Blood Flow Restriction Training: The Next Generation of Anabolic Exercise. BFR

Presser

Admin
Staff member
Administrator
Moderator
[h=1]<h1 style="margin: 0px 0px 6px; padding: 0px 0px 6px; border: 0px; vertical-align: baseline; font-weight: 100; -webkit-font-smoothing: antialiased; line-height: 1.1em; font-size: 2.375em; ">Blood Flow Restriction Training: The Next Generation of Anabolic Exercise</h1>Posted In: Training
“God gave men both a penis and a brain, but unfortunately not enough blood supply to run both at the same time.”
-Robin Wiliams
We all know that blood is vital to support life and various other ‘systems’ as so eloquently stated by Mr. Williams. Blood is responsible for the transport of oxygen, nutrients, and many other molecules crucial for sustained life. Most bodybuilders will also tell you that blood is important for gaining muscle, blood flow to be more specific. Not surprisingly, an entire category of supplements has emerged in the past decade, focused on increasing blood flow and thus purporting to enhance anabolism. But what if I told you that the opposite may be true? What would you say if I told you that occluding blood flow to muscles can have an anabolic effect? You would probably tell me I’m not getting enough blood flow to my brain but you would be wrong. Blood Flow Restriction (BFR) training has years of research to support its effectiveness and in this article I will explain what it is and how to use it to augment your training.
What is Blood Flow Restriction Training?
Quite simply, BFR training involved restricting the venous return of blood flow from the muscle. The goal is not to restrict blood flow to the muscle, but instead prevent blood flow return from the muscle, i.e. you do NOT want to restrict the arterial blood flow to the muscle, only the venous return from the muscle, causing the blood to pool in the muscle. This is accomplished by use of a blood pressure cuff or perhaps more practically using knee wraps tightly secured around the limb(s). For example, to use BFR on arm muscles you would tightly secure a cuff or cloth knee wraps as close to the shoulder as possible. This will restrict blood flow return from the arms and cause the blood to pool.
What is so great about it?
Blood Flow Restriction training when performed properly allows one to use much lower weights than normal training protocols and still achieve sizable anabolic training responses. In fact, occlusion training can increase muscle size and strength using training loads as light as 20% of a 1 rep max (1)! This is especially useful for individuals who individuals who are injured and can only use very light weights or for trainers who are undergoing a deload phase in their training cycle. BFR training allows you to still make gains using light weights while giving your joints, ligaments, and tendons a break from heavy lifting.
How does it work?
BFR training induces an anabolic response through various pathways perhaps the most important of which is by preferentially targeting the large fast twitch muscle fibers. Fast twitch fibers are the biggest muscle fibers and have the most potential for growth. These fibers are recruited last during contractions and are mostly anaerobic (don’t use oxygen) whereas the smaller slow twitch fibers are recruited first during contractions and are aerobic (use oxygen). Slow twitch fibers have a much smaller potential for growth compared to fast twitch fibers. BFR training restricts blood flow to muscles, pre-fatiguing the slow twitch fibers and forcing the anaerobic fast twitch fibers to handle the load even at low intensities (2)! Metabolically, your muscle is getting a similar effect to lifting heavy loads but using much lighter weights. Not only does occlusion training preferentially activate fast twitch muscle fibers, it has been shown to cause a fiber type shift from slow to fast, thus increasing the potential for muscular growth and size (3)!

