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    Default Prolactin suppression using Pramipexole

    For Prevention: when you are taking something that can cause prolactin issues or when you just want to lower prolactin, for the benefits of lowering prolactin.

    0.125 (1/8) to 0.5mg (1/2) per day should generally be sufficient for most users. With prevention slow escalation should not be an issue

    For Treatment: When you have ongoing prolactin issues, Gynecomastia flare, or are attempting to regress gynecomastia tissues (ductal, lobular and central gland mass).

    0.375 up (3/8) to 1mg should generally be sufficient for most users. Most people will not need over 0.5mg. If you do, then SLOWLY escalate the dose. You still should start at 0.25mg and slowly work up. see bottom for exceptions

    doses should be taken in the evening, 2-4 hours prior to bed. For the very low doses, an hour is probably fine. if it keeps you up, take it earlier. If it makes you sleepy "too soon" then take closer to bed. a good number of people will notice niether. taking with last meal of the day may be ideal for a lot of people.



    Now for you people that want high end dosing benefits, which are not prolactin suppression. This is a lot more complex, and generally requires a VERY slow progression in dosing to acheive. Clinicals increased the dose by 0.125 every 3-5 days. there will typicallly be side effects for people at various point along the progression. IT IS EXTREMELY IMPORTANT THAT YOU BE AWARE OF THESE BEFORE YOU LAUNCH INTO HIGH END DOSING.


    EDIT- IMPORTANT NOTE-

    for those that do not have dopaminergic sides, other than "waking up from sleep"-- which is caused by the drop in pramipexole in the plasma and the subsequent surge of dopamine release from the tissues in which they were suppressed, JUMPING the dose up more quickly will generally alleviate this. this is for those for whom interupted sleep is the primary and pretty much only side effect. this applies to treatment and high end dosing (at least until sleep interution abates).

    there are a lot of stickies to compete with, though probably will stick it at some point.

    keep in mind that these are guidelines, they are in point of fact, very generalized guidelines. They may also change, if other users find significant differences at and between dose points and response rates.

    Not everyone will fit tight within the parameters listed above. But most people will fall within those bounds and most people will fall toward the middle or bottom end of each dosing spectrum.

    Treatment of existing gyno will vary more, with a decent # of people leaning toward the upper end of that range, perhaps even slightly higher.

    What is important is that people adjust dosing according to their own response. If its too strong, causing too many sides, or whatever..... CUT BACK THE DOSE.... ride it out at that lower dose and then slowly try to increase again. That is of course if you even need to. People go a bit overboard in trying to get the max dose, to "be sure". this is fine, but if they do that they need to not complain about the sides (sure you should ask about and discuss them, but you should also be aware that usually issues arise from escalation to fast... if you escalate too fast... you should mentioned that when asking questions or making comments. Pramipexole is an innocent . he/she is just here to help you, maybe he/she is annoying at times of "overexposure" and maybe you need to dial back the time you spend with pramipexole (ie dosage). But dont take it out on pramipexole, because its really the parameters of the individuals relationship with pramipexole that need to be fixed, not the prami. He/she is good.

    On a personal note: I don't recommend high dosing for anyone. Most the studies using higher doses were on people who were impaired and had various medical conditions so they may have needed more, and not healthy individuals.

    from the perspective of prolactin suppression, no one really need high end dosing. Anything much over a mg is overkill, there may be some few exceptions to this, but generally 1mg to 1.5m/day would be peak dosing for prolactin suppression during treatment, and that would be for a very limited number of individuals. Generally .5-.75 is going to be fine. But slow escalation to 1mg, as long as its slow. should not be discouraged in those that wish to try it.


    Will agree to disagree on whether people should use higher doses. As you know, IMO, there are a lot of people whose issues stem from the d3/d2. Now do think that people who are so affected should, if able, at least consult their physician on this issue. However, am well aware of the resistance of doctor to do certain off label scripts or even to be involved in non physician emanating treatments.

    ...once again, dose for prolactin suppression does not need to be high, particularly when using pramipexole for prevention. low doses should be taken prior to bed. Daytime low dosing is more problematic.
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    GREAT INFORMATION! I know back when I was getting into bodybuilding, i didnt know jack shit about estrogen , let alone prolactin, progesterone etc...

    Then when I finally figured out the estrogen deal, i was shocked to learn their were other popular steroids that induced to Progesterone , lol,

    Anyways, so much information out there now days, that their is ZERO FUCKING REASON WE SHOULD EVER SEE A YOUNGER GENERATION BODYBUILDER ON STAGE WITH GIANT BITCH TITS DUE TO STEROID CONVERTING TO EITHER ESTROGEN OR PROGESTERONE!

    aside from the adolescent predisposed gyno
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    Prolactin suppression using Pramipexole

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    I used bromocriptine once because my dump ass used high dose of Deca and tren together.
     

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    Quote Originally Posted by PUMPED View Post
    I used bromocriptine once because my dump ass used high dose of Deca and tren together.
    I have used pramipexole many times over the years with great effect. Genotec sells bromocriptine but I still haven't used it. I have heard it is much more forgiving so I may have to try it out one day. Although after my current run I told myself no tren for 6 months
    Use code ELVIA1023 to get 5% off your next Synthetek Order.
    For a limited time only, if your order is $300 or greater, they throw in a product of YOUR choice absolutely FREE.


