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    Arimidex, Letrozole, Clomid, Nolvadex, Caborgoline, Dostinex, Post Cycle Therapy



    igf 1 lr3, igf-1, insulin-like growth factor-1,


    SARM Rad 140 , testolone, sarm s23, Ligandrol, Andarine, Ostarine, Cardarine

    Overview and History CJC-1295

    Modified GRF 1-29 is also known as Mod GRF 1-29, but even more commonly known as CJC-1295 without DAC. The proper terminology, however, is its original name and classification: substituted GRF (1-29). The confusion in regards to the naming and nomenclature of this particular substance must be first clarified before delving into any further discussion, as the majority of performance enhancing drug community and individuals looking to use this substance will undoubtedly become very confused upon reading and researching this product, and especially later on when electing to purchase it (it is listed under all of its names by some vendors and only one of its names by other vendors). The name Mod GRF 1-29 was originally derived by a researcher known as DatBtrue, who coined the term in his internet publicized articles on the substance. Because of the popularity of his articles, the new name was easily and extensively adopted by readers, and the common use of the name spread wildly from there. However, perhaps the most common name for this substance is CJC-1295 without DAC. The importance to understanding the difference in these names is the history of the substance and its structure.

    Mod GRF 1-29 belongs to a category of peptides known as HGH (Human Growth Hormone) secretagogues. It is a modified derivative of an already existing derivative of Growth Hormone Releasing Hormone (GHRH), which is an endogenously produced peptide hormone in the human body. Therefore, it could be referred to more properly as a second generation derivative of GHRH. GHRH is modified to create what is known as Growth hormone Releasing Factor (GRF) 1-29. GRF 1-29 is then further modified to create Mod GRF 1-29. The nomenclature of the evolution of the derivatives should be self-explanatory concerning this. GRF 1-29 is also known by its trade name, Sermorelin (which Mod GRF 1-29 is a derivative of).

    The most popular name for this peptide, however, is CJC-1295 without DAC, and is referred to as such because there is actually a third derivative of GHRH, which is known as CJC-1295 with DAC. The acronym DAC stands for Drug Affinity Complex, which is a modification that is added to the peptide that extends its half-life and active life in the body. CJC-1295 without DAC is simply Mod GRF 1-29.

    For ease of explanation and clarification to the reader, what has been discussed thus far is the following:

    GRF 1-29 is a modification of GHRH (Growth Hormone Releasing Hormone)
    Mod GRF 1-29 is a modification of GRF 1-29
    CJC-1295 with DAC is a modification of Mod GRF 1-29

    Now that the confusing naming system has been clarified, the general description of Mod GRF 1-29 is as follows: Mod GRF 1-29 is a peptide hormone (also known as a protein hormone) that was developed in Canada and first mentioned in medical literature in 2005. It is a protein that is 29 amino acids long, and as explained earlier, it is a GHRH analogue. As a GHRH analogue, Mod GRF 1-29 (CJC-1295 without DAC) acts on receptors at the pituitary gland to stimulate the release of Human Growth Hormone. In order to understand its function and what it is, one must understand the concept behind the protein/peptide structure of these hormones (which will also consequently help the reader to further understand the difference in the naming that has been discussed above).

    Questions PeptidesChemical Characteristics of Modified GRF 1-29 (CJC-1295 without DAC)

    Proteins/peptides are chains of amino acids linked in specific unique orders. Proteins, depending on how many amino acids it is composed of, will manifest itself as one of three structural types: the primary protein structure which is simply a long chain of amino acids, the secondary protein structure which is a folded protein structure resembling a pleated sheet, the tertiary protein structure which is a complex fold of proteins that resembles a tangled ball of yarn, and finally the quaternary protein structure which is several tertiary proteins interconnected. The significance of this in protein hormones such as Human Growth Hormone (HGH), insulin, Luteinizing Hormone (LH), Mod GRF 1-29 (CJC-1295 without DAC), and many others, is the fact that various sections of the protein structure will contribute to different jobs in the body by binding to and activating different receptors. The shape of the peptide hormone, and the different subsections of it, can allow stronger binding affinity or weaker binding affinity.

