Dynabol® (nandrolone cypionate) anabolic steroid profile and use in mass building

akn · Jun 12, 2014

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Nandrolone cypionate is an injectable form of the anabolic
steroid nandrolone. This ester provides a pattern of hormone
release virtually identical to that of testosterone cypionate,
with peak levels of drug being noted approximately 24-48
hours after administration, and a substantial hormone release
sustained for about weeks. In this case the active hormone is
nandrolone, which is a moderately strong anabolic steroid
that carries mild estrogenic and androgenic properties. This
product is essentially identical in overall effect to Deca-
Durabolin® (nandrolone decanoate), producing measurable
gains in strength and lean muscle mass, which tend to be
accompanied by a low level of side effects.The one point of
difference is that nandrolone cypionate may appear to be a
faster-acting compound to some users. Otherwise, there is no
discernable difference between the two compounds, and
nandrolone cypionate could replace nandrolone decanoate in
virtually all cycles.
History:
Nandrolone cypionate was first developed during the 1960’s.
It was sold for a brief time as a human-use pharmaceutical,
under such brand names as Anabo, Depo-Nortestonate,
Nortestrionate, and Sterocrinolo. Such preparations did not
last, however, and in recent years the drug has been
available only as a product of veterinary medicine. The most
notable appearance has come from Jurox in Australia, which
marketed a 50 mg/mL version of the drug called Dynabol 50.
Jurox also included nandrolone cypionate as part of an
anabolic steroid blend called Nandrabolin. Both products,
however, were discontinued in 2001, when Jurox scaled
back its steroid line.This was likely done in response to
media criticisms of heavy Australian veterinary exports to
Mexico, which largely fuel the American black market.
The discontinued Jurox products were quickly transferred to
SYD Group in Australia, assuring they would not be
completely eliminated from commerce. They were
subsequently reintroduced to market in 2002, under the
names Anabolic DN and Anabolic NA, respectively. The
new names made loose reference to the former Jurox
trademarks, likely in an effort to retain some of the original
market for the products. SYD Group had also introduced a
high-dose version of Anabolic DN directly to the Mexican
veterinary drug market, but the product has since been
withdrawn. This time the product was discontinued
following U.S. DEA charges against the firm, alleging that
they were conspiring to illegally export Mexican steroids to
the U.S. Today, the Anabolic DN and Anabolic NA products
remain available on the Australian veterinary drug market,
although tight controls limit diversion for off-label use.
How Supplied:
Nandrolone cypionate is available on the Australian
veterinary drug markets. It is supplied as 50 mg/mL of
steroid dissolved in oil, in a 10 mL vial.
Structural Characteristics:
Nandrolone cypionate is a modified form of nandrolone,
where a carboxylic acid ester (cyclopentylpropionic acid)
has been attached to the 17-beta hydroxyl group. Esterified
steroids are less polar than free steroids, and are absorbed
more slowly from the area of injection. Once in the
bloodstream, the ester is removed to yield free (active)
nandrolone. Esterified steroids are designed to prolong the
window of therapeutic effect following administration,
allowing for a less-frequent injection schedule compared to
injections of free (unesterified) steroid. Nandrolone
cypionate provides a sharp spike in nandrolone release 24-
48 hours following deep intramuscular injection, and sustains
a substantial release of hormone for approximately 2 weeks.
Side Effects (Estrogenic):
Nandrolone has a low tendency for estrogen conversion,
estimated to be only about 20% of that seen with
testosterone.481 This is because while the liver can convert
nandrolone to estradiol, in other more active sites of steroid
aromatization such as adipose tissue nandrolone is far less
open to this process.482 Consequently, estrogen-related side
effects are a much lower concern with this drug than with
testosterone. Elevated estrogen levels may still be noticed
with higher dosing, however, and may cause side effects such
as increased water retention, body fat gain, and
gynecomastia. An anti-estrogen such as clomiphene citrate or
tamoxifen citrate may be necessary to prevent estrogenic side
effects if they occur. One may alternately use an aromatase
inhibitor like Arimidex® (anastrozole), which more
efficiently controls estrogen by preventing its synthesis.
Aromatase inhibitors can be quite expensive in comparison
to anti-estrogens, however, and may also have negative
effects on blood lipids.
It is of note that nandrolone has some activity as a progestin
in the body.483 Although progesterone is a c-19 steroid,
removal of this group as in 19-norprogesterone creates a
hormone with greater binding affinity for its corresponding
receptor. Sharing this trait, many 19-nor anabolic steroids
are shown to have some affinity for the progesterone receptor
as well.484 The side effects associated with progesterone are
similar to those of estrogen, including negative feedback
inhibition of testosterone production and enhanced rate of fat
storage. Progestins also augment the stimulatory effect of
estrogens on mammary tissue growth. There appears to be a
strong synergy between these two hormones here, such that
gynecomastia might even occur with the help of progestins,
without excessive estrogen levels. The use of an antiestrogen,
which inhibits the estrogenic component of this
disorder, is often sufficient to mitigate gynecomastia caused
by nandrolone.
Side Effects (Androgenic):
Although classified as an anabolic steroid, androgenic side
effects are still possible with this substance, especially with
higher doses. This may include bouts of oily skin, acne, and
body/facial hair growth. Anabolic/androgenic steroids may
also aggravate male pattern hair loss. Women are warned of
