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Myostatin blockers destroy tendons
Researchers at the University of Michigan discovered this while doing experiments with mice that had been genetically modified so that they could no longer produce myostatin. The muscles of the mice were bigger and stronger, but their tendons were small and brittle.
Myostatin is a protein that muscles produce if they are over-trained or if they become weaker as a result of ageing (frailty). The only function of myostatin that researchers have found so far in adult organisms is that it retards muscle growth. This is why the pharmaceutical industry is experimenting so avidly with myostatin blockers, in the hope that they can help to keep people with muscle disease or age-related frailty healthy for longer. Wyeth Pharmaceuticals is already at an advanced stage in the process of developing a human myostatin blocker.
The expectation is that myostatin blockers will turn up sooner or later in the sports world – if they are not already there.
The news from Michigan is certainly interesting for sports users. The researchers compared mice with functioning myostatin genes (MSTN +/+) with mice whose myostatin genes had been destroyed (MSTN -/-). The table below shows you the mass of the tibialis anterior muscle in the two groups of mice, and the mass of the tendon.


myostatin.stiffness2.gif



The researchers found myostatin receptors in the tendons. When they looked at the strength of the tendons of the normal mice and those without myostatin, the researchers also noticed that the tendons of the mice without myostatin were more brittle and stiff. You can see the stiffness in the graph below.


myostatin.stiffness.gif



"Those interested in myostatin inhibitors need to be aware of the fact that by doing these things to muscles, they may be having negative effects on tendons", warns research leader John Faulkner. The researchers suspect that muscles manufacture myostatin for a reason: it appears to strengthen the tendons.
The research, which was published in the prestigious PNAS, is bad news for the outer frontier in the chemical sports world. But it's interesting for sports scientists who are seeking ways to make damaged joints healthy again. Perhaps training schedules that are tailored to produce an optimal amount of myostatin will be the solution. A sort of adjusted over-training, you could say.
Sources:
Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):388-93.
 
I remember reading that study a while ago. After that, my thought has always been that if you take a myostatin inhibitor, you should also take something that is known for strengthening tendons to "offset" the effect. And what does that? HGH does. Throw in deca for extra collagen building as well.

I'm quite sure there are a few bodybuilders out there who are actually using an inhibitor. Big Ramy is likely using given how large he is, but there is one bodybuilder I'd say is definitely using.

Take a look at this pic of Flex Lewis. If there was anyone who has the double-muscled look like those double-muscled cows, it's him. Many top bodybuilders are already using AAS, insulin, and HGH. Add in a myostatin inhibitor in a moderate dose and increase the HGH, and I'd bet you get this look (IMO). Who knows if it's safe? Time will tell.
 

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we have a pic of Kai Greene here who looks like a Myostatin cow, flex looks normal to me, just big, but the photo we have here someplace of Kai is muscle bellies on over top of muscle bellies and places i didn't know mucles grew lmao,
 
My thoughts as well. Genetics would also play a big role in the way one reacts to myostatin inhibitors, too.
 
Why does everything good come with something terrible attached?

so true lmao

Money…..
Marriage …….

as a matter a fact i can't think of a fucking good thing that doesn't have its down side, maybe masturbating lol,
 
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