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Traditional Growth Hormone and the Rise of GH Peptides – Part 1
by Mike Arnold
No longer considered a novelty item, the use of growth hormone has expanded rapidly over the last decade, taking up residence in the PED programs of BBr’s worldwide. Just a little over 25 years ago acquiring the drug was difficult and even if one could obtain it, the price was far outside the spending limits of most. Although availability skyrocketed in the 90’s, the price remained unreasonable, limiting its use to either the financially blessed or the desperate. Few could afford to include it in their program with any regularity, but by the turn of the century we witnessed a dramatic shift in the illicit GH market. Non-pharmacy grade growth hormone began to proliferate, providing an opportunity for the previously less fortunate to become acquainted with this area of bodybuilding pharmacology.
Although the new millennium opened up widespread access to the drug, the type of growth hormone being offered at affordable prices was of inferior quality compared to the U.S. pharmacy-grade GH used by the former generation. While pharm-grade GH was still available, prices remained out of reach for the ordinary BB’r, forcing many to forgo the luxury of pharmacy grade GH in favor of under-dosed, impure, and often completely bunk Chinese versions of the drug.
By this point the deciding issue had made a full transition from price to quality, changing our entire approach to purchasing GH. Rather than learning how to identify potential fakes as a prerequisite for purchase, GH serum and IGF-1 testing had now become the norm, with entire websites and numerous forums dedicated to discussing which brands of GH had recently tested well. So unstable was the GH market that it had been proposed that over 90% of available GH products were either under-dosed, fake, or contained no active ingredient at all. Today, pharmacy-grade GH still commands a hefty price tag and non-pharm versions are more unreliable than ever.
Fortunately, we are not at a complete loss. In fact, GH peptides can offer us many, and in numerous cases all of the benefits associated with traditional GH. At the dawn of the GH peptide market, there was a lot of uncertainty regarding the ability of these drugs to elevate GH effectively. A poor understanding of how they worked, along with the majority of peptide companies sourcing their raw materials from compromised Chinese sources, and a lack of 3rd party testing just made the situation worse. Therefore, it was not surprising to see a large portion of traditional GH users exhibit reluctance when presented with this new option for increasing GH levels.
But, over the last 10 years a vast amount of clinical and real-world research has been conducted, broadening our understanding of their actions in the human body and revealing to us new and more effective ways of administering these drugs. Equally important, several of the more conscientious peptide companies began sourcing their raw materials from U.S compounding pharmacies, providing us with a level of assurance previously unattainable. Finally, in effort to quiet the last of the doubting Thomas’, the best of these companies began employing 3rd party lab testing, leaving no stone unturned in their quest to provide the most pure & potent peptides available. With the question of product legitimacy out of the way, we are free to see just what these peptides could do.
The first thing most people want to know when contemplating the use of GH peptides is “how do they compare to exogenous GH?” When making this comparison, there are two primary factors we need to address before we can come to any conclusions–total GH release and total time of elevation. While exo GH is fairly consistent, maintaining fairly even blood levels for roughly 12 hours, GH peptides are all over the place, capable of maintaining elevated GH levels for as little as 90 minutes to well over a week with a single injection. In addition, total GH release can vary tremendously, as can the drug release curve, depending on the type or combination of GH peptides used. While this is all relevant information, the purpose of this article is not to provide you with a detailed explanation of the pharmacokinetics of every GH peptide available, but rather, to supply you with a basic working knowledge of these drugs, so that you can use them to help accomplish your goals.
One of the most popular methods of determining GH blood levels is through GH serum testing. Administered so that it corresponds with peak blood levels, exo GH is normally used as a baseline for comparison. With a single bolus of 10 IU, a reading of 25-35 is generally considered normal. To give you an idea of how powerful GH peptides can be, even a single injection of low dose GHRP-2 & ModGRF1-29 (a mid-strength peptide combination) have routinely resulted in readings of 20 or even higher. In the following chart, a direct comparison is made between exo GH and this particular GH peptide combination. The GH peptides were administered 3X per day at a dose of 100 mcg each and are represented by 3 separate spikes, while the exo GH was administered in a single 7 IU bolus and is represented by a single spike. As you can see, just a single GH peptide injection elevated GH levels roughly twice as high as a 7 IU injection of exo GH.
With the GH peptides resulting in such an extreme spike in GH levels, one might expect 3 injections per day to provide results equivalent to a 7 IU injection of exo GH, but this is not the case. In reality, one should expect results similar to about half that dose of GH, but why?
