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View Full Version : Fertodur® (cyclofenil) non-steroidal anti estrogen profile and its PCT benefits



akn
06-17-2014, 05:05 PM
<!--[if gte mso 9]><xml> <w:WordDocument> <w:View>Normal</w:View> <w:Zoom>0</w:Zoom> <w:TrackMoves/> <w:TrackFormatting/> <w:PunctuationKerning/> <w:ValidateAgainstSchemas/> <w:SaveIfXMLInvalid>false</w:SaveIfXMLInvalid> <w:IgnoreMixedContent>false</w:IgnoreMixedContent> <w:AlwaysShowPlaceholderText>false</w:AlwaysShowPlaceholderText> <w:DoNotPromoteQF/> <w:LidThemeOther>EN-US</w:LidThemeOther> <w:LidThemeAsian>X-NONE</w:LidThemeAsian> <w:LidThemeComplexScript>X-NONE</w:LidThemeComplexScript> <w:Compatibility> <w:BreakWrappedTables/> <w:SnapToGridInCell/> <w:WrapTextWithPunct/> <w:UseAsianBreakRules/> <w:DontGrowAutofit/> <w:SplitPgBreakAndParaMark/> <w:DontVertAlignCellWithSp/> <w:DontBreakConstrainedForcedTables/> <w:DontVertAlignInTxbx/> <w:Word11KerningPairs/> <w:CachedColBalance/> <w:UseFELayout/> </w:Compatibility> <w:DoNotOptimizeForBrowser/> <m:mathPr> <m:mathFont m:val="Cambria Math"/> <m:brkBin m:val="before"/> <m:brkBinSub m:val="--"/> <m:smallFrac m:val="off"/> <m:dispDef/> <m:lMargin m:val="0"/> <m:rMargin m:val="0"/> <m:defJc m:val="centerGroup"/> <m:wrapIndent m:val="1440"/> <m:intLim m:val="subSup"/> <m:naryLim m:val="undOvr"/> </m:mathPr></w:WordDocument> </xml><![endif]--> Description:
Cyclofenil is a non-steroidal anti-estrogen that is used in the
treatment of menstrual disturbances and anovualtory
infertility (an inability to ovulate). It is very similar in
structure to Clomid® and Nolvadex®, and also works in the
body as a mixed estrogen agonist/antagonist. This drug is
commonly used for off-label purposes by male bodybuilders
and athletes, typically at the conclusion of a steroid cycle for
the purpose of increasing endogenous testosterone levels.
This is in an attempt to minimize the negative impact that a
period of low androgen levels may have on the physique,
which can include significant muscle loss. The drug HCG is
also commonly used for this purpose, but it works by
mimicking the action of luteinizing hormone, not as an antiestrogen.
HCG is typically looked at as a rapid acting drug,
used in the first couple of weeks after the steroids are
withdrawn. Anti-estrogens like cyclofenil, Clomid® and/or
Nolvadex® are often used in conjunction with HCG, but may
be continued for several weeks after the HCG has been
removed
Cyclofenil stimulates the release of testosterone via its anti
estrogenic action. The hypothalamus is one target site of this.
By interfering with the binding of estrogen to its receptor in
this area of the body, cyclofenil blocks the negative feedback
inhibition brought fourth by this sex hormone. The enhanced
release of gonadotropin releasing hormone (GnRH) may
result, which in turn would stimulate the pituitary to heighten
the release of luteinizing hormone. LH is the primary signal
for the testes to increase the production of testosterone, so its
increased release (provided the testes are properly sensitive
to LH) leads to an elevation in the androgen level. The antiestrogenic
effect of this drug in breast tissue has also led to
its use during a steroid cycle to prevent gynecomastia,
similar to how Nolvadex® might be used. Cyclofenil,
however, is reported to be somewhat weaker than
Nolvadex®, which is usually preferred as an estrogen
maintenance drug. Women do occasionally find a use for
anti-estrogens, most often around contest time when the
management of endogenous estrogens can help increase fat
loss and definition. The side effects that can be brought about
by a lowering of estrogen activity in the female body are
usually strong and uncomfortable, however, making this
approach less than ideal.
History:
Cyclofenil was developed during the early 1960s, a time
when other agents of the same class (such as tamoxifen and
clomiphene) were being thoroughly investigated.
Cyclofenil was soon released as a prescription drug agent,
sold mainly to increase the chance of conception and to
counter certain menopausal symptoms. Although the drug
seemed to offer a good clinical effect without significant
health concerns, it did not see extensive success on the
global market. Instead, Nolvadex and Clomid dominated this
drug category for many decades. Still, cyclofenil did not
completely disappear, and remained available in certain
nations. The most popular brand was Fertodur, produced by
Schering. It was sold in a few countries, including Brazil,
Germany, Italy, Mexico, Switzerland, and Turkey. Other
popular brands have included Rehibin (U.K.), Menopax
(Brazil), Neoclym (Italy), Sexovid (Japan), and Ondogyne
(France). Today, although most original cyclofenil products
have been discontinued, the drug can still be found in some
areas including Turkey, Italy, and Brazil.
How Supplied:
Cyclofenil is most commonly supplied in tablets of 200 mg.
Structural Characteristics:
Cyclofenil is classified as a selective estrogen receptor
modulator, with both agonist and antagonist properties. It has
the chemical designation
4,4’(Cyclohexylidenemethylene)bis(phenyl acetate).
Side Effects:
Cyclofenil appears to be well tolerated, with a low
incidence of significant side effects. Common adverse
reactions include liver enzyme elevations, vasomotor flushes
(hot flashes), abdominal discomfort, nausea/vomiting, breast
discomfort, headache, and abnormal uterine bleeding.
Premenopausal women may be more susceptible to hot
flashes due to the stronger effect estrogenic disruption can
have on this population. In males, the testosterone boosting
properties of cyclofenil may result in some androgenic side
effects including oily skin, acne, and increased libido.
Administration:
Cyclofenil is most commonly used (medically) to treat
anovulatory infertility. Therapeutic protocols recommend a
dose of 200 mg three times per day for 5 days, which is
initiated near the start of the menstrual cycle. If pregnancy is
not achieved with the first cycle, it may be used for 3 or 4
cycles in total. In some instances the drug is also given in
lower doses to treat menopausal symptoms. When used after
steroid administration (off-label) to increase natural
testosterone production, a dosage 400-600 mg per day is the
most common. It is often used for a period of 4 to 5 weeks as
part of a comprehensive post-cycle recovery program in
place of Clomid Similar
doses are used for estrogen maintenance purposes while oncycle,
although Nolvadex is usually given preference for this
purpose. Some athletes have experimented with using
cyclofenil as a standalone anabolic, finding its ability to
increase testosterone levels beneficial. The dosage used for
this purpose is typically 400-600 mg per day for 6-8 weeks.
While some have reported this approach to be effective,
many others find the drug too mild, especially in light of the
effects of exogenous testosterone.
Availability:
Cyclofenil is not widely produced. Availability is presently
low on the international market. When located in the U.S., the
drug is usually found in the form of Fertodur, made by
Schering in Turkey. Counterfeits of cyclofenil drugs have not
been a significant problem.

BY WL
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