    Growth Hormone Releasing Hormone (GHRH), which is the endogenously secreted GHRH by the arcuate nucleus of the hypothalamus of the human body, is 44 amino acids long. It was discovered, however, that only the first 29 amino acids of the protein were equally as effective in binding to receptors on the pituitary gland as the full 44 amino acid structure.The first 29 amino acids in its protein structure were then isolated, which was then called GRF 1-29, but the problem with this derivative of GHRH was the fact that it was rapidly metabolized and cleared from the body by enzymes. Studies have reported that GRF 1-29’s half-life is less than 10 minutes and as little as 5 minutes. This was obviously not enough time to ensure a maximized and sustained release of HGH from the pituitary gland, as studies have demonstrated that the full potential of an HGH pulse from the pituitary requires at least 30 minutes as evidenced by the fact that much higher HGH levels (50 times greater) were observed 15 – 30 minutes into subcutaneous administration of GHRH analogues.

    Therefore, the solution to this was to modify GRF 1-29 by replacing various amino acids in its structure with other amino acids that would provide a greater resistance to breakdown and cleavage by enzymes. There were many modified analogues developed, and Mod GRF 1-29 (CJC-1295 without DAC) was eventually selected for use, which demonstrated the most promising effects. Mod GRF 1-29 is a modification of GRF 1-29, specifically at amino acids #2, #8, #15, and #27. The result is an extended half-life to that of at least 30 minutes.

    Properties of Modified GRF 1-29 (CJC-1295 without DAC)

    Mod GRF 1-29 acts upon receptors located in the anterior pituitary gland, and signals the pituitary gland to increase Human Growth Hormone production and cause a release of massive quantities of Human Growth Hormone in a pulsatile manner. The effects of Mod GRF 1-29 are very similar from what would be expected from synthetic HGH administration over the long term (see the Human Growth Hormone profile here), although the amount of time that the released human growth hormone will remain in circulation is of a far less amount of time than synthetic Human Growth Hormone does. Therefore, multiple applications of Mod GRF 1-29 is recommended throughout the day in order to simulate Human Growth Hormone levels that remain high on a constant basis. Mod GRF 1-29 (CJC-1295 without DAC) is commonly combined with a Ghrelin mimetic (also known as a GHRP – Growth Hormone Releasing Hexapeptide), such as GHRP-6, GHRP-2, Hexarelin, or Ipamorelin in order to initiate and amplify a greater pulse of HGH from the pituitary compared to Mod GRF 1-29 used solitarily on its own. The effects of a GHRH analogue (such as Mod GRF 1-29) and a Ghrelin mimetic (a GHRP such as GHRP-6 or Ipamorelin) are synergistic and amplify the release of HGH.


    Modified GRF 1-29 (AKA Mod GRF 1-29, CJC-1295 without DAC)
    Half Life: 30 mins


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    Quote Originally Posted by GotTren View Post

    Overview and History CJC-1295

    Modified GRF 1-29 is also known as Mod GRF 1-29, but even more commonly known as CJC-1295 without DAC. The proper terminology, however, is its original name and classification: substituted GRF (1-29). The confusion in regards to the naming and nomenclature of this particular substance must be first clarified before delving into any further discussion, as the majority of performance enhancing drug community and individuals looking to use this substance will undoubtedly become very confused upon reading and researching this product, and especially later on when electing to purchase it (it is listed under all of its names by some vendors and only one of its names by other vendors). The name Mod GRF 1-29 was originally derived by a researcher known as DatBtrue, who coined the term in his internet publicized articles on the substance. Because of the popularity of his articles, the new name was easily and extensively adopted by readers, and the common use of the name spread wildly from there. However, perhaps the most common name for this substance is CJC-1295 without DAC. The importance to understanding the difference in these names is the history of the substance and its structure.

    Mod GRF 1-29 belongs to a category of peptides known as HGH (Human Growth Hormone) secretagogues. It is a modified derivative of an already existing derivative of Growth Hormone Releasing Hormone (GHRH), which is an endogenously produced peptide hormone in the human body. Therefore, it could be referred to more properly as a second generation derivative of GHRH. GHRH is modified to create what is known as Growth hormone Releasing Factor (GRF) 1-29. GRF 1-29 is then further modified to create Mod GRF 1-29. The nomenclature of the evolution of the derivatives should be self-explanatory concerning this. GRF 1-29 is also known by its trade name, Sermorelin (which Mod GRF 1-29 is a derivative of).

