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    Default GHRP-2 vs GHRP-6 vs Ipamorelin...Which to use and Why

    GHRP-2 Peptides.com Research Chemicals and Peptides

    Growth-Hormone-Releasing-Peptide-Two (GHRP-2) is a synthetic ghrelin analogue. It causes the release of endogenous (internal) Growth Hormone (GH) from somatotropes in the anterior pituitary gland. It works synergistically with GHRHs and lacks the lipogenic properties (fat creation/storage) of ghrelin. GHRP-2 excites the hypothalamus and causes a high release of GH which tapers back to baseline by the third hour post admin. This pulse closely represents that of the natural pulse of the human body giving it an advantage over synthetic GH use.


    Benefits and Potential of GHRP-2


    Similar to Ipamorelin, GHRP-2 has great benefit and potential in athletes and wellness. GHRP-2 has been studied and shown to be effective in treating age-related GH decline when used in combination with a GHRH such as CJC-1295. GHRP-2 when use with an equal dose of a GHRH creates a 3-hour pulse of GH that is double the amplitude of 8IU of synthetic GH. This makes it a more effective, healthier substitute to synthetic Growth Hormone with the added safety and lower cost benefits.




    GHRP-6


    Growth-Hormone-Releasing-Peptide-6 (GHRP-6) is a Growth Hormone (GH) secretagogue and ghrelin mimetic.


    The peptide GHRP-6 works similarly to GHRP-2 and Ipamorelin, however it induces hunger consistently in mammals. It also does have some lipogenic properties that are dependent on the status on insulin and glucose. GHRP-6 may cause weight and adipose tissue gain if insulin is present. So don't eat for 30 mins post injection, nothing, nada. You'll be starving but dont eat.


    Benefits and Potential of GHRP-6


    Again, similar to GHRP-2 and Ipamorelin, GHRP-6 has many benefits and uses. Due to the increased GH release, the following benefits may be observed:


    Increased Energy
    Improved Sleep
    Increased Lean Body Mass
    Decreased Body Fat
    Increased Collagen Production
    Increased Healing Capability



    Ipamorelin


    Ipamorelin or NNC 26-0161, a polypeptide hormone, is a growth hormone secretagogue and ghrelin mimetic and analog developed by Novo Nordisk[3]. Ipamorelin belongs to the most recent generation of GHRPs from the mid 1990s and causes significant release of growth hormone by itself, due both to its suppression of somatostatin (an antagonist to GHRH) and stimulation of release of GH from the anterior pituitary, similar to GHRP-2 and GHRP-6 which are compounds from the same class (growth hormone releasing peptides).[1] The cells that produce and release GH are known as somatotropes.[2] Like GHRP-2, ipamorelin does not have ghrelin’s lipogenic properties. Like GHRP-2 and unlike GHRP-6 ipamorelin never induces hunger in mammals. Ipamorelin acts synergistically when applied during a native GHRH (growth-hormone releasing hormone) pulse or when coadministered with GHRH or a GHRH analog such as Sermorelin or GRF 1-29 (growth releasing factor, aminos 1-29).[1] The synergy comes both due to the suppression of somatostatin and the fact that ipamorelin increases GH release per-somatotrope, while GHRH increases the number of somatotropes releasing GH.[1,2] There is also a secondary effect of neuronal excitation in the hypothalamus caused by ipamorelin, which lasts for approximately 3 hours after application, similar to GHRP-2 and GHRP-6.


    Ipamorelin has a unique property among the GHRP class of peptides. That property is known as selectiveness. Whereas GHRP-6 and GHRP-2 cause a release and increase in cortisol and prolactin levels, ipamorelin only selectively releases GH at any dose. Further, a mega-dose of ipamorelin results in a concomitant mega-release of GH (up to the entire amount present in the pituitary), whereas GHRP-2 and GHRP-6 have limits of approximately 1mcg/kg in humans for their maximal GH release.[4,5]



    Now comes some scientific study info. If you cant follow it, just as i'll translate it for you...



