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    Default Ipamorelin (Legitimate HGH Substitute)

    All About Ipamorelin (Legitimate HGH Substitute?)

    For those of you who are completely new to Peptide Science, take this as a rapid crash course in growth hormone secretagogues.

    What is Ipamorelin?

    Ipamorelin has of recently been making rounds, especially in experienced anabolic and peptide users. Simply put, Ipamorelin is the newest synthetic growth hormone releasing peptide (sometimes referred to as a secretagogue), rivaling the older versions, such as GHRP-6. Chemically, there are a few differences, most of which are likely to go over the heads of most of us, except that just keep in mind that Ipamorelin is a penta-peptide (consisting of 5 amino acids), while the classical GHRPs are hexa-peptides (6 amino acids). Of greater interest, however, is the fact that Ipamorelin is the first selective growth hormone secretagogue[i] (that is, without releasing cortisol).

    What Does Ipamorelin Do?

    As could be expected with a growth hormone secretagogue, the end resulting effects are those of growth hormone itself, with the exception of a few which will be discussed later. In general, however, the effects you can expect from administration of it includes:

    Improved Quality of Sleep- growth hormone is one of the primary hormones that contribute to deep, restorative sleep, known as the REM (rapid eye movement) phase. Administration of Ipamorelin, along with supplemental Melatonin, are likely even better than many prescription strength sedatives (based on anecdotal evidence)
    Increased Production and Regeneration of Connective Tissue- one of the major benefits, and sometimes hindrance of GH-secretagogues is their profound effect on connective tissue. They help speed up recovery from cartilaginous injury (that occurs in joints), and also help reduce wear and tear associated with heavy training. However, on the flip side, sometimes they may also promote hypertrophy of these tissues, resulting in unnecessary surgery to remove such growths.
    Bolstered Immune System- intense training takes a toll on both the central nervous system and the body physically, compromising the body’s natural defense mechanism- the immune system. However, under the influence of pulsatile GH-secretagogues, the body’s ability to heal and defend is amplified exponentially. For this reason, many athletes concerned about using anabolics because of their effects on health, may opt for peptides, which are deemed “health compounds”
    Decreased Body Fat- growth hormone is a lipolytic and recomposition agent used for bringing about partition change. By this, it means the user typically loses a few pounds of fat, gains a few pounds of lean mass, but overall maintains the same weight. Research has shown that men with higher levels of circulating growth hormone are leaner than their counterparts, and build more mass, more efficiently
    Can prevent or slow down the demineralization of bone, delaying onset or progression of osteoporosis, and stabilizing bone mineral density[ii]
    How Is Ipamorelin Being Used?

    Currently, Ipamorelin is being used by different “crowds” of people. On the one hand, it is used once daily (at night) by the people using it primarily for its anti-aging effects, while athletes using it specifically for GH mediated effects on performance and body composition, will benefit greatly from multiple injections taken to coincide with the natural pulsatile release of Growth Hormone.

    On the other hand, interestingly, it can be used as a sort of “hormone replacement therapy” for athletes who had chronically used synthetic HGH for years, and whose pituitary have become desensitized to the normal release pattern when not under synthetic stimulation.

    How Is Ipamorelin Different From HGH?

    HGH, in all senses, is the parent drug, or the hormone that elicits positive effects itself. It is naturally produced by the pituitary gland, or may be synthetically administered, and is responsible for some of the important functions listed above. On the other hand, Ipamorelin is a HGH releasing agent, or secretagogue, that signals for the pituitary to release more natural HGH. Also, another way to define the differences between the two would be to consider HGH the “complete” hormone, while Ipamorelin is a fractionated “segment” of it, merely capable of signaling release.

    Is It Different From GHRP-6 or CJC-1295?

    To start, Ipamorelin and GHRP-6 are both growth hormone releasing peptides, while CJC-1295 is referred to as synthetic growth hormone releasing hormone.