Metabolic by-product accumulation is primary mechanism by which occlusion training produces hypertrophy. These metabolic by-products would normally be ‘washed out’ by normal blood flow, but occlusion allows them to accumulate near the muscle. Lactate accumulation in particular seems to have an effect, presumably by increasing growth hormone (GH) concentrations (4-5). In fact, one study found that BFR training caused a GH increase 290 times above baseline (4)! This is a twofold greater increase in GH than what is produced by normal heavy resistance training (6).
If those reasons weren’t convincing enough to try occlusion training, consider that it has also been shown to increase muscle protein synthesis, mTOR signaling, and the expression of NOS-1 which has been shown to increase muscle growth through increased satellite cell activation (7-9). Perhaps even more impressive, BFR training has been demonstrated to reduce myostatin concentrations (9)! For those of you who have been living under a rock for the better part of the last decade, myostatin is a big time inhibitor of muscle growth and is thought to limit the muscle potential of muscle gain. Perhaps occlusion training may be able to increase the overall potential of muscle gain through slow to fast fiber shifts and reductions in myostatin!
So are you saying we should use Blood Flow Restriction Training instead of normal heavy training?
BFR isn’t a replacement for heavy training, it is a supplement. It is also very useful for people who can’t train heavy due to injury or deloading. However, occlusion provides several long term benefits that regular heavy training doesn’t including slow to fast fiber transitions and a greater hormonal response.
Practical application?
Before proceeding further, please keep in mind that BFR training is very difficult even though the loads are very light. It is easily the most painful form of training I have ever performed. As always, before starting any kind of new training protocol, you should talk with a medical professional. BFR can be performed for the thighs, calves, upper arms, and forearms using a blood pressure cuff or tightly wrapped knee wraps (more practical). To occlude the thighs and upper arms, wrap at approximately 70% of maximum tightness around the uppermost part of the muscles. To occlude the calves or forearms wrap at approximately 70% of maximum tightness just below the knee or elbow.
<iframe src="http://www.youtube.com/embed/CpKn8Hav5eM" frameborder="0" width="615" height="346" style="margin: 0px; padding: 0px 0px 20px; border-width: 0px; vertical-align: baseline; width: 639px; clear: both; display: block; "></iframe>
Perform 3-5 sets to muscular failure with 20-50% of your 1 rep max on a given exercise with the muscle occluded the entire time. Rest periods should be 30-60 seconds between sets. After the final set remove the wraps and restore blood flow to the muscle. A word of advice, be prepared for a lot of pain and if you do not find yourself in excruciating pain, the odds are the wraps are not tight enough. Try blood flow restriction training and take your training to another hypertrophic dimension!
References
1) Loenneke JP and Pujol TJ. The Use of Occlusion Training to Produce Muscle Hypertrophy. Strength & Conditioning Journal. 31(3): 77-84, June 2009.
2) Takarada Y, Takazawa H, Sato Y, Takebayashi S, Tanaka Y, and Ishii N. Effects of resistance exercise combined with moderate vascular occlusion on muscle function in humans. J Appl Physiol 88: 2097–2106, 2000.
3) Kawada S and Ishii N. Changes in skeletal muscle size, fiber-type composition and capillary supply after chronic venous occlusion in rats. Acta Physiol 192: 541–549, 2008.
4) Takarada Y, Nakamura Y, Aruga S, Onda T,Miyazaki S, and Ishii N. Rapid increase in plasma growth hormone after low-intensity resistance exercise with vascular occlusion. J Appl Physiol 88: 61–65, 2000.
5) Takano H, Morita T, Iida H, Asada K, Kato M, Uno K, Hirose K, Matsumoto A, Takenaka K, Hirata Y, Eto F, Nagai R, Sato Y, and Nakaajima T. Hemodynamic and hormonal responses to a short-term low-intensity resistance exercise with the reduction of muscle blood flow. Eur J Appl Physiol 95: 65–73, 2005.
6) Kraemer W, Marchitelli L, Gordon S, Harman E, Dziados J, Mello R, Frykman P, McCurry D, and Fleck S. Hormonal and growth factor responses to heavy resistance exercise protocols. J Appl Physiol 69: 1442–1450, 1990.
7) Fujita S, Abe T, Drummond M, Cadenas J, Dreyer H, Sato Y, Volpi E, and Rasmussen B. Blood flow restriction during low-intensity resistance exercise increases S6K1 phosphorylation and muscle protein synthesis. J Appl Physiol 103: 903–910, 2007.
8) Anderson J. A role for nitric oxide in muscle repair: nitric oxide-mediated activation of muscle satellite cells. Mol Biol Cell 11: 1859–1874, 2000.
9) Kawada S and Ishii N. Skeletal muscle hypertrophy after chronic restriction of venous blood flow in rats. Med Sci Sports Exerc 37: 1144–1150, 2005.

