Gluatmine, did u know. . .

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da_Fonz

Banana
I wondered how many ppl realize how important Glutamine is after Chaps suggested that I should add them to my regimine of things to take, I am taking them but good looking bro.

So here's a little info on glutamine:

Glutamine is an amino acid, one of the building blocks of protein that is linked together by peptide bonds in specific chemical arrangements to form proteins. It is found in both plant and animal proteins and is available in a variety of supplemental forms.

Glutamine helps the body maintain the correct acid*alkaline balance and is a necessary part of the synthesis of RNA and DNA. Glutamine also helps promote a healthy digestive tract.

Unlike other amino acids that have a single nitrogen atom, glutamine contains two nitrogen atoms that enable it to transfer nitrogen and remove ammonia from body tissues. Glutamine readily passes the blood*brain barrier and, within the brain, is converted to glutamic acid, which the brain needs to function properly. It also increases the amount of GABA, which is needed to sustain proper brain function and mental activity.

No other nutrient is as important for gastrointestinal health. Glutamine rapidly facilitates healing and restores the health of mucous membranes inside the colon (large intestine). Just 1.6 grams per day, is used to treat peptic ulcers. Research proved that supplementation lessens stomach inflammation caused by chemotherapy and can be useful in treating diarrhea.

The body cannot synthesize enough glutamine to heal wounds, preserve lean tissue, and nourish the immune system following surgery or physical stress. Providing supplemental glutamine avoids these complications, normalizes the amino acid levels, speeds healing, and improves overall surgical recovery.

The primary source of energy for the immune system is glutamine. One of the reasons that cancer patients lose lean tissue and muscle mass is because of a depletion of glutamine. Polyps in the colon, have a significantly lower glutamine content than healthy tissue.

Animal studies show that with glutamine supplementation chemotherapy's toxic side effects can be shielded from the liver and the cancer-killing ability of certain chemotherapeutic drugs may be strengthened.

When our T cell reserve is low, a standard measurement of immune activity, the cells, called macrophages, lose strength. But when L-glutamine is given in dosages of 20-40 grams daily the immune system responds, as demonstrated by the extra infection safeguard it provided in studies of patients with bone marrow transplants.

Glutamine is an essential treatment for AIDS or viral chronic fatigue syndrome.

Glutamine has been used to curb the desire to drink alcohol. A daily dose of 12 grams (about 3 teaspoons) helped 75 percent of the people studied in one experiment. Curbing cravings for sugar can be alleviated by taking 1-2 grams of L-glutamine. The National Institute of Mental Health also acknowledged glutamine's influence on sugar cravings.

By preserving lean tissue, which contributes to burning off fat, the amino acid helps cleanse the body and liver of waste products that are created by fat metabolism. In this way, glutamine may help obese persons with weight loss.

Weight lifters can benefit from glutamine supplementation because it assists in the repair and preservation of muscle tissue. Prolonged exercise causes microscopic injuries to the muscles and, for a long as two weeks after a workout, lowers body's glutamine stores.

So here's the gist of this little article:

*A dosage of 2 grams on an empty stomach has been shown to increase the level of circulating growth hormone in the body. This is good because growth hormone promotes muscle growth and fat loss.

*Another effect is that the body does not have to break down other amino acids to make glutamine. Glutamine is a popular amino in the body and if glutamine levels are low, the body will break down muscle protein to synthesize it.

*The extra glutamine you take in supplement form helps support muscle growth if taken in doses of 5 grams or more at a time (this large amount is necessary to get enough past the digestive system to be of value - the gut sucks up glutamine like a sponge).

*Other effects of glutamine include immune system boosting, improved recovery, cell volumization and enhancement of glycogen replenishment.

The best times to take glutamine are first thing in the morning, right after a workout and right before sleep.

*Dosages can vary from 2 grams (minimum) to about 10 to 15 grams (maximum). The larger doses should be used immediately after a workout to promote anabolism and minimize catabolism (muscle breakdown).


I see many ppl talk about how great Creatine is but I wonder how many ppl realize how much more important L-Glutamine is.
 
