Gear101*
New member
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Active Ingredients
Anastrozole (hormone inhibitor)
Mechanism:
Selective non-steroidal aromatase inhibitor, which inhibits the conversion of androstenedione to oestrone, through the aromatase enzyme complex in peripheral tissue where oesrone is subsequently converted to oestradiol.In post-menopausal women, a daily dose of 1mg produced oestradiol suspension of greater than 80%.
Does not possess any progestogenic, androgenic or oestrogenic activity.
Does not have any effect on cortisol or aldosterone secretion, measured before or after standard ACTH challenge testing.
Indications:
Treatment of advanced breast cancer in post-menopausal women.
Efficacy has not been demonstrated in oestrogen receptor negative patients unless they have had a previous positive clinical response to tamoxifen.
Contra-Indications:
Hypersensitive patients.
Pre-menopausal women.
Pregnant/lactating women.
Patients with severe renal impairment (creatinine clearance less than 20ml/min.
Patients with moderate or severe hepatic disease.
Dosage:
Management of overdose:
Symptoms: There is no clinical experience of acxcidental overdosage. In animal studies, anastrozole demonstrated low acute toxicity Clinical trials have been conducted with various dosages of Arimidex* up to 60mg in a single dose given to healthy male volunteers and up to 10mg daily given to post-menopausal women with advanced breast cancer, these dosages were well tolerated. A single dose of Arimidex* that results in life-threatening symptoms has not been established.
Rx: There is no specific antidote to overdose and treatment must be symptomatic.In management of overdose, consideration should be given to the possibility that multiple agents may have been taken. Vomiting may be induced if the patient is alert. Dialysis may be helpful because the drug is not highly protein bound. General supportive care, including frequent monitoring of vital signs and close observation of the patient is indicated.
Kinetics: Absorption of anastrozole is rapid and maximum plasma concentrations occur after two hours of dosing under fasted conditions.Anastrozole is eliinated slowly with plasma elimination half life of 40 - 50 hours.Food decreases the rate but not the extent of absorption.Approximately 90 - 95% of plasma anastrozole steady-state concentrations are attained after 7 daily doses.There is no evidence of time or dose dependency of anastrozole on pharmacokinetic parameters. Anastrozole pharmacokinetics are independant of age in post- menopausal women. Pharmacokinetics have not been studied in children. Anastrozole is only 40% bound to plasma proteins. Anastrozole is extensively metabolised by post-menopausal women with less than 10% of the d se excreted in urine unchanged within 72 hours of dosing.Metabolism occurs by N-dealkylation, hydroxylation and glucuronidation. The metabolites are excreted primarily via the urine.Triazole, a major metabolite in plasma and urine, does not inhibit aromatase.The apparent iral clearance of anastrozole in volunteers with mild, stable hepatic cirrhosis or mild renal impairment was in the range observed in healthy volunteers.
Dose:
1mg orally, daily.
Side-Effects:
Expected effects include: Hot flushes, vaginal dryness, hair thinning.
May also be associated with: Anorexia, nausea, vomiting, diarrhoea, asthenia, somnolence, headache or rash.
Hepatic changes (elevated gamma-GT or alkaline phosphatase) have been reported in patients with advanced breast cancer, many of whom had liver or bone metastases. A casual relationship for these events has not been established.
Thromboembolism, fluid retention, dizziness, vaginal haemorrhage and slight increases in total cholesterol have been observed in clinical trials with Arimidex*.
Precautions:
Not recommended for use in children as safety and efficacy have not been established.
The menopause should be defined biochemically in
....................................................................................
THIS WAS ORIGINALLY WRITTEN AND POSTED BY RIKER29:
How to Measure Liquidex
Liquidex, the liquid sort of "generic" version of Arimidex, is a very concentrated substance, with 4 mg/ml being its rated concentration.
Arimidex is very potent (and not cheap either) and in many cases a person only needs to do like 1/4 mg of it for it to be effective.
But at that concentration,
1/4 mg of Arimidex,
in Liquidex at 4 mg/ml, means that ,
you would need to adminster 1/16 of a ml (cc)!
How the hell do you measure that?
Well, here is what I did.
The formulation of a "drop" of a liquid is actually a fairly controlled and repeatable process. Meaning, if all factors (liquid viscosity, temperature, pressure, etc.) are the same, the amount of liquid in each drop is fairly constant (if the drop is formed around a constant source .... like .... the head of a hollow needle .....).
So, I took a syringe, and sucked up like 3 CCs+ into it.
With an 18 gauge needle on the syringe, I carefully, slowly, pushed down the plunger, ....... and counted each drop ....
And after several trials, with very low amount of "drift" or changes in data, it turns out that ...
Liquidex, through an 18 gauge needle, at room temp, with the needle held stright down, will create 50 drops per ml.