[/h]
 
[h=1]Exercise and blood flow restriction.[/h]
Pope ZK[SUP]1[/SUP], Willardson JM, Schoenfeld BJ.
[h=3]Author information[/h]

[h=3]Abstract[/h]A growing body of research has demonstrated the effectiveness of exercise (low-intensity resistance training, walking, cycling) combined with blood flow restriction (BFR) for increased muscular strength and hypertrophy. The BFR is achieved via the application of external pressure over the proximal portion of the upper or lower extremities. The external pressure applied is sufficient to maintain arterial inflow while occluding venous outflow of blood distal to the occlusion site. With specific reference to low-intensity resistance training, the ability to significantly increase muscle strength and hypertrophy when combined with BFR is different from the traditional paradigm, which suggests that lifting only higher intensity loads increases such characteristics. The purpose of this review was to discuss the relevant literature with regard to the type and magnitude of acute responses and chronic adaptations associated with BFR exercise protocols vs. traditional non-BFR exercise protocols. Furthermore, the mechanisms that stimulate such responses and adaptations will be discussed in the context of neural, endocrine, and metabolic pathways. Finally, recommendations will be discussed for the practitioner in the prescription of exercise with BFR.

 
[h=1]Muscle size and strength are increased following walk training with restricted venous blood flow from the leg muscle, Kaatsu-walk training[/h]

+Author Affiliations
  • <address style="margin: 0px; padding: 0px; border: 0px; outline-style: none; font-style: normal; font-size: inherit; font-family: inherit; line-height: inherit; text-align: inherit; vertical-align: baseline; display: inline; ">[SUP]1[/SUP]Department of Exercise and Sport Science, Tokyo Metropolitan University, and [SUP]2[/SUP]Department of Ischemic Circulatory Physiology, University of Tokyo, Tokyo, Japan</address>

  • Address for reprint requests and other correspondence: T. Abe, Dept. of Exercise and Sport Science, Tokyo Metropolitan Univ., 1–1 Minami-Ohsawa, Hachioji, Tokyo 192–0397, Japan (e-mail: [email protected])

  • Submitted 3 October 2005.
  • Accepted29 November 2005.
[h=2]Abstract[/h]Previous studies have shown that low-intensity resistance training with restricted muscular venous blood flow (Kaatsu) causes muscle hypertrophy and strength gain. To investigate the effects of daily physical activity combined with Kaatsu, we examined the acute and chronic effects of walk training with and without Kaatsu on MRI-measured muscle size and maximum dynamic (one repetition maximum) and isometric strength, along with blood hormonal parameters. Nine men performed Kaatsu-walk training, and nine men performed walk training alone (control-walk). Training was conducted two times a day, 6 days/wk, for 3 wk using five sets of 2-min bouts (treadmill speed at 50 m/min), with a 1-min rest between bouts. Mean oxygen uptake during Kaatsu-walk and control-walk exercise was 19.5 (SD 3.6) and 17.2 % (SD 3.1) of treadmill-determined maximum oxygen uptake, respectively. Serum growth hormone was elevated (P < 0.01) after acute Kaatsu-walk exercise but not in control-walk exercise. MRI-measured thigh muscle cross-sectional area and muscle volume increased by 4–7%, and one repetition maximum and maximum isometric strength increased by 8–10% in the Kaatsu-walk group. There was no change in muscle size and dynamic and isometric strength in the control-walk group. Indicators of muscle damage (creatine kinase and myoglobin) and resting anabolic hormones did not change in both groups. The results suggest that the combination of leg muscle blood flow restriction with slow-walk training induces muscle hypertrophy and strength gain, despite the minimal level of exercise intensity. Kaatsu-walk training may be a potentially useful method for promoting muscle hypertrophy, covering a wide range of the population, including the frail and elderly.
 
