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View Full Version : Adequan for Bad joints. Winstrol Adequan together. Doses and side effects



LabRat
11-06-2003, 07:53 PM
Adequan (polysulfated glycosaminoglycan) that's all I have to say. A good friend of mine, who just happens to be a vet, turned me on to it. He told me that it is used in race horses that experience DJD. I used it myself after a friend of mine who needs his knee replaced, was able to walk again after 4 days on this stuff. I had injured my shoulder about three weeks ago I was hit with a concrete block in the shoulder, "someone I did not see," and could not even hold the steering wheel in my car. Plus this was in the middle of my last cycle, and I was making great gains and could not even work anything because of the pain. There a different types of connective tissues in the body, blood, adipose, (Hylane, fiberous, elastic) cartilage, plus different connective tissues that make up a mojority of your joints, plus special epithelial glandular cells, simple columnar epithelium to be exact that produce something called synavial fluid. From what I remember from AandP. Anyway, the whole point is all of this tissue has certain cell types, chondrocytes, in cartilage is avascular, which means it does not have a direct blood supply. That's why it's better to break a bone instead of ripping an ACL. Bone has caniculli, which is like veins, so there is more blood. Somehow, this Adequan acts like a catalyst in the matrix within the cell body itself, and speeds the production of Collogenous fibers, and synovial fluid. The results are amazing. New joints, not just something to mask the pain. I have not found out any information about Adequan, I am going into the medical field and this is the only information that makes sense to me. If someone finds out some information please post it. I know that almost all of my friends are on this stuff now, and they are having amazing reasults. The vet told me that there are no long tern effects, just great pain free joints, and that you can stay on this stuff forever and it would not hurt you. I promise, if you have sore of stiff joints, you have to give this a try. BTW its american made get the IM. type for horses.

If you are searching for a product that treats both the symptoms and the underlying degenerative disease process of horses' joint problems, Adequan ® may be a good choice.

First, Adequan has important antiinflammatory effects, so it is able to provide relief from the symptoms of joint damage: heat, swelling, pain and lameness. And Adequan can be found in synovial fluid at full therapeutic levels within only two hours of an intramuscular injection. Also, Adequan is a product with potent ability to block the action of the destructive enzymes that threaten to perpetuate the joint inflammation, attack the cartilage and break down synovial fluid.

Second, Adequan also stimulates the synovial membrane to manufacture new, viscous synovial fluid to replace the thin fluid that was produced when the joint became injured. By improving this fluid, Adequan helps the joint regain its ability to lubricate and guard itself against further inflammation, and helps reestablish nutrition to the cartilage.

And, Adequan attaches itself to damaged cartilage where it has a positive effect on cartilage metabolism. This should favor the cartilage repair process.

Adequan is the only joint treatment proven to reduce the inflammation and pain of degenerative joint disease, but also to help stop the degenerative process while stimulating the production of new joint fluid and new cartilage components. You are no longer just treating symptoms: you're doing something to help stop the degenerative process.

DOSAGE AND ADMINISTRATION: The recommended dose of Adequan IM in horses is 500mg every 4 days for 28 days intramuscularly. The injection site must be thoroughly cleansed prior to injection. Do not mix Adequan IM with other drugs or solvents.

Comes in 500mg/5ml glass vials.

Here's some technical info on it.

Polysulfated Glycosaminoglycan

Chemistry - Polysulfated glycosaminoglycan (PSGAG) is chemically similar to natural mucopolysaccharides found in cartilaginous tissues. PSGAG is reportedly an analog of heparin.

Storage/Stability/Compatibility - Commercial products should be stored in a cool place 8-15°C (46-59°F). The manufacturer recommends discarding the unused portion from a vial or ampule and does not recommend mixing with any other drug or chemical.

Pharmacology - In joint tissue, PSGAG inhibits proteolytic enzymes that can degrade proteoglycans (including naturally occurring glycosaminoglycans), thereby preventing or reducing decreased connective tissue flexibility, resistance to compression and resiliency. By acting as a precursor, PSGAG also increases the synthesis of proteoglycans. PSGAG also reduces inflammation by reducing concentrations of prostaglandin E2 (released in re_sponse to joint injury) and increases hyaluronate concentrations in the joint, thereby restor_ing synovial fluid viscosity.

Uses/Indications - PSGAG administered either IM or IA is indicated for the treatment of non-infectious and/or traumatic joint dysfunction and associated lameness of the carpal joints in horses. Some studies have indicated that PSGAG is much less effective in joints where there has been acute trauma but without the presence of degradative enzymes.

It is also approved for the control of signs associated with non-infectious degenerative and/or traumatic arthritis in dogs.

