gambino
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IGF-1 also known as somatomedin C is a polypeptide of 70 amino acids (7650 daltons), and is one of the number of associated insulin-like growth factors present in the flow. This polypeptide hormone about the same size as insulin and mimics insulin as well. So if one decides to stack the two, be careful because IGF-1 will make the effects of insulin much more potent. It is produced mostly in the Liver in response to growth hormone (GH) release from the pituitary gland. The molecule shows approximately 50% sequence homology with pro insulin and has a number of biological activities comparable to insulin. IGF-1 is a moderator of longitudinal growth in humans which translates to how tall you are capable of becoming. Total Serum IGF-1 concentrations are altered by age, nutritional state, body composition, and of course growth hormone secretion. A single basal IGF-1 level is useful in the assessment of short stature in children and in nutritional support studies of acutely ill patients. For diagnosing the condition acromegaly, a single IGF-1 concentration is much more reliable than a random GH measurement (Oppizi, et al., 1986). IGF-1 can be used for the evaluation of disease activity in acromegaly (Barkan, et al., 198.
IGF-1’s effects are not limited to building new muscle, however. It has a strong effect on lipid/ cholesterol metabolism, and helps the body shed fat at a drastically prominent rate. Also to be noted, IGF-1 is both a neuroprotector and neuro regenerator (nerve reproduction), which improves cognitive functions such as reflexes, memory, and learning ability.IGF is also important for production of connective tissue and insuring proper bone mineral density.
One study displayed rats that were given IGF-1 and did nothing were bigger and stronger than rats that weren’t given IGF-1 but exercised. Logically the group of rats that were given IGF-1 and exercised were the most muscular, and strongest rats in the house. The positive effects of IGF-1 on the rats continued for months even after the rats stopped getting the supply of the peptide hormone, while the exercising rats immediately lost size and strength as soon as they stopped exercising.
In another study, the muscle fibers of 27 month old rats (considered old age for rats) were given IGF-1 during middle age, exhibited no weakening of muscle fibers that indicate the usual and foreseeable signs of aging. These rats did not lose any fast twitch muscle fibers during or post treatment. These fibers are responsible for power and speed which are found in abundance among athletes. Also interesting to note, they had the same speed and power output that they had when they were six months of age.
NOW, most people in general have heard of IGF-1 (insulin like growth factor-1) and the powerful anabolic results it has been reported to have upon protein dominant tissue such as muscle. Des (1-3) IGF-1 is over 10 times or 1000% more anabolic than IGF-1. We know that IGF-1 is in fact produced from both growth hormone and insulin in the Liver of mammals and muscle tissues. IGF-1 is made up of 70 amino acids in a chain. How is Des (1-3) IGF-1 made? When one removes the last 3 amino acids in the IGF-1 chain also known as the N-terminal tri-peptide; it becomes Des (1-3) IGF-1 and as established will become 1000% plus more anabolic. Why? IGF-1 flows through our blood stream and tissue 24 hours a day, 7 days a week and 365 days a year. Unfortunately, most of the IGF-1 is lacking activity because it is bound by another Protein called (get this) IGF-1 Binding Protein-3, or IGF-1-BP-3 for short; just as testosterone gets bounded by SHBG’s. Since; bound hormones in general cannot fit into nor activate a receptor-site, the greater part of circulating and muscle tissue IGF-1 cannot activate an anabolic action. However, when IGF-1 is altered and becomes Des (1-3) IGF-1 the binding Protein IGF-1-BP-3 cannot bind to it and it is fully biological. Also Des (1-3) IGF-1 is so powerful that it has a unique ability to fit into lactic acid altered IGF-1 receptor sites. Lactic acid builds-up in mammals over time; which is called acidosis. Lactic acid destroys the shape of certain receptor-sites for a given period of time. Therefore some anabolic/androgenic/anti-catabolic hormones have difficulty integrating with their own receptor- site and causing a response such as freeing bound IGF.
Quick Reacp: Lactic acid is responsible for cutting off the last 3 amino acids off the 70 amino acid chain of some of the surviving IGF-1 and creates Des (I-3) IGF-1. So acidosis increases GH/IGF-1 production within the liver, which unbinds IGF-1 locally in the muscle being trained and used, destroys some of the IGF-1, and converts some IGF-1 into Des (I-3) IGF-1.
