drtbear1967
Musclechemistry Board Certified Member
theguerillachemist
I get this question a lot bc I think there is some bad info on message boards. Drug Affinity Complex(DAC) is a delivery technology developed by ConjuChem in order to protect peptides from rapid degrading and metabolism by the kidneys. A peptide is "chopped" up by enzymes called peptidases, usually very rapidly. By attaching the synthetic DAC portion to the peptide, it is able to extend the half life from several minutes up to 7 days.
If you look at the structure here, you'll see the DAC includes a "linker" molecule and a maleimide molecule which binds to albumin, a protein found in your blood. Covalent attachment to albumin can block both cleavage by peptidases and various mechanisms of clearance of a variety of peptides. Once in the body, the DAC moiety increases bioavailability, as well.
So to sum up: DAC can increase the half life of many peptides like GRF1-29(CJC-1295 is GRF1-29 plus DAC)by decreasing the activity of peptidases. It also increases bioavailability and maintains biological activity. This study definitively shows there is no "bleed" from CJC-1295. I recommend going with this option over certain peptides without DAC so you can enjoy the benefits of the peptide without injecting multiple times a day.
I get this question a lot bc I think there is some bad info on message boards. Drug Affinity Complex(DAC) is a delivery technology developed by ConjuChem in order to protect peptides from rapid degrading and metabolism by the kidneys. A peptide is "chopped" up by enzymes called peptidases, usually very rapidly. By attaching the synthetic DAC portion to the peptide, it is able to extend the half life from several minutes up to 7 days.
If you look at the structure here, you'll see the DAC includes a "linker" molecule and a maleimide molecule which binds to albumin, a protein found in your blood. Covalent attachment to albumin can block both cleavage by peptidases and various mechanisms of clearance of a variety of peptides. Once in the body, the DAC moiety increases bioavailability, as well.
So to sum up: DAC can increase the half life of many peptides like GRF1-29(CJC-1295 is GRF1-29 plus DAC)by decreasing the activity of peptidases. It also increases bioavailability and maintains biological activity. This study definitively shows there is no "bleed" from CJC-1295. I recommend going with this option over certain peptides without DAC so you can enjoy the benefits of the peptide without injecting multiple times a day.