So, extraploating from that (with a slight amount of "rounding" error),
When using Liquidex, take an 18 gauge needle and with the liquid at room temp, and with the needle held straight down,
for 1 mg Arimidex, 1/4 ml of Liquidex, measure 12 drops.
for 1/2 mg of Arimidex, 1/8 ml of Liquidex, measure 6 drops.
for 1/4 mg of Arimidex, 1/16 ml of Liquidex, measure 3 drops.
Hope this helps some people out there.
And for those that were thinking "did this guy WASTE all of that Liquidex?" - not a chance. I "dropped" it into the back end of another syringe, and then placed it back into the vial.
You can recreate this for yourself.
Grab 2 syringes. No, you wont waste any liquidex by doing this.
Remove the plunger from syringe A so that you have access to the back of the syringe cavity.
Use syringe B, and withdraw 3+ cc (ml) of Liquidex (thats a bit MORE than 3 ml).
Now hold syringe A straight up (upright) so that you can "drop" the liquidex into the back of it (the end opposite the needle end).
Now start pushing on the plunger for syringe B, and make sure that the liquidex which drips out falls into the back of the syringe A cavity.
Now as you push down on syringe B, watch how much liquid is in the syringe. When you hit the 3 ml (cc) mark on syringe B, start counting drops. Keep pushing slowly and surely, and keep counting drops.... keep counting until you get to the 1 ml mark on syringe B.
(Why? There are always inaccuracies at the very end and beginning of the syringe-adminstration process. By starting at 3+ ml, you actually get things flowing regularly. By going from the 3 to 1 ml mark, you have a full 2 cc to measure across. But stopping the measuring at the 1 ml mark, you dont deal with the inaccuracies of the end of the syringe cavity).
Now, you just counted how many drops were in 2 ml of liquid. Divide that by 2 (the 3 cc - 1 cc marks) to get the number of drops in 1 ml of liquid.
Now go ahead and push the remainder of the liquidex in syringe B into the back of syringe A - empty syringe B into it. Now, place the needle from syringe A into the liquidex vial, and place the plunger into the top of the syringe, and push the liquidex into the vial.
Hope that helps.
Now by knowing that Liquidex is 4 mg/ml, and now knowing how many drops are in each ml, you can figure out how to administer a specific dose to yourself.
I you cant do the Math, the either you should have paid more attention in math clas, or you are just too dumb to be doing AS anyway.
_________________
Active Ingredients
Anastrozole (hormone inhibitor)
Mechanism:
Selective non-steroidal aromatase inhibitor, which inhibits the conversion of androstenedione to oestrone, through the aromatase enzyme complex in peripheral tissue where oesrone is subsequently converted to oestradiol.In post-menopausal women, a daily dose of 1mg produced oestradiol suspension of greater than 80%.
Does not possess any progestogenic, androgenic or oestrogenic activity.
Does not have any effect on cortisol or aldosterone secretion, measured before or after standard ACTH challenge testing.
Indications:
Treatment of advanced breast cancer in post-menopausal women.
Efficacy has not been demonstrated in oestrogen receptor negative patients unless they have had a previous positive clinical response to tamoxifen.
Contra-Indications:
Hypersensitive patients.
Pre-menopausal women.
Pregnant/lactating women.
Patients with severe renal impairment (creatinine clearance less than 20ml/min.
Patients with moderate or severe hepatic disease.
Dosage:
Management of overdose:
Symptoms: There is no clinical experience of acxcidental overdosage. In animal studies, anastrozole demonstrated low acute toxicity Clinical trials have been conducted with various dosages of Arimidex* up to 60mg in a single dose given to healthy male volunteers and up to 10mg daily given to post-menopausal women with advanced breast cancer, these dosages were well tolerated. A single dose of Arimidex* that results in life-threatening symptoms has not been established.
Rx: There is no specific antidote to overdose and treatment must be symptomatic.In management of overdose, consideration should be given to the possibility that multiple agents may have been taken. Vomiting may be induced if the patient is alert. Dialysis may be helpful because the drug is not highly protein bound. General supportive care, including frequent monitoring of vital signs and close observation of the patient is indicated.
Kinetics: Absorption of anastrozole is rapid and maximum plasma concentrations occur after two hours of dosing under fasted conditions.Anastrozole is eliinated slowly with plasma elimination half life of 40 - 50 hours.Food decreases the rate but not the extent of absorption.Approximately 90 - 95% of plasma anastrozole steady-state concentrations are attained after 7 daily doses.There is no evidence of time or dose dependency of anastrozole on pharmacokinetic parameters. Anastrozole pharmacokinetics are independant of age in post- menopausal women. Pharmacokinetics have not been studied in children. Anastrozole is only 40% bound to plasma proteins. Anastrozole is extensively metabolised by post-menopausal women with less than 10% of the d se excreted in urine unchanged within 72 hours of dosing.Metabolism occurs by N-dealkylation, hydroxylation and glucuronidation. The metabolites are excreted primarily via the urine.Triazole, a major metabolite in plasma and urine, does not inhibit aromatase.The apparent iral clearance of anastrozole in volunteers with mild, stable hepatic cirrhosis or mild renal impairment was in the range observed in healthy volunteers.