Pharmacokinetics - PSGAG is deposited in all layers of articular cartilage and is prefer_entially taken up by osteoarthritic cartilage. When administered IM, articular levels will with time exceed those found in the serum. Peak joint levels are reached 48 hours after IM injection, and persist for up to 96 hours after injection.

Contraindications/Precautions/Reproductive Safety - PSGAG is contraindicated for intra-articular administration in patients hypersensitive to it. While the manufacturer states there are no contraindications for IM use of the drug, the drug should not be used in place of other therapies in cases where infection is present or suspected, or in place of surgery or joint immobilization in cases where indicated.

Some clinicians feel that PSGAG should not be used within one week of arthrotomy in the dog, because it may cause increased bleeding. This effect apparently has not been confirmed in the literature however.

Reproductive studies have apparently not been performed; use with caution during preg_nancy or in breeding animals (the manufacturer does not recommend use in breeding ani_mals).

Adverse Effects/Warnings - Adverse effects are unlikely when using the IM route. Intraarticular administration may cause a post-injection inflammation (joint pain, effusion, swelling and associated lameness) secondary to sensitivity reactions, traumatic injection technique, overdosage, number or frequency of injections. Treatment consisting of anti-inflammatory drugs, cold hydrotherapy, and rest is recommended. Although rare, joint sepsis secondary to injection is also potentially possible; strict aseptic technique should be employed to minimize its occurrence. In dogs, a dose-related inhibition of coagulation/hemostasis has been described.

Overdosage/Acute Toxicity - Doses five times those recommended (2.5 grams) given IM to horses twice weekly for 6 weeks revealed no untoward toxic effects. Approximately 2% of horses receiving overdoses (up to 1250 mg) IA showed transient symptoms associated with joint inflammation.

Drug Interactions - While specific drug interactions have not been detailed to date, using this product in conjunction with either steroids or non-steroidal antiinflammatory agents could mask the signs and symptoms associated with septic joints.

There is some concern that since PSGAG is a heparin analog that it should not be used in conjunction with other NSAID’s or other anticoagulants. Clinical significance is un_clear, but use together with caution.

I have been using a vial and it working pretty good for joint pains and aches.

5kono4
11-06-2003, 08:37 PM
Sounds interesting I wonder if there are any side effects? Where did you inject in yourself? Im gonna look for a site on the net that sells that.

LabRat
11-06-2003, 08:54 PM
there all over google bro.
I used 29ga 1/2" slin pin and do 1 cc per week in my bad shoulder, well the trap but on-sites are not necessary.

I have had no sides effects as I researched the product quite a bit.

Most places maybe all you need a vet script for it but I bet there are some site selling it without a script.

I seen the are about $50.00 a vial which lasts a month.
I was told do 2 cc first time and 1 cc each week after.

They sell em also in boxes of 4, 5mg vials for around $150.00 I seen em.

I would like to know why this drug has not yet been approved for humans I think it takes 7 yrs for FDA to approve drugs.

5kono4
11-06-2003, 08:58 PM
I checked a few sites and I need a damn script on both of them, My joints could really use an oil change! Maybe Lab-corps will get it research purposes! My lab rats needs their joints lubed up.lol

rugbythug
11-06-2003, 10:41 PM
I am also interested in this research project

Breal
11-06-2003, 11:26 PM
If the pain was in the elbow,where would be the best place to IM it.

B-real

Ruthless
11-06-2003, 11:47 PM
Dangerousground, PM me bro....your mailbox is full, delete your sent msgs too if you have problems.......

LabRat
11-07-2003, 12:47 AM
Originally posted by Breal
If the pain was in the elbow,where would be the best place to IM it.

B-real

on-sites are not necessary, not in elbow bro.

5kono4
11-07-2003, 03:14 PM
Hey I found a site that will send it to me, they confirmed the order and didnt ask for a script (yet)so they should be sending it out to me today!!!!

GetnBigr
11-07-2003, 03:20 PM
bump

LabRat
11-07-2003, 04:30 PM
Originally posted by 5kono4
Hey I found a site that will send it to me, they confirmed the order and didnt ask for a script (yet)so they should be sending it out to me today!!!!

let us know if you receive. A friend of mine put down his dogs name and his dog vet and got a message on his answering machine asking why he needed Adequan. LOL
I would have gave him my cell but probably need a license number to verify.
This was the first site he found to order it also, there are many out there.

bjuicen
11-07-2003, 06:30 PM
hey DangerousGround, how is that stuff working for you?

LabRat
11-07-2003, 07:17 PM
I think it has been on almost 3 weeks and not much pain at all in knees when squatting usually takes me a few sets to get lose.