Succinctly put, the short active life of this combo does not keep GH levels elevated long enough with a 3X daily protocol. Don’t get me wrong, 3 IU per day certainly isn’t shabby…and many BB’rs faced with financial limitations do use this dose of exo GH. It is also worth mentioning that 3 IU of exo GH generally costs anywhere from 4-8X as much as an equivalent dose of these peptides, making them the much more cost-effective option. However, regardless of whether one uses exo GH or its equivalent in GH peptides, 3 IU is not going to impart the degree of muscle gain that many associate with growth hormone use. The truth is that GH/GH peptides are only marginally effective as growth enhancers at this dosage. Over time, 3 IU will still build muscle and decrease bodyfat, but progress will be rather slow and fail to yield the degree of improvement provided by higher dosages.
In order to experience BB’ing type results, one must administer bodybuilding type dosages, but before we go further let’s briefly run over some basic points everyone should know about GH peptides. There are two primary classes of GH peptides; the GHRP’s (growth hormone releasing peptides) and the GHRH’s (growth hormone releasing hormone). Both work to elevate GH, albeit through different mechanisms. While the technical info can be interesting, the most important thing to understand about these 2 classes of GH peptides is that they work better when combined. Used simultaneously, a synergy takes place, resulting in greater GH output compared to using them at separate times. For this reason, nearly every competent GH peptide program includes both a GHRP and a GHRH. This effect is clearly demonstrated in the chart below:
As we go over the different types of GH peptides within each respective class, I am going to limit my discussion only to the most popular. As far as the GHRH’s go, the 2 most well known are ModGRF1-29 (some also incorrectly refer to this peptide as CJC-1295 NO-DAC, which technically doesn’t exist) and CJC-1295 WITH-DAC. There are quite a few others as well, some which show significant promise, but at this point, I would estimate that ModGRF1-29 accounts for at least 80% of all GHRH sales, simply because it works so well when combined with the various GHRP’s. The price is also very reasonable.
The primary difference between these two comes down to one simple factor—duration of action. ModGRF1-29 has a relatively short active life of around 20 minutes, while CJC1295 WITH-DAC is more than a week. With this is mind I cannot fault you for thinking that CJC1295 is the superior peptide. If the two were used alone, it would be, but as mentioned earlier, GHRH’s should always be combined with a GHRP for maximum effect. Once we start bringing GHRP’s into the fold, the picture changes considerably. To make a long story short, bloodwork has repeatedly shown that programs which include ModGRF1-29 and a GHRP result in the greatest increases in GH levels. The downside is that one must administer these compounds multiple times daily in order to yield these results. But, with insulin pins being sufficient for delivery, it is not nearly as bad as it sounds.
The true workhorses are the GHRP’s, as decent GH release can be obtained with GHRP’s alone, but the same cannot be said of the GHRHs. The most commonly used GHRP’s are GHRP-2, GHRP-6, Ipamorelin, and Hexarelin. When it comes to impressive test results, these particular GHRP’s are almost always involved.
Traditional Growth Hormone and the Rise of GH Peptides – Part 2
by Mike Arnold
As we delve more into the application side of things here in Part #2, let us begin right where we left off with a description and review of the various GHRP’s. As mentioned in the previous article, GHRPs form the foundation of any successful GH peptide program. They are the workhorses—the prime movers in our march toward supraphysiological GH levels. When the most potent of these are combined with a short-acting GHRH (e.g., ModGRF1-29), the resultant spike in GH is both instantaneous and massive.
However, not all GHRPs are created equal. They differ widely in their ability to affect GH release, appetite, prolactin, cortisol, and even sleep patterns. Some result in rapid desensitization, while others seem to be immune to this effect. Optimal dosing range, total ceiling dose, and ideal injection frequency also vary.
In terms of achieving peak GH levels, Hexarelin is the most potent of the bunch. When paired with the GHRH known as ModGRF1-29, a synergistic effect takes place, further amplifying the resultant GH spike. In order to appreciate Hex’s true potency let’s compare it against a less powerful, although still quite strong GH peptide combination in the form of GHRP-2 & ModGRF1-29. In Part #1 of this article we looked at a graph comparing the GH elevating properties of this combo to that of 7.5 IU of exo GH. Surprisingly, the peak GH level achieved with the peptides was roughly 2X higher than the reading obtained with the exo GH; similar to what would have been witnessed with a 15 IU inject.