[h=1]Blood flow restriction exercise stimulates mTORC1 signaling and muscle protein synthesis in older men[/h]

+Author Affiliations
  • <address style="margin: 0px; padding: 0px; border: 0px; outline-style: none; font-style: normal; font-size: inherit; font-family: inherit; line-height: inherit; text-align: inherit; vertical-align: baseline; display: inline; ">[SUP]1[/SUP]Division of Rehabilitation Sciences,</address>
  • <address style="margin: 0px; padding: 0px; border: 0px; outline-style: none; font-style: normal; font-size: inherit; font-family: inherit; line-height: inherit; text-align: inherit; vertical-align: baseline; display: inline; ">Departments of [SUP]2[/SUP]Physical Therapy and</address>
  • <address style="margin: 0px; padding: 0px; border: 0px; outline-style: none; font-style: normal; font-size: inherit; font-family: inherit; line-height: inherit; text-align: inherit; vertical-align: baseline; display: inline; ">[SUP]3[/SUP]Internal Medicine,</address>
  • <address style="margin: 0px; padding: 0px; border: 0px; outline-style: none; font-style: normal; font-size: inherit; font-family: inherit; line-height: inherit; text-align: inherit; vertical-align: baseline; display: inline; ">[SUP]4[/SUP]Sealy Center on Aging, University of Texas Medical Branch, Galveston, Texas; and</address>
  • <address style="margin: 0px; padding: 0px; border: 0px; outline-style: none; font-style: normal; font-size: inherit; font-family: inherit; line-height: inherit; text-align: inherit; vertical-align: baseline; display: inline; ">[SUP]5[/SUP]Department of Human and Engineered Environmental Studies, Graduate School of Frontier Sciences, University of Tokyo, Chiba, Japan</address>

  • Address for reprint requests and other correspondence: B. B. Rasmussen, Univ. of Texas Medical Branch, Sealy Center on Aging, Dept. of Physical Therapy, Division of Rehabilitation Sciences, 301 Univ. Blvd., Galveston, TX 77555-1144 (e-mail:[email protected]).

  • Submitted 9 November 2009.
  • Accepted in final form9 February 2010.
[h=2]Abstract[/h]The loss of skeletal muscle mass during aging, sarcopenia, increases the risk for falls and dependence. Resistance exercise (RE) is an effective rehabilitation technique that can improve muscle mass and strength; however, older individuals are resistant to the stimulation of muscle protein synthesis (MPS) with traditional high-intensity RE. Recently, a novel rehabilitation exercise method, low-intensity RE, combined with blood flow restriction (BFR), has been shown to stimulate mammalian target of rapamycin complex 1 (mTORC1) signaling and MPS in young men. We hypothesized that low-intensity RE with BFR would be able to activate mTORC1 signaling and stimulate MPS in older men. We measured MPS and mTORC1-associated signaling proteins in seven older men (age 70 ± 2 yr) before and after exercise. Subjects were studied identically on two occasions: during BFR exercise [bilateral leg extension exercise at 20% of 1-repetition maximum (1-RM) with pressure cuff placed proximally on both thighs and inflated at 200 mmHg] and during exercise without the pressure cuff (Ctrl). MPS and phosphorylation of signaling proteins were determined on successive muscle biopsies by stable isotopic techniques and immunoblotting, respectively. MPS increased 56% from baseline after BFR exercise (P < 0.05), while no change was observed in the Ctrl group (P > 0.05). Downstream of mTORC1, ribosomal S6 kinase 1 (S6K1) phosphorylation and ribosomal protein S6 (rpS6) phosphorylation increased only in the BFR group after exercise (P < 0.05). We conclude that low-intensity RE in combination with BFR enhances mTORC1 signaling and MPS in older men. BFR exercise is a novel intervention that may enhance muscle rehabilitation to counteract sarcopenia.
 
Human muscle gene expression following resistance exercise and blood flow restriction.
(PMID:18317375)

Drummond MJ, Fujita S, Abe T, Takashi A, Dreyer HC, Volpi E, Rasmussen BB
Department of Physical Therapy, University of Texas Medical Branch, Galveston, TX, USA.

