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    Default Mechanisms of vitamin D on skeletal muscle function: oxidative stress, energy metabolism and anabolic state

    European Journal of Applied Physiology


    April 2019, Volume 119, Issue 4, pp 825–839 | Cite as


    Mechanisms of vitamin D on skeletal muscle function: oxidative stress, energy metabolism and anabolic state
    Authors
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    Katarzyna Patrycja DzikJan Jacek KaczorEmail author


    This review provides a current perspective on the mechanism of vitamin D on skeletal muscle function with the emphasis on oxidative stress, muscle anabolic state and muscle energy metabolism. It focuses on several aspects related to cellular and molecular physiology such as VDR as the trigger point of vitamin D action, oxidative stress as a consequence of vitamin D deficiency.


    Method
    The interaction between vitamin D deficiency and mitochondrial function as well as skeletal muscle atrophy signalling pathways have been studied and clarified in the last years. To the best of our knowledge, we summarize key knowledge and knowledge gaps regarding the mechanism(s) of action of vitamin D in skeletal muscle.


    Result
    Vitamin D deficiency is associated with oxidative stress in skeletal muscle that influences the mitochondrial function and affects the development of skeletal muscle atrophy. Namely, vitamin D deficiency decreases oxygen consumption rate and induces disruption of mitochondrial function. These deleterious consequences on muscle may be associated through the vitamin D receptor (VDR) action. Moreover, vitamin D deficiency may contribute to the development of muscle atrophy. The possible signalling pathway triggering the expression of Atrogin-1 involves Src-ERK1/2-Akt- FOXO causing protein degradation.


    Conclusion
    Based on the current knowledge we propose that vitamin D deficiency results from the loss of VDR function and it could be partly responsible for the development of neurodegenerative diseases in human beings.

    Mechanisms of vitamin D on skeletal muscle function: oxidative stress, energy metabolism and anabolic state | SpringerLink
     

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    I use to drink 1 to 2 Gallons of Whole Milk Every fucking day when I was in my early twenties, Thats my hand to God, and you can likely go back and find those posts i made back then on here, lol. Point is when i think of Vitamin D i think Milk , lmao and I really should get back nto drinking more! Or taking a solid Multi Vitamin like a Vital Performance or something from Premier Pharmaceutical
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    Mechanisms of vitamin D on skeletal muscle function: oxidative stress, energy metabolism and anabolic state

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    Quote Originally Posted by Presser View Post
    I use to drink 1 to 2 Gallons of Whole Milk Every fucking day when I was in my early twenties, Thats my hand to God, and you can likely go back and find those posts i made back then on here, lol. Point is when i think of Vitamin D i think Milk , lmao and I really should get back nto drinking more! Or taking a solid Multi Vitamin like a Vital Performance or something from Premier Pharmaceutical
    I had mine checked in February and it was dangerously low even though I worked outside and in Florida. I think the low end of the test is like 30 mine was 10. The body will steel vitamin D to keep other things going.

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