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M4ohn
1qfi4n.jpg
Nomenclature:
4-hydroxy-17a-methyl-19-nortestosterone or 4-hydroxy-17a-methyl-17b-hydroxyestr-4-en-3-one or 17a-methyl-3-oxo-19-norandrostene-4,17-diol
Anabolic/Androgenic Ratio:
1304:281 vs. methyl testosterone by oral administration, and 1304:1024 vs. methylnortestosterone by oral administration. [1]
Synonyms:
M4OHN, methyl hydroxy nandrolone, MOHN, oxavar
History:
This compound is first described in the literature in 1964, when researchers from Milan, Italy, explored the effects of adding a hydroxyl group at C-4 to a variety of steroids. [2]
It was launched on the prohormone market in 2004 as a bulk powder by Designer Supplements and 1fast400. The first capped product was Oxavar by Gaspari Nutrition.
It was shortlived, however, since the Anabolic Steroid Control Act of 2004 [3] saw it added to Schedule III of the Controlled Substances Act, making M4OHN illegal to sell or possess in the USA. It resurfaced in the UK in late 2010; no legislative action has been taken against it in the UK at the time of writing.
Structure and Function:
This is a oral nandrolone-derived steroid. It differs from nandrolone in that it has a 17a-methyl group to improve oral bioavailability, and a 4-hydroxyl group that increases the dissociation of anabolic and androgenic effects. It is essentially a 19-nor version of the steroid oxymesterone.
G. Sala, in his paper on the biological properties of 4-hydroxy-3-keto-Δ4-steroids [2], observed that "4-hydroxy-17a-methyl-19-nortestosterone presents a strong increase of the myotrophic and of the androgenic effect, with a moderate increment of the therapeutic index, as compared with 17a-methyl-19-nortestosterone".
This increase in effect was only seen with oral administration, not with subcutaneous injection of the compound, so he goes on to say that he believes this is due to the hydroxylation at C4 increasing "intestinal absorption of 17a-methyltestosterone derivatives", in addition to "favoring dissociation between myotrophic and androgenic activity".
The 4-hydroxyl group also abolished the progestational effects of all of the testosterone and nortestosterone derivatives studied. The results of his observations of the compound are summarized below:
igf5h2.jpg
The addition of the 4-hydroxyl function is likely to hinder (though not prevent) the reduction of the C-4,5 double bond. This is particularly true of 17a-methylated steroids such as this one. [4]
Whereas testosterone derivatives typically 5a-reduce to stronger androgens, 19-nortestosterone derivatives typically 5a-reduce to weaker androgens. This goes some way to explaining why M4OHT (methyl hydroxy testosterone) is more anabolic and less androgenic than methyl test, while M4OHN (methyl hydroxy nandrolone) is more anabolic and much more androgenic than methyl nandrolone.
Effects:
While the anabolic:androgenic profile would suggest that this was a strong mass-builder, user feedback would suggest it is instead an effective cutter and best used by those looking to shed excess fat.
Side Effects:
One of the issues surrounding nandrolone derivatives, particularly 17a-methylated nandrolone derivatives, is their potential for progestational activity. Fortunately this compound is an exception to the rule, having no progestational effects. Any nipple sensitivity on-cycle will therefore be estrogen related and should be dealt with by a SERM or aromatase inhibitor.
The standard list of steroidal side-effects listed in the other profiles will also apply to this compound.
Recommended Dosages and Cycle Durations:
Due to it's strong profile this compound was originally released in 2mg caps, with other manufacturers dosing them similarly at 2-4mg. Users often ran it much higher, with 12mg being common though some reported the best effects at 40mg or even higher.
The clone currently available on the UK market is dosed at 10mg per cap, which will make it much easier and more cost-effective to experiment with higher dosing. Since it's a methylated compound cycles are generally 6 weeks or less to minimise the risk of hepatic injury.
References
[1] Vida J.: Androgens and Anabolic Agents. Academic Press, New York (1969) p. 280.
[2] Hormonal Steroids Vol 1, p.67. Academic Press, New York, 1964.
[3] Senate Bill 2195
[4] J Steroid Biochem Mol Biol. 2009 May;115(1-2):44-61.