    The most popular name for this peptide, however, is CJC-1295 without DAC, and is referred to as such because there is actually a third derivative of GHRH, which is known as CJC-1295 with DAC. The acronym DAC stands for Drug Affinity Complex, which is a modification that is added to the peptide that extends its half-life and active life in the body. CJC-1295 without DAC is simply Mod GRF 1-29.

    For ease of explanation and clarification to the reader, what has been discussed thus far is the following:

    GRF 1-29 is a modification of GHRH (Growth Hormone Releasing Hormone)
    Mod GRF 1-29 is a modification of GRF 1-29
    CJC-1295 with DAC is a modification of Mod GRF 1-29

    Now that the confusing naming system has been clarified, the general description of Mod GRF 1-29 is as follows: Mod GRF 1-29 is a peptide hormone (also known as a protein hormone) that was developed in Canada and first mentioned in medical literature in 2005. It is a protein that is 29 amino acids long, and as explained earlier, it is a GHRH analogue. As a GHRH analogue, Mod GRF 1-29 (CJC-1295 without DAC) acts on receptors at the pituitary gland to stimulate the release of Human Growth Hormone. In order to understand its function and what it is, one must understand the concept behind the protein/peptide structure of these hormones (which will also consequently help the reader to further understand the difference in the naming that has been discussed above).

    Questions PeptidesChemical Characteristics of Modified GRF 1-29 (CJC-1295 without DAC)

    Proteins/peptides are chains of amino acids linked in specific unique orders. Proteins, depending on how many amino acids it is composed of, will manifest itself as one of three structural types: the primary protein structure which is simply a long chain of amino acids, the secondary protein structure which is a folded protein structure resembling a pleated sheet, the tertiary protein structure which is a complex fold of proteins that resembles a tangled ball of yarn, and finally the quaternary protein structure which is several tertiary proteins interconnected. The significance of this in protein hormones such as Human Growth Hormone (HGH), insulin, Luteinizing Hormone (LH), Mod GRF 1-29 (CJC-1295 without DAC), and many others, is the fact that various sections of the protein structure will contribute to different jobs in the body by binding to and activating different receptors. The shape of the peptide hormone, and the different subsections of it, can allow stronger binding affinity or weaker binding affinity.

    Growth Hormone Releasing Hormone (GHRH), which is the endogenously secreted GHRH by the arcuate nucleus of the hypothalamus of the human body, is 44 amino acids long. It was discovered, however, that only the first 29 amino acids of the protein were equally as effective in binding to receptors on the pituitary gland as the full 44 amino acid structure.The first 29 amino acids in its protein structure were then isolated, which was then called GRF 1-29, but the problem with this derivative of GHRH was the fact that it was rapidly metabolized and cleared from the body by enzymes. Studies have reported that GRF 1-29’s half-life is less than 10 minutes and as little as 5 minutes. This was obviously not enough time to ensure a maximized and sustained release of HGH from the pituitary gland, as studies have demonstrated that the full potential of an HGH pulse from the pituitary requires at least 30 minutes as evidenced by the fact that much higher HGH levels (50 times greater) were observed 15 – 30 minutes into subcutaneous administration of GHRH analogues.

    Therefore, the solution to this was to modify GRF 1-29 by replacing various amino acids in its structure with other amino acids that would provide a greater resistance to breakdown and cleavage by enzymes. There were many modified analogues developed, and Mod GRF 1-29 (CJC-1295 without DAC) was eventually selected for use, which demonstrated the most promising effects. Mod GRF 1-29 is a modification of GRF 1-29, specifically at amino acids #2, #8, #15, and #27. The result is an extended half-life to that of at least 30 minutes.

