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  1. #1
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    Default Do different carrier oils really matter with my gear? (Some interesting facts)

    Yes it does matter for "some".. Carrier oils release at different rates, thus this will effect the serum levels of the parenting hormone, however the carrier really has little effect on a scale that you or anyone would even notice aside from its " kinetic profile under clinical investigation/studies" , although administration with certain carriers may yield different toxicological profiles for the same drug, some reaching supraphysiological serum testosterone levels, but this will vary with administered route (whether IM or subQ), different esters, individuals and so on..Also, different regions favor one oil over the other like western pharmacopoeia practice may often and commonly use Grape-seed, as in other regions of the world with therapies some use tea-seed oil,soy and cottonseed with the same promising returns (pro's and con's with both oils), much like Enanthate is manufactured in Europe for TRT, while Cypionate is manufactured in the U.S. Testosterone Cypionate and Enanthate both steroids have the same effects and functions, whilst there are studies claiming the longevity effect of Cypionate compared to Enanthate differ,but we know it's irrelevant on the small scale..The same can be seen and recognized with carriers to a degree, this is why most UGL's will use the same carriers to keep release time with-in a narrow range of others..

    Now if we're talking about supraphysiological serum testosterone levels, with shorter esters in different carrier oils that possess different half-life/molecule weight (yes carrier half life's), with different routes of administration sub-q or IM? Sure, we can see levels exceeding upper limits, but the extended release will balance out with a decline (ester dependent), this is just a quesstimation as there will be many variables to conciser (age,genetics) but you get the jist on the generalization here.

    In the grand scheme of it all, It comes down to 90% allergies and user sensitivity..

    Site reaction, immune response and even hormone release will have effects on each independent user..(Example - castor oil has a slow, stable, steady release for heavier esters due to its longer half-life)..
    However for most generally used carriers the viscosity really isn't that different when compared through kinematic viscosity measurement (mm2/s) - Fluid resistance..

    When being measured they're off by a few digits, but that's so insignificant..It's mainly immune response/allergies/site irritation..

    Below is a "basic" template of kinematic viscosity measurements (mm2/s) - Fluid resistance with most major carrier oils. Top being thickest, and last being thinnest..

    Castor 297.0
    Crambe 53.6
    High-Oleic Safflower 41.2
    Peanut 39.6
    Sunflower 37.1
    Grapeseed 37.0
    Sesame 35.3
    Corn 34.9
    Cottonseed 33.5
    Soybean 32.6
    Safflower 31.3

    Here is a study explaining how "castor oi" has a longer half-life than most traditionally used carriers in general practice

    Intramuscular injection of testosterone undecanoate for the treatment of male hypogonadism: phase I studies.

    Behre HM1, Abshagen K, Oettel M, Hübler D, Nieschlag E.
    Author information



    Abstract

    OBJECTIVE:

    In the search for long-acting testosterone preparations suited for substitution therapy of hypogonadal men, testosterone undecanoate (TU) dissolved in either tea seed oil or castor oil was investigated.
    DESIGN:

    In study I, 1000 mg TU in tea seed oil (125 mg/ml) were injected in equal parts into the gluteal muscles of seven hypogonadal men. In study II, 1000 mg TU in castor oil (250 mg/ml) were injected into one gluteal muscle of 14 patients.
    RESULTS:

    In comparison with published data on testosterone enanthate, most widely used for i.m. injections, the kinetic profiles of both TU preparations showed extended half-lives and serum levels not exceeding the upper limit of normal. The castor oil preparation had a longer half-life than TU in tea seed oil (33.9+/-4.9 vs 20.9+/-6.0 days (mean pm S.E.M.)).
    CONCLUSION:

    The longer half-life and the smaller injection volume make TU in castor oil a strong candidate for further applications in substitution therapy and in trials for male contraception.


    Abstract
    In the search for long-acting testosterone preparations suited for substitution therapy of hypogonadal men, testosterone undecanoate (TU) dissolved in either tea seed oil or castor oil was investigated.In study I, 1000 mg TU in tea seed oil (125 mg/ml) were injected in equal parts into the gluteal muscles of seven hypogonadal men. In study II, 1000 mg TU in castor oil (250 mg/ml) were injected into one gluteal muscle of 14 patients.In comparison with published data on testosterone enanthate, most widely used for i.m. injections, the kinetic profiles of both TU preparations showed extended half-lives and serum levels not exceeding the upper limit of normal. The castor oil preparation had a longer half-life than TU in tea seed oil (33.9+/-4.9 vs 20.9+/-6.0 days (mean pm S.E.M.)).The longer half-life and the smaller injection volume make TU in castor oil a strong candidate for further applications in substitution therapy and in trials for male contraception.