The issue of DES having a much shorter half-life seems mute because all it needs is time to bind to a receptor once in circulation; however, it’s more concentrated in the muscle than any other IGF analogue. Intramuscular shots would be enough to get it into circulation quickly, giving it a couple minutes to surface each muscle receptors. Many bodybuilders and athletes take it pre workout, since lifting increases blood flow to the pumped body-parts, it as well will increase IGF-1 and Insulin sensitivity. Once the IGF is bound to a receptor, the satellite cell activation takes place and that is when the peptide commits its designated action. Constant supply of it will allow for more constant levels of it, which will allow the body’s glucose disposal abilities to increase.
writeup from needtogetaas blog
Sold at purchase peptides
(information in this thread comes via the internet)
IGF-1’s effects are not limited to building new muscle, however. It has a strong effect on lipid/ cholesterol metabolism, and helps the body shed fat at a drastically prominent rate. Also to be noted, IGF-1 is both a neuroprotector and neuro regenerator (nerve reproduction), which improves cognitive functions such as reflexes, memory, and learning ability.IGF is also important for production of connective tissue and insuring proper bone mineral density.
One study displayed rats that were given IGF-1 and did nothing were bigger and stronger than rats that weren’t given IGF-1 but exercised. Logically the group of rats that were given IGF-1 and exercised were the most muscular, and strongest rats in the house. The positive effects of IGF-1 on the rats continued for months even after the rats stopped getting the supply of the peptide hormone, while the exercising rats immediately lost size and strength as soon as they stopped exercising.
In another study, the muscle fibers of 27 month old rats (considered old age for rats) were given IGF-1 during middle age, exhibited no weakening of muscle fibers that indicate the usual and foreseeable signs of aging. These rats did not lose any fast twitch muscle fibers during or post treatment. These fibers are responsible for power and speed which are found in abundance among athletes. Also interesting to note, they had the same speed and power output that they had when they were six months of age.
NOW, most people in general have heard of IGF-1 (insulin like growth factor-1) and the powerful anabolic results it has been reported to have upon protein dominant tissue such as muscle. Des (1-3) IGF-1 is over 10 times or 1000% more anabolic than IGF-1. We know that IGF-1 is in fact produced from both growth hormone and insulin in the Liver of mammals and muscle tissues. IGF-1 is made up of 70 amino acids in a chain. How is Des (1-3) IGF-1 made? When one removes the last 3 amino acids in the IGF-1 chain also known as the N-terminal tri-peptide; it becomes Des (1-3) IGF-1 and as established will become 1000% plus more anabolic. Why? IGF-1 flows through our blood stream and tissue 24 hours a day, 7 days a week and 365 days a year. Unfortunately, most of the IGF-1 is lacking activity because it is bound by another Protein called (get this) IGF-1 Binding Protein-3, or IGF-1-BP-3 for short; just as testosterone gets bounded by SHBG’s. Since; bound hormones in general cannot fit into nor activate a receptor-site, the greater part of circulating and muscle tissue IGF-1 cannot activate an anabolic action. However, when IGF-1 is altered and becomes Des (1-3) IGF-1 the binding Protein IGF-1-BP-3 cannot bind to it and it is fully biological. Also Des (1-3) IGF-1 is so powerful that it has a unique ability to fit into lactic acid altered IGF-1 receptor sites. Lactic acid builds-up in mammals over time; which is called acidosis. Lactic acid destroys the shape of certain receptor-sites for a given period of time. Therefore some anabolic/androgenic/anti-catabolic hormones have difficulty integrating with their own receptor- site and causing a response such as freeing bound IGF.
Quick Reacp: Lactic acid is responsible for cutting off the last 3 amino acids off the 70 amino acid chain of some of the surviving IGF-1 and creates Des (I-3) IGF-1. So acidosis increases GH/IGF-1 production within the liver, which unbinds IGF-1 locally in the muscle being trained and used, destroys some of the IGF-1, and converts some IGF-1 into Des (I-3) IGF-1.
The issue of DES having a much shorter half-life seems mute because all it needs is time to bind to a receptor once in circulation; however, it’s more concentrated in the muscle than any other IGF analogue. Intramuscular shots would be enough to get it into circulation quickly, giving it a couple minutes to surface each muscle receptors. Many bodybuilders and athletes take it pre workout, since lifting increases blood flow to the pumped body-parts, it as well will increase IGF-1 and Insulin sensitivity. Once the IGF is bound to a receptor, the satellite cell activation takes place and that is when the peptide commits its designated action. Constant supply of it will allow for more constant levels of it, which will allow the body’s glucose disposal abilities to increase.
writeup from needtogetaas blog
Sold at purchase peptides
(information in this thread comes via the internet)