    Properties of Modified GRF 1-29 (CJC-1295 without DAC)

    Mod GRF 1-29 acts upon receptors located in the anterior pituitary gland, and signals the pituitary gland to increase Human Growth Hormone production and cause a release of massive quantities of Human Growth Hormone in a pulsatile manner. The effects of Mod GRF 1-29 are very similar from what would be expected from synthetic HGH administration over the long term (see the Human Growth Hormone profile here), although the amount of time that the released human growth hormone will remain in circulation is of a far less amount of time than synthetic Human Growth Hormone does. Therefore, multiple applications of Mod GRF 1-29 is recommended throughout the day in order to simulate Human Growth Hormone levels that remain high on a constant basis. Mod GRF 1-29 (CJC-1295 without DAC) is commonly combined with a Ghrelin mimetic (also known as a GHRP – Growth Hormone Releasing Hexapeptide), such as GHRP-6, GHRP-2, Hexarelin, or Ipamorelin in order to initiate and amplify a greater pulse of HGH from the pituitary compared to Mod GRF 1-29 used solitarily on its own. The effects of a GHRH analogue (such as Mod GRF 1-29) and a Ghrelin mimetic (a GHRP such as GHRP-6 or Ipamorelin) are synergistic and amplify the release of HGH.


    Modified GRF 1-29 (AKA Mod GRF 1-29, CJC-1295 without DAC)
    Half Life: 30 mins


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    My cycle is over in 4 weeks. Then was to use insulin and igf 1-lr3 as a bridge. However I was also looking into ghrp-6 mixed with mod grf. If I decide to go with the ghrp-6 and cjc. Have 2 questions for you brother first one is would it be okay to buy it pre-mixed as I have a source that sells it pre-mixed or would it be better to buy them individually? Second what would you suggest as far as timing goes I was thinking first thing in the morning middle of the day like 2 or 3 o'clock and then before bed? I'm thinking I will definitely get more benefit since I'm using insulin and igf would you agree? Sorry last but not least should I wait 4 weeks to I'm completely done my cycle or should I start before I'm done?

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    Quote Originally Posted by bigmills View Post
    My cycle is over in 4 weeks. Then was to use insulin and igf 1-lr3 as a bridge. However I was also looking into ghrp-6 mixed with mod grf. If I decide to go with the ghrp-6 and cjc. Have 2 questions for you brother first one is would it be okay to buy it pre-mixed as I have a source that sells it pre-mixed or would it be better to buy them individually? Second what would you suggest as far as timing goes I was thinking first thing in the morning middle of the day like 2 or 3 o'clock and then before bed? I'm thinking I will definitely get more benefit since I'm using insulin and igf would you agree? Sorry last but not least should I wait 4 weeks to I'm completely done my cycle or should I start before I'm done?

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    Im hoping a vet or someone with some peptide experience will chime in on this..

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    Quote Originally Posted by bigmills View Post
    My cycle is over in 4 weeks. Then was to use insulin and igf 1-lr3 as a bridge. However I was also looking into ghrp-6 mixed with mod grf. If I decide to go with the ghrp-6 and cjc. Have 2 questions for you brother first one is would it be okay to buy it pre-mixed as I have a source that sells it pre-mixed or would it be better to buy them individually? Second what would you suggest as far as timing goes I was thinking first thing in the morning middle of the day like 2 or 3 o'clock and then before bed? I'm thinking I will definitely get more benefit since I'm using insulin and igf would you agree? Sorry last but not least should I wait 4 weeks to I'm completely done my cycle or should I start before I'm done?

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    What's up mills? How are you brother? Good questions here. Me personally I would not recommend blends due to the fact you don't actually know how much measure that your actually receiving, it's just an estimate. So I would always go individually. Correct, try your best to split the doses within the same time frames, ex. Every 6 hrs. Of course you would receive much more benefit from any chemical you put in your body while taking slin. Just please o please make sure you have carbs in your stomach before taking. Slin is very dangerous if taken improperly. Lastly since your bridging, does this mean that your not taking a full PCT? What compounds did you run?


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    Quote Originally Posted by GotTren View Post
    What's up mills? How are you brother? Good questions here. Me personally I would not recommend blends due to the fact you don't actually know how much measure that your actually receiving, it's just an estimate. So I would always go individually. Correct, try your best to split the doses within the same time frames, ex. Every 6 hrs. Of course you would receive much more benefit from any chemical you put in your body while taking slin. Just please o please make sure you have carbs in your stomach before taking. Slin is very dangerous if taken improperly. Lastly since your bridging, does this mean that your not taking a full PCT? What compounds did you run?


