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DecaDent*
06-19-2002, 11:00 AM
This study looked at the duration of HGH effect and how that relates to dosage interval. I know most people are currently doing 5on/2off. After reveiwing this,EOD may be the way to go,kits would last longer that way. Unfortunatly this study did not compare ED vs EOD,but only EOD vs Every 3rd day. Still based on the duration of effect achieved with a single dose EOD may be all it takes. I'm still looking for a ED vs EOD study.


What's everyone else's take on this?....Here's the abstract:


Administration of recombinant human growth hormone on alternate days is sufficient to increase whole body protein synthesis and lipolysis in growth hormone deficient adults.

OBJECTIVE: At present, the duration of the effect of recombinant human growth hormone (rhGH) on the rates of protein synthesis and lipolysis in GH deficient (GHD) adults is unknown. This study was designed to establish the frequency of rhGH administration necessary to provide the beneficial metabolic effects of the hormone in GHD adults. DESIGN AND PATIENTS: Two different studies (A and B) were performed in two groups of five GHD men. In study A, whole body protein and lipid kinetics was determined in the basal state (Bas), 12 (GH12h) and 36 (GH36h) h after the last of seven injections of rhGH (3.3 microg/kg), given at bedtime on alternate days. In study B, the same parameters were determined in the basal state (Bas), 60 (GH60h) and 84 (GH84h) h after the last of seven injections of rhGH (3.3 &mgr; g/kg), given at bedtime at 3 day intervals. MEASUREMENTS: The rates of protein metabolism were estimated by infusing [1-13C]leucine, and those of lipolysis by infusing [1,1,2,3, 3-D5]glycerol. RESULTS: Leucine oxidation decreased (P < 0.01) by approximately 30% after GH12h and GH36h but did not change after GH60h and GH84h. Non-oxidative leucine disposal increased after GH12h and GH36h by approximately 13% (P < 0.05) whereas it did not change after GH60h and GH84h. Glycerol appearance increased (P < 0. 01) by approximately 45% after GH12h and GH36h but did not change after GH60h and GH84h. CONCLUSIONS: The effects on protein and lipid metabolism following the injection of rhGH last longer than 36 and less than 60 h. In fact, rhGH administration on alternate days induced a sustained increase in the rates of protein synthesis and lipolysis of GHD adults, whereas a longer interval of administration (3 days) had no effect by 60 h.


Clin Endocrinol (Oxf) 2000 Feb;52(2):173-9 (ISSN: 0300-0664)
Lucidi P; Laureti S; Santoni S; Lauteri M; Busciantella-Ricci N; Angeletti G; Santeusanio F; De Feo P
Department of Internal Medicine, Endocrine and Metabolic Sciences, University of Perugia, Italy

goldenear
06-19-2002, 12:10 PM
This study was conducted on GH deficient adults, not athletes who have no pituitary problems. So I don't think the results are very applicable to what we're trying to do with GH. I found that splitting my dosages up throughout the day and evening worked best.

Also, that study only measured protein synthesis after the final day of injections, not periodically throughout the study. I want to be growing 24/7, not just periodically!

DecaDent*
06-19-2002, 12:40 PM
Good discussion points goldenear,I think the study was designed more to look at the duration of effect of exogenous HGH administration. Using GH-deficent adults negates the effect of any naturally produced GH,if the study was proformed on athletes or subjects with intact pit-GH then the data on duration of effect would be difficult to separate what was administered vs what was naturally produced GH.
The final day readings were taken at baseline,12hr,36hr,60hr and 84hr when both groups are combined and demonstrated activity in protein synthesis and fat burning at 36 hrs post injection that was not present at 60 hrs post injection. I don't think that translates to periodic growth. I read that to say that the effects of dosing HGH were active for at least 36hrs(not 24 which would be ED) but the effect disappeared somewhere between the 36th and the 60th hour after last injection.
I agree it'd be great to have a study on athletes,but goodluck getting funding for that from the NIH....that's a big reason,IMO,that there aren't many.

goldenear
06-19-2002, 03:56 PM
Originally posted by DecaDent*
The final day readings were taken at baseline,12hr,36hr,60hr and 84hr when both groups are combined and demonstrated activity in protein synthesis and fat burning at 36 hrs post injection that was not present at 60 hrs post injection.

Those readings really have little to do with the actual rDNA GH since the half-life is only about 30 minutes. More than likely any benefit stems from increased IGF-1 levels and most importantly increased thyroid function.

DecaDent*
06-19-2002, 04:18 PM
Metabolic effect can persist beyond serum 1/2life so I wouldn't conclude that the readings have little to do with actual rDNA GH. The HGH initiates the cascade. If you reverse the logic ,then you'd have to say with a 30 minute half life, you should shoot HGH every couple of hours to be effective.

goldenear
06-19-2002, 04:28 PM
Originally posted by DecaDent*
Metabolic effect can persist beyond serum 1/2life

That's exactly my point. I have experienced this first hand. I OD'd on GH and experienced hyperthyroidism (essentially a 5 day asthma attack). Even after complete discontinuance, it still took a few days of using an Albuterol inhaler to get my blood pressure and breathing back to baseline. A truly amazing physiological experience that I'll never forget.

DecaDent*
06-19-2002, 04:53 PM
No substitute for real life experience is there Bro. That must have been scarey. How much were you taking?
I had to drop my dosage down from 4.5ED due to carpal tunnel synd. in both hands. Took 2 weeks after stopping to go away,I'm doing 3.5U ed now with 5 on and 2 off. I was debating trying 3.5-4U EOD.

goldenear
06-19-2002, 04:55 PM
I was only using 2.4 IU's daily. Not much, but I know that's the exact dosage because the Upjohn miniquicks came preloaded straight from the pharmacy.