When Hexarelin is substituted for GHRP-2 at optimal dosages, the results are even more stunning, with peak GH levels rivaling a 20IU injection of exo GH and in some cases surpassing it. In order of potency, Hexarelin is trailed by GHRP-2, GHRP-6, and finally Ipamorelin, but even though Hex is the most potent in its class, don’t be fooled into thinking that it is the only GHRP worth using. The unique characteristics associated with each of the GHRP’s, their different pharmacodynamic profiles, and diversity in user goals all play a role in constructing the ideal GH peptide program.
If the primary goal is maximizing GH release, including this powerful peptide in your program makes sense, but what is the best way to go about it? The following facts will help point you in the right direction:
The synergistic effect noted with Hexarelin and ModGRF1-29 is lost after repeated administration, resulting in a reduced GH response after just a single injection.
Hexarelin interferes with slow wave sleep; the stage of sleep responsible for cerebral restoration and physical recovery
Hexarelin results in desensitization with twice daily dosing. In one particular study, GH output decreased by roughly 35% after just a single week of treatment and a full 50% decrease was apparent at week 16. 4 weeks post-treatment, sensitivity was fully restored.
Hexarelin results in an increase in prolactin and cortisol when used at doses of 100 mcg/kg and above.
When Hexarelin is dosed at .25 mcg/kg and .50 mcg/kg, the prolactin & cortisol increasing effect is abolished.
When ModGRF1-29, at a dose of 100 mcg, is combined with lower-dose Hexarelin (.25 mcg/kg and .50 mcg/kg), GH levels were increased beyond those achieved with Hexarelin alone at both 100 mcg/kg and 200 mcg/kg, demonstrating an extreme synergistic effect and an ability to increase GH to near maximal levels without an accompanying increase in prolactin or cortisol.
Hexarelin has no affect on appetite.
Hexarelin and GHRP-2 increase prolactin & cortisol similarly.
Taking into consideration the above factors, we can draw some definite conclusions. For one, Hexarelin is probably not best used right before bed. The degree to which Hexarelin negatively impacts slow wave sleep is not fully understood, but even if the negative effects only extend to a single sleep cycle, we are still better off using another GHRP at this time.
Another factor that will dramatically affect how we how we implement Hex into our program is the loss of synergism that occurs between Hex and ModGRF1-29 after repeated administration, as well as the desensitization experienced with extended use. According to clinical research, when Hex is administered just 2X daily, GH output is diminished by 35% after just one week of use. Although this is significant, the good news is that despite this reduction, GH output remains relatively high and stable for the following 4 weeks.
In my opinion, the best way to deal with these flaws is to alternate Hexarelin with a GHRP that lacks this desensitizing effect. For example, by continuing to administer Hex twice daily, but only 3-4 days per week (with GHRP-2 taking up the slack on the other days), one is able to avoid the rapid desensitization that occurs with daily use, while still taking advantage of Hex’s superior GH releasing benefits.
When it comes to the loss of synergism between Hex and ModGRF1-29, a simple fix may not be so easy to find due to a lack of information on the subject. At this juncture, no research has been conducted with the purpose of examining the relationship between dosing intervals and maintaining synergy. The study responsible for demonstrating the loss of synergy with repeated administration limited dosing intervals to a maximum of 120 minutes—hardly sensible. Assuming this research was aimed at increasing our knowledge of potential human application and with the typical person’s waking day lasting about 16 hours, it would have made much more sense to expand the dosing intervals to at least 12 hours.
Unfortunately, the best we can do is speculate when attempting to determine which dosing intervals are required for maintaining synergy, while using anecdotal evidence as a guide. Based on user bloodwork, synergy remains unaffected when using Hex once daily on a 3-4X weekly dosing schedule. However, with such a short half-life, dosing Hex only 3-4X weekly is far from optimal. The good news is that even if synergy is lost, the Hex & ModGRF1-29 combo still provides greater GH elevating effects than the 2nd most potent GH releasing combo; GHRP-2 & modGRF1-29. Therefore, a loss of synergism, although undesirable, really isn’t the main issue—desensitization is. Regardless, it is still wise to try and maximize this synergistic effect.
After evaluating user bloodwork and the behavior of other GHRP’s, it is my opinion that 2X/daily injections administered at least 8-12 hours apart, 3-4 days per week, is reasonable for avoiding desensitization and maintaining peptide synergy. In terms of dosage, 200 mcg/kg is considered a maximum dose and will yield the largest increases in circulating GH when combined with ModGRF1-29. Lower doses, such as .25 mcg/kg and .50 mcg/kg, will still elevate GH levels substantially–beyond what is achieved with a typical GHRP-2 & mod combo, while eliminating the potential for prolactin or cortisol elevation. It is worth noting that the .25 mcg dose is nearly as effective as the .50 mcg dose, increasing GH levels over 90% of those achieved with the .50 mcg dose.