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    Appreciate that answer on the CJC and ghrp. What do you think about the igf lr3 timing on both workout and now I'm workout days? I have been playing around with insulin for the last eight or nine years so I have it down pretty packed.. and as far as my cycle goes Iran 600 mg test e 400 mg Tren a. Injectable Anadrol and test base pre-workout 4 days a week which probably puts meth 900-1000mg a week.

    PCT is going to be HCG in the last 4 weeks of the cycle and 250 IU's every 3 days. Take my last shot of HCG the same day I take my last shot of test e, 14 days from the day of my last shot I was going to run
    Nolvadex 40/20/20
    Clomid 150/100/50/59

    Even though I've been doing this for ever I still like to hear other people's opinion so let me know what you think about that? Debate was whether to start the HCG now for the last 4 weeks which I think is best or wait till I come off completely?

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    Quote Originally Posted by bigmills View Post
    Appreciate that answer on the CJC and ghrp. What do you think about the igf lr3 timing on both workout and now I'm workout days? I have been playing around with insulin for the last eight or nine years so I have it down pretty packed.. and as far as my cycle goes Iran 600 mg test e 400 mg Tren a. Injectable Anadrol and test base pre-workout 4 days a week which probably puts meth 900-1000mg a week.

    PCT is going to be HCG in the last 4 weeks of the cycle and 250 IU's every 3 days. Take my last shot of HCG the same day I take my last shot of test e, 14 days from the day of my last shot I was going to run
    Nolvadex 40/20/20
    Clomid 150/100/50/59

    Even though I've been doing this for ever I still like to hear other people's opinion so let me know what you think about that? Debate was whether to start the HCG now for the last 4 weeks which I think is best or wait till I come off completely?

    Sent from my SM-G935V using Tapatalk
    I've never ran igf lr3 but I have researched it heavily and have some on the way from MC. What I believe is the best way to take it is per site injection and 30mins preworkout. That's the only time I will take, not on off days. I'm strickly wanting to run only for the pump,not for the healing properties, but that is a plus. Now PCT, I don't run hcg on cycle, only for PCT for me. If I'm on a long ester I would start the hcg 10 days before the ester clears. And run 2000mcg eod for those 10 days. Then nolva 20/20/20/20 clomid 100/ 100/50/50. Also I'm going to be running aromasin at 12.5mg eod and also sarms, gw-501516, ostarine. Perfect PCT. I ran the same PCT without the sarms and I kept 90 percent of my gains last cycle. With the sarms and peptides I believe I will be gaining into and throughout pct
     

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    Quote Originally Posted by GotTren View Post
    I've never ran igf lr3 but I have researched it heavily and have some on the way from MC. What I believe is the best way to take it is per site injection and 30mins preworkout. That's the only time I will take, not on off days. I'm strickly wanting to run only for the pump,not for the healing properties, but that is a plus. Now PCT, I don't run hcg on cycle, only for PCT for me. If I'm on a long ester I would start the hcg 10 days before the ester clears. And run 2000mcg eod for those 10 days. Then nolva 20/20/20/20 clomid 100/ 100/50/50. Also I'm going to be running aromasin at 12.5mg eod and also sarms, gw-501516, ostarine. Perfect PCT. I ran the same PCT without the sarms and I kept 90 percent of my gains last cycle. With the sarms and peptides I believe I will be gaining into and throughout pct
    The only problem is taken the igf preworkout is it works like insulin as far as shuttling nutrients into your muscle. it also has a 23 to 24 hour half life. So I always figure why not take it earlier in the day so every meal you eat your body is using those nutrients a lot better.. if it's a workout that for instance and you workout at 1 o'clock p.m. if you take 40 MCG of igf in the muscle that you are going to train that day you will still get the same pump you get 20 or 30 minutes before your workout. I have tried a lot of different companies for igf and MC seems to be the best I have found so far. So usually what I will do on training days is take 40 MCG bilaterally in the morning then 5iu's insulin preworkout. Insulin will give you the same pump that igf will..

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