    Raun et al demonstrated the selectiveness of ipamorelin for GH release only in a study:
    The development and pharmacology of a new potent growth hormone (GH) secretagogue, ipamorelin, is described. Ipamorelin is a pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2), which displays high GH releasing potency and efficacy in vitro and in vivo. As an outcome of a major chemistry programme, ipamorelin was identified within a series of compounds lacking the central dipeptide Ala-Trp of growth hormone-releasing peptide (GHRP)-1. In vitro, ipamorelin released GH from primary rat pituitary cells with a potency and efficacy similar to GHRP-6 (ECs) = 1.3+/-0.4nmol/l and Emax = 85+/-5% vs 2.2+/-0.3nmol/l and 100%). A pharmacological profiling using GHRP and growth hormone-releasing hormone (GHRH) antagonists clearly demonstrated that ipamorelin, like GHRP-6, stimulates GH release via a GHRP-like receptor. In pentobarbital anaesthetised rats, ipamorelin released GH with a potency and efficacy comparable to GHRP-6 (ED50 = 80+/-42nmol/kg and Emax = 1545+/-250ng GH/ml vs 115+/-36nmol/kg and 1167+/-120ng GH/ml). In conscious swine, ipamorelin released GH with an ED50 = 2.3+/-0.03 nmol/kg and an Emax = 65+/-0.2 ng GH/ml plasma. Again, this was very similar to GHRP-6 (ED50 = 3.9+/-1.4 nmol/kg and Emax = 74+/-7ng GH/ml plasma). GHRP-2 displayed higher potency but lower efficacy (ED50 = 0.6 nmol/kg and Emax = 56+/-6 ng GH/ml plasma). The specificity for GH release was studied in swine. None of the GH secretagogues tested affected FSH, LH, PRL or TSH plasma levels. Administration of both GHRP-6 and GHRP-2 resulted in increased plasma levels of ACTH and cortisol. Very surprisingly, ipamorelin did not release ACTH or cortisol in levels significantly different from those observed following GHRH stimulation. This lack of effect on ACTH and cortisol plasma levels was evident even at doses more than 200-fold higher than the ED50 for GH release. In conclusion, ipamorelin is the first GHRP-receptor agonist with a selectivity for GH release similar to that displayed by GHRH. The specificity of ipamorelin makes this compound a very interesting candidate for future clinical development.[3]



    Cititations:
    [1] Bowers CY, Momany F, Reynolds GA. In vitro and in vivo activity of a small synthetic peptide with potent GH releasing activity. 64th Annual Meeting of the Endocrine Society, San Francisco, 1982, p. 205.
    [2]Bowers CY, Momany F, Reynolds GA, Sartor O. Multiple receptors mediate GH release. 7th International Congress of Endocrinology, Quebec, Canada, 1984, p. 464.
    [3] Raun K, Hansen BS, Johansen NL, Thøgersen H, Madsen K, Ankersen M, Andersen PH. Ipamorelin, the first selective growth hormone secretagogue. Eur J Endocrinol. 1998 Nov;139(5):552-61.
    [4] Brosnan-Cook, M. et al. (1998) Iontophoretic delivery of ipamorelin, a growth hormone secretagogue. Proceedings of 80th Annual Meeting Endocrine Society, New Orleans, USA. Abstract Pp1-186.
    [5] Jogarao V S Gobburu; Henrik Agerso; William J Jusko . Pharmacokinetic-Pharmacodynamic Modeling of Ipamorelin, a Growth Hormone Releasing Peptide in Human Volunteers. Lars Ynddal Pharmaceutical Research: Sep 1999; 16, 9; ProQuest Nursing & Allied Health Source p. 1412.