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    Has anyone experienced prami withdrawal? I know Prami is addictive and my buddy is going through withdrawal right now and said it actually really fucking sucks. I don't really ever hear it talked about much though so I guess because of that I assumed it wasn't that bad. idk
     

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    Quote Originally Posted by trekrider215 View Post
    Has anyone experienced prami withdrawal? I know Prami is addictive and my buddy is going through withdrawal right now and said it actually really fucking sucks. I don't really ever hear it talked about much though so I guess because of that I assumed it wasn't that bad. idk
    Yes I have heard of Prami withdrawal and that totally makes sense. At over 1 mg a day you can have serious mood effects.

    - - - Updated - - -

    Not all dopamine agonist's have the same effects as Prami does. Prami has unique traits to it and has shown to have an antidepressant effect as well. Considering many SSRI's (used for depression research) cause a rise in prolactin which may cause SD, I feel Prami's very positive trait in this area make it a good partner for SSRI research. Prami has also been shown in to have an antidepressant effect in subjects with Parkinson's disease not being administered SSRI's, showing there is more to Prami's anti-depressant qualities then just subjects being administered SSRI's. In a study with more than one dopamine agonist it was shown that; "dopamine receptor D(2) and D(3) expression was up-regulated in the striatum following pramipexole treatment, while imipramine and bromocriptine had no significant effects. These findings support that pramipexole exerts additional therapeutic benefits such as decreasing depression by increasing dopamine receptor D(3) expression in the striatum." Prami binds very well to D(2)/D(3) receptors in the prefrontal cortex, amygdala, and medial and lateral thalamus. These regions are believed to have some relation to depression and this is why I believe Prami to have these positive effects on depression. Even in test subjects not being administered SSRI?s during research or that had normal Prolactin levels Prami was shown to have a positive effect on depression.

    Prami is truly a multifaceted compound with various effects and it is very unique to other dopamine agonists. Prami is well tolerated, shown to boost GH after administration, have multiple neuroprotective mechanisms, effectively lower prolactin and have a very high oral availability! In my opinion this makes Prami a top choice compound for any researcher investigating dopamine agonists, depression, Alzheimer's & Parkinson's diseases, Side effects from SSRI's or even just simply needing a compound to safely and effectively lower prolactin levels in their test subjects. Prami is a top contender for all of the above and may even lead to fewer compounds needed in certain research settings due to its unique multifaceted qualities over other dopamine agonists.

    The possibilities are endless with Prami research and I hope this article helps fellow researchers out in picking the right compound to research with for their specific goals.

    - - - Updated - - -

    I have recently tried both Prami and caber and I would choose Prami hands down every time. Although both tighten my nips up and take the soreness away.
     

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    Administering Pramipexole
    For the purpose of prolactin suppression (gyno, lactation, sexual dysfunction, libido, etc), pramipexole is normally administered at a dose of .5-1.0 mg/ day. However, one should not begin there, but gradually increase their dose over a period of 2-3 weeks in order to minimize side effects. If using liquid-based products, find an oral syringe capable of measuring in small increments and begin at .125 mg/day for the first 3-4 days. Afterwards, move to .25 mg/day for 3-4 days, 3.75 for 3-4 days, and finally .5 mg for 3-4 days. If necessary, continue using this gradual progression scheme up to 1 mg/day.

    Few people will need more than 1mg daily when using a properly dosed product, even when using very high dosages of trenbolone and/or nandrolone. The goal should be to use the lowest effective dose possible, as there is no advantage to using more than necessary, aside from increased growth hormone production. While some may find this to be a worthy goal in itself, I believe there are better, less side effect-prone alternatives for increasing levels of this hormone, such as GH peptides or exogenous growth hormone itself. Lastly, with tiredness being a common side effect of these products, most prefer to administer pramipexole shortly before bed, as it will help induce a sound sleep without significantly impairing wakefulness the following day, although tiredness may persist for the first couple weeks as the body adapts. Gradually increasing the dose over time is the best way to minimize/avoid this side effect.

    These days, with a number of proven, cost-effective anti-prolactin drugs on the market, there is no reason to have to deal with any side effects arising from elevated prolactin levels. Those who choose to use low-moderate doses of trenbolone and/or nandrolone often find that a single 60 ml bottle, when dosed at the typical 1mg/ml, can last for up to 4 months of continuous use or longer, depending on personal response. So, expense is much less of a concern than it is with many other BB’ing drugs.
    If you are like me and are unable to use some of your favorite steroids for longer than 4-5 weeks at a stretch without experiencing unacceptable side effects, then perhaps pramipexole is something you may want to consider. It’s cheap, easy to obtain, and works well. As a prospective weapon in our BB’ing arsenal, pramipexole does exactly what it is supposed to, earning it a place alongside our other reliable ancillaries.
    Prolactin suppression using Pramipexole

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    Prolactin suppression using Pramipexole

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