Thanks Thanks:  0
Recommend Recommend:  0
Likes Likes:  0
  1. #1
    MuscleChemistry Registered Member Board Certified MD
    big in vegas's Avatar
    Join Date
    Jul 2010
    Location
    Hell
    Posts
    18,534
    Rep Power
    2147502195

    Default Obese Dieters’ Brain Chemistry Works Against Their Weight-Loss Efforts

    ScienceDaily – If you’ve been trying to lose weight and suspect your body’s working against you, you may be right, according to a University of Illinois study published in Obesity.

    “When obese persons reduce their food intake too drastically, their bodies appear to resist their weight loss efforts. They may have to work harder and go slower in order to outsmart their brain chemistry,” said Gregory G. Freund, a professor in the U of I College of Medicine and a member of U of I’s Division of Nutritional Sciences.

    He particularly cautions against beginning a diet with a fast or cleansing day, which appears to trigger significant alterations in the immune system that work against weight loss. “Take smaller steps to start your weight loss and keep it going,” he said.

    In the study, the scientist compared the effects of a short-term fast on two groups of mice. For 12 weeks, one group consumed a low-fat diet (10 percent fat); the other group was fed a high-fat (60 percent fat) and had become obese. The mice were then fasted for 24 hours. In that time, the leaner mice lost 18 percent of their body weight compared to 5 percent for the obese mice.

    Freund said that there is an immune component to weight loss that has not been recognized. “Our data show that fasting induces an anti-inflammatory effect on a lean animal’s neuroimmune system, and that effect is inhibited by a high-fat diet. Some of the brain-based chemical changes that occur in a lean animal simply don’t occur in an obese animal,” he said.

    This breakdown occurs because obese animals resist down-regulation of genes that activate the interleukin-1 (IL-1) system and associated anti-inflammatory cytokines, he said.

    The scientist also studied differences in the behavior of the two groups of mice, monitoring how much they moved, administering tests to discern the animals’ ability to learn and remember, and noting whether the mice exhibited signs of depression or anxiety.

    The results suggest that beginning a diet with a fast or near-fast may alter brain chemistry in a way that adversely affects mood and motivation, undermining the person’s weight-loss efforts.

    “The obese mice simply didn’t move as much as the other mice. Not only was there reduced locomotion generally, they didn’t burrow in the way that mice normally do, and that’s associated with depression and anxiety,” he said.

    Beginning a weight-loss program in a depressed frame of mind and with decreased motivation doesn’t bode well for the diet’s success, he noted.
    Funding was provided by grants from the National Institutes of Health, including the Ruth L. Kirschstein National Research Service Award, and the USDA National Institute of Food and Agriculture.

    Story Source:

    The above story is reprinted (with editorial adaptations by ScienceDaily staff) from materials provided by University of Illinois College of Agricultural, Consumer and Environmental Sciences, via EurekAlert!, a service of AAAS.

    Journal Reference:

    Desiree N. Lavin, Jennifer J. Joesting, Gabriel S. Chiu, Morgan L. Moon, Jia Meng, Ryan N. Dilger, Gregory G. Freund. Fasting Induces an Anti-Inflammatory Effect on the Neuroimmune System Which a High-Fat Diet Prevents. Obesity, 2011; DOI: 10.1038/oby.2011.73

    "Pissing excellence and shitting perfection."

  2. #2
    Musclechemistry Guru Board Certified MD
    Ox 51's Avatar
    Join Date
    Aug 2010
    Location
    Down South
    Age
    46
    Posts
    5,191
    Rep Power
    2147488852

    Default

    They take years to get fat, then want to lose it overnight. Of course that won't work.
     

  3. #3
    MuscleChemistry Registered Member Board Certified MD
    big in vegas's Avatar
    Join Date
    Jul 2010
    Location
    Hell
    Posts
    18,534
    Rep Power
    2147502195

    Default

    Quote Originally Posted by Ox 51 View Post
    They take years to get fat, then want to lose it overnight. Of course that won't work.
    That's what I've always said, at what point do you wake up and realize that you're fat as fuck and need to lose weight? I mean if most of them did it 50 pounds before they do, they'd be in better shape to lose it

    "Pissing excellence and shitting perfection."

  4. #4
    Musclechemistry Guru Board Certified MD
    Ox 51's Avatar
    Join Date
    Aug 2010
    Location
    Down South
    Age
    46
    Posts
    5,191
    Rep Power
    2147488852

    Default

    I think that all the time too. You don't just wake up weighing 300 pounds one day. Why didn't they notice at 200 or 250 that they were too fat? And I always tell my wife, "It's got to be hard work to stay that fat." How many calories does a woman have to consume a day to maintain 300 pounds?
     

  5. #5
    MuscleChemistry Registered Member Board Certified MD
    big in vegas's Avatar
    Join Date
    Jul 2010
    Location
    Hell
    Posts
    18,534
    Rep Power
    2147502195

    Default

    Quote Originally Posted by Ox 51 View Post
    I think that all the time too. You don't just wake up weighing 300 pounds one day. Why didn't they notice at 200 or 250 that they were too fat? And I always tell my wife, "It's got to be hard work to stay that fat." How many calories does a woman have to consume a day to maintain 300 pounds?
    I don't know, I just wish I could hit 200

    "Pissing excellence and shitting perfection."

Similar Threads

  1. Best Weight Loss Diets
    By Metal85 in forum MuscleChemistry Discussion
    Replies: 1
    Last Post: 06-08-2011, 07:32 PM
  2. Article: Idiot at Time magazine
    By saudades in forum MuscleChemistry Discussion
    Replies: 7
    Last Post: 11-06-2010, 12:17 AM
  3. Protein and fat loss
    By Get_Swole in forum MuscleChemistry Discussion
    Replies: 1
    Last Post: 05-13-2010, 07:48 AM
  4. A Training Philosophy For Solid Mass Gains by Kelly Bagget
    By Pharm_Fed in forum MuscleChemistry Discussion
    Replies: 8
    Last Post: 06-19-2009, 09:09 PM
  5. v diet from T-nation???
    By Get_Swole in forum MuscleChemistry Discussion
    Replies: 7
    Last Post: 03-20-2009, 12:18 AM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •  

Log in

Log in