    I've included my citations from the articles i've studied. Ive read hundreds of articles on the peptides but this is just what ive used for the Ipam stuff


    See why i always suggest Ipam to everyone, yet no one wants to try it. The GH benefits with it are tremendous.
    Last edited by Presser; 10-09-2016 at 09:38 AM.
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    Default Chart Ive made as a cheat sheet for my clients

    Comparison Chart for GHRP’s




    Name
    Work with GHRH
    Better than Synthetic GH
    Stimulates Hunger
    Stimulate Possible Fat Storage
    Raise ACTH, Cortisol, Prolactin Levels


    GHRP- 2


    Yes


    Yes


    No


    No


    Yes












    GHRP-6
    Yes
    Yes
    Yes
    Yes
    Yes












    Ipamorelin
    Yes
    Yes
    No
    No
    No
















    All GHRP’s Have the Following Benefits:



    • Increased energy
    • Improved sleep and mood
    • Increased lean muscle mass
    • Decreased body fat
    • Increased healing ability
    • Increased collagen production
    • No marked effect on FSH, LH, or TSH plasma levels



    * For best results use with GHRH’s such as CJC-1295
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    love this post!!!
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    Printed it out. This one is great!!!
     

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    Is the rise in prolactin and cortisol in the GHRP's dose related or cycle length related?

    What would you recommend for a IPAM cycle?

    This is good stuff. I can't afford GH but I'm excited to see the benefits of running IPAM.
     

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    I just alternate them. I like GHRP 2 the best. For some reason I see and feel the most benefit from it with CJC. IPAM made me a little tighter and GHRP 6 made me a little softer... probably from pigging out more
    The Dude Abides

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    Quote Originally Posted by Buffalo View Post
    Is the rise in prolactin and cortisol in the GHRP's dose related or cycle length related?

    What would you recommend for a IPAM cycle?

    This is good stuff. I can't afford GH but I'm excited to see the benefits of running IPAM.
    both...after 90 days the body has it figured out so you just come off for a brief period, then hop right back on.

    For the IPAM cycle, use cjc with it and the dose is the same as the ghrp 2 or 6 for the most part. start at 250mcg and go up from there


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    Quote Originally Posted by mike ross View Post
    both...after 90 days the body has it figured out so you just come off for a brief period, then hop right back on.

    For the IPAM cycle, use cjc with it and the dose is the same as the ghrp 2 or 6 for the most part. start at 250mcg and go up from there
    What do you think about that boom dosing protocol? I haven't tried it, but alot of Internet bodybuilders swear by it. I'm curious if it has any merit in real life
    The Dude Abides

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    Quote Originally Posted by The Dude View Post
    What do you think about that boom dosing protocol? I haven't tried it, but alot of Internet bodybuilders swear by it. I'm curious if it has any merit in real life
    i cant buy into the boom method on anything. I remember palumbo and other bodybuilders claiming that gh blast cycles were best. They were using 80ius every 2wks or something ridiculous, yes it was at least 80, then come to find out there was no real merit in that. If it works for you, im all for it. i do better with moderate doses and longer use. You would literally have to test it out and see what sides popped up etc.
    Last edited by mike ross; 08-29-2012 at 09:16 PM.


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    ghrp 2 and cjc1295 is a killer combo...crazy ass fullness

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    Awesome post
     

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    GHRP-2 100mcg and mod 1-29 100mcg makes me hungry. Not like 6 but I deft have to use ipam if I don't want to eat. Took me a long time to figure it out cause everyone says "GHRP 2 doesn't induce hunger" well that's just not true for me.
     

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    AWSOME POST. I'm loving these peps.
     

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    In order of strength for GHRP's:
    Hexalarin
    GRHP-2
    GHRP-6
    Ipam.

    Check out Mike Arnolds discussion of running GHRP and GHRH combos here: Traditional Growth Hormone and the Rise of GH Peptides ? Part 3

    Its a great read.

    Traditional Growth Hormone and the Rise of GH Peptides – Part 3

    May 30, 2014 , Views: 1016






    by Mike Arnold
    When considering any peptide combination, the most pressing question on most peoples’ minds is “how does it compare to growth hormone?” More specifically, they want to know its equivalent in terms of IU’s. This is understandable, as the IU is the most widely used form of measurement when attempting to determine a certain quantity of GH. However, due to differing pharmacodynamic profiles between exogenous growth hormone and the various peptides/peptide combinations, testing for peak GH levels (such as with GH serum testing) provides an inaccurate comparison.

