Lipostabil N (phosphatidylcholine/sodium deoxycholate) Fatloss Agent Profile

akn · Jun 1, 2014

<!--[if gte mso 9]><xml> <w:WordDocument> <w:View>Normal</w:View> <w:Zoom>0</w:Zoom> <w:TrackMoves/> <w:TrackFormatting/> <w

unctuationKerning/> <w:ValidateAgainstSchemas/> <w:SaveIfXMLInvalid>false</w:SaveIfXMLInvalid> <w:IgnoreMixedContent>false</w:IgnoreMixedContent> <w:AlwaysShowPlaceholderText>false</w:AlwaysShowPlaceholderText> <w

oNotPromoteQF/> <w:LidThemeOther>EN-US</w:LidThemeOther> <w:LidThemeAsian>X-NONE</w:LidThemeAsian> <w:LidThemeComplexScript>X-NONE</w:LidThemeComplexScript> <w:Compatibility> <w:BreakWrappedTables/> <w:SnapToGridInCell/> <w:WrapTextWithPunct/> <w:UseAsianBreakRules/> <w

ontGrowAutofit/> <w:SplitPgBreakAndParaMark/> <w

ontVertAlignCellWithSp/> <w

ontBreakConstrainedForcedTables/> <w

ontVertAlignInTxbx/> <w:Word11KerningPairs/> <w:CachedColBalance/> <w:UseFELayout/> </w:Compatibility> <w

