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Boladrol
a2rk2p.jpg
Nomenclature:
7a,17a-dimethyl-androsten-3b,17b-diol
Anabolic/Androgenic Ratio:
Unknown. The anabolic/androgenic ratio for the target hormone of Bolasterone is around 1300:300 vs. methyl test by oral administration. [1]
Synonyms:
7a,17a-dimethyl-androst-4-en-3b,17b-diol, Boladrol, Bolasterone diol, Dimethylandrostenediol.
History:
This is a brand new prohormone from PHF/IBE, never seen before on the prohormone or pharmaceutical market, that converts in vivo to the steroid Bolasterone. Bolasterone was invented in 1959 [2], and in 1962 was described as "the most potent oral anabolic agent which had yet been examined" [3].
Structure and Function:
Boladrol is a "diol" prohormone, and should convert well to the active hormone via the same mechanism as all 3b,17b-diols: the enzyme 3-β-hydroxysteroid dehydrogenase, or 3b-HSD.
Structurally, Boladrol is a testosterone derivative, having the C3-C4 double bond common to this class of hormone. It resembles methyl testosterone in that it has a 17a-methyl group, though differs from it in that it has an additional methyl group at position 7a, and a hydroxyl at position 3b, whereas methyl test has a 3-ketone function. The addition of the methyl group at 7a greatly increases both the androgen receptor affinity and the anabolic properties of the compound [4].
Structurally it would appear likely to aromatise to a potent dimethylated estrogen, though the 7a-methyl may provide steric hindrance to the reaction. In fact there's evidence that some 7a-alkylated testosterone derivatives have aromatase inhibiting properties, with smaller 7a substitutions making stronger inhibitors than bulkier substitutions. [5]
This 7a-methyl group will also prevent the steroid from being 5a-reduced, but does not prevent it from being 5b-reduced, so all metabolites lacking the delta-4 double bond will be (inactive) 5b-reduced metabolites, as you can see from the image below. [6]
33d9wlx.jpg
The metabolites 2, 4, and 5 above are described further here [7]:
33mwe4o.jpg
Effects:
Effects should be similar to the oral anabolic steroid Bolasterone. It's a strongly anabolic, moderately androgenic compound which should elicit significant strength gains and increased accumulation of muscle mass at an appropriate dosage.
Since it's a powerful compound, and aromatisation a likelihood, weight gain is likely to be quick with the user's gains resulting from a mix of acquired muscle mass and a mild increase in water retention on cycle. A SERM PCT protocol should be followed upon cessation.
Side Effects:
The androgenic potential of the compound may have been exaggerated, at least at appropriate dosages, since the anabolic:androgenic ratio of about 4:1 vs. methyl test is not particularly low (especially since test has an A:A of 1:1). Also, low-dosed human testing reported no androgenic side-effects in any users [8].
Side-effects may include (but are not limited to): loss of or heightened libido, elevated liver enzymes and potential temporary liver function impairment, HPTA disruption, adverse shifts in lipoprotein subfractions (lowered HDL, increased LDL cholesterol), acne, hair growth or loss, and an increase in blood pressure. This product should not be used by women or teens.
Recommended Dosages and Cycle Durations:
The clinical evaluation of Bolasterone in the 1960s found it to be effective at promoting weight gain at doses of just 1-2mg. They also found it to be around twice as potent as dianabol by nitrogen retention studies [8]. Bodybuilders typically use dosages several times higher than those administered clinically.
As with any new compound, sensible users will keep dosages low and cycle-lengths short, until those with less caution have established some guidelines of how not to do it (by finding the dosages at which unacceptable side effects are encountered). Early Boladrol adopters have been dosing between 4 and 8mg per day for two to four weeks, and reporting great results.
References:
[1] Structure and effects of anabolic steroids. Pharmacol Ther B 1975;1:233–75.
[2] J Am Chem Soc 1959;81:4069-74.
[3] International Congress on Hormonal Steroids, Milan, Italy, 1962, Excerpta Med., Internat. Congr. Series No. 51.
[4] Steroids. 2009 Feb;74(2):172-97.
[5] Steroids Volume 40, Issue 6, December 1982, Pages 603-614
[6] Clinical Chemistry 42:7 1001-1020 (1996)
[7] J Steroid Biochem Mol Biol. 2009 May;115(1-2):44-61.