Moving on, let’s address Ipamorelin. Despite being a GHRP just like Hex, Ipamorelin is vastly different in how it affects the body. I will tell you right off the bat that its main downside is its potency. Being markedly weaker than its predecessor, it is not capable of matching Hex, or even GHRP-2, in terms of GH release. However, it possesses a unique set of characteristics which makes its inclusion beneficial under certain circumstances. Here are a few facts on Ipamorelin:
Ipamorelin is the most selective of the GHJRP’s, having no effect on other hormones.
Ipamorelin is the weakest of the GHRP’s in terms of GH release, requiring higher dosages in order to be effective.
Ipamorelin has a long half-life compared to other GHRP’s.
Ipamorelin has no effect on the appetite.
Ipamorelin does not disturb sleep patterns.
The most noteworthy feature of Ipamorelin and the reason it has received so much fanfare is because of its selective nature. Unlike the other GHRP’s, Ipamorelin has no effect on prolactin or cortisol levels, regardless of dose. It also lacks the appetite stimulating effects present with GHRP-6 and GHRP-2, making it ideal for contest dieters or anyone else struggling to limit their food intake.
Most readers will likely be familiar with the hormones prolactin and cortisol, as they hinder the muscle growth & fat loss process. This has caused many to gravitate towards the use of Ipamorelin in a misguided attempt to avoid the negative side effects associated with these hormones. What these individuals frequently fail to realize is that when used at normal dosages, the accompanying rise in cortisol and prolactin is almost insignificant—to the point where levels often remain within the normal range. At lower dosages, this effect is avoided completely. Unless someone is suffering from prolactinemia or excess cortisol levels, this side effect usually isn’t a good enough reason to avoid the other GHRP’s.
Ipamorelin has no effect on sleep patterns, as well as a longer active life in the body compared to the other GHRP’s, making it ideal for pre-bedtime use. Most GH peptides have a short half-life, elevating GH levels for a couple hours at best. In this sense Ipamorelin differentiates itself from the rest of the pack by maintaining elevated GH levels for about twice as long. With most users opting to sleep through the night, this sustained increase in GH allows the user to continue reaping the benefits of growth hormone without needing to resort to middle of the night injections.
In my opinion, Ipamorelin isn’t quite worthy of the attention it has received. From a clinical standpoint I can understand the excitement generated by its selectivity, but when viewed from a BBr’s perspective it doesn’t quite meet expectations in terms of total GH release or IGF-1 elevation. Massive dosages can assist in overcoming its inherently weak nature, but mega-dosing isn’t very cost-effective, especially when other peptide combinations can provide superior results at a mere fraction of the cost. Still, when used at dosages of 500-1,000 mcg and combined with a GHRH, I do see a place for this drug as a pre-bedtime GH releaser. Other than that, unless you have a good reason to be worried about the potential, yet small increases in prolactin & cortisol, I would use other GHRP’s instead. Keep in mind that some will disagree with this statement, but when the primary goal is maximizing GH & IGF-1 levels, I believe my recommendation has merit.
The final two GHRP’s we will take a look at are GHRP-6 and GHRP-2; the first two GHRP’s to hit the market. These drugs are very similar, with the only two notable differences between them. GHRP-2 is a more potent GH releaser, while GHRP-6 is better at boosting the appetite. Other than appetite stimulation, I see no reason to use GHRP-6. Both drugs increase prolactin & cortisol, but like Hexarelin, the increase is small to non-existent (depending on dosage). Both drugs increase appetite and both should be administered in the same fashion and at the same dosages. Really, as far as the BB’r is concerned, there are no major differences between these drugs other than what was already mentioned. For this reason, GHRP-6 is best viewed as nothing more than a weaker version of GHRP-2 with slightly superior appetite stimulating effects.
While my description may have sounded less than favorable regarding these two peptides, GHRP-2 is actually a great drug. As the 2nd strongest GHRP, it does not cause desensitization, even when used at high dosages multiple times daily. This makes GHRP-2 the perfect substitute, allowing the user to maintain high GH levels during Hex off-time.
