Micronucleus as biomarkers of cancer risk in anabolic androgenic steroids users.

[Dean Destructo]

The use of anabolic androgenic steroids (AAS) has grown among practitioners of recreational bodybuilding, with significant contributions of designer steroids, aiming muscle hypertrophy in healthy subjects. The abusive use of AAS in general is associated with adverse effects; one of the most worrisome is cancer development. The aim of this study was to evaluate the effectiveness of the cytokinesis block micronucleus (CBMN) test in human lymphocytes in identifying risk groups for cancer development in users of AAS. Blood was collected from 15 AAS users bodybuilders(G1), 20 non-users bodybuilders (G2) and 20 non-users sedentary (G3). MN analysis was performed on a minimum of 1000 binucleated lymphocytes. The occurrence of MN was significantly higher (p < 0.05) in individuals of G1 compared to G2 and G3. The results indicate the sensitivity of CBMN in human lymphocytes in the identification of chromosomal damage in consequence of AAS.

<dt style="display: inline; padding: 0px; margin-top: 0px; margin-right: 0px; margin-bottom: 0px; white-space: nowrap; color: rgb(87, 87, 87); font-family: arial, helvetica, clean, sans-serif; font-size: 11.0045px; margin-left: 0px !important;">PMID:</dt> <dd style="margin: 0px; display: inline; padding: 0px; white-space: nowrap; color: rgb(87, 87, 87); font-family: arial, helvetica, clean, sans-serif; font-size: 11.0045px;">27198677</dd> <dt style="display: inline; padding: 0px; margin-top: 0px; margin-right: 0px; margin-bottom: 0px; white-space: nowrap; color: rgb(87, 87, 87); font-family: arial, helvetica, clean, sans-serif; font-size: 11.0045px; margin-left: 10px !important;">DOI:</dt> <dd style="margin: 0px; display: inline; padding: 0px; white-space: nowrap; color: rgb(87, 87, 87); font-family: arial, helvetica, clean, sans-serif; font-size: 11.0045px;">10.1177/0960327116650005

• 1Department of Biological Sciences, Feira de Santana State University, Bahia, Brazil.
• 2Department of Biological Sciences, Feira de Santana State University, Bahia, Brazil [email protected].

</dd>

 

[Presser]

yeah now lay it on me in lay talk

 

[Iron Game]

yeah now lay it on me in lay talk

LMAO, I know right.

 

[EMW14]

yeah now lay it on me in lay talk

Yeah, really LMAO. Me too, give it to me in English...

First time I heard the term "efficacy" from a doc, I said, "Huh? What the he'll does that mean?" She explained, and I said, "Why don't you just say, 'effectiveness', like everybody else? "

She laughed and said, "I don't know!" LMAO!!

 

[Dean Destructo]

A lymphocyte is one of the subtypes of white blood cell in a vertebrate's immune system.Lymphocytes[FONT=arial, sans-serif] include natural killer cells (NK cells) T cells and B cells .[/FONT]

[FONT=arial, sans-serif]This study is saying that it shows actual biological change to the white blood cells with regular AAS use. By effecting them your chances of cancer are increased.

What I don't like is that they give little info to the age range and gear or even how long they were on. [/FONT]