Catapres (Clonidine HCL) profile and use in sports to counter blood pressure issues

akn · May 28, 2014

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Clonidine is a centrally acting alpha-agonist hypotensive
agent. It is most commonly prepared as a hydrochloride salt
for use in tablets and capsules, although it is also supplied in
oral liquids, injectable solutions, and transdermal patches.
Clonidine stimulates alpha-adrenoceptors in the brain, which
reduces sympathetic outflow from the central nervous system.
This decreases the heart rate, and relaxes the blood vessels

so that blood is allowed to flow more easily. Clonidine is
widely prescribed for the treatment of hypertension
(abnormally high blood pressure), which can have serious
health implications if left untreated. Bodybuilders typically
use this drug for the same purpose, namely to counter blood
pressure elevations caused by anabolic/androgenic steroid
use. Clonidine is also commonly prescribed for off-label
purposes including the treatment of alcohol, opiate, and
nicotine addiction, menopause symptoms, diabetic diarrhea
and neuropathy (nerve damage), and ulcerative colitis.
Clinical studies show that clonidine can also produce a
significant increase in the serum growth hormone level. This
occurs via stimulation of hypothalamic GHRH (Growth
Hormone Releasing Hormone) release, which in turn
supports the secretion of growth hormone from the
pituitary.745 Given the known anabolic properties of growth
hormone, clonidine is sometimes specifically chosen by
bodybuilders (when a blood pressure medication is needed)
because of its perceived added metabolic benefits.
Realistically, however, this drug is rarely reported to
produce performance or body composition improvements.
This may be due to its effects on GH being short lived.
Studies suggest that in many patients, clonidine will not
result in sustained increases in GH with continued daily
use.746 747 The prescribing literature even warns that its GH
elevating properties are acute, and do not result in chronic
elevations with long-term use. Clonidine may be of value for
blood pressure management or other off-label purposes, but
at the present time it is not widely accepted as a GH
stimulating drug for bodybuilders.
Oral clonidine is considered a fast acting medication. Its
blood pressure lowering effects are typically noticed within
30 to 60 minutes after ingestion. Peak blood levels are
achieved within 3-5 hours after administration, and the drug
is metabolized with a half-life of approximately 12-16 hours.
Given the short acting nature of the drug, clonidine is usually
administered at least twice per day in order to maintain
therapeutically effective blood levels. Food does not appear
to influence the pharmacokinetics of clonidine.
The absorption of clonidine from transdermal patches may be
significantly delayed in comparison to oral tablets, and may
take 2-3 days before peak blood levels are achieved.
Tolerance to the blood pressure lowering effects of clonidine
may develop over time. It may be necessary to periodically
reevaluate the dosage during prolonged therapy. Clonidine
may be used alone, but is also commonly combined with a
second antihypertensive agent when a stronger bloodpressure
lowering effect is required.
History:
Clonidine first appeared in clinical studies during the late
1960s,748 and was approved by the U.S. Food and Drug
Administration for prescription sale in 1974.749 Over the
years, its favorable safety profile and level of efficacy have
allowed it to become a somewhat common first-line option
for the treatment of hypertension. The most widely known
trade name for clonidine is Catapres, sold in many different
countries by the international pharmaceutical manufacturer
Boehringer-Ingelheim. In the United States, clonidine
products are also available through many generic drug
manufacturers including Actavis, Bertek, Global, Mutual,
Mylan, Par, Qualitest, UDL Laboratories, Unichem, and
Xanodyne.
How Supplied:
Clonidine hydrochloride is most commonly supplied in oral
tablets of 0.1, 0.2, and 0.3 mg each.
Structural Characteristics:
Clonidine is an alpha-agonist hypotensive agent derived
Clonidine is an alpha-agonist hypotensive agent derived
from imidazoline. It has the chemical designation 2,6-
dichloro-N-2-imidazolidinyldenebenzenamine.
Warnings:
Abrupt discontinuation of clonidine may result in side effects
including rebound hypertension, nervousness, agitation,
headache, and/or tremor. In rare instances clonidine
withdrawal has been associated with serious
cerebrovascular accident and even death. Patients should not
discontinue clonidine treatment without consulting their
physician. When discontinuing clonidine, it is usually
advised to slowly reduce the dosage over a minimum period
of 2-4 days to reduce withdrawal symptoms.
Side Effects:
Common side effects associated with clonidine treatment
include dry mouth (40% of patients during clinical studies),
drowsiness (33%), dizziness (16%), constipation (10%), and
sedation (10%). Less frequent adverse reactions include
physical fatigue, fever, increased sensitivity to alcohol,
abnormal heart beat, congestive heart failure, delirium,
insomnia, nightmares, paraesthesia (tingling of the skin), hair
loss, rash, abdominal pain, anorexia, hepatitis, vomiting,
decreased libido, erectile dysfunction, frequent waking to
urinate during the night (nocturia), leg cramps, muscle pain,
blurred vision, and dryness or burning of the eyes. Some side
effects appear to be dose-dependant. Taking more than the
prescribed amount (overdosage) may result in serious
adverse reactions including hypotension (low blood
pressure), respiratory depression, impaired motor reflexes,
weakness, drowsiness, hypothermia, heart irregularities,
coma, or death.
Administration:
When used medically to treat hypertension, the dosage must
be tailored to the individual needs of the patient. The usual
initial starting dosage in adults is .1 mg given twice daily,
morning and evening (.2 mg per day). This dosage may be
increased once per week by .1 mg/day until the proper
maintenance dosage is achieved. An effective therapeutic
maintenance dosage usually rests between .2 mg and .6 mg
per day, although a small percentage of patients require
significantly higher amounts (2.4 mg/day is considered the
maximum therapeutic dosage).When used by bodybuilders to
offset elevated blood pressure due to anabolic/androgenic
steroid use, therapeutic use guidelines are usually followed.
Some users will initiate clonidine at sub-therapeutic dosages