Typically, GHRP-2 is dosed at no less than 100 mcg, although better results will be achieved with higher dosages. When administering GHRP-2 three times daily and combined with MofGRF1-29, a dose of 100-300 mcg per injection has been proven to provide an increase in GH equivalent to 2.5–4.0 IU of GH daily, as determined by the IGF-1 levels of user bloodwork. In the medical community, IGF-1 testing is the most commonly used method of determining GH levels in the body, so the method is highly reliable.
by Mike Arnold
No longer considered a novelty item, the use of growth hormone has expanded rapidly over the last decade, taking up residence in the PED programs of BBr’s worldwide. Just a little over 25 years ago acquiring the drug was difficult and even if one could obtain it, the price was far outside the spending limits of most. Although availability skyrocketed in the 90’s, the price remained unreasonable, limiting its use to either the financially blessed or the desperate. Few could afford to include it in their program with any regularity, but by the turn of the century we witnessed a dramatic shift in the illicit GH market. Non-pharmacy grade growth hormone began to proliferate, providing an opportunity for the previously less fortunate to become acquainted with this area of bodybuilding pharmacology.
Although the new millennium opened up widespread access to the drug, the type of growth hormone being offered at affordable prices was of inferior quality compared to the U.S. pharmacy-grade GH used by the former generation. While pharm-grade GH was still available, prices remained out of reach for the ordinary BB’r, forcing many to forgo the luxury of pharmacy grade GH in favor of under-dosed, impure, and often completely bunk Chinese versions of the drug.
By this point the deciding issue had made a full transition from price to quality, changing our entire approach to purchasing GH. Rather than learning how to identify potential fakes as a prerequisite for purchase, GH serum and IGF-1 testing had now become the norm, with entire websites and numerous forums dedicated to discussing which brands of GH had recently tested well. So unstable was the GH market that it had been proposed that over 90% of available GH products were either under-dosed, fake, or contained no active ingredient at all. Today, pharmacy-grade GH still commands a hefty price tag and non-pharm versions are more unreliable than ever.
Fortunately, we are not at a complete loss. In fact, GH peptides can offer us many, and in numerous cases all of the benefits associated with traditional GH. At the dawn of the GH peptide market, there was a lot of uncertainty regarding the ability of these drugs to elevate GH effectively. A poor understanding of how they worked, along with the majority of peptide companies sourcing their raw materials from compromised Chinese sources, and a lack of 3rd party testing just made the situation worse. Therefore, it was not surprising to see a large portion of traditional GH users exhibit reluctance when presented with this new option for increasing GH levels.
But, over the last 10 years a vast amount of clinical and real-world research has been conducted, broadening our understanding of their actions in the human body and revealing to us new and more effective ways of administering these drugs. Equally important, several of the more conscientious peptide companies began sourcing their raw materials from U.S compounding pharmacies, providing us with a level of assurance previously unattainable. Finally, in effort to quiet the last of the doubting Thomas’, the best of these companies began employing 3rd party lab testing, leaving no stone unturned in their quest to provide the most pure & potent peptides available. With the question of product legitimacy out of the way, we are free to see just what these peptides could do.
The first thing most people want to know when contemplating the use of GH peptides is “how do they compare to exogenous GH?” When making this comparison, there are two primary factors we need to address before we can come to any conclusions–total GH release and total time of elevation. While exo GH is fairly consistent, maintaining fairly even blood levels for roughly 12 hours, GH peptides are all over the place, capable of maintaining elevated GH levels for as little as 90 minutes to well over a week with a single injection. In addition, total GH release can vary tremendously, as can the drug release curve, depending on the type or combination of GH peptides used. While this is all relevant information, the purpose of this article is not to provide you with a detailed explanation of the pharmacokinetics of every GH peptide available, but rather, to supply you with a basic working knowledge of these drugs, so that you can use them to help accomplish your goals.
One of the most popular methods of determining GH blood levels is through GH serum testing. Administered so that it corresponds with peak blood levels, exo GH is normally used as a baseline for comparison. With a single bolus of 10 IU, a reading of 25-35 is generally considered normal. To give you an idea of how powerful GH peptides can be, even a single injection of low dose GHRP-2 & ModGRF1-29 (a mid-strength peptide combination) have routinely resulted in readings of 20 or even higher. In the following chart, a direct comparison is made between exo GH and this particular GH peptide combination. The GH peptides were administered 3X per day at a dose of 100 mcg each and are represented by 3 separate spikes, while the exo GH was administered in a single 7 IU bolus and is represented by a single spike. As you can see, just a single GH peptide injection elevated GH levels roughly twice as high as a 7 IU injection of exo GH.
With the GH peptides resulting in such an extreme spike in GH levels, one might expect 3 injections per day to provide results equivalent to a 7 IU injection of exo GH, but this is not the case. In reality, one should expect results similar to about half that dose of GH, but why?