    This leaves us with IGF-1 testing; a much more reliable method of measuring GH levels in the human body under the circumstances. With a direct correlation between growth hormone concentrations and IGF-1 levels, we are able to extrapolate the amount of growth hormone present in the body with IGF-1 testing. In the previous article, we looked GHRP-2 and ModGRF1-29; probably the single most commonly used GH peptide combination. When combining 100-300 mcg of GHRP-2 and 100 mcg of ModGRF1-29, 3X daily, user bloodwork has shown a rise in IGF-1 levels comparable to what would be achieved with 2.5-4.0 IU of GH daily. That’s pretty good, especially when considering that these levels can be achieved for about $50-$80/month vs. about $250-$300 a month when using exogenous GH—and that’s when utilizing non-pharm-grade GH.
    While 4 IU will produce somewhat slow, but steady results over an extended period of time and is suitable for beginning or even intermediate BB’rs, most prefer to use higher dosages when financially possible. Like with most PED’s, the effects are dose-dependent, with higher dosages producing more rapid muscle growth and faster reductions in bodyfat. At this juncture, neither science nor user bloodwork has been able to pinpoint the maximum degree to which GH peptides can increase GH levels over a given period of time—a task made difficult by the large number of potential GH peptide combinations and dosing ranges. Traditionally, the medical community has been unwilling to explore the effects of various drug cocktails employed by BB’rs, especially at the typically used dosing ranges, due to obvious ethical considerations. Therefore, it is extremely unlikely that we will ever be provided with these answers through legitimate scientific research. As with other PED’s, anecdotal evidence will likely end up being our go-to source for information on these drugs; a process which will take years before coming to any trustworthy conclusions.
    Some have speculated that the pituitary gland itself is the limiting factor in terms of GH output; a belief born from what I consider to be wholly unreliable user blood work. A couple years ago, a reputable member from a particular BB’ing board decided to perform a serum GH test after several weeks of administering high dose CJC-1295 with Dac. The results showed that GH levels remained unchanged from baseline to the end of treatment. Due to the high dosages employed, the tester speculated that GH stores had been depleted due to the constant stimulation associated with this peptide.
    In my opinion this assumption is irresponsible, as it ignores the available evidence. For one, previous scientific research on CJC-1295 shows it to be a relatively weak compound when used alone, capable of providing steady, yet minimal increases in GH levels over a prolonged period of time. In the picture below (a re-post from Part #1 of this article) CJC-1295 is represented in green.