Medicine and Science in Sports and Exercise [2008, 40(4):691-698]

Type: Journal Article, Research Support, N.I.H., Extramural, Comparative Study
DOI: 10.1249/MSS.0b013e318160ff84
qmark.png

AbstractHighlight Terms
qmark.png
<small><label><input type="checkbox" id="whatizit_highlight2" style="font-family: 'Trebuchet MS', Tahoma, Verdana, Arial, sans-serif; font-size: 1em; "> Genes/Proteins(6)</label> <label><input type="checkbox" id="whatizit_highlight6" style="font-family: 'Trebuchet MS', Tahoma, Verdana, Arial, sans-serif; font-size: 1em; "> Chemicals(1)</label></small>

<tbody>
</tbody>
INTRODUCTION: Blood flow restriction in combination with low-intensity resistance exercise (REFR) increases skeletal muscle size to a similar extent as compared with traditional high-intensity resistance exercise training. However, there are limited data describing the molecular adaptations that occur after REFR.

PURPOSE: To determine whether hypoxia inducible factor-1 alpha (HIF-1alpha) and REDD1 mRNAare expressed differently in REFR compared with low-intensity resistance exercise with no blood flow restriction (CONTROL). Secondly, to determine whether low-intensity resistance exercise is able to induce changes in mRNA expression of several anabolic and catabolic genes as typically seen with high-intensity resistance exercise.

METHODS: Six subjects were studied at baseline and 3 h after a bout of leg resistance exercise (20% 1RM) in REFR and CONTROL subjects. Each subject participated in both groups, with 3 wk separating each visit. Muscle biopsy samples were analyzed for mRNA expression, using qRT-PCR.

RESULT: Our primary finding was that there were no differences between CONTROL and REFR for any of the selected genes at 3 h after exercise (P > 0.05). However, low-intensity resistance exercise increased HIF-1alpha, p21, MyoD, and muscle RING finger 1 (MuRF1) mRNA expression and decreased REDD1 and myostatin mRNA expression in both groups (P < 0.05).

CONCLUSION: Low-intensity resistance exercise can alter skeletal muscle mRNA expression of several genes associated with muscle growth and remodeling, such as REDD1, HIF-1alpha, MyoD,MuRF1, and myostatin. Further, the results from REFR and CONTROL were similar, indicating that the changes in early postexercise gene expression were attributable to the low-intensity resistance exercise bout, and not blood flow restriction.

<tbody>
</tbody>



 

Cross-transfer effects of resistance training with blood flow restriction.
(PMID:18202577)

Madarame H, Neya M, Ochi E, Nakazato K, Sato Y, Ishii N
Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Komaba, Meguro-ku, Tokyo, Japan. [email protected]

Medicine and Science in Sports and Exercise [2008, 40(2):258-263]

Type: Journal Article, Randomized Controlled Trial
DOI: 10.1249/mss.0b013e31815c6d7e
qmark.png

AbstractHighlight Terms
qmark.png
<small><label><input type="checkbox" id="whatizit_highlight6" style="font-family: 'Trebuchet MS', Tahoma, Verdana, Arial, sans-serif; font-size: 1em; "> Chemicals(3)</label></small>

<tbody>
</tbody>
PURPOSE: This study investigated whether muscle hypertrophy-promoting effects are cross-transferred in resistance training with blood flow restriction, which has been shown to evoke strongendocrine activation.

METHODS: Fifteen untrained men were randomly assigned into the occlusive training group (OCC, N = 8) and the normal training group (NOR, N = 7). Both groups performed the same unilateral arm exercise (arm curl) at 50% of one-repetition maximum (1RM) without occlusion (three sets, 10 repetitions). Either the dominant or nondominant arm was randomly chosen to be trained (OCC-T, NOR-T) or to serve as a control (OCC-C, NOR-C). After the arm exercise, OCC performed leg exercise with blood flow restriction (30% of 1RM, three sets, 15-30 repetitions), whereas NOR performed the same leg exercise without occlusion. The training session was performed twice a week for 10 wk. In a separate set of experiments, acute changes in blood hormone concentrations were measured after the same leg exercises with (N = 5) and without (N = 5) occlusion.