Good post Da_Fonz,...Glutamine might the nastiest thingi have ever tasted by it self, but it does serve a great purpose in the human body,....I use it alot with my shakes, even a great combo would be adding the Glutamine with creatine if your creatine doesn't have Glutamin...This should be a great sticky note for everyone....
 
mostly wrong

sorry, i'm going to disagree with a bunch of points here. i'll get the primary agreement out of the way first so i can keep the rest ugly. :D :embarrass glutamine is very, very good for your immune system.

i have no idea where they came up with the 2 grams on an empty stomach boosting GH levels. everything i can find states the contrary. can you get a citation? it won't change it, and might reduce it, though it seems to directly reduce IGF-I instead (more later).

http://www.ncbi.nlm.nih.gov/entrez/...ve&db=pubmed&dopt=Abstract&list_uids=15682473
http://www.ncbi.nlm.nih.gov/entrez/...ve&db=pubmed&dopt=Abstract&list_uids=15705760

glutamine can augment intestinal mucosal and epithelial membranes, and decrease IGF-I levels. it will help your gut grow when you're running the slin+gh combo or extremely high levels of lr3igf-i. there are tons of studies on how to help get short bowels to grow and gh + glutamine is the most common treatment.

http://www.ncbi.nlm.nih.gov/entrez/...ve&db=pubmed&dopt=Abstract&list_uids=12850466
http://www.ncbi.nlm.nih.gov/entrez/...ve&db=pubmed&dopt=Abstract&list_uids=11421603

even better, it's been proven worthless time and time again for skeletal muscle growth:

http://www.ncbi.nlm.nih.gov/entrez/...ve&db=pubmed&dopt=Abstract&list_uids=10683095
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9263279&dopt=Abstract
http://jcem.endojournals.org/cgi/content/full/89/3/1146

that said, it is again very good for your immune system. i don't take it unless i feel myself getting sick and i'm off lr3igf-i.
 
I take spoonfuls of it alone and wash it down with water,no bullshit, you have t get ur glutamine in period, it is a shame it falls into the meaningless supplements catagory by many when in reality its essential bcaa's also is a very overlooked supp, hell there are loads of them, train ur mind to build your body people! lol, musclechemistry.com
 
Glutamine is one of if not the most over looked supplement out their. And yes IT DOES support muscle growth, the falling is written by author L. Rea:

Glutamine is a conditionally essential amino acid. As a rule during hard-core training periods my athletes ingest 50-120g of glutamine daily in divided dosages to decrease catabolism, increase recovery and to act as a glucose precursor for liver and muscle glycogen synthesis without incurring additional fat stores.

This may seem extreme to some, but when you consider that the body must produce 50-120g of glutamine daily it seems almost mandatory when an athlete needs to make the best progress at the fastest rate possible. And second, I have some extreme athletes. Additionally glutamine has a stimulatory effect upon testosterone and GH production that in turn inhibits prolactin and estrogenic influences. Since glutamine supplementation has a positive effect upon insulin insensitivity a better fat-to-muscle ratio is readily supported as well.

Upon waking, immediately after training and just prior to bed at night has shown the greatest benefits for glutamine supplementation. This is due to the fact that these are high catabolic periods when the body normally must destroy healthy muscle tissue to repair other tissues and acquire a supply of glucose. This is largely due to an increase in circulatory cortisol at these times. Those who use creatine products will get the added benefit of increased creatine transport and cell volumization. More volume equals larger muscles.

Glutamine is considered a conditionally essential amino acid. In times of stress the body uses amazing amounts of this anticatabolic goodie to increase anti-oxidant production, as a source of energy and to remove ammonia from the body…among several other actions. Over 60% of the muscle intracellular amino acid pool is glutamine. When stores diminish the response is a catabolic or tissue wasting period.

I've also read that Glutamine can act synergistically with GH and IGF-1 I'll see if I can find the article and post it for everyone to see. I myself use 50g's of glutamine a day, i notice intense pumps, better sleep, better recovery and more muscle fullness.
 
Found it here we go:

Glutamine/insulin/Growth Hormone connection

by: Huck Finn


Hey fellas.

