guardianactual
MuscleChemistry Registered Member
17 beta-acetoxy-2-methyl-5 alpha-androst-1-en-3-one
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</br> Stenbolone is very similar to both dromostanolone and oxymetholone. It is a derivative of DHT with a double bond between carbon 1 and 2 and a methyl group at position 2. The methyl group at position 2 protects the molecule from both aromatization to estrogen and to some degree, inactivation in muscle tissue by 3-alpha hydroxysteroid dehydrogenase. This 2-methyl group does decrease binding to the androgen receptor somewhat. This makes for a molecule that has slightly less binding affinity for the androgen receptor than primobolan but like primobolan, this steroid cannot be converted to estrogenic metabolites through aromatization. Stenbolone is considered by some to be a gentler version of oxymetholone. This steroid has a similar structure to oxymetholone but is not C-17 alpha alkylated so it has minimal effects on liver function. Stenbolone builds up red blood cells like oxymetholone and is metabolized to some degree to dromostanolone which has also been shown to increase red blood cells1,2.
</br>
</br> Stenbolone does not seem to result in as much size gain as anadrol or as much bloat so it likely does not have as much inhibitory activity on 11-beta hydroxylase. Stenbolone tended to be injected daily because of the short half-life of the acetate ester. Additionally, the acetate ester seems to produce pain and swelling at the injection site. Stenbolone has similar androgenic activity compared to 1-testosterone, the unmethylated version of this drug, but with higher anabolic activity. This is likely due to the reduced conversion to 3-alpha hydroxy metabolites. Stenbolone offers many of the advantages of oxymetholone with less bloating and elevated blood pressure.
</br>
</br> William Llewellyn’S ANABDLICS, 9th ed. Anatrofin (stenbolone acetate) Androgenic 115-130 Anabolic 300 Standard Testosterone Chemical Names 2-methyl-Sa-androst-l-en-17b-ol-3-one Estrogenic Activity none Progestational Activity no data available Description: Stenbolone acetate is an injectable anabolic steroid derived from dihydrotestosterone. Stenbolone was actually developed on a 1-testosterone backbone, differing only by the addition of a 2-methyl group. The resulting steroid remains very similar to its non-methylated base, with only modest differences in anabolic and androgenic potency. On the tissue-building side, stenbolone is probably a little weaker on a milligram for milligram basis than 1-testosterone, although it is difficult to make direct comparisons. As an androgen, stenbolone is also probably slightly weaker than 1-testosterone, when you are talking milligram for milligram dose, although the anabolic/androgenic ratio (the more relevant measure) remains very similar. When compared to testosterone, standard assays suggest that stenbolone has roughly three times greater anabolic effect, and somewhere between 150/0 and 30% more androgenic activity. History: Schering AG in Germany introduced stenbolone acetate in 1961.
</br>
</br> Approximately two years later, Syntex would introduce the drug to the United Kingdom, and soon after Mexico, under the brand name Anatrofin. Farmacologico Latino also sold this drug in Spain, under the generic name Stenbolone.397 It was reportedly applied (most commonly) as an injectable alternative to Anadrol in cases of Anemia, although little information about the clinical use of this agent survives today. The distribution of stenbolone acetate did not expand from its original markets, and ultimately enjoyed a relatively short lifespan as a pharmaceutical product. The last commercial preparation containing this ingredient was reportedly withdrawn from market (voluntarily) in the early 1980s.lts demise was likely financially driven, as Anatrofin disappeared at a time when many pharmaceutical manufacturers were dropping their lesser-used anabolic/androgenic steroids. European bodybuilders were disappointed when 157 OH o ~ Stenbolone Anatrofin was removed from the global market a couple of decades ago. Its loss was a hard felt one, very much like the old Primobolan acetate injectables. Old timers often claimed that the likes of this steroid were never replaced with the other popular non-aromatizable anabolics.
</br>
</br> . Whether or not this is based on realistic experience or simple nostalgia remains to be seen. It is difficult today to say how different this agent ultimately is from methenolone or 1-testosterone, close chemical and pharmacological relatives which we have much more modern experience with. Until such time as this agent goes into wide-scale production again, which seems unlikely (at least as a prescription product), the true nature of stenbolone will remain elusive to the modern bodybuilding community. This steroid does, however, remain as an interesting chapter in the history of anabolic steroids. How Supplied: Stenbolone acetate is no longer available as a prescription drug product. When manufactured, it contained 25 mg,50 mg, or 100 mg of steroid per milliliter of oil, packaged in 1 ml glass ampules. Structural Characteristics: Stenbolone is a derivative of dihydrotestosterone. It contains one additional double bond between carbons 1 and 2, and one additional methyl group at carbon 2, which helps to stabilize the 3-keto group and increase the steroid’s anabolic properties. Anatrofin makes use of stenbolone with a carboxylic acid ester (acetic acid) attached to the 17-beta hydroxyl group. Esterified steroids are less polar than free steroids, and are absorbed more slowly from the area of injection. Once in the bloodstream, the ester is removed to yield free (active) stenbolone. Esterified steroids are designed to prolong the window of therapeutic effect following administration, allowing for a less frequent injection schedule compared to injections of free (unesterified) steroid.
