deltmaster
New member
I can get my hands on a pill press however didn't find any info regarding excipients and their use. I think maltodextrine, lactose will be needed. what else? Also what about powders ratio? Help! 
pill press-what do I need for my tabs?
- Thread starter deltmaster
- Start date
Hi
I will answer you question as best as I can.
The excepiants you will need Are:
Silicified microcrystalline cellulose
stearic acid
magnesium stearate
Lactose or dextrose
then your active ingrediant
Mg strearate Stearic Acid are used as lubricants so powder dosent stick in the mold/die
The Cellulose helps things stick together
Lactose and dextrose are fillers
Now for the % of each ingrediant i don't have on hand.
I did a pharmaceutical course and we went through all that and the %. I just need to dig it out of my notes somewhere. As soon as I find it I will post
Hope this helps a bit
I will answer you question as best as I can.
The excepiants you will need Are:
Silicified microcrystalline cellulose
stearic acid
magnesium stearate
Lactose or dextrose
then your active ingrediant
Mg strearate Stearic Acid are used as lubricants so powder dosent stick in the mold/die
The Cellulose helps things stick together
Lactose and dextrose are fillers
Now for the % of each ingrediant i don't have on hand.
I did a pharmaceutical course and we went through all that and the %. I just need to dig it out of my notes somewhere. As soon as I find it I will post
Hope this helps a bit
deltmaster
New member
madchem and brew, thank you very much for your input. Very helpful info.
madchem I'll really appreciate those % you have to look at. I'm not in a hurry so take your time.
Again, thank you bro's. Cheers
madchem I'll really appreciate those % you have to look at. I'm not in a hurry so take your time.
Again, thank you bro's. Cheers
Your main filler will be SMC (Silicified microcrystalline cellulose).
Your lubricant will be a mix of Stearic Acid and Magnesium Stearate 2:1 respectively.
Now you want to use 1% of the total weight of the final tablet or mix
Say you want to prepare 1kg of powder to be pressed
you want your tablet to weight 250mg and want 25mg of active Ingredient.
250g of active ingredient
740g of SMC
10g of lubricating Mix (2:1)
Now when you press your tablet will contain 1% lubricant mix (ie: 2.5mg per 250mg tablet)
as for mixing the powder, I suggest a GMP compliant V-mixer. Essentially a V-Mixer is a
hallow V with an opening somewhere. this V is attached to a shaft which rotates
on a horizontal axis. So it splits the powder in half then recombines it over and over.
This gives you a uniform powder.
The V mixers usually have NO DEAD spots where powder can accumulate and not get mixed which can have serious consequences. A good size mixer can cost 1500$ or you can simply buy the V and attach it to a motor. Really up too you, but its critical that your powder is well mixed; not only would you end up with unequal dosing but your pill might not press well due to too high or low concentration of lubricant.
I hope this all helps. Let me know if something is unclear.
Your lubricant will be a mix of Stearic Acid and Magnesium Stearate 2:1 respectively.
Now you want to use 1% of the total weight of the final tablet or mix
Say you want to prepare 1kg of powder to be pressed
you want your tablet to weight 250mg and want 25mg of active Ingredient.
250g of active ingredient
740g of SMC
10g of lubricating Mix (2:1)
Now when you press your tablet will contain 1% lubricant mix (ie: 2.5mg per 250mg tablet)
as for mixing the powder, I suggest a GMP compliant V-mixer. Essentially a V-Mixer is a
hallow V with an opening somewhere. this V is attached to a shaft which rotates
on a horizontal axis. So it splits the powder in half then recombines it over and over.
This gives you a uniform powder.
The V mixers usually have NO DEAD spots where powder can accumulate and not get mixed which can have serious consequences. A good size mixer can cost 1500$ or you can simply buy the V and attach it to a motor. Really up too you, but its critical that your powder is well mixed; not only would you end up with unequal dosing but your pill might not press well due to too high or low concentration of lubricant.
I hope this all helps. Let me know if something is unclear.
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