Succinctly put, the short active life of this combo does not keep GH levels elevated long enough with a 3X daily protocol. Don’t get me wrong, 3 IU per day certainly isn’t shabby…and many BB’rs faced with financial limitations do use this dose of exo GH. It is also worth mentioning that 3 IU of exo GH generally costs anywhere from 4-8X as much as an equivalent dose of these peptides, making them the much more cost-effective option. However, regardless of whether one uses exo GH or its equivalent in GH peptides, 3 IU is not going to impart the degree of muscle gain that many associate with growth hormone use. The truth is that GH/GH peptides are only marginally effective as growth enhancers at this dosage. Over time, 3 IU will still build muscle and decrease bodyfat, but progress will be rather slow and fail to yield the degree of improvement provided by higher dosages.
In order to experience BB’ing type results, one must administer bodybuilding type dosages, but before we go further let’s briefly run over some basic points everyone should know about GH peptides. There are two primary classes of GH peptides; the GHRP’s (growth hormone releasing peptides) and the GHRH’s (growth hormone releasing hormone). Both work to elevate GH, albeit through different mechanisms. While the technical info can be interesting, the most important thing to understand about these 2 classes of GH peptides is that they work better when combined. Used simultaneously, a synergy takes place, resulting in greater GH output compared to using them at separate times. For this reason, nearly every competent GH peptide program includes both a GHRP and a GHRH. This effect is clearly demonstrated in the chart below:
As we go over the different types of GH peptides within each respective class, I am going to limit my discussion only to the most popular. As far as the GHRH’s go, the 2 most well known are ModGRF1-29 (some also incorrectly refer to this peptide as CJC-1295 NO-DAC, which technically doesn’t exist) and CJC-1295 WITH-DAC. There are quite a few others as well, some which show significant promise, but at this point, I would estimate that ModGRF1-29 accounts for at least 80% of all GHRH sales, simply because it works so well when combined with the various GHRP’s. The price is also very reasonable.
The primary difference between these two comes down to one simple factor—duration of action. ModGRF1-29 has a relatively short active life of around 20 minutes, while CJC1295 WITH-DAC is more than a week. With this is mind I cannot fault you for thinking that CJC1295 is the superior peptide. If the two were used alone, it would be, but as mentioned earlier, GHRH’s should always be combined with a GHRP for maximum effect. Once we start bringing GHRP’s into the fold, the picture changes considerably. To make a long story short, bloodwork has repeatedly shown that programs which include ModGRF1-29 and a GHRP result in the greatest increases in GH levels. The downside is that one must administer these compounds multiple times daily in order to yield these results. But, with insulin pins being sufficient for delivery, it is not nearly as bad as it sounds.
The true workhorses are the GHRP’s, as decent GH release can be obtained with GHRP’s alone, but the same cannot be said of the GHRHs. The most commonly used GHRP’s are GHRP-2, GHRP-6, Ipamorelin, and Hexarelin. When it comes to impressive test results, these particular GHRP’s are almost always involved.
Traditional Growth Hormone and the Rise of GH Peptides – Part 2
by Mike Arnold
As we delve more into the application side of things here in Part #2, let us begin right where we left off with a description and review of the various GHRP’s. As mentioned in the previous article, GHRPs form the foundation of any successful GH peptide program. They are the workhorses—the prime movers in our march toward supraphysiological GH levels. When the most potent of these are combined with a short-acting GHRH (e.g., ModGRF1-29), the resultant spike in GH is both instantaneous and massive.
However, not all GHRPs are created equal. They differ widely in their ability to affect GH release, appetite, prolactin, cortisol, and even sleep patterns. Some result in rapid desensitization, while others seem to be immune to this effect. Optimal dosing range, total ceiling dose, and ideal injection frequency also vary.
In terms of achieving peak GH levels, Hexarelin is the most potent of the bunch. When paired with the GHRH known as ModGRF1-29, a synergistic effect takes place, further amplifying the resultant GH spike. In order to appreciate Hex’s true potency let’s compare it against a less powerful, although still quite strong GH peptide combination in the form of GHRP-2 & ModGRF1-29. In Part #1 of this article we looked at a graph comparing the GH elevating properties of this combo to that of 7.5 IU of exo GH. Surprisingly, the peak GH level achieved with the peptides was roughly 2X higher than the reading obtained with the exo GH; similar to what would have been witnessed with a 15 IU inject.
When Hexarelin is substituted for GHRP-2 at optimal dosages, the results are even more stunning, with peak GH levels rivaling a 20IU injection of exo GH and in some cases surpassing it. In order of potency, Hexarelin is trailed by GHRP-2, GHRP-6, and finally Ipamorelin, but even though Hex is the most potent in its class, don’t be fooled into thinking that it is the only GHRP worth using. The unique characteristics associated with each of the GHRP’s, their different pharmacodynamic profiles, and diversity in user goals all play a role in constructing the ideal GH peptide program.