</br>
</br> GP still makes this.
</br>
</br>
</br>
</br> Stenbolone is very similar to both dromostanolone and oxymetholone. It is a derivative of DHT with a double bond between carbon 1 and 2 and a methyl group at position 2. The methyl group at position 2 protects the molecule from both aromatization to estrogen and to some degree, inactivation in muscle tissue by 3-alpha hydroxysteroid dehydrogenase. This 2-methyl group does decrease binding to the androgen receptor somewhat. This makes for a molecule that has slightly less binding affinity for the androgen receptor than primobolan but like primobolan, this steroid cannot be converted to estrogenic metabolites through aromatization. Stenbolone is considered by some to be a gentler version of oxymetholone. This steroid has a similar structure to oxymetholone but is not C-17 alpha alkylated so it has minimal effects on liver function. Stenbolone builds up red blood cells like oxymetholone and is metabolized to some degree to dromostanolone which has also been shown to increase red blood cells1,2.
</br>
</br> Stenbolone does not seem to result in as much size gain as anadrol or as much bloat so it likely does not have as much inhibitory activity on 11-beta hydroxylase. Stenbolone tended to be injected daily because of the short half-life of the acetate ester. Additionally, the acetate ester seems to produce pain and swelling at the injection site. Stenbolone has similar androgenic activity compared to 1-testosterone, the unmethylated version of this drug, but with higher anabolic activity. This is likely due to the reduced conversion to 3-alpha hydroxy metabolites. Stenbolone offers many of the advantages of oxymetholone with less bloating and elevated blood pressure.
</br>
</br> William Llewellyn’S ANABDLICS, 9th ed. Anatrofin (stenbolone acetate) Androgenic 115-130 Anabolic 300 Standard Testosterone Chemical Names 2-methyl-Sa-androst-l-en-17b-ol-3-one Estrogenic Activity none Progestational Activity no data available Description: Stenbolone acetate is an injectable anabolic steroid derived from dihydrotestosterone. Stenbolone was actually developed on a 1-testosterone backbone, differing only by the addition of a 2-methyl group. The resulting steroid remains very similar to its non-methylated base, with only modest differences in anabolic and androgenic potency. On the tissue-building side, stenbolone is probably a little weaker on a milligram for milligram basis than 1-testosterone, although it is difficult to make direct comparisons. As an androgen, stenbolone is also probably slightly weaker than 1-testosterone, when you are talking milligram for milligram dose, although the anabolic/androgenic ratio (the more relevant measure) remains very similar. When compared to testosterone, standard assays suggest that stenbolone has roughly three times greater anabolic effect, and somewhere between 150/0 and 30% more androgenic activity. History: Schering AG in Germany introduced stenbolone acetate in 1961.
</br>
</br> Approximately two years later, Syntex would introduce the drug to the United Kingdom, and soon after Mexico, under the brand name Anatrofin. Farmacologico Latino also sold this drug in Spain, under the generic name Stenbolone.397 It was reportedly applied (most commonly) as an injectable alternative to Anadrol in cases of Anemia, although little information about the clinical use of this agent survives today. The distribution of stenbolone acetate did not expand from its original markets, and ultimately enjoyed a relatively short lifespan as a pharmaceutical product. The last commercial preparation containing this ingredient was reportedly withdrawn from market (voluntarily) in the early 1980s.lts demise was likely financially driven, as Anatrofin disappeared at a time when many pharmaceutical manufacturers were dropping their lesser-used anabolic/androgenic steroids. European bodybuilders were disappointed when 157 OH o ~ Stenbolone Anatrofin was removed from the global market a couple of decades ago. Its loss was a hard felt one, very much like the old Primobolan acetate injectables. Old timers often claimed that the likes of this steroid were never replaced with the other popular non-aromatizable anabolics.
</br>
</br> . Whether or not this is based on realistic experience or simple nostalgia remains to be seen. It is difficult today to say how different this agent ultimately is from methenolone or 1-testosterone, close chemical and pharmacological relatives which we have much more modern experience with. Until such time as this agent goes into wide-scale production again, which seems unlikely (at least as a prescription product), the true nature of stenbolone will remain elusive to the modern bodybuilding community. This steroid does, however, remain as an interesting chapter in the history of anabolic steroids. How Supplied: Stenbolone acetate is no longer available as a prescription drug product. When manufactured, it contained 25 mg,50 mg, or 100 mg of steroid per milliliter of oil, packaged in 1 ml glass ampules. Structural Characteristics: Stenbolone is a derivative of dihydrotestosterone. It contains one additional double bond between carbons 1 and 2, and one additional methyl group at carbon 2, which helps to stabilize the 3-keto group and increase the steroid’s anabolic properties. Anatrofin makes use of stenbolone with a carboxylic acid ester (acetic acid) attached to the 17-beta hydroxyl group. Esterified steroids are less polar than free steroids, and are absorbed more slowly from the area of injection. Once in the bloodstream, the ester is removed to yield free (active) stenbolone. Esterified steroids are designed to prolong the window of therapeutic effect following administration, allowing for a less frequent injection schedule compared to injections of free (unesterified) steroid.
</br>
</br> GP still makes this.
</br>
</br>