    Now this may sound confusing, but basically they both elicit the same effect- which is to stimulate growth hormone release, but differ primarily in their duration of action, potency and inhibitory effect of somatostatin (which itself causes suppression of GH release)

    CJC-1295 is capable of binding albumin in blood, and may remain active for days in the body, triggering the pulses of GH. Ipamorelin, on the other hand, has a much shorter duration of action, but can cause more pronounced releases of GH during natural pulses. CJC-1295 mediates a more powerful release (quantity) of GH, while Ipamorelin signals the time for release

    So, in a nutshell, the two may be used simultaneously to exert a synergistic effect; where normally 1+1=2, in the case of CJC-1295 and Ipamorelin (or GHRP-6), 1+1= 6.

    Side Effects of Ipamorelin

    While the possibility of side effects while using GH congeners is still real, athletes using judicious doses will likely not cause any major trouble. However, common side effects may include:

    Headaches
    Dizziness
    Very minor effect on bone growth (such as in the face or extremities), if measurable at all
    Reduced insulin sensitivity (but lesser than GHRP-6)
    Lethargy
    Possible diabetogenic properties[iii] (promoting development of diabetes)
    These are all potential 'side effects' of HGH, which hardly anyone experiences if they are using the compound as directed.

    Can Ipamorelin Cause Hair Loss?
    (By: Good Looking Loser)

    Although unlikely, any hair loss from Ipamorelin falls under the category of "shedding" and not androgenic alopecia (male pattern baldness involving the miniaturization of hairs). Any hair that "sheds" should return and regrow to full capacity.

    For more on "Hair Loss vs. Shedding" please see "Good Looking Loser's Guide to Hair Loss Prevention".
    (scroll down to Hair Loss vs. Shedding)

    How is It Normally Dosed?

    Ipamorelin is typically dosed at 1 microgram per kilogram of body weight, normally administered 2-4 times daily, to coincide with the natural release patterns of GH.

    The typical dose is 100 micrograms, administered 3 times everyday, 8 hours apart to ensure a stable HGH level.

    Bigger or more experienced guys will administer 150-300 micrograms, 3 times a day.

    Ipamorelin may also be administered via subcutaneous injection (SQ, under the skin) or intramuscularly, although many opt for SQ. At a minimum, a cycle of Ipamorelin should be ran at least 6 weeks, since that is the time for effects to be obvious. Longer cycles shouldn’t be a problem though, as no artificial hormone is being exogenously administered.

    Most people stay on for months at a time, like HGH.

    Can It Be Combined With Anabolic Steroids or Synthetic HGH?

    It is quite common for GHRPs to be combined with steroids, to potentiate their muscle building potential, or to strike a balance between mass gain and fat loss (such as with milder, non-aromatizing steroids).

    It would make no sense to combine GHRPs with synthetic HGH, since upon administration of the latter, natural GH production becomes suppressed via the negative feedback loop, hence rendering the GHRP obsolete.

    What Can I Expect From Ipamorelin?

    Ipamorelin will deliver many similar effects as HGH administration, albeit possibly not to the same magnitude or at the same risk.

    For example;

    Ipamorelin is thus far the only GHRP that will not increase hunger via the hormone Ghrelin.
    It significantly decreases levels of somatostatin, responsible for signaling the shutdown mechanism upon GH production.
    You will NOT gain a ton of muscle mass. Neither will you lose remarkable fat. You will, however, display marked recomposition effects via net change of fat loss to muscle gain.
    Ipamorelin does not significantly increase levels of prolactin or cortisol.
    It shares several similarities to HGH, for example;

    Like HGH, Ipamorelin requires several months to see pronounced results such as lowered body fat or significant muscle growth.
    Like HGH, Ipamorelin is dose-dependent.
    I have found that the typical Ipamorelin dosing protocol (100mcg, 3x/daily) is similar to the typical HGH dosing protocol (4ius, 1x/daily).
    Ipamorelin closely mirrors generic HGH or "blue tops" but is less potent than pharmaceutical grade HGH, which is very expensive.
    This is just my opinion.

    Experiences and comparisons to HGH will vary based on the quality of your source and the other compounds that you have tried.

    I do feel that many will consider it a decent alternative to HGH.

    What is The Current Legal Status of Ipamorelin?