the potential virilizing effects of anabolic/androgenic
steroids. These may include a deepening of the voice,
menstrual irregularities, changes in skin texture, facial hair
growth, and clitoral enlargement. Nandrolone is a steroid
with relatively low androgenic activity relative to its tissuebuilding
actions, making the threshold for strong androgenic
side effects comparably higher than with more androgenic
agents such as testosterone, methandrostenolone, or
fluoxymesterone. It is also important to point out that due to
its mild androgenic nature and ability to suppress
endogenous testosterone, nandrolone is prone to interfering
with libido in males when used without another androgen.
Note that in androgen-responsive target tissues such as the
skin, scalp, and prostate, the relative androgenicity of
nandrolone is reduced by its reduction to dihydronandrolone
(DHN).485 486 The 5-alpha reductase enzyme is responsible
for this metabolism of nandrolone. The concurrent use of a 5-
alpha reductase inhibitor such as finasteride or dutasteride
will interfere with site-specific reduction of nandrolone
action, considerably increasing the tendency of nandrolone to
produce androgenic side effects. Reductase inhibitors should
be avoided with nandrolone if low androgenicity is desired.
Side Effects (Hepatotoxicity):
Nandrolone is not c-17 alpha alkylated, and not known to
have hepatotoxic effects. Liver toxicity is unlikely.
Side Effects (Cardiovascular):
Anabolic/androgenic steroids can have deleterious effects on
serum cholesterol. This includes a tendency to reduce HDL
(good) cholesterol values and increase LDL (bad)
cholesterol values, which may shift the HDL to LDL balance
in a direction that favors greater risk of arteriosclerosis. The
relative impact of an anabolic/androgenic steroid on serum
lipids is dependant on the dose, route of administration (oral
vs. injectable), type of steroid (aromatizable or nonaromatizable),
and level of resistance to hepatic metabolism.
Studies administering 600 mg of nandrolone decanoate per
week for 10 weeks demonstrated a 26% reduction in HDL
cholesterol levels.487 This suppression is slightly greater
than that reported with an equal dose of testosterone
enanthate, and is in agreement with earlier studies showing a
slightly stronger negative impact on HDL/LDL ratio with
nandrolone decanoate as compared to testosterone
cypionate.488 Nandrolone injectables, however, should still
have a significantly weaker impact on serum lipids than c-17
alpha alkylated agents. Anabolic/androgenic steroids may
also adversely affect blood pressure and triglycerides,
reduce endothelial relaxation, and support left ventricular
hypertrophy, all potentially increasing the risk of
cardiovascular disease and myocardial infarction.
To help reduce cardiovascular strain it is advised to
maintain an active cardiovascular exercise program and
minimize the intake of saturated fats, cholesterol, and simple
carbohydrates at all times during active AAS administration.
Supplementing with fish oils (4 grams per day) and a natural
cholesterol/antioxidant formula such as Lipid Stabil or a
product with comparable ingredients is also recommended.
Side Effects (Testosterone Suppression):
All anabolic/androgenic steroids when taken in doses
sufficient to promote muscle gain are expected to suppress
endogenous testosterone production. For sake of comparison,
studies administering 100 mg per week of nandrolone
decanoate for 6 weeks have demonstrated an approximate
57% reduction in serum testosterone levels during therapy.
At a dosage of 300 mg per week, this reduction reached
70%.489 It is believed that the progestational activity of
nandrolone notably contributes to the suppression of
testosterone synthesis during therapy, which can be marked
in spite of a low tendency for estrogen conversion.490
Without the intervention of testosterone-stimulating
substances, testosterone levels should return to normal within
2-6 months of drug secession. Note that prolonged
hypogonadotrophic hypogonadism can develop secondary to
steroid abuse, necessitating medical intervention.
Administration (Men):
When used for physique- or performance-enhancing
purposes, a dose of 200-400 mg per week is most common,
taken in cycles 8 to 12 weeks in length. This level is
sufficient for most users to notice measurable gains in lean
muscle mass and strength, which should be accompanied by a
low level of estrogenic and androgenic activity. Although
higher doses (450-600 mg) may produce a stronger anabolic
effect, given the relatively low concentration in which this
drug is found (50 mg/mL), doses above 400 mg are not
commonly applied. Instead, the drug is often stacked with
another agent, usually an androgen such as an injectable
testosterone, which also helps offset the very low level of
androgenicity of nandrolone. An oral steroid with
pronounced androgenicity, such as methandrostenolone or
oxymetholone, is sometimes used as well, but will also
present some hepatotoxicity and have a stronger effect on
serum lipids (negatively).
Administration (Women):

When used for physique- or performance-enhancing
purposes, a dosage of 50 mg per week is most common.
Although only slightly androgenic, women are occasionally
confronted with virilization symptoms when taking this
compound. Should virilizing side effects become a concern,
nandrolone cypionate should be discontinued immediately to
help prevent their permanent appearance. After a sufficient
period of withdrawal, the shorter-acting nandrolone
Durabolin® might be considered a safer (more controllable)
option. This drug stays active for only several days, greatly
reducing the withdrawal time if indicated.
Availability:
The only remaining pure nandrolone cypionate product is
Anabolic DN from Australia, produced only in a 50 mg/mL
concentration. It comes in the form of a 10 mL vial, which is
contained in an orange tube.

Dynabol® (nandrolone cypionate) anabolic steroid profile and use in mass building

akn

Musclechemistry Member

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