(.1 mg per day) if they are unsure of their responsiveness to
the drug, or their relative need for a hypotensive agent.
Individuals should be reminded that it is important to monitor
blood pressure closely whenever taking any medications that
can have hypertensive or hypotensive effects.
Availability Trends:
Clonidine is widely sold throughout the developed world.
Low demand, low cost, and high availability make this drug
a low-profit target for counterfeiting. Counterfeits are
unlikely to be a significant problem.

By William Llewellyn

Presser · May 29, 2014

good post once again brutha! Your killing it here with solid info that I haven't read before! thanks!

HackTwat · May 29, 2014

Presser said:
good post once again brutha! Your killing it here with solid info that I haven't read before! thanks!

I was thinking that very thing when I read this last night. I have a bottle of these to take in the event my BP gets out of control and needs to come down rapidly. Last time I was taking Tren my BP went up to 188/136 and I was very glad to have these. My BP is always pretty jacked up, but Tren really fucks with it BAD!!

Presser · May 29, 2014

Are these in the "valium" family?

HackTwat · May 29, 2014

You know, I'm not exactly sure. This particular medicine has a wide range of use. Blood pressure as well as anti anxiety. Some Pediatricians even use it to counteract the effects of ADHD medicine of the evening to help kids go to sleep after being "sped" up all day on Adderall or whatever. Kinda seems like an oxy moron to me though. Give em something that speeds them up and then something else to slow them down. Whatever works I guess. lol

csuperman · May 29, 2014

Presser said:
Are these in the "valium" family?

NO,

in addition if you start taking this medication, there can be major rebound hypertension if you randomly stop after using it for a while.

Catapres (Clonidine HCL) profile and use in sports to counter blood pressure issues

akn

Musclechemistry Member

Presser

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HackTwat

MuscleChemistry Registered Member

Presser

Admin

HackTwat

MuscleChemistry Registered Member

csuperman

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