Striant (testosterone buccal tablets ) performance enhancing drug profile

akn · Jun 13, 2014

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Striant® is a mucoadhesive buccal testosterone delivery
system. It is prepared in the form of a small (aspirin-sized)
tablet, which contains 30 mg of (free) testosterone. The tablet
is not taken orally, but is affixed to the gums, where it
transfers testosterone across the inner lining of the cheek and
into the bloodstream. The buccal delivery of
anabolic/androgenic steroids is not new, and has been used
in the past (with limited success) on agents like
methyltestosterone and testosterone propionate. The adhesive
Striant system, however, is an improvement over the old
rapidly dissolving buccal tablets, as it is much more stable in
the mouth (it stays affixed for 12 hours and needs to be
removed). As such, it provides a much more prolonged and
efficacious delivery of hormone in comparison. Twice daily
dosing is enough to maintain physiological hormone levels
over a 24-hour period.
History:
Striant® was developed in the United States by Columbia
Laboratories. It was approved by the FDA for sale as a
prescription drug in June of 2003, and is indicated for use in
men with conditions associated with a deficiency or absence
of endogenous testosterone. With this product, Columbia was
likely trying to target those hormone replacement therapy
(HRT) consumers that do not welcome biweekly injections,
and find patches and gels uncomfortable or cosmetically
objectionable. Striant was shipped to pharmacies in late
2003, and quickly met with mixed reviews. Some patients
find it a very convenient option for HRT, while others find
the oral tablets too uncomfortable to use for long periods of
time. Striant was released in the UK in 2004 under the Striant
SR (Sustained Release) brand name, licensed and sold by
Ardana Bioscience. Columbia’s partnership with Ardana
expects to see sale of Straint in 18 European markets.
How Supplied:
Striant® mucoadhesive buccal testosterone delivery system
is available in various human drug markets. Product comes in
the form of a small buccal tablet; usually packaged in strips
of 10 tablets, 6 strips to a box.
Structural Characteristics:
Striant® mucoadhesive buccal testosterone delivery system
is a buccal tablet containing 30 mg of (free) testosterone. The
system is adhered to the inside of the mouth, where the gum
meets the upper lip above the incisor teeth.With exposure to
saliva the tablet softens into a gel-like consistency, which
can stay in place for 12 hours. The product delivers
physiological concentrations of testosterone through the
mucous membrane, where it is absorbed into the bloodstream
via the superior vena cava (major blood vessel), bypassing
the liver.
Side Effects (Estrogenic):
Testosterone is readily aromatized in the body to estradiol
(estrogen). The aromatase (estrogen synthetase) enzyme is
responsible for this metabolism of testosterone. Elevated
estrogen levels can cause side effects such as increased
water retention, body fat gain, and gynecomastia.
Testosterone is considered a moderately estrogenic steroid.
Exceeding therapeutic doses will increase the likelihood of
estrogenic side effects. In such cases, an anti-estrogen such
as clomiphene citrate or tamoxifen citrate is commonly
applied to prevent estrogenic side effects. One may
alternately use an aromatase inhibitor like Arimidex®
(anastrozole), which more efficiently controls estrogen by
preventing its synthesis. Aromatase inhibitors can be quite
expensive in comparison to anti-estrogens, however, and
may also have negative effects on blood lipids.
Side Effects (Androgenic):
Testosterone is the primary male androgen, responsible for
maintaining secondary male sexual characteristics.
Exceeding normal therapeutic doses is likely to produce
androgenic side effects including oily skin, acne, and
body/facial hair growth. Men with a genetic predisposition
for hair loss (androgenetic alopecia) may notice accelerated
male pattern balding. Women are warned of the potential
virilizing effects of anabolic/androgenic steroids, especially
with a strong androgen such as testosterone. These may
include deepening of the voice, menstrual irregularities,
changes in skin texture, facial hair growth, and clitoral
enlargement.
In androgen-responsive target tissues such as the skin, scalp,
and prostate, the high relative androgenicity of testosterone is
dependant on its reduction to dihydrotestosterone (DHT).
The 5-alpha reductase enzyme is responsible for this
metabolism of testosterone. The concurrent use of a 5-alpha
reductase inhibitor such as finasteride or dutasteride will
interfere with site-specific potentiation of testosterone
action, lowering the tendency of testosterone drugs to
produce androgenic side effects. It is important to remember
that anabolic and androgenic effects are both mediated via
the cytosolic androgen receptor. Complete separation of
