DecaDent*
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When you juice do AR's increase or decrease?
This study dealing with androgen receptor(AR)expression showed NO downregulation of the AR with AAS use. In other words AAS use does not reduce AR number,just the opposite was shown,in powerlifters on AAS they had a HIGHER number of AR's than non-AAS using powerlifters.
Is it really necessary to take time "off" to let the AR#'s recover?Doesn't seem to be necessary based on these results.
Here's a brief summary:
The expression of androgen receptors in human neck and limb muscles: effects of training and self-administration of androgenic-anabolic steroids.
.
The purpose of this study was to investigate the immunohistochemical expression of androgen receptors (AR) in human vastus lateralis and trapezius muscles and to determine whether long-term strength training and self-administration of androgenic-anabolic steroids are accompanied by changes in AR content. Biopsy samples were taken from eight high-level power-lifters (P), nine high-level power-lifters who used anabolic steroids (PAS) and six untrained subjects (U). Myonuclei and AR were visualised in cross-sections stained with the monoclonal antibody against AR and 4',6-diamidino-2-phenylindole. The proportion of AR-containing myonuclei per fibre cross-section was higher in the trapezius than in the vastus lateralis (P<0.05). In the trapezius, the proportion of AR-containing myonuclei was higher in P compared to U and in PAS compared to both P and U (P<0. 05). On the contrary, in the vastus lateralis, there were no differences in AR content between the three groups. Myonuclear number in both muscles was higher in P compared to U and in PAS compared to both P and U (P<0.05). In conclusion, AR content differs greatly between human neck and limb muscles. Moreover, the regulation of AR-containing myonuclei following training and self-administration of androgenic-anabolic steroids is muscle dependent.
Histochem Cell Biol 2000 Jan;113(1):25-9 (ISSN: 0948-6143)
Kadi F; Bonnerud P; Eriksson A; Thornell LE
Department of Integrative Medical Biology, Section for Anatomy, Umea University, 901 87, Umea, Sweden. [email protected].
This study dealing with androgen receptor(AR)expression showed NO downregulation of the AR with AAS use. In other words AAS use does not reduce AR number,just the opposite was shown,in powerlifters on AAS they had a HIGHER number of AR's than non-AAS using powerlifters.
Is it really necessary to take time "off" to let the AR#'s recover?Doesn't seem to be necessary based on these results.
Here's a brief summary:
The expression of androgen receptors in human neck and limb muscles: effects of training and self-administration of androgenic-anabolic steroids.
.
The purpose of this study was to investigate the immunohistochemical expression of androgen receptors (AR) in human vastus lateralis and trapezius muscles and to determine whether long-term strength training and self-administration of androgenic-anabolic steroids are accompanied by changes in AR content. Biopsy samples were taken from eight high-level power-lifters (P), nine high-level power-lifters who used anabolic steroids (PAS) and six untrained subjects (U). Myonuclei and AR were visualised in cross-sections stained with the monoclonal antibody against AR and 4',6-diamidino-2-phenylindole. The proportion of AR-containing myonuclei per fibre cross-section was higher in the trapezius than in the vastus lateralis (P<0.05). In the trapezius, the proportion of AR-containing myonuclei was higher in P compared to U and in PAS compared to both P and U (P<0. 05). On the contrary, in the vastus lateralis, there were no differences in AR content between the three groups. Myonuclear number in both muscles was higher in P compared to U and in PAS compared to both P and U (P<0.05). In conclusion, AR content differs greatly between human neck and limb muscles. Moreover, the regulation of AR-containing myonuclei following training and self-administration of androgenic-anabolic steroids is muscle dependent.
Histochem Cell Biol 2000 Jan;113(1):25-9 (ISSN: 0948-6143)
Kadi F; Bonnerud P; Eriksson A; Thornell LE
Department of Integrative Medical Biology, Section for Anatomy, Umea University, 901 87, Umea, Sweden. [email protected].