    To date, Ipamorelin is not approved by the FDA as a POM (prescription only medication), so the only real way to get it is from labs specializing in the sale of “research peptides”.

    While they are in no way less safe than drugs made by big pharma, their prices may be much more competitive.

    How Is Ipamorelin Reconstituted (Mixed)?

    The general consensus when reconstituting many GHRPs, is to mix with as little bacteriostatic water (yes, water) as possible. In the case of Ipamorelin, the ratio of actual peptide to water (referred to as BW) is 1:2, meaning that for every 1ml of water, 2ml of powder would be added.

    Also note- never shake the vial containing peptides. If it doesn’t dissolve naturally in a few minutes, gently swirl it around.

    The reason for this is the fact that peptides by themselves are not extremely stable.

    You can break them.
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    Masher, thanks for posting this up. Never heard of this stuff before; it looks EXTREMELY interesting!
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    GHRP6 is sloppier in that it activates a wider array of effects beyond GH release. It causes intense hunger and gastic motility. It can have a mild effect on cortisol and prolactin. It is a first generation GHRP.


    GHRP2 is less sloppy with a more intense GH release, no gastric motility and less hunger effect. It can have an effect within the normal range on prolcatin and cortisol. It is a second generation peptide.


    Ipamorelin is not sloppy at all. It does not release as much GH as GHRP2 but it causes virtually no hunger or gastric motility and for the most part does not effect cortisol or prolactin. It is a third generation peptide


    You would choose GHRP2 unless you wanted GHRP-6 for the hunger effect or for the lower release profiles.


    You would choose GHRP2 normally as the most bang for the buck.


    If you are very sensitive to perturbations in cortisol or prolactin you would choose the more expensive Ipamorelin.
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    I really like the limited side effects noted with Ipa-whatever-it's -called. And I see some blends available which includes CJC-1295. There are other blends available, too, including GHRP-2 with CHC1295. They're all a little pricey.

    Also, since reading Masher's post, I've read a few articles on this stuff. Most say pretty much the same thing, but I see conflicting info about the life of it after reconstituting. Extremes fro 8 weeks to 1-1/2 weeks.

    Any comments on that?
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    Quote Originally Posted by EMW14 View Post
    I really like the limited side effects noted with Ipa-whatever-it's -called. And I see some blends available which includes CJC-1295. There are other blends available, too, including GHRP-2 with CHC1295. They're all a little pricey.

    Also, since reading Masher's post, I've read a few articles on this stuff. Most say pretty much the same thing, but I see conflicting info about the life of it after reconstituting. Extremes fro 8 weeks to 1-1/2 weeks.

    Any comments on that?
    I store my Lyophilized powder in the freezer and try to use the reconstituted vials in 4-6 weeks, which I store in a refrigerator, some say room temp will last 4-6 but I dont trust it.Also recon with BAC water.
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    Cool, thanks.
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    Some sites I visited have the Ipamorelin cheaper than the GHRP-2. It's definitely worth looking into as a first run on these types of peptides. Then you have a baseline and can experiment with the others.
     

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    Quote Originally Posted by Masher59 View Post
    Some sites I visited have the Ipamorelin cheaper than the GHRP-2. It's definitely worth looking into as a first run on these types of peptides. Then you have a baseline and can experiment with the others.
    Ipam was much more expensive where i was getting mine from. Very interesting
     