If the primary goal is maximizing GH release, including this powerful peptide in your program makes sense, but what is the best way to go about it? The following facts will help point you in the right direction:
The synergistic effect noted with Hexarelin and ModGRF1-29 is lost after repeated administration, resulting in a reduced GH response after just a single injection.
Hexarelin interferes with slow wave sleep; the stage of sleep responsible for cerebral restoration and physical recovery
Hexarelin results in desensitization with twice daily dosing. In one particular study, GH output decreased by roughly 35% after just a single week of treatment and a full 50% decrease was apparent at week 16. 4 weeks post-treatment, sensitivity was fully restored.
Hexarelin results in an increase in prolactin and cortisol when used at doses of 100 mcg/kg and above.
When Hexarelin is dosed at .25 mcg/kg and .50 mcg/kg, the prolactin & cortisol increasing effect is abolished.
When ModGRF1-29, at a dose of 100 mcg, is combined with lower-dose Hexarelin (.25 mcg/kg and .50 mcg/kg), GH levels were increased beyond those achieved with Hexarelin alone at both 100 mcg/kg and 200 mcg/kg, demonstrating an extreme synergistic effect and an ability to increase GH to near maximal levels without an accompanying increase in prolactin or cortisol.
Hexarelin has no affect on appetite.
Hexarelin and GHRP-2 increase prolactin & cortisol similarly.
Taking into consideration the above factors, we can draw some definite conclusions. For one, Hexarelin is probably not best used right before bed. The degree to which Hexarelin negatively impacts slow wave sleep is not fully understood, but even if the negative effects only extend to a single sleep cycle, we are still better off using another GHRP at this time.
Another factor that will dramatically affect how we how we implement Hex into our program is the loss of synergism that occurs between Hex and ModGRF1-29 after repeated administration, as well as the desensitization experienced with extended use. According to clinical research, when Hex is administered just 2X daily, GH output is diminished by 35% after just one week of use. Although this is significant, the good news is that despite this reduction, GH output remains relatively high and stable for the following 4 weeks.
In my opinion, the best way to deal with these flaws is to alternate Hexarelin with a GHRP that lacks this desensitizing effect. For example, by continuing to administer Hex twice daily, but only 3-4 days per week (with GHRP-2 taking up the slack on the other days), one is able to avoid the rapid desensitization that occurs with daily use, while still taking advantage of Hex’s superior GH releasing benefits.
When it comes to the loss of synergism between Hex and ModGRF1-29, a simple fix may not be so easy to find due to a lack of information on the subject. At this juncture, no research has been conducted with the purpose of examining the relationship between dosing intervals and maintaining synergy. The study responsible for demonstrating the loss of synergy with repeated administration limited dosing intervals to a maximum of 120 minutes—hardly sensible. Assuming this research was aimed at increasing our knowledge of potential human application and with the typical person’s waking day lasting about 16 hours, it would have made much more sense to expand the dosing intervals to at least 12 hours.
Unfortunately, the best we can do is speculate when attempting to determine which dosing intervals are required for maintaining synergy, while using anecdotal evidence as a guide. Based on user bloodwork, synergy remains unaffected when using Hex once daily on a 3-4X weekly dosing schedule. However, with such a short half-life, dosing Hex only 3-4X weekly is far from optimal. The good news is that even if synergy is lost, the Hex & ModGRF1-29 combo still provides greater GH elevating effects than the 2nd most potent GH releasing combo; GHRP-2 & modGRF1-29. Therefore, a loss of synergism, although undesirable, really isn’t the main issue—desensitization is. Regardless, it is still wise to try and maximize this synergistic effect.
After evaluating user bloodwork and the behavior of other GHRP’s, it is my opinion that 2X/daily injections administered at least 8-12 hours apart, 3-4 days per week, is reasonable for avoiding desensitization and maintaining peptide synergy. In terms of dosage, 200 mcg/kg is considered a maximum dose and will yield the largest increases in circulating GH when combined with ModGRF1-29. Lower doses, such as .25 mcg/kg and .50 mcg/kg, will still elevate GH levels substantially–beyond what is achieved with a typical GHRP-2 & mod combo, while eliminating the potential for prolactin or cortisol elevation. It is worth noting that the .25 mcg dose is nearly as effective as the .50 mcg dose, increasing GH levels over 90% of those achieved with the .50 mcg dose.
