In conclusion, our study shows that a once-daily injection of CJC-1295 is sufficient to maintain normal growth parameters and body composition. Although the efficacy of the same dose is reduced when administered every 48 or 72 h, it is possible that higher doses may elicit effects similar to those of daily treatment. These findings also suggest that the determination of dosing intervals of this compound in other species must take into consideration the pharmacodynamics of the drug, which are dependent on the species-specific half-lives of albumin.
found this mice study on the net, so it seems that once daily injections are more beneficial???"
what you guys think
Am J Physiol Endocrinol Metab 291: E1290-E1294, 2006. First published July 5, 2006; doi:10.1152/ajpendo.00201.2006
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Articles by Alba, M.
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Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse
Maria Alba,1 Danilo Fintini,1 Alessia Sagazio,1 Betty Lawrence,2 Jean-Paul Castaigne,2 Lawrence A. Frohman,3 and Roberto Salvatori1
1Department of Medicine, Division of Endocrinology, Johns Hopkins University School of Medicine, Baltimore, Maryland; 2Conjuchem, Incorporated, Montreal, Quebec, Canada; 3Department of Medicine, Section of Endocrinology, University of Illinois at Chicago, Chicago, Illinois
Submitted 26 April 2006 ; accepted in final form 29 June 2006
found this mice study on the net, so it seems that once daily injections are more beneficial???"
what you guys think
Am J Physiol Endocrinol Metab 291: E1290-E1294, 2006. First published July 5, 2006; doi:10.1152/ajpendo.00201.2006
0193-1849/06 $8.00
This Article
Abstract
Full Text (PDF)
All Versions of this Article:
291/6/E1290 most recent
00201.2006v1
Alert me when this article is cited
Alert me if a correction is posted
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Citing Articles
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Citing Articles via Web of Science (2)
Citing Articles via Google Scholar
Google Scholar
Articles by Alba, M.
Articles by Salvatori, R.
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PubMed
PubMed Citation
Articles by Alba, M.
Articles by Salvatori, R.
Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse
Maria Alba,1 Danilo Fintini,1 Alessia Sagazio,1 Betty Lawrence,2 Jean-Paul Castaigne,2 Lawrence A. Frohman,3 and Roberto Salvatori1
1Department of Medicine, Division of Endocrinology, Johns Hopkins University School of Medicine, Baltimore, Maryland; 2Conjuchem, Incorporated, Montreal, Quebec, Canada; 3Department of Medicine, Section of Endocrinology, University of Illinois at Chicago, Chicago, Illinois
Submitted 26 April 2006 ; accepted in final form 29 June 2006