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12-01-2015, 10:57 PM #1
IGF-1 New study further proves IGF-1s vital role in muscle regeneration and repair
Abstract Skeletal muscle is a highly dynamic tissue that responds to endogenous and external stimuli, including alterations in mechanical loading and growth factors. In particular, the antigravity soleus muscle experiences significant muscle atrophy during disuse and extensive muscle damage upon reloading. Since insulin-like growth factor-1 (IGF-1) has been implicated as a central regulator of muscle repair and modulation of muscle size, we examined the effect of viral mediated overexpression of IGF-1 on the soleus muscle following hindlimb cast immobilization and upon reloading. Recombinant IGF-1cDNA virus was injected into one of the posterior hindlimbs of the mice, while the contralateral limb was injected with saline (control). At 20 weeks of age, both hindlimbs were immobilized for two weeks to induce muscle atrophy in the soleus and ankle plantar flexor muscle group. Subsequently, the mice were allowed to reambulate and muscle damage and recovery was monitored over a period of 2 to 21 days. The primary finding of this study was that IGF-1 overexpression attenuated reloading-induced muscle damage in the soleus muscle, and accelerated muscle regeneration and force recovery. Muscle T2 assessed by MRI, a nonspecific marker of muscle damage, was significantly lower in IGF-1 injected, compared to contralateral soleus muscles at 2 and 5 days reambulation (P<0.05).
The reduced prevalence of muscle damage in IGF-1 injected soleus muscles was confirmed on histology, with a lower fraction area of abnormal muscle tissue in IGF-I injected muscles at 2 days reambulation (33.2±3.3%vs 54.1±3.6%, P<0.05). Evidence of the effect of IGF-1 on muscle regeneration included timely increases in the number of central nuclei (21% at 5 days reambulation), paired-box transcription factor 7 (36% at 5 days), embryonic myosin (37% at 10 days), and elevated MyoD mRNA (7-fold at 2 days) in IGF-1 injected limbs (P<0.05). These findings demonstrate a potential role of IGF-1 in protecting unloaded skeletal muscles from damage and accelerating muscle repair and regeneration.
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12-02-2015, 12:26 AM #2
good find bro
Iron Game liked this post
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05-30-2016, 09:42 AM #3
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06-01-2016, 06:03 PM #4
- Join Date
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06-01-2016, 10:28 PM #5
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06-28-2016, 08:28 AM #6
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08-21-2016, 10:38 AM #7
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10-17-2016, 07:48 AM #8
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01-30-2019, 12:20 PM #9
I am loading up on igf 1 lr3 as we speak to my torn bicep region ! I really fucked the pooch this time in terms of fucking my bicep up! So yeah IGF-1 lr3 has saved me from serious Nerve damage in quad years ago to a full recovery and well, I am hoping it does the same thing now for my bicep
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07-01-2019, 02:59 PM #10
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07-03-2019, 09:59 AM #11
I have a buddy who has a "dead" muscle and igf is bringing it back............he is so excited and is very thankful that I shared the info with him since nothing else was working.
Presser, jimbosmith316 thanked for this postPresser, jimbosmith316 liked this post
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07-06-2019, 12:11 PM #12
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07-05-2023, 12:52 PM #13
insulin-like growth factor-1 lr3 has been in every cycle ive ever run! Great read for those researching it before adding it to their cycle
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