[8] Clin Pharmacol Ther. 1963 Nov-Dec;4:734-9.
a2rk2p.jpg
Nomenclature:
7a,17a-dimethyl-androsten-3b,17b-diol
Anabolic/Androgenic Ratio:
Unknown. The anabolic/androgenic ratio for the target hormone of Bolasterone is around 1300:300 vs. methyl test by oral administration. [1]
Synonyms:
7a,17a-dimethyl-androst-4-en-3b,17b-diol, Boladrol, Bolasterone diol, Dimethylandrostenediol.
History:
This is a brand new prohormone from PHF/IBE, never seen before on the prohormone or pharmaceutical market, that converts in vivo to the steroid Bolasterone. Bolasterone was invented in 1959 [2], and in 1962 was described as "the most potent oral anabolic agent which had yet been examined" [3].
Structure and Function:
Boladrol is a "diol" prohormone, and should convert well to the active hormone via the same mechanism as all 3b,17b-diols: the enzyme 3-β-hydroxysteroid dehydrogenase, or 3b-HSD.
Structurally, Boladrol is a testosterone derivative, having the C3-C4 double bond common to this class of hormone. It resembles methyl testosterone in that it has a 17a-methyl group, though differs from it in that it has an additional methyl group at position 7a, and a hydroxyl at position 3b, whereas methyl test has a 3-ketone function. The addition of the methyl group at 7a greatly increases both the androgen receptor affinity and the anabolic properties of the compound [4].
Structurally it would appear likely to aromatise to a potent dimethylated estrogen, though the 7a-methyl may provide steric hindrance to the reaction. In fact there's evidence that some 7a-alkylated testosterone derivatives have aromatase inhibiting properties, with smaller 7a substitutions making stronger inhibitors than bulkier substitutions. [5]
This 7a-methyl group will also prevent the steroid from being 5a-reduced, but does not prevent it from being 5b-reduced, so all metabolites lacking the delta-4 double bond will be (inactive) 5b-reduced metabolites, as you can see from the image below. [6]
33d9wlx.jpg
The metabolites 2, 4, and 5 above are described further here [7]:
33mwe4o.jpg
Effects:
Effects should be similar to the oral anabolic steroid Bolasterone. It's a strongly anabolic, moderately androgenic compound which should elicit significant strength gains and increased accumulation of muscle mass at an appropriate dosage.
Since it's a powerful compound, and aromatisation a likelihood, weight gain is likely to be quick with the user's gains resulting from a mix of acquired muscle mass and a mild increase in water retention on cycle. A SERM PCT protocol should be followed upon cessation.
Side Effects:
The androgenic potential of the compound may have been exaggerated, at least at appropriate dosages, since the anabolic:androgenic ratio of about 4:1 vs. methyl test is not particularly low (especially since test has an A:A of 1:1). Also, low-dosed human testing reported no androgenic side-effects in any users [8].
Side-effects may include (but are not limited to): loss of or heightened libido, elevated liver enzymes and potential temporary liver function impairment, HPTA disruption, adverse shifts in lipoprotein subfractions (lowered HDL, increased LDL cholesterol), acne, hair growth or loss, and an increase in blood pressure. This product should not be used by women or teens.
Recommended Dosages and Cycle Durations:
The clinical evaluation of Bolasterone in the 1960s found it to be effective at promoting weight gain at doses of just 1-2mg. They also found it to be around twice as potent as dianabol by nitrogen retention studies [8]. Bodybuilders typically use dosages several times higher than those administered clinically.
As with any new compound, sensible users will keep dosages low and cycle-lengths short, until those with less caution have established some guidelines of how not to do it (by finding the dosages at which unacceptable side effects are encountered). Early Boladrol adopters have been dosing between 4 and 8mg per day for two to four weeks, and reporting great results.
References:
[1] Structure and effects of anabolic steroids. Pharmacol Ther B 1975;1:233–75.
[2] J Am Chem Soc 1959;81:4069-74.
[3] International Congress on Hormonal Steroids, Milan, Italy, 1962, Excerpta Med., Internat. Congr. Series No. 51.
[4] Steroids. 2009 Feb;74(2):172-97.
[5] Steroids Volume 40, Issue 6, December 1982, Pages 603-614
[6] Clinical Chemistry 42:7 1001-1020 (1996)
[7] J Steroid Biochem Mol Biol. 2009 May;115(1-2):44-61.
[8] Clin Pharmacol Ther. 1963 Nov-Dec;4:734-9.