RESULTS: Cross-sectional area (CSA) and isometric torque of elbow flexor muscles increased significantly in OCC-T, whereas no significant changes were observed in OCC-C, NOR-T, and NOR-C. CSA and isometric torque of thigh muscles increased significantly in OCC, whereas no significant changes were observed in NOR. Noradrenaline concentration showed a significantly larger increase after leg exercise with occlusion than after exercises without occlusion, though growth hormone andtestosterone concentrations did not show significant differences between these two types of exercises.

CONCLUSION: The results indicate that low-intensity resistance training increases muscular size and strength when combined with resistance exercise with blood flow restriction for other muscle groups. It was suggested that any circulating factor(s) was involved in this remote effect of exercise on muscular size.

<tbody>
</tbody>



 
[h=1]Blood flow restriction during low-intensity resistance exercise increases S6K1 phosphorylation and muscle protein synthesis[/h]

+Author Affiliations
  • <address style="margin: 0px; padding: 0px; border: 0px; outline-style: none; font-style: normal; font-size: inherit; font-family: inherit; line-height: inherit; text-align: inherit; vertical-align: baseline; display: inline; ">Departments of [SUP]1[/SUP]Internal Medicine and [SUP]2[/SUP]Physical Therapy; and [SUP]3[/SUP]Division of Rehabilitation Sciences, University of Texas Medical Branch, Galveston, Texas; and [SUP]4[/SUP]Department of Human and Engineered Environmental Studies, Graduate School of Frontier Sciences, University of Tokyo, Chiba, Japan</address>

  • Address for reprint requests and other correspondence: S. Fujita, Univ. of Tokyo, Graduate School of Frontier Sciences, 5-1-5, Kashiwanoha, Kashiwa-shi, Chiba 277-8563, Japan (e-mail: [email protected])

  • Submitted 16 February 2007.
  • Accepted11 June 2007.
[h=2]Abstract[/h]Low-intensity resistance exercise training combined with blood flow restriction (REFR) increases muscle size and strength as much as conventional resistance exercise with high loads. However, the cellular mechanism(s) underlying the hypertrophy and strength gains induced by REFR are unknown. We have recently shown that both the mammalian target of rapamycin (mTOR) signaling pathway and muscle protein synthesis (MPS) were stimulated after an acute bout of high-intensity resistance exercise in humans. Therefore, we hypothesized that an acute bout of REFR would enhance mTOR signaling and stimulate MPS. We measured MPS and phosphorylation status of mTOR-associated signaling proteins in six young male subjects. Subjects were studied once during blood flow restriction (REFR, bilateral leg extension exercise at 20% of 1 repetition maximum while a pressure cuff was placed on the proximal end of both thighs and inflated at 200 mmHg) and a second time using the same exercise protocol but without the pressure cuff [control (Ctrl)]. MPS in the vastus lateralis muscle was measured by using stable isotope techniques, and the phosphorylation status of signaling proteins was determined by immunoblotting. Blood lactate, cortisol, and growth hormone were higher following REFR compared with Ctrl (P < 0.05). Ribosomal S6 kinase 1 (S6K1) phosphorylation, a downstream target of mTOR, increased concurrently with a decreased eukaryotic translation elongation factor 2 (eEF2) phosphorylation and a 46% increase in MPS following REFR (P < 0.05). MPS and S6K1 phosphorylation were unchanged in the Ctrl group postexercise. We conclude that the activation of the mTOR signaling pathway appears to be an important cellular mechanism that may help explain the enhanced muscle protein synthesis during REFR.
 
i use do this when i was young since i seen the warrior workout and his arms look bigger then usual. We use tear up a shirt into strips tie them up on ours and get swole lol. Do curls just curls like a hr in which seem forever at the time.
 
Back
Top