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MrPerfect
07-02-2010, 12:18 PM
since ive started my igf this week i was wondering on if i should take a different approach this time. im taking 60 mcgs post work out when i get some from the gym subq....

what i as gonna try was 50 mcgs in the morning, and 50 mcgs at night.

do any experienced users think this is over kill?
will i be wasting it by taking such a high dose?
will any negative side effects come of it?

Presser
07-02-2010, 01:41 PM
i think its a great idea to try new ways to use it bro! especialy the splitting it up, i know alot of other guys swear by splitting the doses up through out the day, if you do decide to approach this different maybe you can keep a log or journal for us to read?

nuknuk
07-02-2010, 01:54 PM
what is the active life of IGF when you inject it? Or does it just do what it does and the more you do the more it does?--to a degree

MrPerfect
07-02-2010, 02:26 PM
ok , so 50 in the am and 50 at night should be a problem then??

if so im going to give it a shot starting tomorrow... and yes ill keep a weekly log of my progress press

franconian
07-02-2010, 02:41 PM
I don't know over 50 micrograms per day,receptor downgrade increases exponentially. I know Palumbo is a big proponent of keeping the dosage @ 10-20 mcg/day to avoid rapid downregulation

nuknuk
07-02-2010, 03:02 PM
I don't know over 50 micrograms per day,receptor downgrade increases exponentially. I know Palumbo is a big proponent of keeping the dosage @ 10-20 mcg/day to avoid rapid downregulation

mmm--interesting. Does palumbo have a write up on IGF out there some where that can be posted?

franconian
07-02-2010, 03:28 PM
Yeah Ill hopefully dig it up!

franconian
07-02-2010, 03:55 PM
HOW TO MIX, MEASURE, and DOSE IGF-1

(1)-STORAGE OF IGF-1(prior to mixing)
lyophilized (dry) IGF-1is stable at room temperture for three weeks;however,it should be stored below -18 degrees celsius (in the freezer section).

(2)WEIGHT OF IGF-1
1 milligram (mg) IGF-1 = 1,000 mcg (micrograms) IGF-1 (dry weight- before mixing).

(3) WHAT TO MIX THE IGF-1 WITH
when reconstituting,its important to remember IGF-1 can get "stuck" in the grooves of the glass bottle it comes packaged in. while glass appears smooth to the naked eye, under a microscope, it's a convoluted landscape of grooves and hidden recesses.
By mixing the lyophilized IGF-1 with an "acid water" (e.g., 10mM HCL -very dilute hydochloric acid), the IGF-1 molecules are efficiently detached from the glass and solubilized in the mixture. Any online "compounding" laboratory could mix up a 10mM HCL solution. likewise, any intro chemistry student should be able to do the same.
If a reliable source of "acid water" can't be located, mix your IGF-1 powder with BACTERIOSTATIC WATER - you'll lose, at worst, 10 percent of the IGF-1 solution.

(4) ADDING THE ACID WATER
For the purposes of mathematical ease, I suggest mixing the dry 1 milligram (1,000 microgram) IGF-1 with 3ml (or 3cc) of the "acid water" mixture.

(5) PRESERVATION OF THE IGF-1
Next,using a 1cc insulin syringe,draw out 1cc out of the bottle containing the 3cc acid water/IGF-1 mixture.In a seperate 1cc insulin syringe,draw up another 1cc of the solution.Freeze these two loaded insulin syringes.They will be utilized at a later date.

NOTE:Freezing can safely and effectively preserve IGF-1(even after its been mixed)

(6)THE CORRECT DILUTION
To the remaining 1cc of IGF-1 thats left in the glass bottle,add 2cc of bacteriostatic water.This will return the total volume back up to 3cc.

(7)THE MATHEMATICS
(A)The original concentration of the IGF-1 solution was 1mg(1000 micrograms)
IGF-1 in 3cc of water.

(B)Each 1cc that was removed,then,contained approximately 333 micrograms IGF-1 per 1cc.

1,000 micrograms/3cc = 333 micrograms per 1cc

(C) The 1cc that was left in the bottle,then,also contains 333 micrograms of IGF-1.

(D)Next,we added 2cc of bacteriostatic water to the bottle and brought the volume back up to 3cc.The difference is we now have 333 micrograms in 3cc of water (instead of in 1cc)

(E)To determine how much IGF-1 is in 1cc,you must divide by three.

333 micrograms/3cc=111 micrograms per 1cc

(F)To determine how much IGF-1 is in .10cc (or 1/10thcc) we do the following.

111 micrograms/10=11micrograms per .10cc

(8)EFFECTIVE DOSAGES OF IGF-1

Dosages in the range of 10 to 20 micrograms per day(taken 10 to 15 minuters after training) are quite effective for building and repairing muscle tissue.
More importantly,these moderate dosages (by some peoples estimation)
stimulate muscle growth yet escape rapid "downregulation" of the all important IGF-1 receptors.
Without receptors to recognize the IGF-1, it doesnt matter how much you inject.
NOTHING will happen.
As dosages climb to over 50 micrograms per day,receptor downgrade increases exponentially and,from what I've observed among bodybuilders,muscle gains come to a screeching hault.

Bodybuilders will have the most sucess with IGF-1 if they follow the protocol I outlined below. REMEMBER, more isn't always better.

11 micrograms per day for 30 days (cycle 1) 333 micrograms

2 weeks OFF

11 micrograms per day for 30 days (cycle 2)** 333 micrograms

2 weeks OFF

11 micrograms per day for 30 days (cycle 3)** 333 micrograms

8 weeks OFF

** The second and third cycles of IGF-1 treatment require that the two Frozen 1cc insulin syringes be defrosted(only defrost one per cycle).
Next,inject the defrosted solution into an empty bottle.
Further dilute with 2cc bacteriostatic water. When adding the 2cc of water,use the syringe that originally held the frozen IGF-1.
This also helps to wash the syringe and ensure that no IGF-1 is stuck inside of it.



OTHER NOTES:
1. IGF-1 does not need to be injected into the muscle trained. 30 seconds after you inject the IGF-1, it's in the blood stream and out of the muscle you injected it into.

2. Take it right after training and right before drinking your shake. IGF-1 acts like insulin and will push nutrients and supplements (creatine, etc) into the cells.

3. To recap above, take 11 mcg every day = 0.1 cc

4. Easiest is delt or lat, but it does not matter.

5. On off days, take it in the morning with breakfast.

6. Keep the vial so you can re-fill it from the frozen syringes.
__________________
www.davepalumbo.com

saudades
07-02-2010, 07:31 PM
what is the active life of IGF when you inject it? Or does it just do what it does and the more you do the more it does?--to a degree

Half life is said to be 20-30 hours for the long form IGF 1-lr3. Technically, yes, the more you take, the more of an effect you will get at once--to the limit of how many satellite cells you have available to it.

The Dude
07-03-2010, 11:44 AM
There's a few things missing here that are key in my opinion. Muscle growth due to the maturation of satellite cells is based on the number of satellite cells present. The larger the muscle, the more satellite cells it will have floating around given sufficient time. What are your stats Jon?? I know I had substantially better results using 60mcg a week for ten weeks then I did at 50mcg for 6 weeks. I'm at 70mcg now and loving it!
Also IGF affects glucose ability to cross the cellular membrane causing a positive effect on fat loss, preventing fat accumulation, and aiding glucose transport to working muscle cells.
Lastly IGF also recruits satellite cells for collagen repair for tendons, ligaments, and cartilagenous tissue.