Moving on, let’s address Ipamorelin. Despite being a GHRP just like Hex, Ipamorelin is vastly different in how it affects the body. I will tell you right off the bat that its main downside is its potency. Being markedly weaker than its predecessor, it is not capable of matching Hex, or even GHRP-2, in terms of GH release. However, it possesses a unique set of characteristics which makes its inclusion beneficial under certain circumstances. Here are a few facts on Ipamorelin:
Ipamorelin is the most selective of the GHJRP’s, having no effect on other hormones.
Ipamorelin is the weakest of the GHRP’s in terms of GH release, requiring higher dosages in order to be effective.
Ipamorelin has a long half-life compared to other GHRP’s.
Ipamorelin has no effect on the appetite.
Ipamorelin does not disturb sleep patterns.
The most noteworthy feature of Ipamorelin and the reason it has received so much fanfare is because of its selective nature. Unlike the other GHRP’s, Ipamorelin has no effect on prolactin or cortisol levels, regardless of dose. It also lacks the appetite stimulating effects present with GHRP-6 and GHRP-2, making it ideal for contest dieters or anyone else struggling to limit their food intake.
Most readers will likely be familiar with the hormones prolactin and cortisol, as they hinder the muscle growth & fat loss process. This has caused many to gravitate towards the use of Ipamorelin in a misguided attempt to avoid the negative side effects associated with these hormones. What these individuals frequently fail to realize is that when used at normal dosages, the accompanying rise in cortisol and prolactin is almost insignificant—to the point where levels often remain within the normal range. At lower dosages, this effect is avoided completely. Unless someone is suffering from prolactinemia or excess cortisol levels, this side effect usually isn’t a good enough reason to avoid the other GHRP’s.
Ipamorelin has no effect on sleep patterns, as well as a longer active life in the body compared to the other GHRP’s, making it ideal for pre-bedtime use. Most GH peptides have a short half-life, elevating GH levels for a couple hours at best. In this sense Ipamorelin differentiates itself from the rest of the pack by maintaining elevated GH levels for about twice as long. With most users opting to sleep through the night, this sustained increase in GH allows the user to continue reaping the benefits of growth hormone without needing to resort to middle of the night injections.
In my opinion, Ipamorelin isn’t quite worthy of the attention it has received. From a clinical standpoint I can understand the excitement generated by its selectivity, but when viewed from a BBr’s perspective it doesn’t quite meet expectations in terms of total GH release or IGF-1 elevation. Massive dosages can assist in overcoming its inherently weak nature, but mega-dosing isn’t very cost-effective, especially when other peptide combinations can provide superior results at a mere fraction of the cost. Still, when used at dosages of 500-1,000 mcg and combined with a GHRH, I do see a place for this drug as a pre-bedtime GH releaser. Other than that, unless you have a good reason to be worried about the potential, yet small increases in prolactin & cortisol, I would use other GHRP’s instead. Keep in mind that some will disagree with this statement, but when the primary goal is maximizing GH & IGF-1 levels, I believe my recommendation has merit.
The final two GHRP’s we will take a look at are GHRP-6 and GHRP-2; the first two GHRP’s to hit the market. These drugs are very similar, with the only two notable differences between them. GHRP-2 is a more potent GH releaser, while GHRP-6 is better at boosting the appetite. Other than appetite stimulation, I see no reason to use GHRP-6. Both drugs increase prolactin & cortisol, but like Hexarelin, the increase is small to non-existent (depending on dosage). Both drugs increase appetite and both should be administered in the same fashion and at the same dosages. Really, as far as the BB’r is concerned, there are no major differences between these drugs other than what was already mentioned. For this reason, GHRP-6 is best viewed as nothing more than a weaker version of GHRP-2 with slightly superior appetite stimulating effects.
While my description may have sounded less than favorable regarding these two peptides, GHRP-2 is actually a great drug. As the 2nd strongest GHRP, it does not cause desensitization, even when used at high dosages multiple times daily. This makes GHRP-2 the perfect substitute, allowing the user to maintain high GH levels during Hex off-time.
Typically, GHRP-2 is dosed at no less than 100 mcg, although better results will be achieved with higher dosages. When administering GHRP-2 three times daily and combined with MofGRF1-29, a dose of 100-300 mcg per injection has been proven to provide an increase in GH equivalent to 2.5–4.0 IU of GH daily, as determined by the IGF-1 levels of user bloodwork. In the medical community, IGF-1 testing is the most commonly used method of determining GH levels in the body, so the method is highly reliable.