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    You need much more than 100mcg Ipamorelin for it to be truly effective. I would recommend a minimum of 300mcg twice daily. It also needs to be dosed with a GHRH such as Mod GRF 1-29 or CJC 1295 with DAC. GHRP 2/6 don't effect prolactin/cortisol as much as many think but can be troublesome for sensitive individuals. Although Ipam is definitely a better choice if prolactin or cortisol are a concern. I would also recommend looking into hexarelin which is similar to GHRP-2 in regards to GH output. The best way to go about things is you a standard cycle of a GHRH with GHRP (ghrp 2 for example) in the daytime (2-3 injections). Or you could run 100-200mcg Hexarelin as that can elicit a large gh spike without the need of a GHRH. Then pre bed use a large dose of Ipamorelin. The more the better but 500mcg is a nice amount. I have seen 100mcg mod grf and 500mcg ipam score a 12 on a gh serum. The ipam is ideal pre bed as it's longer acting that the other ghrp's and of course will cause no increase prolactin or cortisol. It should also improve your sleep quality and put you in REM for longer.
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    Quote Originally Posted by Elvia1023 View Post
    You need much more than 100mcg Ipamorelin for it to be truly effective. I would recommend a minimum of 300mcg twice daily. It also needs to be dosed with a GHRH such as Mod GRF 1-29 or CJC 1295 with DAC. GHRP 2/6 don't effect prolactin/cortisol as much as many think but can be troublesome for sensitive individuals. Although Ipam is definitely a better choice if prolactin or cortisol are a concern. I would also recommend looking into hexarelin which is similar to GHRP-2 in regards to GH output. The best way to go about things is you a standard cycle of a GHRH with GHRP (ghrp 2 for example) in the daytime (2-3 injections). Or you could run 100-200mcg Hexarelin as that can elicit a large gh spike without the need of a GHRH. Then pre bed use a large dose of Ipamorelin. The more the better but 500mcg is a nice amount. I have seen 100mcg mod grf and 500mcg ipam score a 12 on a gh serum. The ipam is ideal pre bed as it's longer acting that the other ghrp's and of course will cause no increase prolactin or cortisol. It should also improve your sleep quality and put you in REM for longer.
    Ipam for me was just too expensive.
     

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    Quote Originally Posted by jimbosmith316 View Post
    Ipam for me was just too expensive.
    That's why when guys are on a budget I tend to recommend hexarelin or one of the others. Although you can get some good deals from time to time. But Ipam is more expensive than the others. If a budget permits it one big dose pre bed is a great addition to a cycle though. That's the other issue though you need much more ipam than the others but for sleep and recovery it's the best injectable ghrp for me.
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    These peptides are pretty interesting

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    Quote Originally Posted by Elvia1023 View Post
    You need much more than 100mcg Ipamorelin for it to be truly effective. I would recommend a minimum of 300mcg twice daily. It also needs to be dosed with a GHRH such as Mod GRF 1-29 or CJC 1295 with DAC. GHRP 2/6 don't effect prolactin/cortisol as much as many think but can be troublesome for sensitive individuals. Although Ipam is definitely a better choice if prolactin or cortisol are a concern. I would also recommend looking into hexarelin which is similar to GHRP-2 in regards to GH output. The best way to go about things is you a standard cycle of a GHRH with GHRP (ghrp 2 for example) in the daytime (2-3 injections). Or you could run 100-200mcg Hexarelin as that can elicit a large gh spike without the need of a GHRH. Then pre bed use a large dose of Ipamorelin. The more the better but 500mcg is a nice amount. I have seen 100mcg mod grf and 500mcg ipam score a 12 on a gh serum. The ipam is ideal pre bed as it's longer acting that the other ghrp's and of course will cause no increase prolactin or cortisol. It should also improve your sleep quality and put you in REM for longer.
    I use 300 mcg at night before bed.
    I take gh in morning and afternoon
    I wake up full of sweat after 3 hours and after 4 more feel great to get up

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    do people use ipamorelin anymore now that mk677 is the new growth hormone secretagogue of choice.
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    Quote Originally Posted by Pro Quest Nutrition View Post
    do people use ipamorelin anymore now that mk677 is the new growth hormone secretagogue of choice.
    I had some store credit and just got 4 vials I'm about to try out and already have a 10 pack sitting in my cart for my next order

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    Quote Originally Posted by IronJulius View Post
    I had some store credit and just got 4 vials I'm about to try out and already have a 10 pack sitting in my cart for my next order
    its your first go with it brutha??
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    Quote Originally Posted by Presser View Post
    its your first go with it brutha??
    Yes took it the past 2 night about 250mcg before bed and have had really good sleep seem to have good recovery

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    Nice! Can't argue with a good nights sleep


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    Quote Originally Posted by Presser View Post
    Nice! Can't argue with a good nights sleep
    I took some after my surgery with some MC IGF.
    I also added generic Hgh.
    I healed fast.



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