    Below is a great read about treatments, and serum levels with carrier oils!
    Intramuscular injection of testosterone undecanoate for the treatment of male hypogonadism: Phase I studies

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    from 39.7 6 6.2 to a nadir of 35.3 6 5.4 U/l at study
    day 21 (P = 0.017) (Fig. 3, lower panel).
    Body weight and blood pressure
    Body weight as well as systolic and diastolic blood
    pressure did not change significantly throughout
    study II.
    Clinical chemistry and hematology
    No significant changes in clinical chemistry, including
    cholesterol, HDL cholesterol, LDL cholesterol and liver
    function tests were observed throughout study II.
    Hemoglobin, erythrocytes and hematocrit were not
    different from baseline. No significant change was seen
    in leukocyte or platelet counts throughout the study.
    No significant change was seen in blood coagulation
    as assessed by partial thromboplastin time and pro-
    thrombin time.
    Serum levels of PSA increased significantly
    (P < 0.001) from baseline of 0.33 6 0.06 to 0.56 6
    0.07 mg/l at day 28. Levels at day 56 of 0.48 6 0.08 mg/l
    were no longer statistically different from baseline.
    All individual PSA values remained well within the
    normal range (C
    max
    1.6 mg/l in one patient at day 35).
    Discussion
    Intramuscularly injected TE is the most widely used
    testosterone preparation when depot effects are
    required, e.g. for substitution of hypogonadism (1) or
    in trials for hormonal male contraception (10). How-
    ever, after injection of the commonly administered
    dose of 200 or 250 mg, TE has the disadvantage that
    it produces supraphysiological serum testosterone
    levels during the days immediately following adminis-
    tration with a slow decline to the lower limit of normal
    following within 10–14 days (11). Patients dislike
    these swings in serum testosterone levels, which they
    experience as ups and downs in vigour, mood and
    sexual activity. Other testosterone esters in clinical use
    such as testosterone cypionate or cyclohexanecarboxy-
    late show pharmacokinetic profiles almost identical to
    that of TE (12, 13), so that these preparations offer
    no therapeutic advantage.
    Although the current study deals with a much
    higher dose of testosterone than administered in
    previous studies, TU does not result in supranormal
    serum testosterone levels, but in much prolonged
    action. Extrapolating from single-dose kinetics it
    appears that upon repeated injections of 1000 mg,
    injection intervals of 6–10 weeks will be possible. The
    prolonged intervals and the normal serum testosterone
    levels throughout the injection-free period would be
    welcomed by the hypogonadal patient requiring sub-
    stitution as well as by the eugonadal male seeking
    contraceptive protection.
    Although different routes of administration may
    yield different toxicological profiles for the same drug,
    the lack of serious side-effects from TU administered
    orally at doses of 80–160 mg/day over many years (14)
    gives reason to assume that TU applied i.m. might also
    be well tolerated. Indeed, no untoward side-effects
    have been reported from i.m. use in China (7, 15).
    The reason for the prolonged half-life of TU in
    comparison with TE is the longer aliphatic, and thus
    more hydrophobic, side-chain, comprising 11 instead
    of 7 carbon atoms. Similarly, testosterone buciclate
    has a prolonged duration of action, which is caused
    by the hydrophobic benzol ring incorporated into the
    side-chain.
    Recently, it was shown in Chinese men that i.m.
    injection of 1000 mg TU dissolved in tea seed oil at a
    concentration of 125 mg/ml has a similar pharmacoki-
    netic profile with a t
    ½
    b of 23.7 6 2.7 days compared
    with our study with the tea seed oil preparation in
    Caucasian men (15). The longer duration of action of
    TU in castor oil compared with TU in tea seed oil
    could be due to the properties of the oils, the different
    concentrations (125 vs 250 mg/ml) and injection
    volumes (4 vs 8 ml), as well as unilateral vs bilateral
    gluteal application. It is conceivable that the larger
    surface of the depot produced by 2 ×4 ml injections
    leads to a slightly faster release of the testosterone
    Do different carrier oils really matter with my gear? (Some interesting facts)

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