oNotOptimizeForBrowser/> <m:mathPr> <m:mathFont m:val="Cambria Math"/> <m:brkBin m:val="before"/> <m:brkBinSub m:val="--"/> <m:smallFrac m:val="off"/> <m:dispDef/> <m:lMargin m:val="0"/> <m:rMargin m:val="0"/> <m:defJc m:val="centerGroup"/> <m:wrapIndent m:val="1440"/> <m:intLim m:val="subSup"/> <m:naryLim m:val="undOvr"/> </m:mathPr></w:WordDocument> </xml><![endif]--> Description:
Lipostabil N is an injectable medication that contains
phosphatidylcholine (PPC), a natural phospholipid. Sodium
deoxycholate (a bile salt) is also added (among other
ingredients) to solubilize PPC in water. It was originally
developed as an intravenous solution for the improvement of
serum lipids, reduction of arterial plaque, improving liver
values, and the prevention or treatment of blood vessel
blockages by fat particles (fat embolism). It is approved as
an intravenous drug in a number of countries, mainly in
Europe. Lipostabil has also had a very popular off-label use
over the past several years, namely as a localized fat loss
agent. Clinics in many areas of the world including Brazil,
Europe, and the United States have actually marketed this as
a nonsurgical alternative to liposuction. In recent years,
bodybuilders have been paying some attention to this drug as
well, using it as a cutting or finishing agent.
The mechanism behind Lipostabil’s lipolytic (fat loss
promoting) effect is unique. Upon injection, the solution acts
as a detergent, causing nonspecific lysis (breakdown) of cell
membranes.698 The bile salt sodium deoxycholate is actually
believed to play an important role here, and is therefore
considered an active constituent of Lipostabil for the context
of this profile (it is normally considered an inactive
ingredient). During this process the fatty acids stored in the
cell membrane are released, which includes arachidonic
acid. This will trigger the inflammatory cascade, benefiting
lipolysis (the inflammatory system can be a powerful
remodeler of body composition) but also causing unwelcome
pain and swelling. Phosphatidylcholine itself also triggers
the release of lipases used in the removal of fat.699 All of this
works together to dismantle localized fat stores, which are
removed via the liver in the form of gall acids.
History:
Lipostabil first appeared as a medication during the 1950s.
Although not approved for prescription use in the U.S., it is
approved for medical use in a number of other countries. The
most popular brand name is Lipostabil N by Nattermann,
although it is also found as Lipostabil Forte and simply as
Lipostabil.The application of this drug for fat loss is
generally viewed as an “off-label” use of the medication,
although it undoubtedly remains a highly popular factor in its
sales. Some doctors do believe that using Lipostabil for
cosmetic purposes is controversial, and advise against using
it for cosmetic reasons.When you look at the available data,
however, its safety profile appears to be admittedly very
high. Lipostabil has been widely used as an intravenous drug
for more than 40 years, and has displayed very few clinically
significant side effects during that time. Injecting the same
drug subcutaneously is not likely to present any significant
new or serious risks to the patient.
Network Lipolysis (an organization of some 350 doctors
worldwide that supports this use of Lipostabil) reports over
18,000 cosmetic treatments without unexpected adverse
events. Additionally, Dr. Hasengschwandtner, the medical
director of the Austrian clinic Therapy Centre Bad
Loefelden, has reported on bilirubin and gamma glutamyl
transferases (markers of liver stress) values after
subcutaneous Lipostabil use,700 to see if this new method of
fat remodeling is causing liver strain. The results were in
line with IV use, showing no abnormal change in these
values. Although we do not have a great deal of data on this
off-label use of Lipostabil, what can be found is generally
very positive, and suggests this drug (or natural drug, if you
will) is quite safe. Lipostabil is presently sold in Germany,
Spain, Italy, Czech Republic, Hong Kong, and South Africa
How Supplied:
Lipostabil is most commonly supplied in injectable ampules
containing 5 mL of solution each.
Structural Characteristics:
The primary active ingredients in Lipostabil are
phosphatidylcholine (phosphatidyl-Nt-rimethylethanolamine)
and sodium deoxycholate (cholan-24-oic acid, 3,12-
dihydroxy-, monosodium salt).
Side Effects:
Potential side effects associated with subcutaneous
Lipostabil injections include localized swelling, redness of
the skin, burning, pain, tenderness, and bruising. Systemic
side effects are reported in approximately 3% of users and
may include diarrhea, nausea, dizziness, and intermenstrual
bleeding.701
Administration:
The typical practice for using this drug to promote localized
fat loss involves a series of subcutaneous injections. A total
dosage of 1250-2500 mg is often used, which equates to 25-
50 mL of injectable solution. This dosage is divided into 20
or more separate smaller injections. These are spaced
throughout the problematic area (quite commonly the
abdominals or thighs), and are all given during the same
office visit or application period. The drug is not
administered on a daily basis.
Lipostabil injections usually cause a significant amount of
inflammation in the area, which may take a week or longer to
fully subside. When the inflammation does subside, however,
it usually unveils a noticeable amount of fat loss. In a clinical
setting, this procedure is often repeated a few times, so as to
sculpt the area and achieve the desired level of fat reduction.
The current guidelines set forth by Network Lipolysis call
for an 8-week break between treatment periods. When taken
outside of a clinical setting, it is usually advised to apply the
first course at a much lower dosage in order to judge
individual sensitivity to the drug. Some find it simply too
painful to use, while others seem to tolerate the whole
procedure extremely well.
As for the ultimate question of how well it works, it is
difficult to give exact numbers, as few clinical studies have
been conducted on this use of the drug. The anecdotal
feedback is mixed. Many people who try it report positive
results, particularly for the removal of those last stubborn
areas of fat interfering with muscle definition. There do not
seem to be many reports of dramatic weight loss, however,
nor does it seem to be the “pharmaceutical liposuction” that
some clinics describe it to be. Regardless, the reports of
visible improvements in fat loss and muscle definition are
consistent and compelling enough to be given credit. For
those extremely overweight, this product is not likely to
perform well, but as a finishing touch it may hold value.
Availability:
Lipostabil is not a controlled drug in the U.S. or Europe, and
as such is fairly easy to obtain on the black market or via
mail order drug distributors. “Mesotherapy” clinics selling
procedures with Lipostabil are also fairly common.

By WILLIAM LLEWELLYN

Presser · Jun 2, 2014

yeah we use to sell this stuff abut 13 years ago here lol, got it from Brazil and people loved it who used it properly

akn · Jun 2, 2014

0hh brazil i would love to go there ,not for lipostabil though

lol

Lipostabil N (phosphatidylcholine/sodium deoxycholate) Fatloss Agent Profile

akn

Musclechemistry Member

Presser

Admin

akn

Musclechemistry Member

Similar threads