guardianactual
MuscleChemistry Registered Member
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SARM LGD-4033 (Ligandrol)
- Thread starter guardianactual
- Start date
jimbosmith316
MuscleChemistry
Bump it up!
What is this ligandrol l keep hearing about
jimbosmith316
MuscleChemistry
bump
i thought you were kidding until i seen your second comment after this one lol, I would have thought Ligandrol was a more popular term than LGD but i guess maybe i was wrong, and maybe most folks know this sarm by LGD - 4033
Yeah all these sarms are new to me like 10 weeks i have been reading loggs
jimbosmith316
MuscleChemistry
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LGD 4033 from Our store is dosed at 10mg per ml.
I am constantly getting inundated with questions about how to figure out the proper dosage.
So whenever you want to use 10mg of our Ligandrol you just need to know this:
A FILLED UP GLASS DROPPER IS EQUAL TO 1ML
Now I just received this question last night, which I promptly responded to with what I just wrote above, and the next email from customer was, ok if a full dropper is 1ml, then how do I get 10mg of LGD Ligandrol . I have yet to respond to that customer, as im pretty sure or hope at least he figured it out by now lol.
Anyways, our ProSarms1 Brand currently is not using glass pipet with measurements etched into glass, however its very easy to figure out dosing once u understand that 1ml is a filled up dropper.
Next, I would like to say or announce rather, that shortly after the new year all of our SARMs will have measurements etched into the glass pipet droppers for much more precise measuring for those who like to break up dosages throughout day and use not so flat even numbers per dosage.
So look for our 2.0 Version of Ligandrol, Ostarine and Andarine Come January 2017
I am constantly getting inundated with questions about how to figure out the proper dosage.
So whenever you want to use 10mg of our Ligandrol you just need to know this:
A FILLED UP GLASS DROPPER IS EQUAL TO 1ML
Now I just received this question last night, which I promptly responded to with what I just wrote above, and the next email from customer was, ok if a full dropper is 1ml, then how do I get 10mg of LGD Ligandrol . I have yet to respond to that customer, as im pretty sure or hope at least he figured it out by now lol.
Anyways, our ProSarms1 Brand currently is not using glass pipet with measurements etched into glass, however its very easy to figure out dosing once u understand that 1ml is a filled up dropper.
Next, I would like to say or announce rather, that shortly after the new year all of our SARMs will have measurements etched into the glass pipet droppers for much more precise measuring for those who like to break up dosages throughout day and use not so flat even numbers per dosage.
So look for our 2.0 Version of Ligandrol, Ostarine and Andarine Come January 2017
My buddy runs it with propionate in place of traditional oral steroids, but only for a few weeks.
cybrsage
Full Access
I think using AAS and SARMs in combo is a very smart thing to do. They compliment each other very well. LGD is highly suppressive, so using it with a test base is a great idea. I love adding GW50 to the mix for the extra endurance it provides.
So you have run lgd 4033 along with testosterone base before? If so I would love hearing how you ran it and such brutha, plus I think it will help a lot of the newer questions coming around, which are, Can I use Ostarine or andarine or ligandrol with testosterone, or tren ace or any number of injectable steroids, so yeah those questions are of the newer variety thank GOD, cause man I have heard some of the standard questions on traditional steroids a million times, lol,
So I for one welcome these questions and in this case New Info From people who have combined a SARM with an injectable hormone.
cybrsage
Full Access
I have not run lgd with test yet but I have run S4 with 500mg of test weekly and I found that an amazing recomp for me. I was losing weight while gaining muscle.
I do have some lgd on hand for my next bulk so I will run it with a high level test and see how it works out for me.
Edit: I am on trt so technically I am always running test, but my normal trt dose just puts me at the normal male test level so I don't count that. I will definitely run or walk though of my next sarm and AAS combo run.
I do have some lgd on hand for my next bulk so I will run it with a high level test and see how it works out for me.
Edit: I am on trt so technically I am always running test, but my normal trt dose just puts me at the normal male test level so I don't count that. I will definitely run or walk though of my next sarm and AAS combo run.
[h=1]Older study I have seen around, and thought it would serve this LGD 4033 thread well. It may be posted in another ligandrol thread here on MuscleChem but this is the thread everyone reads.