I am testing my shoulders out tonight.

5kono4
11-08-2003, 01:03 AM
I just got a e-mail from the place asking for dogs name vets # and fax# :angry: what should I do anyone want to be my vet?

homonunculus
11-08-2003, 09:42 AM
FYI: the GAG in Adequan are primarily chondrointin sulfate, so it might not be as effective if you're already taking that.

Also, the point about it being a heparinoid is important, as its prob not too uncommon to find people with joint pain also taking an NSAID. Obviously if you're a hemophiliac, watch out.

-Randy

LabRat
11-08-2003, 12:35 PM
It was explained to me in scientific terms tendons and ligaments don't heal nearly as fast as a broken bone because a bone gets direct blood supply and joint and ligaments don't but this allows more blood to go to the problem areas..

The thing about tendon and ligaments is they have very little blood flow in them and that is why they take forever to heal. When I hurt my patella tendon the trainers actually gave me a weeks worth of aggressive deep tissue message to induce bleeding in the tendon. It hurt like a mother but the increase bleeding made the tendon heel much faster.

Thats why they always say its better to break a bone sometimes than strain or tear a tendon or ligament.

SevnthWarrior
11-08-2003, 08:07 PM
Originally posted by 5kono4
I just got a e-mail from the place asking for dogs name vets # and fax# :angry: what should I do anyone want to be my vet?
Crap,
5kono4, I got excited and I PM'd you before i saw this post, Dammit, Let us know if you figure out how to pull it off!
I've GOT to find this stuff! My elbow & Shoulder suck some days so bad it Really effects my workout, and if I go to heavy, sometimes I have to skip it the next time around.

BioChem55
11-08-2003, 08:27 PM
wow, man thats great! my joints bother me all the time, im gonna look for this stuff, thanks Dangerous Ground bro!

5kono4
11-09-2003, 02:13 AM
By golly we shall find a way!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!1:D

GetnBigr
11-10-2003, 10:59 AM
bump for people who may need a product like this

and for 5kono4, what happened? Did you find a way?

SevnthWarrior
11-10-2003, 11:08 AM
Originally posted by GetnBigr
bump for people who may need a product like this

and for 5kono4, what happened? Did you find a way?
Yes, Bump, Bump, Bump!
I'd give my peanut sized left nut to find Something that actually worked on joints!

5kono4
11-10-2003, 08:39 PM
Man I had my boy who has a fax # call the guy and try to do the script overe the phone. The guy started asking some technical shit and my boy fumbled. Swing and a miss! Any suggestions?

blackhand
03-31-2004, 09:42 AM
has anyone tried a canadian vet supply shop shipping to the US?

Im still looking......its frustrating when rec drugs are easier to get than joint fixes.....lol

jeffskee
03-31-2004, 12:30 PM
DG, how is this stuff working out for you?

deathknell3000
04-01-2004, 12:38 AM
May have to find a way to get this stuff. I'd probably weigh about 250lbs right now if it wasn't for my joints.

Thump
04-02-2004, 04:34 PM
bump

Arabian_Freak
04-03-2004, 11:59 AM
thx for the info bro ... I cant imagine any serious lifter without any joint problems what so ever ... ill go look for the stuff here .. hopefully ill find it in the vet .. but is it clean ? i.e. wont it give u the rashes or hot feeling in your shoulder from vet drugs ? just wondering .

Presser
11-11-2013, 03:46 PM
adding to Articles forum, just found this oldy

Presser
05-25-2014, 07:58 AM
bump for adequan

Jet
08-30-2016, 06:14 PM
Have you received any noticeable long-term results since you took th Adequan. It seems to have helped my dog and I sure could use some help with my joints right now Thanks

Iron Game
08-30-2016, 07:53 PM
Have you received any noticeable long-term results since you took th Adequan. It seems to have helped my dog and I sure could use some help with my joints right now Thanks

Welcome to MuscleChemistry, Jet. This is an old thread. I'm not sure if you will get a response. Maybe post a new thread.

citywildcat
11-04-2018, 10:06 AM
Hi, I recently started my cat on it and she's doing so well after only one injection, I figured why can't I try it myself? I have terrible arthritis in all my joints/ have had two joint replacements and still have pain. I was a gym rat for over 15 years. Question: where do you get yours & isn't it costly? (Because my cat's supply was quite expensive/in the USA) THANKS!

Moondawg99
12-11-2020, 03:13 PM
Hey I found a site that will send it to me, they confirmed the order and didnt ask for a script (yet)so they should be sending it out to me today!!!!
hey did that site end up working? if so what site was it?

drtbear1967
12-11-2020, 03:21 PM
Going to research this as I need all the help I can get.