HackTwat
MuscleChemistry Registered Member
FOLLISTATIN and BODYBUILDING
With new products entering the market all the time, nothing has hit like the recent storm about Follistatin. But the problem is; no one knows anything about this compound and its true power! So I’m here to break some things down for you.
Follistatin, simply put, it a protein that is a myostatin antagonist (or myostatin-binding protein). Myostatin, as we know, regulates our body’s muscle growth, kind of like a governor in cars. Myostatin is produced by our bodies naturally to limit our skeletal muscle growth, so that our muscles grow “in proportion” to our body. Thus, we have circulating in our blood stream, a gene that will literally inhibit our growth naturally. Not something we want right? Also, myostatin levels have been seen to be dramatically higher in later weeks of anabolic cycles. This is believed to be the reason as to why most gains are usually seen in the first 10 weeks of a cycle, because after that, myostatin levels peak and really limit your muscle growth. But what if that could be changed? If we could block myostatin, we could potentially see these 12 to 15 weeks cycles making constant gains, which would be something that is rarely to never seen. “In men treated with graded doses of testosterone, myostatin levels were significantly higher on day 56 than baseline in both young and older men; changes in myostatin levels were significantly correlated with changes in total and free testosterone in young men.”This is where follistatin comes in. Follistatin is used to inhibit myostatin activity in vitro resulting in skeletal muscle growth in vivo. Simply, when follistatin is introduced, a shortage in myostatin is seen which results muscle growth. Studies have backed up this, and research on monkeys and other mammals began after rodent trials were shown successful. The result of follistatin treatment was a significant increase in muscle mass and strength. In one study I paid particular attention to, Follistatin over expression increased the muscle weight by about 37% in control animals! Another study looked at, showed not only an increase in skeletal muscle, but a decrease in fat accumulation! What we also found interesting is that our bodies already produce an increased amount of follistatin with exercise! I see this as another one of the ways our body is kind of “turned=on” to muscle growth in retaliation of exercise. After many trials, it was conclusive that follistatin seems to be quite successful in inhibiting myostatin, which results in these muscle and strength gains.
So what we have here is, a protein that binds with another which limits our muscle growth, that is naturally released with exercise, which induces an increase in muscle mass and a decrease in fat storage. A way for us to take our longer cycles to full potential, and see gains past week 10, while off cycle still pushing our bodies to produce gains that have normally been inhibited. This amazing compound is new to the market, and at a price as it is quite an expensive compound to produce. But with its potential to be a staple in long cycles, and off-cycle growth, it may just be gold. Dosing for follistatin is pretty high, usually around 100mcg a day as a 1mg bottle will only be good in the fridge for about a week before some serious degradation happens, and at the price we are paying for it, it is best to make sure we use it fast and at its full potential. Recent logs have shown gains of a little more then 1 pound per day in small 7 to 10 day cycles.
With new products entering the market all the time, nothing has hit like the recent storm about Follistatin. But the problem is; no one knows anything about this compound and its true power! So I’m here to break some things down for you.
Follistatin, simply put, it a protein that is a myostatin antagonist (or myostatin-binding protein). Myostatin, as we know, regulates our body’s muscle growth, kind of like a governor in cars. Myostatin is produced by our bodies naturally to limit our skeletal muscle growth, so that our muscles grow “in proportion” to our body. Thus, we have circulating in our blood stream, a gene that will literally inhibit our growth naturally. Not something we want right? Also, myostatin levels have been seen to be dramatically higher in later weeks of anabolic cycles. This is believed to be the reason as to why most gains are usually seen in the first 10 weeks of a cycle, because after that, myostatin levels peak and really limit your muscle growth. But what if that could be changed? If we could block myostatin, we could potentially see these 12 to 15 weeks cycles making constant gains, which would be something that is rarely to never seen. “In men treated with graded doses of testosterone, myostatin levels were significantly higher on day 56 than baseline in both young and older men; changes in myostatin levels were significantly correlated with changes in total and free testosterone in young men.”This is where follistatin comes in. Follistatin is used to inhibit myostatin activity in vitro resulting in skeletal muscle growth in vivo. Simply, when follistatin is introduced, a shortage in myostatin is seen which results muscle growth. Studies have backed up this, and research on monkeys and other mammals began after rodent trials were shown successful. The result of follistatin treatment was a significant increase in muscle mass and strength. In one study I paid particular attention to, Follistatin over expression increased the muscle weight by about 37% in control animals! Another study looked at, showed not only an increase in skeletal muscle, but a decrease in fat accumulation! What we also found interesting is that our bodies already produce an increased amount of follistatin with exercise! I see this as another one of the ways our body is kind of “turned=on” to muscle growth in retaliation of exercise. After many trials, it was conclusive that follistatin seems to be quite successful in inhibiting myostatin, which results in these muscle and strength gains.
So what we have here is, a protein that binds with another which limits our muscle growth, that is naturally released with exercise, which induces an increase in muscle mass and a decrease in fat storage. A way for us to take our longer cycles to full potential, and see gains past week 10, while off cycle still pushing our bodies to produce gains that have normally been inhibited. This amazing compound is new to the market, and at a price as it is quite an expensive compound to produce. But with its potential to be a staple in long cycles, and off-cycle growth, it may just be gold. Dosing for follistatin is pretty high, usually around 100mcg a day as a 1mg bottle will only be good in the fridge for about a week before some serious degradation happens, and at the price we are paying for it, it is best to make sure we use it fast and at its full potential. Recent logs have shown gains of a little more then 1 pound per day in small 7 to 10 day cycles.