The Safety, Pharmacokinetics, and Effects of LGD-4033, a Nonsteroidal Oral, Selective Androgen Receptor Modulator, in Healthy Young Men
Author Site: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111291/
Abstract[/h]
[h=3]Background.[/h]Concerns about potential adverse effects of testosterone on prostate have motivated the development of selective androgen receptor modulators that display tissue-selective activation of androgenic signaling. LGD-4033, a novel nonsteroidal, oral selective androgen receptor modulator, binds androgen receptor with high affinity and selectivity.
[h=3]Objectives.[/h]To evaluate the safety, tolerability, pharmacokinetics, and effects of ascending doses of LGD-4033 administered daily for 21 days on lean body mass, muscle strength, stair-climbing power, and sex hormones.
[h=3]Methods.[/h]In this placebo-controlled study, 76 healthy men (21–50 years) were randomized to placebo or 0.1, 0.3, or 1.0 mg LGD-4033 daily for 21 days. Blood counts, chemistries, lipids, prostate-specific antigen, electrocardiogram, hormones, lean and fat mass, and muscle strength were measured during and for 5 weeks after intervention.
[h=3]Results.[/h]LGD-4033 was well tolerated. There were no drug-related serious adverse events. Frequency of adverse events was similar between active and placebo groups. Hemoglobin, prostate-specific antigen, aspartate aminotransferase, alanine aminotransferase, or QT intervals did not change significantly at any dose. LGD-4033 had a long elimination half-life and dose-proportional accumulation upon multiple dosing. LGD-4033 administration was associated with dose-dependent suppression of total testosterone, sex hormone–binding globulin, high density lipoprotein cholesterol, and triglyceride levels. follicle-stimulating hormone and free testosterone showed significant suppression at 1.0-mg dose only. Lean body mass increased dose dependently, but fat mass did not change significantly. Hormone levels and lipids returned to baseline after treatment discontinuation.
[h=3]Conclusions.[/h]LGD-4033 was safe, had favorable pharmacokinetic profile, and increased lean body mass even during this short period without change in prostate-specific antigen. Longer randomized trials should evaluate its efficacy in improving physical function and health outcomes in select populations.
Keywords: Selective androgen receptor modulators, SARMs, Sarcopenia, Function promoting anabolic therapies, Cachexia
The Safety, Pharmacokinetics, and Effects of LGD-4033, a Nonsteroidal Oral, Selective Androgen Receptor Modulator, in Healthy Young Men
Author Site: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111291/
Abstract[/h]
[h=3]Background.[/h]Concerns about potential adverse effects of testosterone on prostate have motivated the development of selective androgen receptor modulators that display tissue-selective activation of androgenic signaling. LGD-4033, a novel nonsteroidal, oral selective androgen receptor modulator, binds androgen receptor with high affinity and selectivity.
[h=3]Objectives.[/h]To evaluate the safety, tolerability, pharmacokinetics, and effects of ascending doses of LGD-4033 administered daily for 21 days on lean body mass, muscle strength, stair-climbing power, and sex hormones.
[h=3]Methods.[/h]In this placebo-controlled study, 76 healthy men (21–50 years) were randomized to placebo or 0.1, 0.3, or 1.0 mg LGD-4033 daily for 21 days. Blood counts, chemistries, lipids, prostate-specific antigen, electrocardiogram, hormones, lean and fat mass, and muscle strength were measured during and for 5 weeks after intervention.
[h=3]Results.[/h]LGD-4033 was well tolerated. There were no drug-related serious adverse events. Frequency of adverse events was similar between active and placebo groups. Hemoglobin, prostate-specific antigen, aspartate aminotransferase, alanine aminotransferase, or QT intervals did not change significantly at any dose. LGD-4033 had a long elimination half-life and dose-proportional accumulation upon multiple dosing. LGD-4033 administration was associated with dose-dependent suppression of total testosterone, sex hormone–binding globulin, high density lipoprotein cholesterol, and triglyceride levels. follicle-stimulating hormone and free testosterone showed significant suppression at 1.0-mg dose only. Lean body mass increased dose dependently, but fat mass did not change significantly. Hormone levels and lipids returned to baseline after treatment discontinuation.
[h=3]Conclusions.[/h]LGD-4033 was safe, had favorable pharmacokinetic profile, and increased lean body mass even during this short period without change in prostate-specific antigen. Longer randomized trials should evaluate its efficacy in improving physical function and health outcomes in select populations.
Keywords: Selective androgen receptor modulators, SARMs, Sarcopenia, Function promoting anabolic therapies, Cachexia
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