For those of you that are unaware, glutamine is the most highly concentrated amino acid present in muscle tissue. A lack of it can be severely detrimental, not only to training/growth, but overall health as well (as it supports healthy immune system function). I've dug up yet another interesting read from the notorious Dharkam on this special amino acid, and drugs that work to effectively enhance its absorption /prevent its escape. ENJOY.....


INSULIN TRANSPORTS GLUTAMINE
If some hormones cause glutamine depletion (cortisol being a primary culprit), then others have the opposite effect. Insulin is your first ally in glutamine manipulation. Glutamine is one of the few amino acids whose entry into the muscle cell can be enhanced by insulin, and you can certainly see the advantage of that. Any attempt to load up on glutamine should take advantage of an insulin-boosting effect. Some of the favorable actions of insulin are brought about by its influence on sodium. Insulin helps your muscle cells get rid of the extra sodium, which is a very interesting property in light of the sodium invasion that normally follows training. What's more, the anabolic effects of insulin and glutamine reinforce each other and can only be maximum when both are present.


THE MIGHTY GH
Growth hormone (GH) was made to work with glutamine, and vice versa. Bodybuilders have long been aware of the close relationship between the two because the fact that oral glutamine can increase GH. On the other hand, they may not be aware that GH also increases glutamine levels in both blood and muscles without the necessity of any particular dietary alterations. Therefore, GH is truly the mighty ally you're looking for in glutamine manipulation. One of the ways GH works is to limit the wasting of glutamine in the liver, where it can be transformed into urea. The urea is ultimately excreted in the urine,which means the glutamine is wasted, simply because there's a catabolic process at work. Research has shown that GH shunts the "extracted glutamine nitrogen from urea via hapatic glutamate release". The newly formed glutamate can be transformed into glutamine in the muscle cells. So, instead of allowing glutamine to be urinated as a waste product, GH favors the recycling of it. GH also has another major preserving effect on glutamine in the kidneys. One of the major reasons glutamine degradation is accelerated after training is that lactic acid accumulates in the blood. That lowers blood plasma pH and forces the kidneys to extract circulating glutamine at a very fast pace. GH helps your kidneys to get rid of the acid load and as a result reduces their need for glutamine. Oral glutamine synergizes with GH at that point, not only by increasing the GH level, but also by helping the hormone get rid of the lactic acid that's generated by training. Other favorable effects of GH on glutamine are brought about indirectly by the elevation of Insulin-like growth-factor(IGF-1),a peptide that shares many of the positive actions of insulin on glutamine.
Well, you fellas that are using GH and insulin should really consider loading up on glutamine in conjunction with these hormones in the future (if not already doing so)as you can see glutamine has the ability to ENHANCE their performance, and vice versa.



As always, hope you guys enjoyed, and happy growing.....Huck
 
i'd love to see the studies cited by these guys. i mean, i have 8 studies saying the exact opposite up there. conjecture and marketing are great and all, but... :nope:
 
You can always find medical journals and articles by just about anyone to say one thing and then if you look hard enough you can find something that states something else. If ya want I can source all the references to med journals and articles for my info.

Hell, ppl on here would say you need carbs immediately after a workout and i have studies that say carbs immediately impede the assimiliation of protein in the body. SO you can always find articles that say one thing or another if your look hard enough.
 
da_Fonz said:
You can always find medical journals and articles by just about anyone to say one thing and then if you look hard enough you can find something that states something else..................................................................................................................................................... you can always find articles that say one thing or another if your look hard enough.


Exactly. It gets confusing sometimes. I know when I go to do research, I'll read 100 different opinions about the same subject and they will all contradict each other.
 
Exactly, the best way to find out what works for you after researching something is to try it for an length of time and discern for yourself whether or not it help you. Personall, i dont like creatine but i dont knock it b/c i know others benefit from it where i didnt get much from it.
 
Ok for those guys that have the faith in glutamine and like it, what are your favorite brands? I'm about to buy some and I wanted to kno which one you thought was best?
 
tilla52 said:
Ok for those guys that have the faith in glutamine and like it, what are your favorite brands? I'm about to buy some and I wanted to kno which one you thought was best?