Dose:
1mg orally, daily.
Side-Effects:
Expected effects include: Hot flushes, vaginal dryness, hair thinning.
May also be associated with: Anorexia, nausea, vomiting, diarrhoea, asthenia, somnolence, headache or rash.
Hepatic changes (elevated gamma-GT or alkaline phosphatase) have been reported in patients with advanced breast cancer, many of whom had liver or bone metastases. A casual relationship for these events has not been established.
Thromboembolism, fluid retention, dizziness, vaginal haemorrhage and slight increases in total cholesterol have been observed in clinical trials with Arimidex*.
Precautions:
Not recommended for use in children as safety and efficacy have not been established.
The menopause should be defined biochemically in
....................................................................................
THIS WAS ORIGINALLY WRITTEN AND POSTED BY RIKER29:
How to Measure Liquidex
Liquidex, the liquid sort of "generic" version of Arimidex, is a very concentrated substance, with 4 mg/ml being its rated concentration.
Arimidex is very potent (and not cheap either) and in many cases a person only needs to do like 1/4 mg of it for it to be effective.
But at that concentration,
1/4 mg of Arimidex,
in Liquidex at 4 mg/ml, means that ,
you would need to adminster 1/16 of a ml (cc)!
How the hell do you measure that?
Well, here is what I did.
The formulation of a "drop" of a liquid is actually a fairly controlled and repeatable process. Meaning, if all factors (liquid viscosity, temperature, pressure, etc.) are the same, the amount of liquid in each drop is fairly constant (if the drop is formed around a constant source .... like .... the head of a hollow needle .....).
So, I took a syringe, and sucked up like 3 CCs+ into it.
With an 18 gauge needle on the syringe, I carefully, slowly, pushed down the plunger, ....... and counted each drop ....
And after several trials, with very low amount of "drift" or changes in data, it turns out that ...
Liquidex, through an 18 gauge needle, at room temp, with the needle held stright down, will create 50 drops per ml.
So, extraploating from that (with a slight amount of "rounding" error),
When using Liquidex, take an 18 gauge needle and with the liquid at room temp, and with the needle held straight down,
for 1 mg Arimidex, 1/4 ml of Liquidex, measure 12 drops.
for 1/2 mg of Arimidex, 1/8 ml of Liquidex, measure 6 drops.
for 1/4 mg of Arimidex, 1/16 ml of Liquidex, measure 3 drops.
Hope this helps some people out there.
And for those that were thinking "did this guy WASTE all of that Liquidex?" - not a chance. I "dropped" it into the back end of another syringe, and then placed it back into the vial.
You can recreate this for yourself.
Grab 2 syringes. No, you wont waste any liquidex by doing this.
Remove the plunger from syringe A so that you have access to the back of the syringe cavity.
Use syringe B, and withdraw 3+ cc (ml) of Liquidex (thats a bit MORE than 3 ml).
Now hold syringe A straight up (upright) so that you can "drop" the liquidex into the back of it (the end opposite the needle end).
Now start pushing on the plunger for syringe B, and make sure that the liquidex which drips out falls into the back of the syringe A cavity.
Now as you push down on syringe B, watch how much liquid is in the syringe. When you hit the 3 ml (cc) mark on syringe B, start counting drops. Keep pushing slowly and surely, and keep counting drops.... keep counting until you get to the 1 ml mark on syringe B.
(Why? There are always inaccuracies at the very end and beginning of the syringe-adminstration process. By starting at 3+ ml, you actually get things flowing regularly. By going from the 3 to 1 ml mark, you have a full 2 cc to measure across. But stopping the measuring at the 1 ml mark, you dont deal with the inaccuracies of the end of the syringe cavity).
Now, you just counted how many drops were in 2 ml of liquid. Divide that by 2 (the 3 cc - 1 cc marks) to get the number of drops in 1 ml of liquid.
Now go ahead and push the remainder of the liquidex in syringe B into the back of syringe A - empty syringe B into it. Now, place the needle from syringe A into the liquidex vial, and place the plunger into the top of the syringe, and push the liquidex into the vial.
Hope that helps.
Now by knowing that Liquidex is 4 mg/ml, and now knowing how many drops are in each ml, you can figure out how to administer a specific dose to yourself.
I you cant do the Math, the either you should have paid more attention in math clas, or you are just too dumb to be doing AS anyway.
_________________
