Anyone heard of THG

The Big Cheese

New member
tetrahydrogestrinone (THG),
SAN FRANCISCO -- Three track and field athletes who flunked drug tests have been subpoenaed to testify before a federal grand jury that is investigating whether a prominent San Francisco nutritionist has links to what one anti-doping official calls "an international doping conspiracy," ESPN has learned.

The three athletes were tested at the U.S. Track & Field Nationals in Palo Alto, Calif., in June. The results were reported in the last several weeks. One of the athletes was a client of BALCO Labs, the supplement and nutrition company run by Victor Conte. The controversial nutritionist boasts of a roster of professional and Olympic sports stars as customers.

As many as 40 other athletes also may have received subpoenas, according to a source close to the case, who added: "The names I've heard are some of the biggest names in sports."

"I know of no other drug bust that is larger than this involving the number of athletes involved," anti-doping official Terry Madden, director of the U.S Anti-Doping Agency, told The Associated Press. He refused to reveal the names or genders of the athletes, or to be more specific about how many had tested positive.

On Thursday, Madden identified Conte as the alleged supplier of the previously undetected steroid THG, which was detected in the three athletes -- a charge Conte denied.

"What we have uncovered appears to be intentional doping of the worst sort," Madden said during a telephone news conference. He called the case "a conspiracy involving chemists, coaches and certain athletes to defraud their competitors, and the American and world public who pay to attend sporting events."

THG was discovered in early May, when a source whom Madden would identify only as a "high-profile" track coach called USADA, an independent agency charged with handling drug cases for the U.S. Olympic Committee.

Although the coach refused to identify himself, he offered to send USADA a syringe filled with the drug that he said was being used by cheaters, according to Madden. The syringe was delivered to the Olympic Analysis Lab at UCLA, which has made several high-profile discoveries of underground designer steroids in the last two years. The lab's director, Don Catlin, ultimately identified the substance as tetrahydrogestrinone, a relative of the banned steroid trenbolone.

Until then, USADA hadn't tested for THG because it didn't know the drug existed, Madden said.

Madden described THG as a "very sophisticated designer steroid created by some very sophisticated chemists" who are under federal investigation. He said the athletes placed a few drops of the oil-based steroid under their tongues and expected that any trace of it would pass through their bodies quickly.

But the drug did not pass as quickly as they apparently thought. Catlin developed a test for the steroid in secret, then used it to retest samples taken from the athletes at the Nationals. About 350 tests were conducted on competitors at that event. A hundred more tests were done in other sports.

Madden would not identify which sports were targeted, or say how many athletes have tested positive. He also would not comment on the investigation that led USADA officials to identify Conte publicly. He did say, however, that the ongoing inquiry into the use of THG has expanded to include American professional sports leagues.

NFL spokesman Greg Aiello said Friday he could not comment on whether the NFL was involved in the USADA probe, but said the league will soon include THG in its steroid tests.

"Is this something we are or will be testing for? The answer is yes," Aiello said in a telephone interview on Friday. "This is clearly a new type of steroid and we will be testing for it. Nobody was aware of it until recently."

"This is a serious warning for cheaters," Dick Pound, chairman of the World Anti-Doping Agency, told AP on Thursday. "It shows that supposedly undetectable substances can be detected as new tests are developed."

In September, agents for the Internal Revenue Service raided BALCO, in Burlingame, Calif., carting out boxes of records and raising suspicions that federal agents are interested in its finances. By then, Madden said, they already had been told about USADA's findings. BALCO's clients include Barry Bonds, Bill Romanowksi, and Olympic stars Marion Jones and Tim Montgomery.

Sprinter Kelli White, who flunked the test for the stimulant modafinil at the recent world track and field championships, also is associated with BALCO, and has been subpoenaed to testify before the federal grand jury, according to The San Francisco Chronicle. Her case is being considered by USADA, and could cost her a pair of gold medals. That drug, a stimulant, has no connection with THG.

Madden said that his staff has not contacted Conte. Don Clay, the assistant U.S. attorney in San Francisco who is heading up the case, did not return calls seeking comment.

In e-mails to several newspapers Thursday, Conte denied BALCO was the source of the substance.

But Conte, in an e-mail Thursday to The Associated Press and other news organizations, said BALCO was not the source of the substance.

"In my opinion, this is about jealous competitive coaches and athletes that all have a history of promoting and using performance-enhancing agents being completely hypocritical in their actions," he said.

In another e-mail Friday to the AP, Conte wrote that the USADA was wrong to compare THG to anabolic steroids.

"In short, my opinion is that this case is more about politics than science," he said. "There is absolutely zero evidence that this substance has any anabolic effects."

Conte, a former bassist for the group Tower of Power, has been a nutritional consultant in the Bay area since the mid-1980s. He is widely known for touting the use of zinc to boost testosterone production, and monitoring athletes' mineral levels through blood and urine tests.

In the June issue of Muscle & Fitness magazine, Bonds enthused about Conte's physical fitness regimen and nutritional advice, saying, "I'm just shocked by what they've been able to do for me."

Bonds' agent, Scott Boras, told The San Francisco Chronicle this week that the investigation "really doesn't involve Bonds."
 
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In the wake of the budding track and field steroid scandal, the NFL announced Friday that it will begin testing for tetrahydrogestrinone (THG), the New York Times reported in Saturday's editions.

NFL spokesman Greg Aiello told the paper that the league expects to add the substance to its banned list by the end of the season, if not sooner. The league has the power to test for THG under the collective bargaining agreement, according to Aiello.

The first rumblings of a THG presence in the NFL may have come this past August. According to the report, two NFL team officials said recently several players from different teams were approached during training camp by people peddling an undetectable performance-enhancing drug that, they said, worked like a steroid without the negative side effects. Those officials then described a drug practically identical to what anti-doping officials are now calling THG, according to the Times.