I've spoken with some very knowledgable & credible people who are involved in the supplement industry & I have been told it's all the same. Just go with what's cheapest.

L-Glutamine & Glutamine are also the same thing if anyone is wondering about that.
 
Studies can be misleading though, I mean my doctor took out a study that was trying to show that steroids don't work! No i don't have studies to back up what i've posted above, but considering that is straight from an article from Author L. Rea who is a genius when it comes to manipulating the human body i'll have to put my faith in him.
 
i personally use L-Gluatamine dont waste your money on glutamine peptides there not better even though some ppl would like to say otherwise and yes i have a article to explain it if someone would like to read it, lol
 
bashing the scientific method is fun and all, but find me some studies that support the use of oral glutamine to build muscle mass.

since your authors are very quiet, bodybuilding.com cites a bunch of studies in favour of glutamine use, but the studies conclude completely different things from what bodybuilding.com likes to push.

http://www.bodybuilding.com/fun/goulet10.htm

bb.com: "Rennie, Bowtell, Bruce, and Khogali (2001) also reports that intravenous or oral glutamine supplementation promoted skeletal muscle glycogen storage."

study: "However, neither endurance time nor the extent of phosphocreatine depletion or lactate accumulation during the exercise was altered, suggesting either that TCA intermediates were not limiting for energy production or that the severity of exercise was insufficient for the limitation to be operational."

http://www.ncbi.nlm.nih.gov/entrez/...ve&db=PubMed&list_uids=11533298&dopt=Abstract

it's a joke of a study and doesn't even have a methods or results, so we can't really evaluate how good it was.

bb.com: "Further evidence from Boelens, Nijveldt, Houdijk, Meijer, and Van Leeuwen (2001), and Hickson and Wegrzyn (1996), and Hickson and Czerwinski (1995) shows that glutamine is important as an anticatabolic and prevents muscle tissue atrophy (muscle wasting) and prevents downregulation of myosin heavy chain synthesis."

studies: "Adding glutamine to the nutrition of clinical patients, enterally or parenterally, may reduce morbidity. Several excellent clinical trials have been performed to prove efficacy and feasibility of the use of glutamine supplementation in parenteral and enteral nutrition. The increased intake of glutamine has resulted in lower septic morbidity in certain critically ill patient populations."

"Although glutamine had no effect on MHC synthesis in vehicle-treated animals (10.1/9.4), it prevented 50% (7.6/4.2) of the hormone-induced decline in MHC synthesis rates. The same results were obtained with total protein synthesis measurements. Changes in muscle mass did not appear related to estimates of protein breakdown."

greaaat, it'll help if i'm getting cortisol shots.

"Higher serum glutamine was found in the AG-infused (1.72 +/- 0.28 mumol/ml) compared with the AA-infused group (1.32 +/- 0.06 mumol/ml), but muscle glutamine concentrations were not elevated by AG infusion."

that's from the three different studies the cite there. i could go on all day. oh, that one where gh concentrations were elevated from oral glutamine? the shit was dissolved in soda. soda's got a ph of 3.1, which accounts for some of what they observed. the increased GH? well, guess what soda's full of: glucose. guess what glucose leads to rebound elevation of? GH. i can only find one other study that even references it. it's total bullshit.

http://jcem.endojournals.org/cgi/content/abstract/40/3/387
http://jcem.endojournals.org/cgi/content/abstract/79/4/1152
http://www.ajcn.org/cgi/content/abstract/61/5/1058

go ahead and keep patting yourselves on the back and wasting your cash. :greedy: there's a ton of evidence this stuff won't do shit for muscle growth.
 
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IMO, glutamine by itself won't do much for muscle growth, but taking your regular protein at those intervals that are deemed catabolic, i.e., upon waking, after exercising, and before sleeping, should be very beneficial for muscle recovery and growth. There are many different amino acids that your body needs when you are in a catabolic state (whether exercised-induced or not), not just one. I've taken glutamine before, and it didn't do a thing for me on its own. What has worked for me is getting that regular protein during those critical times. Miss that window of opportunity during those catabolic times, and you end up screwed.
 
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