1qfi4n.jpg
Nomenclature:
4-hydroxy-17a-methyl-19-nortestosterone or 4-hydroxy-17a-methyl-17b-hydroxyestr-4-en-3-one or 17a-methyl-3-oxo-19-norandrostene-4,17-diol
Anabolic/Androgenic Ratio:
1304:281 vs. methyl testosterone by oral administration, and 1304:1024 vs. methylnortestosterone by oral administration. [1]
Synonyms:
M4OHN, methyl hydroxy nandrolone, MOHN, oxavar
History:
This compound is first described in the literature in 1964, when researchers from Milan, Italy, explored the effects of adding a hydroxyl group at C-4 to a variety of steroids. [2]
It was launched on the prohormone market in 2004 as a bulk powder by Designer Supplements and 1fast400. The first capped product was Oxavar by Gaspari Nutrition.
It was shortlived, however, since the Anabolic Steroid Control Act of 2004 [3] saw it added to Schedule III of the Controlled Substances Act, making M4OHN illegal to sell or possess in the USA. It resurfaced in the UK in late 2010; no legislative action has been taken against it in the UK at the time of writing.
Structure and Function:
This is a oral nandrolone-derived steroid. It differs from nandrolone in that it has a 17a-methyl group to improve oral bioavailability, and a 4-hydroxyl group that increases the dissociation of anabolic and androgenic effects. It is essentially a 19-nor version of the steroid oxymesterone.
G. Sala, in his paper on the biological properties of 4-hydroxy-3-keto-Δ4-steroids [2], observed that "4-hydroxy-17a-methyl-19-nortestosterone presents a strong increase of the myotrophic and of the androgenic effect, with a moderate increment of the therapeutic index, as compared with 17a-methyl-19-nortestosterone".
This increase in effect was only seen with oral administration, not with subcutaneous injection of the compound, so he goes on to say that he believes this is due to the hydroxylation at C4 increasing "intestinal absorption of 17a-methyltestosterone derivatives", in addition to "favoring dissociation between myotrophic and androgenic activity".
The 4-hydroxyl group also abolished the progestational effects of all of the testosterone and nortestosterone derivatives studied. The results of his observations of the compound are summarized below:
igf5h2.jpg
The addition of the 4-hydroxyl function is likely to hinder (though not prevent) the reduction of the C-4,5 double bond. This is particularly true of 17a-methylated steroids such as this one. [4]
Whereas testosterone derivatives typically 5a-reduce to stronger androgens, 19-nortestosterone derivatives typically 5a-reduce to weaker androgens. This goes some way to explaining why M4OHT (methyl hydroxy testosterone) is more anabolic and less androgenic than methyl test, while M4OHN (methyl hydroxy nandrolone) is more anabolic and much more androgenic than methyl nandrolone.
Effects:
While the anabolic:androgenic profile would suggest that this was a strong mass-builder, user feedback would suggest it is instead an effective cutter and best used by those looking to shed excess fat.
Side Effects:
One of the issues surrounding nandrolone derivatives, particularly 17a-methylated nandrolone derivatives, is their potential for progestational activity. Fortunately this compound is an exception to the rule, having no progestational effects. Any nipple sensitivity on-cycle will therefore be estrogen related and should be dealt with by a SERM or aromatase inhibitor.
The standard list of steroidal side-effects listed in the other profiles will also apply to this compound.
Recommended Dosages and Cycle Durations:
Due to it's strong profile this compound was originally released in 2mg caps, with other manufacturers dosing them similarly at 2-4mg. Users often ran it much higher, with 12mg being common though some reported the best effects at 40mg or even higher.
The clone currently available on the UK market is dosed at 10mg per cap, which will make it much easier and more cost-effective to experiment with higher dosing. Since it's a methylated compound cycles are generally 6 weeks or less to minimise the risk of hepatic injury.
References
[1] Vida J.: Androgens and Anabolic Agents. Academic Press, New York (1969) p. 280.
[2] Hormonal Steroids Vol 1, p.67. Academic Press, New York, 1964.
[3] Senate Bill 2195
[4] J Steroid Biochem Mol Biol. 2009 May;115(1-2):44-61.