Other professional leagues may soon join the NFL in testing for the drug. A spokesman for the National Basketball Association told the Times that the league, which randomly tests for steroids, might add THG to its list of banned substances in the near future but has not yet discussed it with the players' union.

Major League Baseball said it might add THG to its testing plan if the league begins mandatory steroid testing. MLB is still awaiting the results of this year's random test run. The National Hockey League did not return calls, according to the report.

THG has become big news in recent weeks in the wake of a burgeoning scandal that now includes over 40 track and field athletes facing subpoenas. Dr. Don Catlin, who runs the Olympic drug-testing lab at UCLA, created the test that caught several track stars and created the furor. The NFL also uses Catlin's lab to test its players, according to the Times.
 
Tetrahydrogestrinone, or THG, is a designer steroid whose effects are probably similar to related classes of anabolic steroids. Users become bigger and stronger, says a leading expert, but it has side effects: "Men become more ladylike and women more manlike."

Composed of 21 carbon atoms, 28 hydrogen atoms and two oxygen atoms, each molecule of THG is shaped "like a pretzel or popcorn," says Dr. Don Catlin, director of the UCLA Olympic Analytical Laboratory in Los Angeles.

But that little molecule likely can dramatically alter cell functions in the bodies of athletes who use it. "THG is a typical anabolic steroid -- it'll make you bigger and stronger.

"It'll also make hair grow on your face if you're a woman and make you balder if you're a man," Catlin said in a phone interview Thursday. "A man's testicles will shrink and his breasts will grow, while a woman's breasts will get smaller. And your blood chemistry will get out of whack in ways it would take me a long time to explain."

THG is definitely artificial, meaning that it was created by someone, somewhere. That's because there's zero evidence it exists in nature, Catlin explained.

Routine tests for detecting anabolic steroids are "totally blind" to THG, Catlin said. One of his goals is to find an easier way to identify it in routine tests of athletes' urine -- more routine, that is, than his UCLA team's summer-long investigation into the mystery drug.

This summer, Catlin's team members discovered THG when they noticed an odd-looking "peak" on a jagged pattern of 25 "peaks" on a computer printout from a device called a mass spectrometer. Each peak represented the spectral "signature" of a particular organic molecule, one of 25 molecules from a syringe that a concerned track and field coach sent early this summer to the U. S. Anti-Doping Agency (USADA), a nonprofit corporation responsible for drug testing of U.S. Olympic athletes.

"We got the syringe in the middle of June. It took eight chemists (on our team) two months to figure out the first step -- namely, what it was," says Catlin, who has an M.D. from the University of Rochester and has run the UCLA lab since 1982.

After figuring out the molecular structure of THG, Catlin and his team successfully manufactured samples in the lab, he said.

Typically, steroid molecules "have a certain (characteristic) structure. If I were to draw (THG) next to (a picture of) testosterone on a piece of paper, you'd say, 'Oh yes, I can see the similarity.' But the details are a little different."

Although others have called it a "designer steroid," Catlin says he prefers to call it an NCE or "new chemical entity."
 
The Big Cheese said:
Tetrahydrogestrinone, or THG, "Men become more ladylike and women more manlike."

it'll make you bigger and stronger.

"A man's testicles will shrink and his breasts will grow,

I have to get me some. I can now be one ass kicking cross dresser. LMAO
 
The Big Cheese said:
It took eight chemists (on our team) two months to figure out the first step -- namely, what it was," says Catlin, who has an M.D. from the University of Rochester and has run the UCLA lab since 1982.


Hey big cheese this doesn't surprise me look where Catlin got his M.D. from LOL.
 
This is the guy who raced Lavrone

Dwain Chambers near suicidal; By Adrian Warner, Evening Standard, Oct 22

Britain's top sprinter Dwain Chambers told today how he is "almost suicidal" after becoming embroiled in a drugs scandal which threatens to wreck his career. The London-born athlete, favourite for gold in Athens next year, could now face a life ban from the Olympic Games. Sources have confirmed that the 25-year-old failed a test for the new designer steroid tetrahydrogestrinone (THG).

Chambers is protesting his innocence, telling friends he was assured the pills that led to him failing a drugs test were legal.
The European 100 metres champion said he was "devastated" by the scandal which has engulfed British sport, but is pleading ignorance over the failed test. One friend said: "He is totally devastated, almost suicidal, and has been in tears all night. He claims that he was assured what he was being given was not illegal."

The drug had previously been considered undetectable, but scientists in America discovered a method of identifying it after they were tipped off that many athletes were using it. Asked about the allegation, Chambers's manager John Regis said: "I'm not prepared to comment."

No details of the test have been announced officially. However, Chambers is said to have been tested during a training camp in Germany in early August. The analysis took place at the International Olympic Committee-accredited laboratory in Los Angeles.
He has the right to a second analysis of his urine sample. If that confirms the presence of THG, he faces a two-year ban from all athletics competitions that would rule him out of next year's Athens Games. Before the news of his positive test, Britain's drug test agency, UK Sport, is believed to have already requested that four of Chambers's samples from summer events be subjected to the new testing. UK Sport was suspicious of Chambers'sinvolvement with California company the Bay Area Laboratory Co-Operative (Balco), which is said to have developed THG.

Balco's owner Victor Conte runs a track club in San Francisco with Chambers's coach Remi Korchemny. The athlete is known to use one of Balco's leading mineral supplements, ZMA. Chambers said yesterday, before news of his test broke: "I'm annoyed that I have been caught up in it, but what can I do? I've worked with Victor for two years and never had a problem."
 
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