    As you can see, even when dosed at a full 3 mg, GH levels barely make a blip on the radar compared to the other peptides. In fact, the levels achieved with CJC-1295 are still within a “normal” range for both teens and many adults! At no point did the pituitary come anywhere close to releasing an amount of GH capable of depleting pituitary stores. Although the dosage used by the aforementioned board member was higher than that used by the medical researchers, the fact is that GH output would have had to increase many times over just to equal the levels obtained with GHRP-2 & Mod—something the medical community has never even come close to duplicating with CJC-1295 with Dac, regardless of dose. We also know that GHRP-2 & Mod can continue to be used at this dose, long-term, without ever depleting pituitary stores of this hormone.
    Furthermore, by using different combinations of compounds, adjusting injection frequency, and/or increasing dosage, it is not difficult to elevate GH levels significantly beyond what was witnessed in the GHRP-2 & Mod study. Knowing this, it seems unreasonable to suggest that CJC-1295 is capable of depleting GH stores. In addition, there was a total failure to verify the CJC-1295 used by this board member as genuine via 3rd party lab testing (which could easily explain the results), not to mention an inadequate number of test subjects (only one in this case), completely invalidating this particular user’s test results. Although this does not answer the question “what is the weak link in the chain in terms of GH release?”, I felt it was necessary to at least address it, due to the significant influence it has had on the beliefs of many in the BB’ing community.
    Without any clinical or anecdotal evidence to turn to, we may be able to get an idea of the pituitary’s true GH producing potential by evaluating GH production in individuals suffering with certain medical conditions, such as acromegaly. While such a condition does not reflect the pituitary’s normal production capabilities, it still shows that it is able, at least under certain circumstances, of producing very large quantities of GH on a daily basis. Although time constraints prohibited me from ascertaining the degree of GH production in those afflicted with the disease, we can be absolutely certain that the quantity is massive.
    If we look at professional BB’rs as a comparison, many of whom are well known to administer excessive amounts of GH for extended periods of time, not a single one will be found who exhibits the extreme acromegalic features associated with the disease. The contrast between these two groups can be so extreme that it is difficult to detect any degree of deformity among BB’rs, while those in the diseased state often exhibit deformities so severe that they are considered grotesque. If pro BB’rs are able to maintain normal facial features despite the regular use of high dose GH (5-20 IU daily), one can only wonder how much is being dumped into the systems of the afflicted, in order to cause such a pronounced deformation of facial features. Certainly, it is more than any BB’r would ever need—for obvious reasons.
    We should also consider that prior to the invention of synthetic GH in 1985, the drug was extracted from the pituitary glands of cadavers. If pharmaceutical companies had not been able to extract enough GH to be profitable, then cadaveric GH never would have become a viable prescription drug to begin with—a market which existed for over 20 years from 1963-1985. While we don’t know just how much GH the pituitary is able to produce under normal circumstances, we do know that it is quite a bit. Based on the information we currently have, I would speculate that it is easily in excess of 10 IU daily. Even if 10 IU was the limit, I know plenty of BB’rs who would be more than happy to use that amount of GH, especially from a consistently reliable source—myself included.
    Although speculating on the pituitary’s GH producing potential is important when attempting to determine GH peptide limitations, it becomes irrelevant if the pituitary won’t release this hormone into the system. So, assuming that the pituitary is able to produce enough growth hormone to rival the GH concentrations obtained with moderate-high dosage exo GH use, the limiting factor then becomes the growth hormone releasing potential of GH peptides. The problem is that the pituitary is normally a bit of a GH hog—it likes to keep most of it to itself. However, by coaxing this master gland into being a bit less stingy with its GH supply via GH peptide administration, we are able to take greater advantage of its GH producing capabilities, but the real question is “to what degree?”
    While no one really knows the answer to this question, I believe that, in light of the available evidence, 8-10 IU per day is well within the capabilities of these peptides. I realize that the closest we have previously come is about 4 IU daily, but keep in mind that this was achieved with only a moderately potent GH peptide program consisting of 250 mcg of GHRP-2 & 100 mcg ModGRF1-29, 3X daily. By incorporating other, more powerful peptides such as Hexarelin, along with an increased injection frequency and larger dosages, it should be relatively easy to exceed 4 IU.
    While the common side effect of hand and feet swelling is not necessarily an accurate indicator of growth hormone levels in exo GH users, it is true that higher dosages typically result in a greater degree of swelling. Just to give you an idea, doses of 3 IU and under generally produce little to no swelling, with large dosages of 8+ IU often produce very significant swelling that is visible to causal onlookers. Over the last couple years of evaluating this side effect in my clients and others, I have repeatedly found that some of the more potent peptide combinations often result in a degree of swelling commensurate with 10 IU of exo GH or even more. While other factors may also be at play here, I think it would be foolish to automatically discount these observations just because we can’t draw exact conclusions. We also see the same thing happening with a large number of prescription drugs, in which the presentation/severity of side effects often correlates with a particular dosing range. There are always exceptions to the rule, but in many cases it is a fairly reliable determinant of overall dosage.
