welcome to MuscleChemistry, and how old are you? as tingling left arm, is associated with other problems as you know, so just curious
Iron Game
Veteran
Welcome to musclechemistry. Let us know how it works out.
jimbosmith316
MuscleChemistry
MT2
- Peptides. 2010 Apr;31(4):639-43. doi: 10.1016/j.peptides.2009.12.019. Epub 2009 Dec 23.
Intermittent MTII application evokes repeated anorexia and robust fat and weight loss.
Zhang Y1, Collazo R, Gao Y, Li G, Scarpace PJ.
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Abstract
<abstracttext>Central melanocortins (MC) evoke potent but transient anorectic responses with tachyphylaxis developing within days. We hypothesized that intermittent therapy using the MC analog, melanotan II (MTII), would minimize the tachyphylaxis and enhance the long-term efficacy of MTII treatment. F344/BN rats were infused with MTII or vehicle into the lateral ventricle by mini pump for 14 days. Half the MTII-infused rats were then given vehicle (MTII-On/Off), while the remaining received fresh MTII (MTII-On) for 10 days. Finally, pumps in both groups were replaced with ones containing fresh MTII for an additional 6 days. The first MTII application induced a 30% food reduction that attenuated within 5 days. Reapplication of MTII in MTII-On/Off rats, after the off period, invoked a new and equally robust anorectic response while continuation of MTII supplement in the MTII-On group did not change food intake from the control level. Body weights decreased similarly in both MTII groups at termination (day 30). Hypothalamic MC3 receptor, AgRP, and POMC expressions were unchanged, but MC4 receptor expression was diminished by 25%, and adiposity reduced by 80% in both MTII groups. Acetyl-CoA carboxylase 1 phosphorylation was elevated in perirenal fat by over 10 fold with either MTII treatment. In conclusion, intermittent MTII treatment preserves anorectic responses but does not prevent tachyphylaxis, whereas constant MTII application blunts further food response after the initial tachyphylaxis. Either form of MTII administration results in significant weight and adiposity reductions, involving perhaps fatty acid oxidation within specific adipose tissues.</abstracttext>
Published by Elsevier Inc.
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jimbosmith316
MuscleChemistry
Could be a allergic reaction. Try taking an antihistamine.
LeatherHead
New member
When I use it, I pin right before bed. I pass out and have no trouble sleeping, and no stomach irritation. I just wake up the next day a little darker with a few more freckles.
Sent from my SM-G900V using Tapatalk
Sent from my SM-G900V using Tapatalk
Lmao I always got red as hell in the sun now I have a brown neck its great.
I'd be embarrassed to if everyone seen my boner was all of 4 inches :crap:
crash
New member
LMAO that just made my day I look like I have a pocket full of quarters ha ha
lol, the emoticon face was perfect lmao and for the record, im walking around with dimes daddio lmao poor me lmao
The Dude
MuscleChemistry Registered Member
You learn to work with it. I blame it on the girl now. I tell her that normally it's alot bigger, but she just isn't all that pretty. You've got to capitalize on those insecurities
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