testosterone’s anabolic and androgenic properties is not
possible, even with total 5-alpha reductase inhibition.
Side Effects (Hepatotoxicity):
Testosterone does not have hepatotoxic effects; liver toxicity
is unlikely. One study examined the potential for
hepatotoxicity with high doses of testosterone by
administering 400 mg of the hormone per day (2,800 mg per
week) to a group of male subjects. The steroid was taken
orally so that higher peak concentrations would be reached in
hepatic tissues compared to intramuscular injections. The
hormone was given daily for 20 days, and produced no
significant changes in liver enzyme values including serum
albumin, bilirubin, alanine-amino-transferase, and alkaline
phosphatases.580
Side Effects (Cardiovascular):
Anabolic/androgenic steroids can have deleterious effects on
serum cholesterol. This includes a tendency to reduce HDL
(good) cholesterol values and increase LDL (bad)
cholesterol values, which may shift the HDL to LDL balance
in a direction that favors greater risk of arteriosclerosis. The
relative impact of an anabolic/androgenic steroid on serum
lipids is dependant on the dose, route of administration (oral
vs. injectable), type of steroid (aromatizable or nonaromatizable),
and level of resistance to hepatic metabolism.
Anabolic/androgenic steroids may also adversely affect
blood pressure and triglycerides, reduce endothelial
relaxation, and support left ventricular hypertrophy, all
potentially increasing the risk of cardiovascular disease and
myocardial infarction. Therapeutic doses of testosterone
used to correct insufficient androgen production in otherwise
healthy aging men are unlikely to increase atherogenic risk,
and may actually reduce the risk of cardiovascular
mortality.581
To help reduce cardiovascular strain it is advised to
maintain an active cardiovascular exercise program and
minimize the intake of saturated fats, cholesterol, and simple
carbohydrates at all times during active AAS administration.
Supplementing with fish oils (4 grams per day) and a natural
cholesterol/antioxidant formula such as Lipid Stabil or a
product with comparable ingredients is also recommended.
Side Effects (Testosterone Suppression):
All anabolic/androgenic steroids when taken in doses
sufficient to promote muscle gain are expected to suppress
endogenous testosterone production. Testosterone is the
primary male androgen, and offers strong negative feedback
on endogenous testosterone production. Testosterone-based
drugs will, likewise, have a strong effect on the hypothalamic
regulation of natural steroid hormones. Without the
intervention of testosterone-stimulating substances,
testosterone levels should return to normal within 1-4 months
of drug secession. Note that prolonged hypogonadotrophic
hypogonadism can develop secondary to steroid abuse,
necessitating medical intervention.
Administration (General):
The Striant mucoadhesive buccal testosterone delivery
system is placed on the gums just above the incisor tooth. It
is left affixed for 12 hours, at which point it is carefully
removed. The product is usually administered twice daily.
The application site should be rotated between left and right
sides of the mouth with each dose.
Administration (Men):
To treat androgen insufficiency, the prescribing guidelines
for Striant recommend administering one buccal tablet twice
daily. Doses are given once in the morning and once at night,
12 hours apart. For physique- or performance-enhancing
purposes, higher doses would be necessary to achieve
supraphysiological levels of testosterone. This will be
difficult, if not impractical, given the method of delivery.
Such use would require a minimum of 4 systems per day, a
level sufficient for most users to notice significant gains in
muscle size and strength, but not much comfort. Lower
(therapeutic) doses may be effective when accompanied by
other anabolic/androgenic steroids. Testosterone is
ultimately very versatile, and can be combined with many
other anabolic/androgenic steroids to tailor the desired
effect.
Administration (Women):
The Striant mucoadhesive buccal testosterone delivery
system is not FDA-approved for use in women. Testosterone
is not recommended for women for physique- or
performance-enhancing purposes due to its strong androgenic
nature and tendency to produce virilizing side effects.
Availability:
Given its high relative price and low delivery of
testosterone, Striant is not commonly traded on the black
market. Counterfeits have not yet been reported.

Presser · Jun 13, 2014

i don't think i would want something fixed to my gums for 12 hours, thats insane , good read though brutha

akn · Jun 13, 2014

guys who keep tobacco can manage i guess lol

Striant (testosterone buccal tablets ) performance enhancing drug profile

akn

Musclechemistry Member

Presser

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akn

Musclechemistry Member

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