    We’ve spent a good deal of time speculating about the potency of these peptides for GH release, but what about the differences between exo GH and GH peptides? Are there any advantages to using GH peptides over traditional GH? In today’s volatile GH market, there are more than ever. In the last 3 months alone, I have had over a dozen long-term exo GH users ask me for advice on how to best implement this class of peptides into their program after becoming disillusioned with the current exo GH market, The ever-growing number of fake, under-dosed, and bunk GH products being passed off as legitimate has resulted in many lost dollars, causing large numbers of people to pursue a different path for GH elevation. Quite simply, the acquisition of high quality GH products at reasonable prices has become increasingly difficult, leaving many with second thoughts as to the viability of a once semi-reliable market.
    Unlike the traditional GH market, which has taken a stead downturn for the worse in recent years, the peptide market has grown steadily in terms of quality, consistency, and availability, making it easy for anyone to access these items as wanted. This rapid growth can be attributed to three primary factors: the legality of the business, affordable pricing, and a gradual transition from Chinese-based manufacturing to U.S-based production. With the more quality conscious companies now having their products synthesized by American compounding pharmacies, the quality issues of yesteryear have been resolved. With a top-shelf product virtually guaranteed, we no longer have to worry if we are getting what we pay for. Both purity & potency are now assumed.
    When we stop to consider what this actually means to the consumer—to have products made under GMP approval—it quickly becomes apparent that this is the main distinction between prescription drugs and UGL-made gear. The bottom line is that this is the highest quality assurance you are going to get. Not only that, but some of these companies will subject their products to additional testing by an independent lab to further confirm their authenticity. Keep in mind that only a handful of peptide companies actually have their products produced and tested in this fashion.
    All of this is possible because of the business’s legitimacy from a legality standpoint. Most peptides, including GH peptides, are 100% legal to buy, own, and sell as of this writing. Aside from the elimination of legal risk, this makes it possible for these products to be manufactured and tested in these types of facilities. Otherwise, it wouldn’t be happening. We would be left with unproven and untrustworthy peptides on par with your typical UGL-made gear. Aside from the quality & legality aspects associated with certain sectors of the peptide industry, the relatively low cost of GH peptides compared to exo GH has made them an attractive option to more than just a few. Many people figure “why should I pay X amount of dollars every month to use a certain quantity of GH when I can spend 1/4th to 1/8th that amount and get the same results?” For those using 8 IU or less, I believe this is a very valid question.
    Neither should we forget the formation of GH anti-bodies; an act which takes place when using exo GH for an extended period of time and which has the potential to drastically undermine the body’s ability to use exo GH. GH peptides are immune to this effect, as the body does not respond in this fashion to its own GH. This means GH peptides can be used indefinitely without the need for a clean-out period.
    For those of you who are fed-up with the unreliability of the traditional GH market or who don’t have the cash to invest hundreds of dollars per month on a single hormone, GH peptides can provide you with a way to use this drug without having to risk your hard-earned dollars or deplete your bank account. The days of wondering whether GH peptides work are long over and anyone who expresses such a sentiment is clearly out of touch with not only the available scientific research, but also the numerous users who have supplied their own bloodwork results to the general public. The question anymore isn’t “do they work”, but rather “how do we best use them to achieve maximum GH levels?” Hopefully, the information presented in this 3-part article will help you do just that.
    Last edited by Presser; 09-27-2014 at 10:00 AM.
     

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    good read worth a bump, found our article on google search
    GHRP-2 vs GHRP-6  vs Ipamorelin...Which to use and Why

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    Great article.
    Thanks Presser thanked for this post
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    Thanks for finding the article Presser.
    Likes Presser liked this post
     

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    yeah i thought it was a good bump
    GHRP-2 vs GHRP-6  vs Ipamorelin...Which to use and Why

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    floating this read for the community
    GHRP-2 vs GHRP-6  vs Ipamorelin...Which to use and Why

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    Bump excellent read
     

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    Not the best peptides but theyre among some of the better peptides one can use, and this information is fantastic!
    GHRP-2 vs GHRP-6  vs Ipamorelin...Which to use and Why

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    Just going to bump this
     

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    ghrp 6
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