All Hail ALA...

[sndmn6]

In addition to a liver protectant, which I need anyway (especially with five or six weeks of d-bol), ALA also helps with nutrient partitioning, and in so few words, shuttles the carbs from a heavy meal into the muscles as opposed to the fat cell stores. Is this somewhat accurate?

I've also read that many of you take this stuff year round. Is this stuff that good? I even read that in high doses it can even be compared to a weak version of Primo. Yeesh.

I've seen that most of you recommend taking 1,000 mg to
2,000 mg daily, and right after heavy carb meals?

Is Anabolical the cheapest place for this stuff, being that 100 tabs at 500 mg/tab will only last a little over a month, if taking
1,500 mg/day?

 

[rugbythug]

What you said is true as far as I know. Although the primo comment seems a stretch-You may look into going with ALA-r instead of ALA. I saw a study somewhere that Heavy doses of ALA shortened mice lifespan-However the r version did not. ALA-r Has all the same good points and can be used at 1/2 the dosages of ALA.

 

[midwtchamp]

bump fro where to get ALA

 

[rugbythug]

I found this on www.1fast400.com I did not go through and read the actual study they mentioned.

So if I take half the amount of R-ala compared to ALA, I'll get the same results?
It’s not quite that simple, although until recently researchers thought this was the case. There is new evidence surfacing that the unnatural S-form may actually interfere with the beneficial properties of the R-form. In one study with mice, alpha Lipoic acid at high doses shortened the mean lifespan, but even at low doses, the R- form increased total life-span. So it is best to avoid the S-form altogether in order to achieve maximum benefits.

Do you have a list of studies I can reference for R-ALA?

1. Nichols, T.W. Alpha lipoic Acid: Biological Effects and Clinical Implications,

2. Moini, H., Tirosh, O., R-Alpha Lipoic Acid Action on Cell Redox Status, the Insulin Receptor, and Glucose Uptake in 3T3-L1 Adipocytes; Archives of Biochem & BioPhys 397, No2 384-391 (2002)

3. Liu, J. Killilea, D.W. et.al., Age-associated mitochondrial oxidative decay: Improvement of carnitine acetyltransferase substrate binding affinity and activity in brain by feeding old rats acetyl-L-carnitine and/or R-alpha-lipoic acid. Proc Nat Acad Sci 99, 1876-1881 (2002)

4. Liu, J., Atamna, H., et.al. Delaying Brain Mitochondrial Decay and Aging with Mitochondrial Antioxidants and metabolites. Ann NY Acad Sci 959:133-166 (2002)

5. Liu, J., Head, E., et.al., Memory Loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: Partial reversal by feeding acetyl-l-carnitine and/or R-alpha lipoic acid. Proc Natl Acad Sci USA 99, 2356-2361 (2002)

6. Hagen, T.M., Liu, J., et. al.; Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress, Proc Nat Acad Sci USA vol99, issue 4, 1870-1875 (2002)

7. Hager, K., Marahrens, A.,et.al. Alpha lipoic acid as a new treatment option for Alzheimer type dementia, Arch Geron Geriatr 32 (3): 275-282 (2001)

8. Hagen, T.M., Shigeno,E.T. et.al. Oxidative Stress in the Aging Rat Heart is Reversed by Dietary Supplementation with (R)-Lipoic Acid. FASEB J. 15, 700-706. (2001)

9. Hagen, T.M. Increased mitochondrial decay and oxidative stress in the aging rat heart: improvement by dietary supplementation with (R)-lipoic acid. In, Free Radicals in Chemistry, Biology and Medicine 27, 262-271. (2000)

10. Hagen, T.M., Vinarsky, V., et.al. (R)-alpha-lipoic acid reverses the age-associated increase in susceptibility of hepatocytes to tert-butylhydroperoxide both in vitro and in vivo. Antiox. Redox Signaling 2, 473-483. (2000)

11. Hagen, T.M., Ingersoll, R.T. et.al. (R)-alpha-lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate. FASEB J. 13, 411-418. (1999)

12. Lykkesfeldt, J. Hagen, T.M., Age-associated decline in ascorbic acid concentration, recycling and biosynthesis in rat hepatocytes-reversal with (R)-alpha-lipoic acid supplementation. FASEB J. 12, 1183-1189. (1998)

13. Packer, L; Tritschler, H.J.; Neuroprotection by the Metabolic Antioxidant Alpha Lipoic Acid; Free Rad Biol Med 22, Nos 1 / 2, 359-378 (1997)

14. Hermann, R.; Niebch, G.; Enantioselective pharmacokinetics and bioavailability of different racemic alpha lipoic acid formulations in healthy volunteers. Eur J Pharm Sci 4: 167-174 (1996)

 

[E_C_BODYBUILDER]

I've seen that most of you recommend taking 1,000 mg to
2,000 mg daily, and right after heavy carb meals?

Should be taken before carb meals not after.

E_C_BODYBUILDER

 

[LA]

I use ALA for the liver. I've heard of the miraculous results from R-ALA as a macro partitioner, so I've tried it. For a good long time I may add. I didn't get anything from it. It doesn't even compare to metformin. IMO doesn't even come close. Metformin works.

But on another note, that is just my experience with it. My wife has had modest success with and there seems to be no shortage of people reporting good results with it on the boards these days.

 

[E_C_BODYBUILDER]

If you were using regular ala at a low does thats why. Most people that see the results take a high does of regular ALA or they use r-ala ant 1/3 of the dose as its 3x as strong.

EAST_COAST_BODYBUILDER

 

[LA]

If you were using regular ala at a low does thats why. Most people that see the results take a high does of regular ALA or they use r-ala ant 1/3 of the dose as its 3x as strong.

EAST_COAST_BODYBUILDER

Nope, 100mg of r-Ala per 25g. Like I said, my wife got results but I got zippo. Price wise compared to metformin it costs more too. Of course r-ALA is OTC and Met isn't.

 

[poopoo]

I get insane heartburn from ala

 

[buyb12]

It's about 3-4 weeks away and it will be cheaper than anabolical.....yet another one of the things t o come from the Lion ...........

 

[ColdHeartBear]

http://smi2le.biz/
sells in any amount you want by the gram for ala and rla.