<center>NFL Point Spreads For Week 16 - Week Sixteen NFL Football Point Spread - NFL Spreads 12/22 - 12/23, 2013</center>
| Date & Time | Favorite | Spread | Underdog |
| 12/22 1:00 ET | Miami | -2.5 | At Buffalo |
| 12/22 1:00 ET | At Carolina | -3 | New Orleans |
| 12/22 1:00 ET | Dallas | -3 | At Washington |
| 12/22 1:00 ET | At St. Louis | -5.5 | Tampa Bay |
| 12/22 8:30 ET | At Philadelphia | -3 | Chicago |
| 12/22 1:00 ET | At NY Jets | -2 | Cleveland |
| 12/22 1:00 ET | At Kansas City | -7 | Indianapolis |
| 12/22 1:00 ET | At Cincinnati | -7.5 | Minnesota |
| 12/22 1:00 ET | Denver | -10.5 | At Houston |
| 12/22 1:00 ET | Tennessee | -5.5 | At Jacksonville |
| 12/22 4:05 ET | At Seattle | -10.5 | Arizona |
| 12/22 4:05 ET | At Detroit | -9 | NY Giants |
| 12/22 4:25 ET | At San Diego | -10 | Oakland |
| 12/22 4:25 ET | At Green Bay | Off | Pittsburgh |
| 12/22 4:25 ET | At Baltimore | -2.5 | New England |
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