration of exposure. On the other hand, low levels of IGF-1 are associated with inflammation and ageing-related diseases (ischaemic heart disease, congestive heart failure). Both IGF-1 and TL diminish with age and are positively and strongly correlated with each other. It is not clear whether this positive correlation reflects a single association or a cause-effect relationship. Further research will ideally investigate longitudinal changes in telomeres and both these hormonal axes. To our knowledge, TL dysfunction has not been described in either endogenous hypercortisolism (Cushing's syndrome) or acromegaly where excessive amounts of GH and consequently IGF-1 are produced. This review focuses on the possible relationships between telomere dysfunction and the hypothalamic-pituitary-adrenal (HPA) axis and GH-IGF-1 system.

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    Good information, thx
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    thnx, i watched a documentary on telomeres, so i found this information to fucking awsome!
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    Studies on aging and how IGF-1 can not only slow aging process but actually slowly reverse it!
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    Quote Originally Posted by Presser View Post
    Studies on aging and how IGF-1 can not only slow aging process but actually slowly reverse it!
    Ive been skimming through different studies on this. Did they give cycle length Press?
     

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    i didnt see it
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    I believe member Jagger posted information on Telomeres today in Steroid discussion forum, and I thought I would bump this read up to bounce off his new post which showed a direct connection between igf-1 and telomeres, and I remembered I had posted similar studies myself!

    And remember this: WE ARE NOT JUST TALKING ABOUT SLOWING THE AGING PROCESS, BUT RATHER ACTUALLY SLOWLY REVERSING IT....AS IN (GETTING YOUNGER)

    ANYONE INTERESTED IN THIS PROCESS OF EXTENDING YOUR TELOMERES LIFE THROUGH USING IGF-1 LR3 CAN FIND IT LINKED BELOW:

    WWW.MUSCLECHEMADVANCEDSUPPS.COM
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    Did they say anything about the dosage needed or the length before noticeable changes began to occur?
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    Sorry just seen your reply and we have some other studies posted on this IGF-1 & telomere linkage, but in all honesty I dont think any of them get into dose specifics, theyre all basically "conclusion" based parts of the studies but with links back to the original publication like pubmed or the like
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    MC IGF is great stuff!
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    Great information
     

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    bumping solid information regarding the cause and effect between telomeres length and igf-1 levels!

    Telomeres length indications:

    Longer Telomeres = Longer Healthier Life!

    Shorter Telomeres = Shorter Life.

    Higher IGF-1 Lr3 Levels = Longer Telomeres

    You do the Math!
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    Quote Originally Posted by Presser View Post
    bumping solid information regarding the cause and effect between telomeres length and igf-1 levels!

    Telomeres length indications:

    Longer Telomeres = Longer Healthier Life!

    Shorter Telomeres = Shorter Life.

    Higher IGF-1 Lr3 Levels = Longer Telomeres

    You do the Math!
    Makes sense to me
     

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    to the top
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    I been meaning to post copy of new telomere to igf connection publication
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    I did post it in the Articles forum! The NEW Telomere IGF connection study. See if I can’t link it here as I said I would
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    Great read for anyone trying to slow down the aging process
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    Bumping this up to go along with yesterday’s new thread regarding the activation of telomere
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    Telomeres crucial to aging, or shall I say anti-aging. If any of you are not familiar with this subject, I suggest you get acquainted with what telomeres are at the very least!

    I will see if any new studies have been published regarding telomeres length and igf-1
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    Anyone else have anything new on telomeres? or igf-1 and length of telomere?
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